Iron and copper as virulence modulators in human fungal pathogens

Candida albicans SOD5 represents the prototype of an unprecedented class of Cu-only superoxide dismutases required for pathogen defense

(2014) J. E. Gleason et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel role of the Candida albicans ferric reductase gene CFL1 in iron acquisition, oxidative stress tolerance, morphogenesis and virulence

(2014) Ning Xu et al.   RESEARCH IN MICROBIOLOGY

Bimodular Peptide Synthetase SidE Produces Fumarylalanine in the Human Pathogen Aspergillus fumigatus

(2013) Wieland Steinchen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Cryptococcus neoformans Copper Detoxification Machinery Is Critical for Fungal Virulence

(2013) Chen Ding et al.   Cell Host & Microbe

The ZrfC alkaline zinc transporter is required forAspergillus fumigatusvirulence and its growth in the presence of the Zn/Mn-chelating protein calprotectin

(2013) Jorge Amich et al.   CELLULAR MICROBIOLOGY

Iron acquisition in the human fungal pathogen Cryptococcus neoformans

(2013) Won Hee Jung et al.   CURRENT OPINION IN MICROBIOLOGY

The crucial role of iron uptake in Aspergillus fumigatus virulence

(2013) Margo M Moore   CURRENT OPINION IN MICROBIOLOGY

Laccases Involved in 1,8-Dihydroxynaphthalene Melanin Biosynthesis in Aspergillus fumigatus Are Regulated by Developmental Factors and Copper Homeostasis

(2013) Srijana Upadhyay et al.   EUKARYOTIC CELL

Role of Ferric Reductases in Iron Acquisition and Virulence in the Fungal Pathogen Cryptococcus neoformans

(2013) Sanjay Saikia et al.   INFECTION AND IMMUNITY

The Mannoprotein Cig1 Supports Iron Acquisition From Heme and Virulence in the Pathogenic Fungus Cryptococcus neoformans

(2013) Brigitte Cadieux et al.   JOURNAL OF INFECTIOUS DISEASES

A copper hyperaccumulation phenotype correlates with pathogenesis in Cryptococcus neoformans

(2013) Meera R. Raja et al.   Metallomics

Novel insight into the expression and function of the multicopper oxidases in Candida albicans

(2013) X. Cheng et al.   MICROBIOLOGY-SGM

The Cryptococcus neoformans Rim101 Transcription Factor Directly Regulates Genes Required for Adaptation to the Host

(2013) T. R. O'Meara et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcriptional remodelling in response to changing copper levels in the Wilson and Menkes disease model of Saccharomyces cerevisiae

(2013) Ayca Cankorur-Cetinkaya et al.   Molecular BioSystems

An encapsulation of iron homeostasis and virulence in Cryptococcus neoformans

(2013) James W. Kronstad et al.   TRENDS IN MICROBIOLOGY

Regulation of Sulphur Assimilation Is Essential for Virulence and Affects Iron Homeostasis of the Human-Pathogenic Mould Aspergillus fumigatus

(2013) Jorge Amich et al.   PLoS Pathogens

Charting the travels of copper in eukaryotes from yeast to mammals

(2012) Tracy Nevitt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Copper in Microbial Pathogenesis: Meddling with the Metal

(2012) Marie I. Samanovic et al.   Cell Host & Microbe

Structural Requirements for the Activity of the MirB Ferrisiderophore Transporter of Aspergillus fumigatus

(2012) Isabelle Raymond-Bouchard et al.   EUKARYOTIC CELL

Cryptococcus neoformans Requires the ESCRT Protein Vps23 for Iron Acquisition from Heme, for Capsule Formation, and for Virulence

(2012) Guanggan Hu et al.   INFECTION AND IMMUNITY

Mammalian metallothioneins: properties and functions

(2012) Petr Babula et al.   Metallomics

The interplay between vacuolar and siderophore-mediated iron storage in Aspergillus fumigatus

(2012) Fabio Gsaller et al.   Metallomics

The siderophore yersiniabactin binds copper to protect pathogens during infection

(2012) Kaveri S Chaturvedi et al.   Nature Chemical Biology

Nutritional immunity: transition metals at the pathogen–host interface

(2012) M. Indriati Hood et al.   NATURE REVIEWS MICROBIOLOGY

Role of CTR4 in the Virulence of Cryptococcus neoformans

(2012) S. R. Waterman et al.   mBio

The Link between Morphotype Transition and Virulence in Cryptococcus neoformans

(2012) Linqi Wang et al.   PLoS Pathogens

Post-Transcriptional Regulation of the Sef1 Transcription Factor Controls the Virulence of Candida albicans in Its Mammalian Host

(2012) Changbin Chen et al.   PLoS Pathogens

Candida albicans Scavenges Host Zinc via Pra1 during Endothelial Invasion

(2012) Francesco Citiulo et al.   PLoS Pathogens

Iron – A Key Nexus in the Virulence of Aspergillus fumigatus

(2012) Hubertus Haas   Frontiers in Microbiology

War-Fe-re: iron at the core of fungal virulence and host immunity

(2011) Tracy Nevitt   BIOMETALS

An Iron Homeostasis Regulatory Circuit with Reciprocal Roles in Candida albicans Commensalism and Pathogenesis

(2011) Changbin Chen et al.   Cell Host & Microbe

Iron homeostasis—Achilles’ heel of Aspergillus fumigatus?

(2011) Markus Schrettl et al.   CURRENT OPINION IN MICROBIOLOGY

Adaptation of Cryptococcus neoformans to Mammalian Hosts: Integrated Regulation of Metabolism and Virulence

(2011) Jim Kronstad et al.   EUKARYOTIC CELL

The metalloreductase FreB is involved in adaptation of Aspergillus fumigatus to iron starvation

(2011) Michael Blatzer et al.   FUNGAL GENETICS AND BIOLOGY

Zn- and Cu-thioneins: a functional classification for metallothioneins?

(2011) Òscar Palacios et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

The copper regulon of the human fungal pathogen Cryptococcus neoformans H99

(2011) Chen Ding et al.   MOLECULAR MICROBIOLOGY

Conserved and Divergent Roles of Bcr1 and CFEM Proteins in Candida parapsilosis and Candida albicans

(2011) Chen Ding et al.   PLoS One

Copper resistance is essential for virulence of Mycobacterium tuberculosis

(2011) F. Wolschendorf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Candida albicans heme oxygenase and its product CO contribute to pathogenesis of candidemia and alter systemic chemokine and cytokine expression

(2010) Dhammika H.M.L.P. Navarathna et al.   FREE RADICAL BIOLOGY AND MEDICINE

Functional analysis of the superoxide dismutase family inAspergillus fumigatus

(2010) Karine Lambou et al.   MOLECULAR MICROBIOLOGY

Ctr2 Links Copper Homeostasis to Polysaccharide Capsule Formation and Phagocytosis Inhibition in the Human Fungal Pathogen Cryptococcus neoformans

(2010) Cheryl D. Chun et al.   PLoS One

Iron–sulfur proteins in health and disease

(2010) Alex Sheftel et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

HapX-Mediated Adaption to Iron Starvation Is Crucial for Virulence of Aspergillus fumigatus

(2010) Markus Schrettl et al.   PLoS Pathogens

HapX Positively and Negatively Regulates the Transcriptional Response to Iron Deprivation in Cryptococcus neoformans

(2010) Won Hee Jung et al.   PLoS Pathogens

The Battle for Iron between Bacterial Pathogens and Their Vertebrate Hosts

(2010) Eric P. Skaar   PLoS Pathogens

Ferricrocin, a Siderophore Involved in Intra- and Transcellular Iron Distribution in Aspergillus fumigatus

(2009) A. Wallner et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Iron in innate immunity: starve the invaders

(2009) Tomas Ganz   CURRENT OPINION IN IMMUNOLOGY

Aspergillus fumigatus Survival in Alkaline and Extreme Zinc-Limiting Environments Relies on the Induction of a Zinc Homeostasis System Encoded by thezrfCandaspf2Genes

(2009) Jorge Amich et al.   EUKARYOTIC CELL

Role of Ferroxidases in Iron Uptake and Virulence ofCryptococcus neoformans

(2009) Won Hee Jung et al.   EUKARYOTIC CELL

A copper-responsive factor geneCUF1 is required for copper induction of laccase inCryptococcus neoformans

(2009) Nan Jiang et al.   FEMS MICROBIOLOGY LETTERS

A Role for the ATP7A Copper-transporting ATPase in Macrophage Bactericidal Activity

(2009) Carine White et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The iron-sulfur clusters of dehydratases are primary intracellular targets of copper toxicity

(2009) L. Macomber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biofilm Matrix Regulation by Candida albicans Zap1

(2009) Clarissa J. Nobile et al.   PLOS BIOLOGY

Cooperation of Two mRNA-Binding Proteins Drives Metabolic Adaptation to Iron Deficiency

(2008) Sergi Puig et al.   Cell Metabolism

Candida albicansFerric Reductases Are Differentially Regulated in Response to Distinct Forms of Iron Limitation by the Rim101 and CBF Transcription Factors

(2008) Yong-Un Baek et al.   EUKARYOTIC CELL

Effects of the Aspergillus fumigatus siderophore systems on the regulation of macrophage immune effector pathways and iron homeostasis

(2008) M. Seifert et al.   IMMUNOBIOLOGY

SreA-mediated iron regulation in Aspergillus fumigatus

(2008) Markus Schrettl et al.   MOLECULAR MICROBIOLOGY

An endocytic mechanism for haemoglobin-iron acquisition inCandida albicans

(2008) Ziva Weissman et al.   MOLECULAR MICROBIOLOGY

Candida albicanscell surface superoxide dismutases degrade host-derived reactive oxygen species to escape innate immune surveillance

(2008) Ingrid E. Frohner et al.   MOLECULAR MICROBIOLOGY

Mechanisms for copper acquisition, distribution and regulation

(2008) Byung-Eun Kim et al.   Nature Chemical Biology

Iron Source Preference and Regulation of Iron Uptake in Cryptococcus neoformans

(2008) Won Hee Jung et al.   PLoS Pathogens

Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses

(2008) Brian D. Corbin et al.   SCIENCE

The Hyphal-Associated Adhesin and Invasin Als3 of Candida albicans Mediates Iron Acquisition from Host Ferritin

(2008) Ricardo S. Almeida et al.   PLoS Pathogens

Patterns of Correlation of Plasma Ceruloplasmin in Sepsis

(2007) Carlo Chiarla et al.   JOURNAL OF SURGICAL RESEARCH