Article
Cell Biology
Claire Bryant, Rachel Cianciolo, Rajgopal Govindarajan, Shipra Agrawal
Summary: Adriamycin-induced nephropathy is a common model for studying FSGS, but its application in C57BL/6 mice is limited. We systematically investigated the specifics of ADR-nephrosis in C57BL/6 N and J substrains. Our findings showed that N substrain exhibited more severe proteinuria and renal lesions compared to J substrain. This provides a reproducible mouse model for FSGS in a previously assumed ADR-resistant strain and highlights the differences between J and N substrains.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Plant Sciences
Alona Telerman, Uzi Ravid, Nativ Dudai, Anat Elmann
Summary: Geranium oil improved motor performance and prevented dopaminergic neuron death in a mouse model for Parkinson's disease, potentially through its antioxidant and anti-inflammatory properties.
PLANT FOODS FOR HUMAN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Seulah Lee, Yeon Ji Suh, Yujeong Lee, Seonguk Yang, Dong Geun Hong, Dinakaran Thirumalai, Seung-Cheol Chang, Ki Wung Chung, Young-Suk Jung, Hyung Ryong Moon, Hae Young Chung, Jaewon Lee
Summary: This study investigated the neuroprotective effects of the barbiturate derivative, MHY2699, in a mouse model of Parkinson's disease. The results showed that MHY2699 ameliorated neuroinflammation, inhibited motor dysfunction, and prevented dopaminergic neuronal death in the MPTP-induced mouse model, suggesting its potential as a treatment for PD.
Article
Virology
Huan Yang, Xiaoli Wang, Zhao Wang, Guowei Wang, Shihong Fu, Fan Li, Liping Yang, Yanping Yuan, Kaichun Shen, Huanyu Wang, Zhenhai Wang
Summary: This study established a mouse model of JEV infection using JEV GIb NX1889 strain. The model showed general neurological signs on day 3, with motor function deteriorating the most in the 10^5 PFU and 10^6 PFU groups. Microscopy and immunofluorescence staining revealed varying degrees of demyelination and axonal degeneration in the sciatic nerves. Electrophysiological recordings demonstrated peripheral neuropathy with reduced nerve conduction velocity. Increased expression of JEV-E protein and viral RNA in the injured sciatic nerves suggested its role in early stage PNI. Inflammatory cell infiltration and increased inflammatory cytokines indicated neuroinflammation involvement in JEV-induced PNI.
JOURNAL OF VIROLOGY
(2023)
Article
Immunology
Yunjuan Zhao, Vilma Urbonaviciute, Bingze Xu, Weiwei Cai, Zeynep Sener, Changrong Ge, Rikard Holmdahl
Summary: A new model for rheumatoid arthritis has been established in C57BL/6 mice by immunization with human cartilage oligomeric matrix protein (COMP). This model is dependent on a COMP specific peptide binding A(b) and induces severe arthritis with high incidence in C57BL/6NJ (B6N) mice.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Manuj Ahuja, Navneet Ammal Kaidery, Otis C. Attucks, Erin McDade, Dmitry M. Hushpulian, Arsen Gaisin, Irina Gaisina, Young Hoon Ahn, Sergey Nikulin, Andrey Poloznikov, Irina Gazaryan, Masayuki Yamamoto, Mitsuyo Matsumoto, Kazuhiko Igarashi, Sudarshana M. Sharma, Bobby Thomas
Summary: Research suggests that genetic deletion or pharmacologic inhibition of Bach1 could be a promising therapeutic approach for Parkinson's disease, offering neuroprotection and reducing oxidative damage and neuroinflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Toxicology
Ziwei Wang, Shen Chen, Yaqin Pang, Lizhu Ye, Qi Zhang, Xinhang Jiang, Rui Zhang, Miao Li, Zhanyu Guo, Yue Jiang, Daochuan Li, Xiumei Xing, Liping Chen, Michael Aschner, Wen Chen
Summary: Intestinal organoids can be used as an alternative model for toxicity testing, but the relationship between specific morphological changes in organoids and chemical-induced toxicity needs further exploration. In this study, we generated mouse intestinal organoids and analyzed the morphological changes induced by four metals (cadmium, lead, hexavalent chromium, and trivalent arsenic). These morphological alterations were concentration-dependent and correlated with specific intestinal toxic effects. The benchmark dose values of morphological alterations were lower than those of conventional bioassays. We also found that the morphological features of organoids were metal-specific and mediated by different signaling pathways. These findings provide valuable insights into the relevance of morphological alterations in organoids to specific toxic endpoints.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sangeun Han, Sabina Lim, Sujung Yeo
Summary: This study investigated the potential relationship between ITGA7 and alpha-syn in the muscle of MPTP-induced mice and C2C12 cells. The results suggest that decreased ITGA7 expression in muscle could increase alpha-syn expression, which may contribute to the pathology of Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ya-Jen Chiu, Chih-Hsin Lin, Chung-Yin Lin, Pei-Ning Yang, Yen-Shi Lo, Yu-Chieh Chen, Chiung-Mei Chen, Yih-Ru Wu, Ching-Fa Yao, Kuo-Hsuan Chang, Guey-Jen Lee-Chen
Summary: Neuroinflammation and oxidative stress are important contributors to Parkinson's disease (PD) pathogenesis. The indole derivative NC009-1 shows potential against neuroinflammation, oxidative stress, and neurodegeneration in PD. In vitro, NC009-1 reduces cytotoxicity and inflammatory factor production, and suppresses inflammasome activation. In vivo, NC009-1 improves motor deficits and depression, increases dopamine levels, and reduces oxidative stress and glial cell reactivity. These effects are achieved by regulating inflammatory and antioxidant factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Musa Mustapha, Che Norma Mat Taib
Summary: MPTP, a neurotoxin commonly used in mouse models of Parkinson's disease, has led to new perspectives on PD research and the development of promising therapeutic agents.
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2021)
Article
Biology
Molly C. Craig, Larissa O. Silva, Steven J. Swoap
Summary: The study found that fasted mice tend to prefer warmer ambient temperatures when given the choice, especially in a selective environment. Additionally, fasted mice are more likely to maintain a higher body temperature in warm environments, which is beneficial for metabolism.
JOURNAL OF THERMAL BIOLOGY
(2021)
Article
Environmental Sciences
Camila G. Dantas, Ailma O. da Paixao, Tassia L. G. M. Nunes, Italo J. F. Silva, Bruno dos S. Lima, Adriano A. S. Araujo, Ricardo L. C. de Albuquerque-Junior, Katia P. Gramacho, Francine F. Padilha, Luiz P. da Costa, Patricia Severino, Juliana C. Cardoso, Eliana B. Souto, Margarete Z. Gomes
Summary: This study evaluated the neuroprotective effects of Africanized bee venom (BV) on a mice model of Parkinson's disease induced by 6-hydroxydopamine (6-OHDA). The results showed that BV could counteract the symptoms caused by 6-OHDA, reduce cell death, and protect the striatum from damage. These findings suggest that Africanized bee venom may have potential as a novel therapeutic approach for Parkinson's disease.
Article
Biochemistry & Molecular Biology
Xuexia Li, Linfeng Le, Qingqing Shi, Hao Xu, Chao Wang, Yufang Xiong, Xun Wang, Guoli Wu, Qiong Liu, Xiubo Du
Summary: The pathogenesis of Alzheimer's disease (AD) is complex and multifactorial. Tau pathology is more related to clinical symptoms and severity of AD compared to A beta. The interaction between Zn2+ and tau plays a role in tau toxicity, but the mechanism is not fully understood.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Immunology
Harrison C. Bergeron, Zachary Beau Reneer, Aakash Arora, Stephen Reynolds, Tamas Nagy, Ralph A. Tripp
Summary: Influenza B viruses primarily infect humans and cause severe respiratory diseases, particularly in young children and the elderly. The immune response to the virus is the major cause of morbidity, mortality, and lung pathology.
Article
Multidisciplinary Sciences
Khairiah Razali, Mohd Hamzah Mohd Nasir, Noratikah Othman, Abd Almonem Doolaanea, Jaya Kumar, Wisam Nabeel Ibrahim, Wael M. Y. Mohamed
Summary: Parkinson's disease is a common brain motor disorder characterized by motor impairments. Research on the pathogenesis of PD is ongoing, and zebrafish has emerged as a useful model for studying PD. This study demonstrates the effects of MPTP on zebrafish swimming behavior and provides insights into the establishment of PD animal models.
