Review
Allergy
Julie Weidner, Sabine Bartel, Ayse Kilic, Ulrich M. Zissler, Harald Renz, Jurgen Schwarze, Carsten B. Schmidt-Weber, Tania Maes, Ana Rebane, Susanne Krauss-Etschmann, Madeleine Radinger
Summary: In the past decade, miRNAs have garnered scientific interest due to their crucial role in allergic diseases, acting as master post-transcriptional regulators of cellular processes. Dysregulated miRNA expression may contribute to disease development. Research focuses on understanding the specific functions and molecular mechanisms of miRNAs in allergic diseases, particularly in regulating immune responses and responses to environmental factors.
Article
Immunology
Sharon Van Nevel, Judith van Ovost, Gabriele Holtappels, Natalie De Ruyck, Nan Zhang, Harald Braun, Tania Maes, Claus Bachert, Olga Krysko
Summary: This study investigates the role of neutrophils in allergic airway inflammation in BALB/c and C57BL/6 mice exposed to Alternaria alternata. The findings demonstrate that BALB/c mice show a neutrophilic response to Alt extract, while C57BL/6 mice exhibit eosinophilic infiltration as the main response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Physiology
Mirjam P. Roffel, Tania Maes, Corry-Anke Brandsma, Maarten van den Berge, Bart M. Vanaudenaerde, Guy F. Joos, Guy G. Brusselle, Irene H. Heijink, Ken R. Bracke
Summary: The study demonstrated that miR-223-3p is increased in the lungs of COPD patients and cigarette smoke-exposed mice, and is associated with neutrophilic inflammation. In vivo data suggest that miR-223 acts as a negative regulator of acute cigarette smoke-induced neutrophilic and monocytic inflammation. Furthermore, in vitro data indicate that miR-223-3p suppresses proinflammatory responses in airway epithelial cells, but is less effective in COPD-derived cells.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Review
Respiratory System
Fien Gysens, Pieter Mestdagh, Eric de Bony de Lavergne, Tania Maes
Summary: This review focuses on the study of long non-coding RNAs (lncRNAs) in asthma. The research finds that many lncRNAs are differentially expressed in asthma and are associated with asthma severity or inflammatory phenotype. Moreover, the mechanisms of action of specific lncRNAs have been identified through in vivo and in vitro functional studies.
Article
Biochemistry & Molecular Biology
Merit Wildung, Christian Herr, Dietmar Riedel, Cornelia Wiedwald, Alena Moiseenko, Fidel Ramirez, Hataitip Tasena, Maren Heimerl, Mihai Alevra, Naira Movsisyan, Maike Schuldt, Larisa Volceanov-Hahn, Sharen Provoost, Tabea Noethe-Menchen, Diana Urrego, Bernard Freytag, Julia Wallmeier, Christoph Beisswenger, Robert Bals, Maarten van den Berge, Wim Timens, Pieter S. Hiemstra, Corry-Anke Brandsma, Tania Maes, Stefan Andreas, Irene H. Heijink, Luis A. Pardo, Muriel Lize
Summary: Airway mucociliary regeneration and function are impaired in chronic obstructive pulmonary disease (COPD). This study establishes a link between microRNA-449 (miR449), ciliary dysfunction, and COPD pathogenesis. miR449 plays a key role in regulating ciliary homeostasis and epithelial regeneration, and its absence leads to impaired ciliated epithelial regeneration and more severe COPD manifestations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Arne Temmerman, Belen Marquez-Garcia, Stephen Depuydt, Silvia Bruznican, Carolien De Cuyper, Annick De Keyser, Francois-Didier Boyer, Danny Vereecke, Sylwia Struk, Sofie Goormachtig
Summary: MAX2 signaling affects the competence of root explants for callus formation and shoot regeneration. The defective shoot regeneration of max2 is attributed to delayed callus primordium formation, resulting in less material for shoot regeneration. Additionally, the phenotype of in vitro shoot regeneration in max2 may be related to a defect in KAI2 signaling rather than DWARF14.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Critical Care Medicine
Grace E. Cooper, Jemma Mayall, Chantal Donovan, Tatt J. Haw, Kurtis F. Budden, Nicole G. Hansbro, Evy E. Blomme, Tania Maes, Chia Wei Kong, Jay C. Horvat, Salim Khakoo, Tom M. A. Wilkinson, Philip M. Hansbro, Karl J. Staples
Summary: This study investigates the phenotype and antiviral responses of tissue-resident natural killer (trNK) cells in murine chronic obstructive pulmonary disease (COPD) and human COPD lung tissue. The results show that CD49a(+) NK cells in the lung have a distinct phenotype compared to circulating NK cells and their proportions increase with worsening disease. The study suggests that trNK cell function is altered in cigarette smoke-induced disease and may contribute to excessive inflammation during viral exacerbations of COPD.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Respiratory System
Hannelore P. Van Eeckhoutte, Chantal Donovan, Richard Y. Kim, Thomas M. Conlon, Meshal Ansari, Haroon Khan, Ranjith Jayaraman, Nicole G. Hansbro, Yves Dondelinger, Tom Delanghe, Allison M. Beal, Brad Geddes, John Bertin, Tom Vanden Berghe, Joyceline De Volder, Tania Maes, Peter Vandenabeele, Bart M. Vanaudenaerde, Dieter Deforce, Sonja Skevin, Filip Van Nieuwerburgh, Fien M. Verhamme, Guy F. Joos, Sobia Idrees, Herbert B. Schiller, Ali Oender Yildirim, Alen Faiz, Mathieu J. M. Bertrand', Guy G. Brusselle, Philip M. Hansbro, Ken R. Bracke
Summary: RIPK1 plays a key role in COPD pathogenesis by mediating cell death and inflammation. Inhibition of RIPK1 kinase activity can alleviate airway inflammation and cell death caused by COPD, making it a potential therapeutic approach.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Editorial Material
Respiratory System
Guy Brusselle, Sebastian Riemann, Tania Maes
Article
Environmental Sciences
Joyceline De Volder, Annelies Bontinck, Katrien De Grove, Iris Dirven, Valerie Haelterman, Guy Joos, Guy Brusselle, Tania Maes
Summary: Experimental studies suggest that neutrophils could contribute to allergic asthma pathogenesis, that is mainly driven by type 2 immunity. Inhalation of diesel exhaust particles (DEP) is implicated in both exacerbation and development of asthma. Since exposure to DEP is associated with a neutrophilic component, we aimed to investigate how exposure to the combination of allergens and DEP modulates neutrophilic responses.
ENVIRONMENTAL POLLUTION
(2023)
Meeting Abstract
Critical Care Medicine
J. De Volder, A. Bontinck, K. De Grove, I. Dirven, G. G. Brusselle, G. F. Joos, T. Maes
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Respiratory System
Mirjam P. Roffel, Ilse M. Boudewijn, Jos L. L. van Nijnatten, Alen Faiz, Corneel J. Vermeulen, Antoon J. van Oosterhout, Karen Affleck, Wim Timens, Ken R. Bracke, Tania Maes, Irene H. Heijink, Corry-Anke Brandsma, Maarten van den Berge
Summary: In this study, several differentially expressed miRNAs were identified and their associations with asthma were explored. miR-125b-5p, miR-223-3p, and miR-26a-5p were identified as potential regulators that could contribute to the pathogenesis of asthma.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Meeting Abstract
Respiratory System
Annelies Bontinck, Joyceline De Volder, Mirjam P. Roffel, Guy G. Brusselle, Guy F. Joos, Tania Maes
EUROPEAN RESPIRATORY JOURNAL
(2021)
Meeting Abstract
Critical Care Medicine
A. Bontinck, J. De Volder, M. P. Roffel, G. G. Brusselle, G. F. Joos, T. Maes
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Immunology
Evy E. Blomme, Sharen Provoost, Elise G. De Smet, Katrien C. De Grove, Hannelore P. Van Eeckhoutte, Joyceline De Volder, Philip M. Hansbro, Matteo Bonato, Marina Saetta, Sara R. A. Wijnant, Fien Verhamme, Guy F. Joos, Ken R. Bracke, Guy G. Brusselle, Tania Maes
Summary: ILC1 subset is increased in COPD patients and correlates with smoking and severity of respiratory symptoms. ILCs increase upon CS exposure in C57BL/6J mice. In the absence of adaptive immunity, ILCs contribute to CS-induced pro-inflammatory mediator release, but are redundant in CS-induced innate inflammation.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
