Journal
MOLECULAR MICROBIOLOGY
Volume 79, Issue 2, Pages 279-282Publisher
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1365-2958.2010.07459.x
Keywords
-
Categories
Funding
- NIGMS NIH HHS [R01 GM027068-31, R01 GM027068] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM027068] Funding Source: NIH RePORTER
Ask authors/readers for more resources
P>Experiments of Pranting and Andersson demonstrate how bacteria adapt to the growth limitation caused by antibiotic resistance mutations. The process of adaptation relies on gene copy number changes that arise at high rates, including duplications (10-4 per cell per generation), amplifications (10-2 per cell per generation) and mutant copy loss (10-2 per cell per division). Reversible increases in copy number improve growth by small steps and provide more targets for rare sequence alterations (10-9 per cell per division) that can stably improve growth. After sequence alteration, selection favours loss of the still mutant gene copies that accelerated adaptation. The results strongly support the amplification-reversion model for fast adaptation and argue against the alternative idea of 'stress-induced mutagenesis'.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available