Spatial tethering of kinases to their substrates relaxes evolutionary constraints on specificity

Evolution of Two-Component Signal Transduction Systems

(2012) Emily J. Capra et al.   Annual Review of Microbiology

Adaptive Mutations that Prevent Crosstalk Enable the Expansion of Paralogous Signaling Protein Families

(2012) Emily J. Capra et al.   CELL

Orphan and hybrid two-component system proteins in health and disease

(2010) Varsha Raghavan et al.   CURRENT OPINION IN MICROBIOLOGY

Evolution and phyletic distribution of two-component signal transduction systems

(2010) Kristin Wuichet et al.   CURRENT OPINION IN MICROBIOLOGY

The mechanism of signal transduction by two-component systems

(2010) Patricia Casino et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The Receiver Domain of Hybrid Histidine Kinase VirA: an Enhancing Factor for vir Gene Expression in Agrobacterium tumefaciens

(2010) A. A. Wise et al.   JOURNAL OF BACTERIOLOGY

Using Structural Information to Change the Phosphotransfer Specificity of a Two-Component Chemotaxis Signalling Complex

(2010) Christian H. Bell et al.   PLOS BIOLOGY

Systematic Dissection and Trajectory-Scanning Mutagenesis of the Molecular Interface That Ensures Specificity of Two-Component Signaling Pathways

(2010) Emily J. Capra et al.   PLoS Genetics

Evolution of prokaryotic two-component systems: insights from comparative genomics

(2009) David E. Whitworth et al.   AMINO ACIDS

Structural Insight into Partner Specificity and Phosphoryl Transfer in Two-Component Signal Transduction

(2009) Patricia Casino et al.   CELL

The Atypical Hybrid Histidine Protein Kinase RodK in Myxococcus xanthus: Spatial Proximity Supersedes Kinetic Preference in Phosphotransfer Reactions

(2009) S. Wegener-Feldbrugge et al.   JOURNAL OF BACTERIOLOGY

Synthetic protein scaffolds provide modular control over metabolic flux

(2009) John E Dueber et al.   NATURE BIOTECHNOLOGY

Rewiring the Specificity of Two-Component Signal Transduction Systems

(2008) Jeffrey M. Skerker et al.   CELL