Differential regulation of detoxification enzymes in hepatic and mammary tissue by hops (Humulus lupulus) in vitro and in vivo

Hops (Humulus lupulus) Inhibits Oxidative Estrogen Metabolism and Estrogen-Induced Malignant Transformation in Human Mammary Epithelial cells (MCF-10A)

(2011) L. P. Hemachandra et al.   Cancer Prevention Research

Induction of NAD(P)H-quinone oxidoreductase 1 by antioxidants in female ACI rats is associated with decrease in oxidative DNA damage and inhibition of estrogen-induced breast cancer

(2011) B. Singh et al.   CARCINOGENESIS

Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents

(2011) Larry G. Higgins et al.   DRUG METABOLISM REVIEWS

Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration

(2011) LeeCole Legette et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer

(2010) Yuan Yao et al.   BREAST CANCER RESEARCH AND TREATMENT

Cancer Chemopreventive Activity and Metabolism of Isoliquiritigenin, a Compound Found in Licorice

(2010) M. Cuendet et al.   Cancer Prevention Research

Xanthohumol, a chalcon derived from hops, inhibits hepatic inflammation and fibrosis

(2010) Christoph Dorn et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Xanthohumol, a prenylated flavonoid contained in beer, prevents the induction of preneoplastic lesions and DNA damage in liver and colon induced by the heterocyclic aromatic amine amino-3-methyl-imidazo[4,5-f]quinoline (IQ)

(2010) Franziska Ferk et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

A randomized, double-blind, placebo-controlled, cross-over pilot study on the use of a standardized hop extract to alleviate menopausal discomforts

(2010) R. Erkkola et al.   PHYTOMEDICINE

Estrogen Receptor α Enhances the Rate of Oxidative DNA Damage by Targeting an Equine Estrogen Catechol Metabolite to the Nucleus

(2009) Zhican Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antioxidant-induced modification of INrf2 cysteine 151 and PKC-δ-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance

(2009) Suryakant K. Niture et al.   JOURNAL OF CELL SCIENCE

Targeting NRF2 signaling for cancer chemoprevention

(2009) Mi-Kyoung Kwak et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Epigallocatechin activates haem oxygenase-1 expression via protein kinase Cδ and Nrf2

(2008) Richard M. Ogborne et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Modification of the cysteine residues in I B  kinase and NF- B (p65) by xanthohumol leads to suppression of NF- B-regulated gene products and potentiation of apoptosis in leukemia cells

(2008) K. B. Harikumar et al.   BLOOD

Soy isoflavones decrease the catechol-O-methyltransferase-mediated inactivation of 4-hydroxyestradiol in cultured MCF-7 cells

(2008) Leane Lehmann et al.   CARCINOGENESIS

In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin

(2008) Cassia R. Overk et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Polymeric black tea polyphenols induce phase II enzymes via Nrf2 in mouse liver and lungs

(2008) Rachana Patel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2 as a Master Redox Switch in Turning on the Cellular Signaling Involved in the Induction of Cytoprotective Genes by Some Chemopreventive Phytochemicals

(2008) Young-Joon Surh et al.   PLANTA MEDICA

Antigenotoxic effect of Xanthohumol in rat liver slices

(2007) Janja Plazar et al.   TOXICOLOGY IN VITRO