Crosstalk Between Inflammation and Glutamate System in Depression: Signaling Pathway and Molecular Biomarkers for Ketamine’s Antidepressant Effect

Change in cytokine levels is not associated with rapid antidepressant response to ketamine in treatment-resistant depression

(2017) Minkyung Park et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Altered peripheral immune profiles in treatment-resistant depression: response to ketamine and prediction of treatment outcome

(2017) D D Kiraly et al.   Translational Psychiatry

Effects of IL1B single nucleotide polymorphisms on depressive and anxiety symptoms are determined by severity and type of life stress

(2016) David Kovacs et al.   BRAIN BEHAVIOR AND IMMUNITY

Interleukin-6 promoter polymorphism interacts with pain and life stress influencing depression phenotypes

(2016) David Kovacs et al.   JOURNAL OF NEURAL TRANSMISSION

The role of adipokines in the rapid antidepressant effects of ketamine

(2016) R Machado-Vieira et al.   MOLECULAR PSYCHIATRY

Conceptual convergence: increased inflammation is associated with increased basal ganglia glutamate in patients with major depression

(2016) E Haroon et al.   MOLECULAR PSYCHIATRY

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

(2016) Panos Zanos et al.   NATURE

BDNF – a key transducer of antidepressant effects

(2016) Carl Björkholm et al.   NEUROPHARMACOLOGY

Genetic Contributions of Inflammation to Depression

(2016) Jacob Barnes et al.   NEUROPSYCHOPHARMACOLOGY

Inflammation, Glutamate and Glia: A Trio of Trouble in Mood Disorders

(2016) Ebrahim Haroon et al.   NEUROPSYCHOPHARMACOLOGY

Effectiveness of low-dose intravenous ketamine to attenuate stress response in patients undergoing emergency cesarean section with spinal anesthesia

(2016) AA Gde Putra Semara Jaya et al.   Journal of Pain Research

Cytokine Polymorphisms in the Pathophysiology of Mood Disorders

(2016) Mario Clerici et al.   CNS SPECTRUMS

Peripheral proinflammatory markers associated with ketamine response in a preclinical model of antidepressant-resistance

(2015) Adam J. Walker et al.   BEHAVIOURAL BRAIN RESEARCH

Serum Interleukin-6 Is a Predictive Biomarker for Ketamine’s Antidepressant Effect in Treatment-Resistant Patients With Major Depression

(2015) Jian-jun Yang et al.   BIOLOGICAL PSYCHIATRY

Effects of chronic interpersonal stress exposure on depressive symptoms are moderated by genetic variation at IL6 and IL1β in youth

(2015) Margaret Tartter et al.   BRAIN BEHAVIOR AND IMMUNITY

Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder

(2015) Rita Haapakoski et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammation and clinical response to treatment in depression: A meta-analysis

(2015) R. Strawbridge et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Inflammatory Biomarkers as Differential Predictors of Antidepressant Response

(2015) Kenji Hashimoto   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Serum BDNF as a peripheral biomarker of treatment-resistant depression and the rapid antidepressant response: A comparison of ketamine and ECT

(2015) A.P. Allen et al.   JOURNAL OF AFFECTIVE DISORDERS

Neuroimmune mechanisms of depression

(2015) Georgia E Hodes et al.   NATURE NEUROSCIENCE

NMDA receptor activation regulates sociability by its effect on mTOR signaling activity

(2015) Jessica A. Burket et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

C-reactive protein gene variants: independent association with late-life depression and circulating protein levels

(2015) M-L Ancelin et al.   Translational Psychiatry

BDNF Release Is Required for the Behavioral Actions of Ketamine

(2015) A. E. Lepack et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Requirement of AMPA receptor stimulation for the sustained antidepressant activity of ketamine and LY341495 during the forced swim test in rats

(2014) Hiroyuki Koike et al.   BEHAVIOURAL BRAIN RESEARCH

Toll-like receptors in the depressed and suicide brain

(2014) Ghanshyam N. Pandey et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses

(2014) E. S. Gideons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intranigral lipopolysaccharide induced anxiety and depression by altered BDNF mRNA expression in rat hippocampus

(2014) Lucian Hritcu et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity

(2014) Francesca Calabrese et al.   Frontiers in Cellular Neuroscience

Effect of Anti-inflammatory Treatment on Depression, Depressive Symptoms, and Adverse Effects

(2014) Ole Köhler et al.   JAMA Psychiatry

Antidepressant Efficacy of Ketamine in Treatment-Resistant Major Depression: A Two-Site Randomized Controlled Trial

(2013) James W. Murrough et al.   AMERICAN JOURNAL OF PSYCHIATRY

Activation of Mammalian Target of Rapamycin and Synaptogenesis: Role in the Actions of Rapid-Acting Antidepressants

(2013) Jason M. Dwyer et al.   BIOLOGICAL PSYCHIATRY

Ketamine and Peripheral Inflammation

(2013) Marc De Kock et al.   CNS Neuroscience & Therapeutics

Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex

(2013) W. Zhou et al.   EUROPEAN PSYCHIATRY

Plasma brain derived neurotrophic factor (BDNF) and response to ketamine in treatment-resistant depression

(2013) C. N. Haile et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

CRP, IL-6 and depression: A systematic review and meta-analysis of longitudinal studies

(2013) Vyara Valkanova et al.   JOURNAL OF AFFECTIVE DISORDERS

Acute Suppression of Spontaneous Neurotransmission Drives Synaptic Potentiation

(2013) E. Nosyreva et al.   JOURNAL OF NEUROSCIENCE

A recollection of mTOR signaling in learning and memory

(2013) T. E. Graber et al.   LEARNING & MEMORY

mTOR complexes in neurodevelopmental and neuropsychiatric disorders

(2013) Mauro Costa-Mattioli et al.   NATURE NEUROSCIENCE

Conceptual Confluence: The Kynurenine Pathway as a Common Target for Ketamine and the Convergence of the Inflammation and Glutamate Hypotheses of Depression

(2013) Andrew H Miller   NEUROPSYCHOPHARMACOLOGY

GSK-3 Inhibition Potentiates the Synaptogenic and Antidepressant-Like Effects of Subthreshold Doses of Ketamine

(2013) Rong-Jian Liu et al.   NEUROPSYCHOPHARMACOLOGY

NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL/6J Mice

(2013) Adam K Walker et al.   NEUROPSYCHOPHARMACOLOGY

A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers

(2013) Adrian L. Lopresti et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Serotonin and interleukin-6: The role of genetic polymorphisms in IFN-induced neuropsychiatric symptoms

(2013) Marc Udina et al.   PSYCHONEUROENDOCRINOLOGY

Antidepressant effects of AMPA and ketamine combination: role of hippocampal BDNF, synapsin, and mTOR

(2013) Luli Akinfiresoye et al.   PSYCHOPHARMACOLOGY

Ketamine exerts antidepressant effects and reduces IL-1β and IL-6 levels in rat prefrontal cortex and hippocampus

(2013) CHUN YANG et al.   Experimental and Therapeutic Medicine

Does Intraoperative Ketamine Attenuate Inflammatory Reactivity Following Surgery? A Systematic Review and Meta-Analysis

(2012) Ola Dale et al.   ANESTHESIA AND ANALGESIA

Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Antidepressant Efficacy of Ketamine in Depressed Patients

(2012) Gonzalo Laje et al.   BIOLOGICAL PSYCHIATRY

The Role of Eukaryotic Elongation Factor 2 Kinase in Rapid Antidepressant Action of Ketamine

(2012) Lisa M. Monteggia et al.   BIOLOGICAL PSYCHIATRY

Rapid and Longer-Term Antidepressant Effects of Repeated Ketamine Infusions in Treatment-Resistant Major Depression

(2012) James W. Murrough et al.   BIOLOGICAL PSYCHIATRY

The role of immune genes in the association between depression and inflammation: A review of recent clinical studies

(2012) Chiara Bufalino et al.   BRAIN BEHAVIOR AND IMMUNITY

Tyrosine metabolism during interferon-alpha administration: Association with fatigue and CSF dopamine concentrations

(2012) Jennifer C. Felger et al.   BRAIN BEHAVIOR AND IMMUNITY

Cytokine gene variation is associated with depressive symptom trajectories in oncology patients and family caregivers

(2012) Laura B. Dunn et al.   European Journal of Oncology Nursing

Candidate Genes Expression Profile Associated with Antidepressants Response in the GENDEP Study: Differentiating between Baseline ‘Predictors’ and Longitudinal ‘Targets’

(2012) Annamaria Cattaneo et al.   NEUROPSYCHOPHARMACOLOGY

Acute administration of ketamine in rats increases hippocampal BDNF and mTOR levels during forced swimming test

(2012) Chun Yang et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Multigene interactions and the prediction of depression in the Wisconsin Longitudinal Study

(2012) Nicholas S Roetker et al.   BMJ Open

A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-Resistant Depression

(2012) Charles L. Raison et al.   JAMA Psychiatry

Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression

(2011) Hiroyuki Koike et al.   BEHAVIOURAL BRAIN RESEARCH

Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: A meta-analysis and meta-regression

(2011) Yang Liu et al.   JOURNAL OF AFFECTIVE DISORDERS

Preliminary Findings Regarding Proinflammatory Markers and Brain-Derived Neurotrophic Factor Among Adolescents with Bipolar Spectrum Disorders

(2011) Benjamin I. Goldstein et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims

(2011) Ghanshyam N. Pandey et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Comparison of Antidepressant Efficacy-related SNPs Among Taiwanese and Four Populations in the HapMap Database

(2011) Mei-Hung Chi et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice

(2011) E Beurel et al.   MOLECULAR PSYCHIATRY

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

Towards a glutamate hypothesis of depression

(2011) Gerard Sanacora et al.   NEUROPHARMACOLOGY

Effects of antipsychotic drugs on BDNF, GSK-3β, and β-catenin expression in rats subjected to immobilization stress

(2011) Sung Woo Park et al.   NEUROSCIENCE RESEARCH

Rapid decrease in depressive symptoms with an N-methyl-d-aspartate antagonist in ECT-resistant major depression

(2011) Lobna Ibrahim et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder

(2011) Courtney S. Jernigan et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Genome-Wide Pharmacogenetics of Antidepressant Response in the GENDEP Project

(2010) Rudolf Uher et al.   AMERICAN JOURNAL OF PSYCHIATRY

A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression

(2010) Nancy Diazgranados et al.   ARCHIVES OF GENERAL PSYCHIATRY

Association of Existing and New Candidate Genes for Anxiety, Depression and Personality Traits in Older People

(2010) Michelle Luciano et al.   BEHAVIOR GENETICS

Inflammation-Induced Anhedonia: Endotoxin Reduces Ventral Striatum Responses to Reward

(2010) Naomi I. Eisenberger et al.   BIOLOGICAL PSYCHIATRY

Early Life Stress Combined with Serotonin 3A Receptor and Brain-Derived Neurotrophic Factor Valine 66 to Methionine Genotypes Impacts Emotional Brain and Arousal Correlates of Risk for Depression

(2010) Justine M. Gatt et al.   BIOLOGICAL PSYCHIATRY

Decreased levels of serum brain-derived neurotrophic factor in both depressed and euthymic patients with unipolar depression and in euthymic patients with bipolar I and II disorders

(2010) P Monteleone et al.   BIPOLAR DISORDERS

Inflammation and social experience: An inflammatory challenge induces feelings of social disconnection in addition to depressed mood

(2010) Naomi I. Eisenberger et al.   BRAIN BEHAVIOR AND IMMUNITY

The association between brain-derived neurotrophic factor polymorphism (BDNF Val66Met) and suicide

(2010) Peter Pregelj et al.   JOURNAL OF AFFECTIVE DISORDERS

Rapid Resolution of Suicidal Ideation After a Single Infusion of anN-Methyl-D-Aspartate Antagonist in Patients With Treatment-Resistant Major Depressive Disorder

(2010) Nancy DiazGranados et al.   JOURNAL OF CLINICAL PSYCHIATRY

Long-Term Duloxetine Treatment Normalizes Altered Brain-Derived Neurotrophic Factor Expression in Serotonin Transporter Knockout Rats through the Modulation of Specific Neurotrophin Isoforms

(2010) F. Calabrese et al.   MOLECULAR PHARMACOLOGY

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

The role of glutamate on the action of antidepressants

(2010) Kenji Hashimoto   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The BDNF Val66Met polymorphism and anxiety: Support for animal knock-in studies from a genetic association study in humans

(2010) Christian Montag et al.   PSYCHIATRY RESEARCH

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

-308(G/A) TNF-α GENE POLYMORPHISM AND RISK OF DEPRESSION LATE IN THE LIFE

(2009) A.P. Cerri et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Inflammation Causes Mood Changes Through Alterations in Subgenual Cingulate Activity and Mesolimbic Connectivity

(2009) Neil A. Harrison et al.   BIOLOGICAL PSYCHIATRY

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression

(2009) Andrew H. Miller et al.   BIOLOGICAL PSYCHIATRY

The Interleukin 1 Beta (IL1B) Gene Is Associated with Failure to Achieve Remission and Impaired Emotion Processing in Major Depression

(2009) Bernhard T. Baune et al.   BIOLOGICAL PSYCHIATRY

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

Polymorphisms in the CRP gene moderate an association between depressive symptoms and circulating levels of C-reactive protein

(2009) Indrani Halder et al.   BRAIN BEHAVIOR AND IMMUNITY

Stress-induced dendritic remodeling in the medial prefrontal cortex: Effects of circuit, hormones and rest

(2009) Rebecca M. Shansky et al.   BRAIN RESEARCH

Depression and anxiety in inflammatory bowel disease: A review of comorbidity and management

(2009) Lesley A. Graff et al.   INFLAMMATORY BOWEL DISEASES

Polymorphisms of the CRP gene inhibit inflammatory response and increase susceptibility to depression: The Health in Men Study

(2009) O. P. Almeida et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Interaction between genetic polymorphisms and stressful life events in first episode depression

(2009) Jens Drachmann Bukh et al.   JOURNAL OF AFFECTIVE DISORDERS

The Met allele of the BDNF Val66Met polymorphism is associated with increased BDNF serum concentrations

(2009) U E Lang et al.   MOLECULAR PSYCHIATRY

Interleukin-1 Beta −511C/T Genetic Polymorphism is Associated with Age of Onset of Geriatric Depression

(2009) Jen-Ping Hwang et al.   NEUROMOLECULAR MEDICINE

Translational Control of Long-Lasting Synaptic Plasticity and Memory

(2009) Mauro Costa-Mattioli et al.   NEURON

Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

(2009) M Bryant Howren et al.   PSYCHOSOMATIC MEDICINE

mTOR signaling: At the crossroads of plasticity, memory and disease

(2009) Charles A. Hoeffer et al.   TRENDS IN NEUROSCIENCES

Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications

(2008) Srijan Sen et al.   BIOLOGICAL PSYCHIATRY

Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators

(2008) Bruce S. McEwen   EUROPEAN JOURNAL OF PHARMACOLOGY

Depression-prone mice with reduced glucocorticoid receptor expression display an altered stress-dependent regulation of brain-derived neurotrophic factor and activity-regulated cytoskeleton-associated protein

(2008) R. Molteni et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Functional polymorphisms in the interleukin-6 and serotonin transporter genes and depression and fatigue induced by interferon-α and ribavirin treatment

(2008) S J Bull et al.   MOLECULAR PSYCHIATRY

Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response

(2008) M-L Wong et al.   MOLECULAR PSYCHIATRY

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY

Cytokine Genes TNF, IL1A, IL1B, IL6, IL1RN and IL10, and Childhood-Onset Mood Disorders

(2008) V.L. Misener et al.   NEUROPSYCHOBIOLOGY

Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors

(2007) Sungho Maeng et al.   BIOLOGICAL PSYCHIATRY

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE

BDNF genotype potentially modifying the association between incident stroke and depression

(2007) Jae-Min Kim et al.   NEUROBIOLOGY OF AGING

Cytokine-induced enhancement of calcium-dependent glutamate release from astrocytes mediated by nitric oxide

(2007) Tomoaki Ida et al.   NEUROSCIENCE LETTERS

Pro-inflammatory cytokines and treatment response to escitaloprsam in major depressive disorder

(2007) Triin Eller et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus

(2007) Lêda S.B. Garcia et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY