Article
Chemistry, Applied
Manzar Alam, Sabeeha Ali, Ghulam Md Ashraf, Anwar L. Bilgrami, Dharmendra Kumar Yadav, Md Imtaiyaz Hassan
Summary: Epigallocatechin 3-gallate (EGCG), a polyphenolic component derived from green tea extract, possesses various biological functions, including anti-cancer and anti-inflammatory properties. It modulates multiple signaling pathways to inhibit tumor growth and induce cell death. EGCG also exhibits antioxidant, anti-angiogenic, and apoptotic effects. Therefore, EGCG shows potential in cancer treatment.
Article
Biochemistry & Molecular Biology
Yi-Ping Luo, Xiao-Fang Tang, Yi-Chi Zhang, Su-Mei Chen, Qiong Wu, Wen-Juan Li
Summary: The study demonstrated that epigallocatechin-3-gallate (EGCG), a tea polyphenol, could modulate gut-brain communication in a mouse aging model. EGCG improved aging-associated changes by increasing immune organ and brain indexes, as well as enhancing learning and memory abilities. The protection of the aging brain by EGCG was associated with reduced lipid peroxidation and increased antioxidant activities. Additionally, EGCG attenuated the hypothalamic-pituitary-adrenal axis and enhanced the content of short-chain fatty acids (SCFAs) in aging mice.
Article
Cell Biology
Dongjie Zhou, Ming -Hong Sun, Wen-Jie Jiang, Xiao-Han Li, Song -Hee Lee, Geun Heo, Ying- Jie Niu, Sun A. Ock, Xiang -Shun Cui
Summary: This study found that EGCG can delay porcine oocyte aging by inhibiting oxidative stress and promoting mitochondrial biogenesis. An optimal concentration of EGCG can maintain oocyte morphology and developmental competence, and prevent aging-induced oxidative stress, apoptosis, and autophagy.
Review
Biochemistry & Molecular Biology
Daniela Mokra, Jana Adamcakova, Juraj Mokry
Summary: This article reviews the biological effects of (-)-Epigallocatechin-3-gallate (EGCG) in respiratory diseases, including antioxidant, anti-inflammatory, anti-fibrotic, pro-apoptotic, anti-tumorous, and metabolic effects. EGCG may be beneficial in respiratory diseases through modulation of various intracellular signaling cascades.
Review
Pharmacology & Pharmacy
Sze Wan Hung, Yiran Li, Xiaoyan Chen, Kai On Chu, Yiwei Zhao, Yingyu Liu, Xi Guo, Gene Chi-Wai Man, Chi Chiu Wang
Summary: Green tea, with its main component EGCG, shows potential in suppressing reproductive cancers by regulating autophagy and other cellular processes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Honghui Zhang, Wei Su, Rusong Zhao, Mei Li, Shigang Zhao, Zi-Jiang Chen, Han Zhao
Summary: This study delves into the precise impact and underlying mechanisms of EGCG on aged oocytes. Both in vitro and in vivo experiments demonstrate EGCG's capacity to enhance the quality of aged oocytes. In vitro application of EGCG yields remarkable improvements, including heightened rates of first polar body extrusion, refined spindle morphology, enhanced mitochondrial function, and reduced oxidative stress. Besides, EGCG may enhance Arf6 expression through direct interaction in aged oocytes, consequently promoting the assembly of spindle-associated F-actin and mitigating the aneuploidy induced by the disruption of spindle F-actin. In addition, these positive outcomes are corroborated by enhanced fertility observed in aged mice, providing a therapeutic intervention to address fertility challenges associated with advanced age.
CELL PROLIFERATION
(2023)
Article
Biochemistry & Molecular Biology
Sejin Kim, Hyunjae Lee, Hanbyeol Moon, Ran Kim, Minsuk Kim, Seongtae Jeong, Hojin Kim, Sang Hyeon Kim, Soo Seok Hwang, Min Young Lee, Jongmin Kim, Byeong-Wook Song, Woochul Chang
Summary: Cardiac tissue damage following ischemia leads to cardiomyocyte apoptosis and myocardial fibrosis. The active polyphenol flavonoid or catechin epigallocatechin-3-gallate (EGCG) protects ischemic myocardium and is involved in the regulation of endothelial-to-mesenchymal transition (EndMT). In this study, EGCG treatment was shown to regenerate ischemic tissue and induce cardioprotection by regulating proteins associated with the EndMT process, as well as positively regulating cardiomyocyte apoptosis and fibrosis.
Review
Biochemistry & Molecular Biology
Daniela Mokra, Marta Joskova, Juraj Mokry
Summary: (
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jana Adamcakova, Sona Balentova, Romana Barosova, Juliana Hanusrichterova, Pavol Mikolka, Kristian Prso, Juraj Mokry, Zuzana Tatarkova, Dagmar Kalenska, Daniela Mokra
Summary: This study aimed to evaluate the early effects of EGCG on markers of inflammation and lung fibrosis in silicotic rats. The results showed that early treatment with EGCG had the potential to alleviate inflammation and oxidative stress-induced changes, and prevent fibrotic changes in the bronchioles and pulmonary vessels. However, further investigations are needed to elucidate the effects of EGCG in the lung silicosis model and its potential adverse effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Feng Li, Syeda Qasim, Dapeng Li, Q. Ping Dou
Summary: In-depth insights on cancer biology have highlighted the important roles of epigenetic mechanisms in tumorigenesis. Targeting the cancer epigenome with epi-drugs, including phytochemicals like EGCG, offers promising strategies for cancer chemoprevention and therapy. However, there are limitations to using EGCG as an epigenetic modulator in cancer treatment.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Liangwei Mei, Yi Zheng, Teng Ma, Bing Xia, Xue Gao, Yiming Hao, Zhuojing Luo, Jinghui Huang
Summary: The circadian clock is crucial for managing daily physiological and metabolic processes, and disturbances can lead to degenerative diseases. EGCG, a compound with antioxidant properties, has been found to have protective effects on intervertebral disc degeneration by entraining the biological clock. This study provides evidence that EGCG's protective effects on NPCs are related to the circadian clock and depend on the core clock gene Bmal1.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ken-Ichiro Tanaka, Shunsuke Nakaguchi, Sachie Shiota, Yuka Nakada, Kaho Oyama, Okina Sakakibara, Mikako Shimoda, Akio Sugimoto, Masaki Ichitani, Takanobu Takihara, Hitoshi Kinugasa, Masahiro Kawahara
Summary: Components of green tea, such as EGCG, have protective effects against respiratory diseases and prevent acute lung injury caused by urban aerosols by inhibiting oxidative stress reactions and inflammation.
Article
Medicine, Research & Experimental
Hong Wei, Jun Qin, Quanxin Huang, Zhiqiang Jin, Li Zheng, Jinmin Zhao, Zainen Qin
Summary: Metal-polyphenol nanoformulations (Cu-EGCG nanosheets) were synthesized and found to possess antioxidant and anti-inflammatory effects. The nanosheets effectively reduced pro-inflammatory cytokine expression and shifted macrophages to M2 phenotypes. The secreted factor from the treated macrophages showed anti-inflammatory potential in chondrocytes. This study suggests a novel strategy for osteoarthritis therapy targeting macrophages.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Yumin Wang, Shuang Wu, Qiang Li, Weihong Lang, Wenjing Li, Xiaodong Jiang, Zhirong Wan, Jichao Chen, Hongquan Wang
Summary: This review summarizes the recent updates and knowledge of the molecular mechanisms underlying the neuroprotective effects of epigallocatechin 3-gallate (EGCG) derived from green tea extract in Parkinson's disease (PD). The review highlights the pleiotropic effects of EGCG, including anti-apoptotic, anti-oxidative stress, anti-inflammatory, modulation of dopamine production, and inhibition of alpha-synuclein aggregation, which make it a promising neuroprotective compound for the treatment of PD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
John M. Starbuck, Sergi Llambrich, Ruben Gonzalez, Julia Albaiges, Anna Sarle, Jens Wouters, Alejandro Gonzalez, Xavier Sevillano, James Sharpe, Rafael De La Torre, Mara Dierssen, Greetje Vande Velde, Neus Martinez-Abadias
Summary: The study found that in the DS mouse model, low doses of GTE-EGCG were beneficial for improving facial skeletal morphology, while early supplementation of EGCG in DS children was associated with reduced facial dysmorphology. However, high doses of GTE-EGCG usage led to increased facial dysmorphology, indicating dose-dependent effects of GTE-EGCG on modulating facial development.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Chesney K. Richter, Ann C. Skulas-Ray, Trent L. Gaugler, Joshua D. Lambert, David N. Proctor, Penny M. Kris-Etherton
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2017)
Article
Chemistry, Applied
Shannon L. Glisan, Kimberly A. Grove, Neela H. Yennawar, Joshua D. Lambert
Article
Biochemistry & Molecular Biology
Zachary T. Bitzer, Amy L. Wopperer, Benjamin J. Chrisfield, Ling Tao, Timothy K. Cooper, Jairam Vanamala, Ryan J. Elias, John E. Hayes, Joshua D. Lambert
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2017)
Article
Oncology
Xingpei Hao, Hang Xiao, Jihyeung Ju, Mao-Jung Lee, Joshua D. Lambert, Chung S. Yang
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2017)
Article
Biochemistry & Molecular Biology
Caroline M. Ryan, Weslie Khoo, Amanda C. Stewart, Sean F. O'Keefe, Joshua D. Lambert, Andrew P. Neilson
Article
Endocrinology & Metabolism
J. A. Vernarelli, J. D. Lambert
NUTRITION & DIABETES
(2017)
Article
Food Science & Technology
Karma D. James, Mary J. Kennett, Joshua D. Lambert
FOOD AND CHEMICAL TOXICOLOGY
(2018)
Article
Chemistry, Applied
Todd H. Stanley, Charlene B. Van Buiten, Scott A. Baker, Ryan J. Elias, Ramaswamy C. Anantheswaran, Joshua D. Lambert
Article
Food Science & Technology
Charlene B. Van Buiten, Joshua D. Lambert, Ryan J. Elias
MOLECULAR NUTRITION & FOOD RESEARCH
(2018)
Article
Food Science & Technology
Kathryn C. Racine, Andrew H. Lee, Brian D. Wiersema, Haibo Huang, Joshua D. Lambert, Amanda C. Stewart, Andrew P. Neilson
Meeting Abstract
Biochemistry & Molecular Biology
Weslie Y. H. Khoo, Shu-Wei Huang, Benjamin J. Chrisfield, Sudathip Sae-tan, Joshua D. Lambert
Meeting Abstract
Biochemistry & Molecular Biology
Benjamin J. Chrisfield, Weslie Y. H. Khoo, Joshua D. Lambert
Meeting Abstract
Biochemistry & Molecular Biology
Charlene B. Van Buiten, Joshua D. Lambert, Sudathip Sae-tan, Ryan J. Elias
Meeting Abstract
Zoology
A. B. Johnson, N. S. Fogel, J. D. Lambert
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2017)
Article
Education, Scientific Disciplines
Alexandra B. Ferrante, Joshua Lambert, Markos Leggas, Esther P. Black
AMERICAN JOURNAL OF PHARMACEUTICAL EDUCATION
(2017)