Glia and Mast Cells as Targets for Palmitoylethanolamide, an Anti-inflammatory and Neuroprotective Lipid Mediator

Amyotrophic Lateral Sclerosis Treatment with Ultramicronized Palmitoylethanolamide: A Case Report

(2013) Simonetta Clemente   CNS & Neurological Disorders-Drug Targets

Palmitoylethanolamide Reduces Formalin-Induced Neuropathic-Like Behaviour Through Spinal Glial/Microglial Phenotypical Changes in Mice

(2013) Livio Luongo et al.   CNS & Neurological Disorders-Drug Targets

Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase

(2012) Yumiko Yamano et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Administration of palmitoylethanolamide (PEA) protects the neurovascular unit and reduces secondary injury after traumatic brain injury in mice

(2012) Akbar Ahmad et al.   BRAIN BEHAVIOR AND IMMUNITY

Reduction of ischemic brain injury by administration of palmitoylethanolamide after transient middle cerebral artery occlusion in rats

(2012) Akbar Ahmad et al.   BRAIN RESEARCH

Palmitoylethanolamide Restores Myelinated-Fibre Function in Patients with Chemotherapy-Induced Painful Neuropathy

(2012) A. Truini et al.   CNS & Neurological Disorders-Drug Targets

Conference Report

(2012) Stephen D. Skaper   CNS & Neurological Disorders-Drug Targets

Microglia and mast cells: two tracks on the road to neuroinflammation

(2012) Stephen D. Skaper et al.   FASEB JOURNAL

Testing NF-κB-based Therapy in Hemiparkinsonian Monkeys

(2012) Susanta Mondal et al.   Journal of Neuroimmune Pharmacology

Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α

(2012) Caterina Scuderi et al.   Journal of Neuroinflammation

Neuroprotective function for ramified microglia in hippocampal excitotoxicity

(2012) Jonathan Vinet et al.   Journal of Neuroinflammation

Early Activation of Microglia Triggers Long-Lasting Impairment of Adult Neurogenesis in the Olfactory Bulb

(2012) F. Lazarini et al.   JOURNAL OF NEUROSCIENCE

Palmitoylethanolamide Protects Against the Amyloid-β25-35-Induced Learning and Memory Impairment in Mice, an Experimental Model of Alzheimer Disease

(2012) Giuseppe D'Agostino et al.   NEUROPSYCHOPHARMACOLOGY

Neuroprotective Activities of Palmitoylethanolamide in an Animal Model of Parkinson's Disease

(2012) Emanuela Esposito et al.   PLoS One

Multimodal stepped care approach with acupuncture and PPAR-α agonist palmitoylethanolamide in the treatment of a patient with multiple sclerosis and central neuropathic pain

(2012) David J Kopsky et al.   Acupuncture in Medicine

Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series

(2012) Jan Keppel Hesselink et al.   Journal of Pain Research

Glia as a Link between Neuroinflammation and Neuropathic Pain

(2012) Mithilesh Kumar Jha et al.   Immune Network

Systemic inflammation induces axon injury during brain inflammation

(2011) Beatriz Moreno et al.   ANNALS OF NEUROLOGY

Effects of palmitoylethanolamide on release of mast cell peptidases and neurotrophic factors after spinal cord injury

(2011) Emanuela Esposito et al.   BRAIN BEHAVIOR AND IMMUNITY

Acute amygdaloid response to systemic inflammation

(2011) Harald Engler et al.   BRAIN BEHAVIOR AND IMMUNITY

Mast cell degranulation distinctly activates trigemino-cervical and lumbosacral pain pathways and elicits widespread tactile pain hypersensitivity

(2011) Dan Levy et al.   BRAIN BEHAVIOR AND IMMUNITY

Evidence that Microglia Mediate the Neurobiological Effects of Chronic Psychological Stress on the Medial Prefrontal Cortex

(2011) M. Hinwood et al.   CEREBRAL CORTEX

Possible Role of Glia in Cognitive Impairment in Schizophrenia

(2011) Bernhard J. Mitterauer   CNS Neuroscience & Therapeutics

Involvement of mast cells in a mouse model of postoperative pain

(2011) Sara Marchesan Oliveira et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effects of intra-ventrolateral periaqueductal grey palmitoylethanolamide on thermoceptive threshold and rostral ventromedial medulla cell activity

(2011) Vito de Novellis et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Identification of a microglia phenotype supportive of remyelination

(2011) Marta Olah et al.   GLIA

Palmitoylethanolamide counteracts reactive astrogliosis induced by β-amyloid peptide

(2011) Caterina Scuderi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Palmitoylethanolamide Stimulation Induces Allopregnanolone Synthesis in C6 Cells and Primary Astrocytes: Involvement of Peroxisome-Proliferator Activated Receptor-α

(2011) G. Mattace Raso et al.   JOURNAL OF NEUROENDOCRINOLOGY

Social disruption induced priming of CNS inflammatory response to Theiler's virus is dependent upon stress induced IL-6 release

(2011) E.G. Vichaya et al.   JOURNAL OF NEUROIMMUNOLOGY

Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L

(2011) Dae Kim et al.   Journal of Neuroinflammation

Central Nervous System Mast Cells in Peripheral Inflammatory Nociception

(2011) Dimitris N Xanthos et al.   Molecular Pain

Palmitoylethanolamide Reduces Granuloma-Induced Hyperalgesia by Modulation of Mast Cell Activation in Rats

(2011) Daniele De Filippis et al.   Molecular Pain

Cannabidiol and Other Cannabinoids Reduce Microglial Activation In Vitro and In Vivo: Relevance to Alzheimer's Disease

(2011) A. M. Martin-Moreno et al.   MOLECULAR PHARMACOLOGY

Repertoire of microglial and macrophage responses after spinal cord injury

(2011) Samuel David et al.   NATURE REVIEWS NEUROSCIENCE

High Levels of N-Palmitoylethanolamide and N-Stearoylethanolamide in Microdialysate Samples from Myalgic Trapezius Muscle in Women

(2011) Nazdar Ghafouri et al.   PLoS One

Purinergic signalling: From normal behaviour to pathological brain function

(2011) Geoffrey Burnstock et al.   PROGRESS IN NEUROBIOLOGY

Cerebral Mast Cells Mediate Blood-Brain Barrier Disruption in Acute Experimental Ischemic Stroke Through Perivascular Gelatinase Activation

(2011) Olli S. Mattila et al.   STROKE

IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease

(2011) C Barcia et al.   Cell Death & Disease

Minimally invasive biomarker confirms glial activation present in Alzheimer's disease: a preliminary study

(2011) Napapon Sailasuta et al.   Neuropsychiatric Disease and Treatment

Chemical genetics of neuroinflammation: natural and synthetic compounds as microglial inhibitors

(2011) Kyoungho Suk et al.   INFLAMMOPHARMACOLOGY

A granular variant of CD63 is a regulator of repeated human mast cell degranulation

(2010) T. Schäfer et al.   ALLERGY

N-palmitoyl-ethanolamine: Biochemistry and new therapeutic opportunities

(2010) Stefania Petrosino et al.   BIOCHIMIE

Mast Cells as Early Responders in the Regulation of Acute Blood–Brain Barrier Changes after Cerebral Ischemia and Hemorrhage

(2010) Perttu Johannes Lindsberg et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Signaling Pathways in the Activation of Mast Cells Cocultured with Astrocytes and Colocalization of Both Cells in Experimental Allergic Encephalomyelitis

(2010) D. Y. Kim et al.   JOURNAL OF IMMUNOLOGY

Glial Cells and Chronic Pain

(2010) Romain-Daniel Gosselin et al.   NEUROSCIENTIST

Chronic stress induces transient spinal neuroinflammation, triggering sensory hypersensitivity and long-lasting anxiety-induced hyperalgesia

(2010) Cyril Rivat et al.   PAIN

Microglial Interactions with Synapses Are Modulated by Visual Experience

(2010) Marie-Ève Tremblay et al.   PLOS BIOLOGY

Synthesis and biological evaluation of new potential inhibitors of N-acylethanolamine hydrolyzing acid amidase

(2009) Carmela Saturnino et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-κB nuclear signalling in dorsal root ganglia

(2009) Giuseppe D'Agostino et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Bone Marrow-Derived Mast Cells Accumulate in the Central Nervous System During Inflammation but Are Dispensable for Experimental Autoimmune Encephalomyelitis Pathogenesis

(2009) J. L. Bennett et al.   JOURNAL OF IMMUNOLOGY

Behavioral Phenotypes of Mice Lacking Purinergic P2X4 Receptors in Acute and Chronic Pain Assays

(2009) Makoto Tsuda et al.   Molecular Pain

Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia

(2009) Stefan A Grathwohl et al.   NATURE NEUROSCIENCE

Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation

(2009) C. Solorzano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mast Cells Are Early Responders After Hypoxia-Ischemia in Immature Rat Brain

(2009) Yuxuan Jin et al.   STROKE

Effects of palmitoylethanolamide on immunologically induced histamine, PGD2 and TNFα release from canine skin mast cells

(2009) S. Cerrato et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

MAP kinase and pain

(2008) Ru-Rong Ji et al.   BRAIN RESEARCH REVIEWS

Mast cell activation by myelin through scavenger receptor

(2008) Nevenka Medic et al.   JOURNAL OF NEUROIMMUNOLOGY

P2Y12 Receptors in Spinal Microglia Are Required for Neuropathic Pain after Peripheral Nerve Injury

(2008) H. Tozaki-Saitoh et al.   JOURNAL OF NEUROSCIENCE

Systemic Glucocorticoid Therapy Reduces Pain and the Number of Endoneurial Tumor Necrosis Factor-Alpha (TNFα)-Positive Mast Cells in Rats With a Painful Peripheral Neuropathy

(2008) Reiko Hayashi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Effects of Palmitoylethanolamide on Signaling Pathways Implicated in the Development of Spinal Cord Injury

(2008) T. Genovese et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The endocannabinoid system is modulated in response to spinal cord injury in rats

(2008) Daniel Garcia-Ovejero et al.   NEUROBIOLOGY OF DISEASE

The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB1, TRPV1 and PPARγ receptors and neurotrophic factors

(2008) Barbara Costa et al.   PAIN

Brain mast cells link the immune system to anxiety-like behavior

(2008) K. M. Nautiyal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia produce and hydrolyze palmitoylethanolamide

(2007) Giulio G. Muccioli et al.   NEUROPHARMACOLOGY

Deficiency of Inducible Nitric Oxide Synthase Protects Against MPTP Toxicity In Vivo

(2003) Thomas Dehmer et al.   JOURNAL OF NEUROCHEMISTRY