Article
Neurosciences
Logan J. Bigelow, Melissa A. Perry, Sarah L. Ogilvie, R. Andrew Tasker
Summary: The consumption of cycad seeds is linked to the development of ALS-PDC in humans. Researchers attempted to replicate and further characterize the BSSG model, but observed no changes in behavior or immunohistochemistry, indicating an inability to replicate previous reports. Further investigation into the sources of variability in the model is necessary.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Yareth Gopar-Cuevas, Ana P. Duarte-Jurado, Rosa N. Diaz-Perez, Odila Saucedo-Cardenas, Maria J. Loera-Arias, Roberto Montes-de-Oca-Luna, Humberto Rodriguez-Rocha, Aracely Garcia-Garcia
Summary: Parkinson's disease is a leading neurodegenerative movement disorder worldwide, often occurring in idiopathic form. The diagnostic accuracy is relatively low, highlighting the urgent need to establish a panel of biomarkers for early and accurate diagnosis. Accurate diagnosis may lead to unraveling the pathogenesis and ultimately finding a cure.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Geriatrics & Gerontology
Minjing Ke, Cheong-Meng Chong, Qi Zhu, Ke Zhang, Cui-Zan Cai, Jia-Hong Lu, Dajiang Qin, Huanxing Su
Summary: Parkinson's disease research utilizes various preclinical models, including cellular and animal models, each with its own strengths and limitations. The selection of models depends on the research interest, and none of the current models can fully replicate all features of PD.
Article
Chemistry, Analytical
Lazzaro di Biase, Luigi Raiano, Maria Letizia Caminiti, Pasquale Maria Pecoraro, Vincenzo Di Lazzaro
Summary: The aim of this study was to evaluate which kind of gait analysis (dynamic or kinematic) is more informative in discriminating gait features between Parkinson's disease (PD) patients and healthy subjects (HS). The results showed that kinematic features, such as gait speed and selected kinematic dispersion indices, were significantly different between PD patients and HS. However, dynamic features did not show any statistically significant difference.
Review
Chemistry, Medicinal
Eun-Joo Shin, Ji Hoon Jeong, Yeonggwang Hwang, Naveen Sharma, Duy-Khanh Dang, Bao-Trong Nguyen, Seung-Yeol Nah, Choon-Gon Jang, Guoying Bing, Toshitaka Nabeshima, Hyoung-Chun Kim
Summary: Methamphetamine (MA) intoxication can cause neurological deficits similar to Parkinson's disease (PD), and anti-Parkinsonian medications have been shown to mitigate the motor impairments induced by MA. Various mechanisms such as mitochondrial dysfunction, oxidative stress, and neuroinflammation play important roles in MA neurotoxicity, sharing commonalities with PD pathogenesis. Rodent models of neurotoxic binge administration of MA have been suggested as a valid tool for studying the neuropathogenesis of PD.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Computer Science, Artificial Intelligence
Yi-Wei Ma, Jiann-Liang Chen, Yan-Ju Chen, Ying-Hsun Lai
Summary: This paper develops an explainable learning architecture for gait detection in Parkinson's disease (PD) patients, aiming to improve the accuracy of diagnosis. The architecture achieves promising results with different algorithms and provides an early detection system for doctors.
Article
Clinical Neurology
Michael Bartl, Mohammed Dakna, Sebastian Schade, Birgit Otte, Tamara Wicke, Elisabeth Lang, Maritta Starke, Jens Ebentheuer, Sandrina Weber, Karl Toischer, Moritz Schnelle, Friederike Sixel-Doering, Claudia Trenkwalder, Brit Mollenhauer
Summary: This study assessed established markers of neuronal function, inflammation, and cardiovascular risk in Parkinson's disease (PD) patients. The results showed differential expression of plasma markers in PD, indicating reduced endothelial/atherosclerotic processes, increased thromboembolic risk, and neuroinflammation. Several markers correlated with cognitive decline and motor symptom progression. These findings provide insights into the molecular processes underlying PD and its progression.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Ryul Kim, Han-Joon Kim, Jung Hwan Shin, Chan Young Lee, Seung Ho Jeon, Beomseok Jeon
Summary: This study found that peripheral inflammation in early-stage Parkinson's disease (PD) may be related to the progression of nonmotor symptoms (NMSs), particularly mood symptoms. By measuring six inflammatory markers, the researchers found that elevated levels of IL-2 and IL-6 were associated with the progression of NMSs.
MOVEMENT DISORDERS
(2022)
Article
Geriatrics & Gerontology
Kui Chen, Kangshuai Du, Yichen Zhao, Yongzhe Gu, Yanxin Zhao
Summary: This study identified distinct trajectories of orthostatic blood pressure changes in Parkinson's disease patients, including rapidly increasing, low-stable, and high-stable classes. Male sex, lower supine diastolic blood pressure, and lower total protein levels were significant predictors of a rapidly increasing Delta SBP trajectory.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Clinical Neurology
LinLin Xie, LuDong Hu
Summary: This article summarizes the pathogenesis and prodromal manifestations of Parkinson's disease, discusses the diagnostic challenges, and explores the application of emerging neuroimaging technologies.
NEUROLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Samar K. Alselehdar, Monami Chakraborty, Suman Chowdhury, Roy N. Alcalay, Matthew Surface, Robert Ledeen
Summary: The study shows that GM1 ganglioside levels are lower in PD patients, especially in PBMCs, which could potentially apply to early and developing stages of the disease. These findings suggest new directions for future research and disease treatment in PD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Mariana Alves, Patricia Pita Lobo, Linda Azevedo Kauppila, Leonor Rebordao, M. Manuela Cruz, Fatima Soares, Joao Cruz, Ana Tornada, Daniel Caldeira, Sofia Reimao, Victor Oliveira, Jose M. Ferro, Joaquim J. Ferreira
Summary: The study did not find a difference in CIMT between PD and controls. A higher frequency of carotid plaques and abnormal dipper profile support the hypothesis that PD patients are not protected from cardiovascular and cerebrovascular disease.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Materials Science, Composites
Fei Wang, Yong Liu, Hongyan Cao, Yanyan Zhao, Yaqing Ge, Xinfeng Song, Chunhui Li, Xueting Yang, Xubao Jiang, Xiangling Gu
Summary: The early diagnosis of parkinson's disease is crucial for preventing patient dysfunctions and improving healthcare. However, the current smart devices used for early diagnosis are limited by flexibility, unwieldiness, and insensitivity. To address this, researchers prepared PANI NPs@(CS-PAA) hydrogel that significantly improved mechanical performance and conductivity. The hydrogel exhibited an inverted-V trend, and hydrogen bonding and hydrophobic association were found to play important roles in its properties. It showed reliable data and fast response time for early diagnosis of parkinson's disease when used as a flexible electrode.
COMPOSITES SCIENCE AND TECHNOLOGY
(2023)
Article
Computer Science, Interdisciplinary Applications
Yuan Zhou, Sule Tinaz, Hemant D. Tagare
Summary: This study proposes a model for quantifying the heterogeneous progression of Parkinson's disease in DaTscan images, revealing different progression subtypes with varying speeds and trajectories. The model also identifies characteristic spatial progression patterns in the brain, which can serve as markers of disease progression, and the subtypes exhibit different rates of progression in clinical symptoms.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Review
Neurosciences
Axelle Dovonou, Cyril Bolduc, Victoria Soto Linan, Charles Gora, Modesto R. R. Peralta, Martin Levesque
Summary: Parkinson's disease (PD) is a progressive neurodegenerative disorder with motor and non-motor symptoms. Despite its long history and extensive research, there is still no cure or disease-modifying therapy available. Animal models have been developed to study PD, providing valuable insights into the disease. This review comprehensively summarizes the different animal models used in PD research, their characteristics, and ability to replicate PD-like phenotypes, aiming to assist researchers in selecting appropriate models for their research questions.
TRANSLATIONAL NEURODEGENERATION
(2023)
Article
Biochemistry & Molecular Biology
J. Nikolenko, M. M. Kurshakova, A. N. Krasnov, S. G. Georgieva
Summary: The study confirms the interaction between MLE and the SWI/SNF chromatin remodelling complex, and reveals the important role of MLE in ensuring timely activation and high level expression of the ftz-f1 gene.
DOKLADY BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Medicine, Research & Experimental
Alexander Kim, Ekaterina Pavlova, Anna Kolacheva, Vsevolod Bogdanov, Liliya Dilmukhametova, Viktor Blokhin, Lev Valuev, Ivan Valuev, Marina Gorshkova, Michael Ugrumov
Summary: The fight against neurodegenerative diseases, including Parkinson's disease (PD), is a global challenge. This study aims to develop an early diagnosis of PD using an intranasal provocative test on animal models.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Neurosciences
V. G. Konkov, V. S. Kudrin, V. B. Narkevich, A. O. Efimova, T. D. Nikiforova, L. G. Kolik
Summary: Alcohol-related mental health problems may be passed down through generations. This study aimed to investigate the effect of prolonged alcohol exposure on anxiety behavior and neurochemical changes in the brain structures of rats' offspring. The results showed that prolonged alcohol consumption induced sex-dependent changes in neurotransmitter content in the brain structures responsible for emotional and motivational behavior.
NEUROCHEMICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Darya Chetverina, Nadezhda E. Vorobyeva, Marina Yu Mazina, Lika Fab, Dmitry Lomaev, Alexandra Golovnina, Vladic Mogila, Pavel Georgiev, Rustam H. Ziganshin, Maksim Erokhin
Summary: The Polycomb group (PcG) and Trithorax group (TrxG) proteins are key epigenetic regulators controlling gene expression in multicellular organisms. This study investigates the recruitment and interactions of PRE DNA-binding proteins in Drosophila. The results suggest that Combgap, Zeste, Psq, and Adf1 have associations with different protein complexes involved in regulatory activities, indicating their potential multifunctional role in transcription regulation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
J. Nikolenko, N. A. Fursova, M. Y. Mazina, N. E. Vorobyeva, A. N. Krasnov
Summary: It has been found that the CG9890 protein interacts with ENY2-containing complexes and is mainly located on the promoters of active genes. This protein plays a role in regulating the expression of ecdysone-dependent genes and acts as a repressor in most cases.
Article
Neurosciences
V. G. Kon'kov, V. S. Kudrin, V. B. Narkevich, L. G. Kolik
Summary: The aim of this study was to compare neurochemical changes induced by the dipeptide analogue of piracetam, the ethyl ester of N-phenylacetyl-L-prolylglycine (noopept), in the brain structures of BALB/c and C57BL/6 mice with different genetically determined responses to emotional stress. It was found that noopept reduced the content of dopamine and its metabolite homovanillic acid in the frontal cortex of both strains of mice. In highly anxious BALB/c mice, noopept increased the turnover of dopamine and the metabolic rate of noradrenaline, dopamine, and serotonin in specific brain regions.
NEUROCHEMICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Marina Yu Mazina, Elena Kovalenko, Aleksandra A. Evdokimova, Maksim Erokhin, Darya Chetverina, Nadezhda E. Vorobyeva
Summary: This study investigated the recruitment and pausing mechanism of RNA polymerase II during Drosophila metamorphosis. The results indicate that, similar to mid-embryogenesis, promoters are bound by paused RNA polymerase II during metamorphosis, preparing for activation in later developmental stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
V. S. Kudrin, V. B. Narkevich, G. I. Kovalev
Summary: The article explores the scientific achievements of K.S. Raevskii and his students in the field of neurochemistry, particularly in the study of the mechanism of action of neuropsychotropic drugs. It highlights the establishment of a scientific school and the recognition of K.S. Raevskii's contributions both domestically and internationally.
NEUROCHEMICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Sophie D. Shirenova, Nadezhda N. Khlebnikova, Viktor B. Narkevich, Vladimir S. Kudrin, Nataliya A. Krupina
Summary: Social isolation (SI) is a chronic psycho-emotional stress that affects humans and socially living species. In a recent study, the behavioral effects of prolonged SI on 69 male and female rats were investigated. The results showed that single-housed rats exhibited hyperactivity, reduced reactivity to novelty, and impaired passive avoidance learning. Additionally, these rats showed decreased pain sensitivity and anxiety levels compared to group-housed animals. The study also found that SI led to changes in monoamine levels in various brain structures.
NEUROCHEMICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Maksim Erokhin, J. Lesley Brown, Dmitry Lomaev, Nadezhda E. Vorobyeva, Liangliang Zhang, Lika Fab, Marina Yu Mazina, Ivan Kulakovskiy, Rustam H. Ziganshin, Paul Schedl, Pavel Georgiev, Ming-an Sun, Judith A. Kassis, Darya Chetverina
Summary: The Polycomb group (PcG) proteins are important epigenetic regulators in multicellular organisms. This study identified the transcription factor Crooked legs (Crol) as a novel PcG recruiter, which directly binds to poly(G)-rich DNA sequences. Knockout of Crol impairs the recruitment of PcG proteins and leads to dysregulated transcription of target genes.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Aleksey N. Krasnov, Aleksandra A. Evdokimova, Marina Yu Mazina, Maksim Erokhin, Darya Chetverina, Nadezhda E. Vorobyeva
Summary: Ecdysone signaling in Drosophila is a popular model for studying steroid action in eukaryotes. This study found that coregulators that can respond to 20-hydroxyecdysone in Drosophila S2 cells are not bound to enhancers, but rather at transcription start sites and boundaries associated with CP190. The binding levels of these coregulators showed minor changes after 20-hydroxyecdysone treatment. Therefore, the 20-hydroxyecdysone signal enhances the functional activity of coregulators rather than promoting their binding to regulatory regions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
K. B. Lebedeva-Georgievskaya, A. A. Perevezentsev, O. S. Kuznetsova, V. S. Kudrin, A. A. Masanova, A. S. Stemberg
Summary: This study examines the long-term effects of gamma-irradiation and anti-orthostatic suspension on the brain activity and neurochemical metabolism of rats. The results show that these effects can be successfully balanced within six months, but differences related to the typological characteristics of the animals persist in the long term.
Meeting Abstract
Biochemistry & Molecular Biology
A. Krasnov, N. Fursova, M. Mazina, J. Nikolenko, N. Vorobyeva
Article
Neurosciences
V. B. Narkevich, S. A. Litvinova, V. S. Rogovskii, I. B. Tsorin, V. S. Kudrin
Summary: In a study on the effects of afobazol on mice with serotonin deficit induced by PCPA, differences in neurochemical parameters and metabolism were found between strains. Afobazol influenced dopamine neurotransmission parameters, restoring serotonin and norepinephrine levels in different brain structures across strains. The results confirm the role of serotonergic systems in the mechanism of action of afobazol, impacting stress-resistant and emotionally labile animals.
NEUROCHEMICAL JOURNAL
(2021)