Journal
MOLECULAR NUTRITION & FOOD RESEARCH
Volume 58, Issue 7, Pages 1519-1527Publisher
WILEY
DOI: 10.1002/mnfr.201300723
Keywords
CORDIOPREV study; Gene-diet interaction; Metabolic syndrome; Postprandial lipemia; TNF-alpha gene
Categories
Funding
- Fundacion Patrimonio Comunal Olivarero
- Junta de Andalucia (Consejeria de Salud)
- Junta de Andalucia (Consejeria de Agricultura y Pesca)
- Junta de Andalucia (Consejeria de Innovacion)
- Junta de Andalucia (Ciencia y Empresa)
- Diputaciones de Jaen y Cordoba
- Centro de Excelencia en Investigacion sobre Aceite de Oliva y Salud
- Ministerio de Medio Ambiente, Medio Rural y Marino, Gobierno de Espana
- Ministerio de Ciencia e Innovacion [AGL2009-122270, FIS PI10/01041]
- Ministerio de Economia y Competitividad [AGL2012/39615]
- Consejeria de Salud, Junta de Andalucia [PI0193/09]
- Proyecto de Excelencia, Consejeria de Economia, Innovacion, Ciencia y Empleo [CVI-7450]
- Merck Serono
- Fundacion 2000 (Clinical research in Cardiometabolic)
- ISCIII
- [PI-0252/09]
- [PI-0058/10]
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Scope: To examine whether the consumption of a Mediterranean diet (MedDiet), compared with a low-fat diet, interacts with two single nucleotide polymorphisms at the tumor necrosis factor alpha gene (rs1800629, rs1799964) in order to improve triglycerides (TG), glycemic control, and inflammation markers. Methods and results: Genotyping, biochemical measurements, dietary intervention, and oral fat load test meal were determined in 507 metabolic syndrome (MetS) patients selected from all the subjects included in CORDIOPREV clinical trial (n = 1002). At baseline, G/G subjects (n = 408) at the rs1800629 polymorphism, showed higher fasting and postprandial TG (p = 0.003 and p = 0.025, respectively), and high sensitivity C-reactive protein (hsCRP) (p = 0.003) plasma concentrations than carriers of the minorA-allele (G/A + A/A) (n = 99). After 12 months of MedDiet, baseline differences between genotypes disappeared. The decrease in TG and hsCRP was statistically significant in G/G subjects (n = 203) compared with carriers of the minor A-allele (p = 0.005 and p = 0.034, respectively) (n = 48). No other gene-diet interactions were observed in either diet. Conclusion: These results suggest that the rs1800629 at the tumor necrosis factor alpha gene interacts with MedDiet to influence TG metabolism and inflammation status in MetS subjects. Understanding the role of gene-diet interactions may be the best strategy for personalized treatment of MetS.
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