4.8 Article

HLA class II genes modulate vaccine-induced antibody responses to affect HIV-1 acquisition

Journal

SCIENCE TRANSLATIONAL MEDICINE
Volume 7, Issue 296, Pages -

Publisher

AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.aab4005

Keywords

-

Funding

  1. Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. [W81XWH-07-2-0067]
  2. U.S. Department of Defense, Bill & Melinda Gates Foundation (Collaboration for AIDS Vaccine Discovery) [W81XWH-07-2-0067, OPP1032144]
  3. NIH/NIAID [UM1 AI068618, AI064518]
  4. U.S. National Institute of Allergy and Infectious Disease

Ask authors/readers for more resources

In the RV144 vaccine trial, two antibody responses were found to correlate with HIV-1 acquisition. Because human leukocyte antigen (HLA) class II-restricted CD4(+) T cells are involved in antibody production, we tested whether HLA class II genotypes affected HIV-1-specific antibody levels and HIV-1 acquisition in 760 individuals. Indeed, antibody responses correlated with acquisition only in the presence of single host HLA alleles. Envelope (Env)-specific immunoglobulin A (IgA) antibodies were associated with increased risk of acquisition specifically in individuals with DQB1*06. IgG antibody responses to Env amino acid positions 120 to 204 were higher and were associated with decreased risk of acquisition and increased vaccine efficacy only in the presence of DPB1*13. Screening IgG responses to overlapping peptides spanning Env 120-204 and viral sequence analysis of infected individuals defined differences in vaccine response that were associated with the presence of DPB1*13 and could be responsible for the protection observed. Overall, the underlying genetic findings indicate that HLA class II modulated the quantity, quality, and efficacy of antibody responses in the RV144 trial.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available