Journal
MOLECULAR NEUROBIOLOGY
Volume 53, Issue 1, Pages 155-162Publisher
HUMANA PRESS INC
DOI: 10.1007/s12035-014-8979-z
Keywords
Alpha-synuclein; Down syndrome; Demethylation; Ts65Dn mice; EGCG
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Funding
- OPWDD, State of New York
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Alpha-synuclein (SNCA), a presynaptic protein, is significantly reduced in individuals with Down syndrome (DS) and Ts65Dn mice, a mouse model of DS. Methylation analyses of promoter proximal CpG sites indicate similar reduction in Ts65Dn mice compared to control mice. Epigallocatechin-3-gallate (EGCG), a polyphenolic catechin present in green tea extract, increases methylation of SNCA promoter proximal CpG sites and expression in Ts65Dn mice. These results suggest a positive link between CpG methylation and SNCA expression in Down syndrome.
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