Review
Pharmacology & Pharmacy
Chunying Xiao, Sheng Liu, Ge Ge, Hao Jiang, Liezhi Wang, Qi Chen, Chong Jin, Jinggang Mo, Jin Li, Kunpeng Wang, Qianqian Zhang, Jianyu Zhou
Summary: Hepatocellular carcinoma (HCC) is a common digestive malignancy and a leading cause of cancer mortality worldwide. Local ablation therapies, such as radiofrequency ablation (RFA) and high-intensity focused ultrasound (HIFU) ablation, have shown effectiveness in treating HCC. However, the molecular mechanisms and HCC recurrence after ablation still need further understanding.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Oncology
Huan Chen, Jing Chen, Huixin Yuan, Xiuhui Li, Weihua Li
Summary: Hypoxia-induced high expression of HIF-1 alpha is associated with invasion and metastasis in HCC. Modulating HIF-1 alpha can reduce drug resistance and improve prognosis, making it a potential critical target for inhibiting HCC metastasis in the future.
Article
Biotechnology & Applied Microbiology
Lingchun Kong, Jingjing Li, Yuqin Yang, Huixin Tang, Hong Zou
Summary: This study found that Paeoniflorin (PF) can alleviate the progression of retinal vein occlusion (RVO) by inhibiting the HIF-1 alpha/VEGF/STAT3 pathway. The results of this study may provide theoretical knowledge for exploring novel treatments for RVO patients.
Review
Oncology
Kenneth N. Huynh, Sriram Rao, Bradley Roth, Theodore Bryan, Dayantha M. Fernando, Farshid Dayyani, David Imagawa, Nadine Abi-Jaoudeh
Summary: Hypoxia-inducible factor 1 alpha (HIF-1a) is a transcription factor that regulates the cellular response to hypoxia and is upregulated in all types of solid tumor. Hepatocellular carcinoma (HCC) is a highly vascular and hypoxic tumor, and treatments like TACE and TAE can exacerbate hypoxia in HCC. Hypoxia-activated prodrugs (HAPs) have potential as a targeted treatment for hypoxic HCC, but more research is needed to understand their effects in combination with embolization.
Review
Biotechnology & Applied Microbiology
Lei Wang, Jin-lin Peng
Summary: This study systematically investigated the association between HIF-1 alpha expression and the development and prognosis of HBV-induced HCC. The results showed that HIF-1 alpha overexpression was closely associated with invasion and metastasis in HBV-induced HCC tissues.
INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS
(2023)
Article
Gastroenterology & Hepatology
Lin Zhou, Yang Zhao, Li-Chao Pan, Jing Wang, Xian-Jie Shi, Guo-Sheng Du, Qiang He
Summary: This study found that HIF-1 alpha plays a role in promoting tumor proliferation and invasion in liver cancer. Inhibiting the PI3K/Akt/mTOR-HIF-1 alpha and HIF-1 alpha-PTEN signaling pathways can enhance the anti-cancer effect of Huai Er.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Ryuta Tagawa, Hiroshi Soda, Yosuke Dotsu, Hiroaki Senju, Satoshi Irifune, Masataka Yoshida, Shota Nakashima, Asuka Umemura, Keisuke Iwasaki, Hirokazu Taniguchi, Shinnosuke Takemoto, Yuichi Fukuda, Hiroshi Mukae
Summary: This article presents the case of a 69-year-old man who developed intractably painful hypertrophic osteoarthropathy (HOA) secondary to lung cancer. Treatment with carboplatin, paclitaxel, and bevacizumab reduced tumor size and plasma vascular endothelial growth factor (VEGF) levels, relieving the patient's leg pain. The immunohistochemical examination showed that lung cancer cells were positive for VEGF, suggesting a potential role of hypoxia-inducible factor-1a in VEGF production. The findings of this study may lead to the development of novel management strategies for painful HOA.
Article
Virology
Nicholas J. Duchemin, Ronak Loonawat, Kyle Yeakle, Andrea Rosenkranz, Michael J. Bouchard
Summary: Globally, chronic hepatitis B virus (HBV) infection is the main cause of hepatocellular carcinoma (HCC). Previous studies have shown elevated levels of hypoxia-inducible factor 1 (HIF1) in HCC and HBV-infected hepatocytes; however, the impact of HIF1 activity on the HBV lifecycle is not well understood. Using liver-derived cell line and ex vivo cultured primary hepatocytes, researchers discovered that HIF1 increases HBV RNA transcript levels, core protein levels, cytoplasmic localization of core protein, and HBV genome replication. Inhibiting the transcription activity of HIF1 blocked its effects on the HBV lifecycle. These findings suggest that HIF1 plays a key role in regulating various stages of the HBV lifecycle and could be a potential therapeutic target for blocking HBV replication and associated diseases.
Article
Oncology
Ahmed Alzamzamy, Huda Elsayed, Mona Abd Elraouf, Hanan Eltoukhy, Tarek Megahed, Ashraf Aboubakr
Summary: This study demonstrates that serum VEGF and VEGF/PLT have high sensitivity and specificity in the early diagnosis of HCC, serving as reliable biomarkers. A VEGF cut-off value of 250 pg/mL has 80% sensitivity and 81.7% specificity, while VEGF/PLT ratio has 77.5% sensitivity and 80% specificity, with a combination increasing diagnostic accuracy to over 95% for HCC.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Oncology
Chiara Rocha, Erin H. Doyle, Chip A. Bowman, M-Isabel Fiel, Ashley E. Stueck, Nicolas Goossens, Kian Bichoupan, James F. Crismale, Jasnit Makkar, Sara Lewis, Ponni V. Perumalswami, Thomas D. Schiano, Yujin Hoshida, Myron Schwartz, Andrea D. Branch, Neal Patel
Summary: Successful treatment of hepatitis C reduces liver inflammation and fibrosis, but patients are still at risk of developing hepatocellular carcinoma. Risk factors for post-SVR HCC include non-Caucasian race, smoking, age over 60, low albumin level, elevated AST/ALT ratio, and low platelet count. AFP may be a promising marker for post-SVR HCC risk.
Article
Cell Biology
Meng Wang, Haoyu Liu, Xu Zhang, Wenbo Zhao, Xiaoyan Lin, Fei Zhang, Danyang Li, Chengpeng Xu, Fei Xie, Zhen Wu, Qibing Yang, Xiangzhi Li
Summary: MOF negatively regulates HIF-1α expression in hepatocellular carcinoma, mediating its N-terminal acetylation and degradation, affecting cellular tolerance to hypoxia and drug resistance in hepatocellular carcinoma cells, highlighting its role in oncogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Carolina Mendez-Blanco, Paula Fernandez-Palanca, Flavia Fondevila, Javier Gonzalez-Gallego, Jose L. Mauriz
Summary: The study evaluated the expression of HIF-1 alpha and HIF-2 alpha in HCC patients and their relationship with prognosis and clinicopathological features. Results indicate that HIF-1 alpha overexpression is associated with poor overall survival, disease-free/recurrence-free survival, and several clinicopathological features in HCC patients.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Hui Liang, Jian-Guo Wu, Fei Wang, Bo-Xuan Chen, Shi-Tian Zou, Cong Wang, Shuai-Wu Luo
Summary: The expression of caspase-3 decreases and HIF-1 alpha increases in HCC tissues complicated by pathological changes of hemorrhage and necrosis, and these are related to clinicopathological features and prognosis.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Oncology
Meng Xue, Xiaona Lin, Qiu-Xiong Lin, Xiaoyong Pu, Jiumin Liu, Xing-Fang Li, Jun Hou, Xudong Liu, Ren Chen
Summary: This study found that HBV infection was associated with an increased risk of HCC compared to HEV infection, and that HEV infection may mitigate the promoting impact of HBV on HCC development.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Oncology
Zhi Zeng, Qiliang Lu, Yang Liu, Junjun Zhao, Qian Zhang, Linjun Hu, Zhan Shi, Yifeng Tu, Zunqiang Xiao, Qiuran Xu, Dongsheng Huang
Summary: Sorafenib is a first-line drug for treating advanced hepatocellular carcinoma, but its efficacy is limited by drug resistance in some patients. Combinatorial therapy with HIFs-targeted therapy or HIFs inhibitors can overcome sorafenib resistance in HCC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Engineering, Electrical & Electronic
Huali Lu, Yuanyuan Hao, Chenji Guo, Xunhua Huang, Hui Hao, Dongmei Guo, Hua Zhao, Wanchun Tang, Peng Wang, Hongpu Li
Summary: A nano-displacement measurement system based on a modified Mach-Zehnder interferometer was proposed and demonstrated theoretically and experimentally, achieving stable and robust interference patterns. By introducing a reflection module and a novel phase-demodulation method, tiny displacements ranging from 50 to 800 nm were successfully measured with a resolution of about 50 pm. This approach may have applications in ultra-high precision displacement sensors as well as temperature, strain, and refractive index sensors.
IEEE JOURNAL OF QUANTUM ELECTRONICS
(2022)
Review
Optics
Chengliang Zhu, Lei Wang, Hongpu Li
Summary: This paper reviews the past and recent advances in phase-inserted fiber gratings (PI-FGs), highlighting their principles, design methods, fabrication techniques, and applications in optical filtering, optical signal processing, and optical sensing. PI-FGs have been used as complex filters that are difficult or impossible to realize with ordinary fiber gratings.
Article
Optics
Yuanyuan Hao, Chenji Guo, Xunhua Huang, Jiannan Xu, Huali Lu, Hua Zhao, Peng Wang, Hongpu Li
Summary: This study proposes a simple and reliable method for synthesizing the complex orbit-angular-momentum (OAM) spectrum of hybrid mode in a few-mode fiber. The method utilizes the inverse scattering method based on the genetic algorithm (GA) to optimize the main Fourier components in a specially-selected ring in the intensity distribution of the hybrid mode. A proof-of-concept example demonstrates the successful reconstruction of the power spectrum of a hybrid mode consisting of first- and second-order OAM modes with an accuracy higher than 0.99.
Article
Pharmacology & Pharmacy
Li Li, Xulin Xu, Keyu Lv, Guijuan Zheng, Hao Wang, Shuai Chen, Lang Huang, Yi Liu, Yadong Zhang, Zhaoming Tang, Lili Zhang, Jinyu Wang, Jianlin Qiao, Hongliang Li, Xuanbin Wang, Guangmin Yao, Chao Fang
Summary: Asebogenin exhibits potent antithrombotic effects by inhibiting platelet activation and neutrophil extracellular trap formation, and its mechanism of action is mediated by targeting Syk.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Optics
Chengliang Zhu, Qingxia Piao, Yong Zhao, Hongpu LI
Summary: A novel and reliable method using a periodically-twisted graded-index few-mode fiber (GI-FMF) to produce an ultra-broad edge-filter (UBEF) is proposed and demonstrated both theoretically and experimentally. The UBEF achieved high performances, surpassing those of previously reported fiber-based optical edge-filters (OEFs). It can be utilized as an ultra-broadband power interrogation component and a highly-sensitive power-interrogated sensor, and has been successfully applied in a power-interrogated temperature sensor.
Article
Physics, Applied
Huali Lu, Xunhua Huang, Chenji Guo, Jiayang Xu, Jiannan Xu, Hui Hao, Hua Zhao, Wanchun Tang, Peng Wang, Hongpu Li
Summary: A compact and stable Fizeau interferometer based on orbital angular momentum (OAM) beams is proposed and demonstrated in this study. A phase-demodulation method operating in the domain of the OAM complex spectrum is also proposed. This provides a robust alternative for accurately extracting the phase from the OAM interferogram.
APPLIED PHYSICS LETTERS
(2022)
Article
Engineering, Electrical & Electronic
Chenji Guo, Jiayang Xu, Jiannan Xu, Huali Lu, Hui Hao, Hua Zhao, Peng Wang, Hongpu Li
Summary: Orbital-angular-momentum (OAM) beams-based interferometers have attracted significant interest and found various applications in optical precision measurement. In this study, an all-fiber OAM beams-based interferometer was proposed and experimentally demonstrated, utilizing helical long-period fiber gratings (HLPGs) to generate conjugated OAM beams for testing and referencing. The interferograms obtained had polarization independence, robustness, and were particularly suitable for phase-demodulation in the azimuthal angle domain. The proposed interferometer showed high sensitivity and measurement accuracy for temperature and strain, making it suitable for ultra-high precision and sensing measurements.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Zhen Zhang, Heng Zhang, Kaiyue Gao, Jinxin Wu, Hui Hao, Hua Zhao, Peng Wang, Hongpu Li
Summary: A temperature-insensitive torsion and strain sensor based on a helical long-period fiber grating (HLPG) is proposed and demonstrated. The sensor utilizes a second-order HLPG in a thinned four-mode fiber to achieve simultaneous measurement of torsion and strain. The sensor's maximum torsion sensitivity is 665 pm/(rad/m) and maximum strain sensitivity is -5.42 pm/με, which are significantly higher than those of conventional long-period fiber grating (LPG)-based sensors. Additionally, the sensor exhibits a temperature sensitivity of 13.7 pm/°C, which is about 4 times lower than that of conventional LPGs.
IEEE JOURNAL OF QUANTUM ELECTRONICS
(2023)
Article
Engineering, Electrical & Electronic
Chengliang Zhu, Qingxia Piao, Lei Wang, Zhenhao Bing, Yong Zhao, Hua Zhao, Hongpu Li
Summary: An ultra-wideband orbital-angular-momentum (OAM) mode generator based on a helical long period fiber grating (HLPG) written in a graded-index few-mode fiber (GIFMF) has been proposed and demonstrated. Unlike previous HLPG-based broadband OAM generators, which operated at wavelengths close to the dispersion-turning point (DTP), the GIFMF-based HLPG proposed in this study operates at wavelengths far from the DTP, enabling the production of a ultra-wideband OAM mode generator with high conversion efficiency and flexibility in controlling the central wavelength. A first-order OAM mode generator with a central wavelength of approximately 1510 nm, a bandwidth of approximately 235 nm, and a conversion efficiency larger than 99% (approximately 20.7 dB) has been successfully obtained, marking the first practical demonstration of the GIFMF-based HLPG.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Meng Zhang, Chengliang Zhu, Hongpu Li
Summary: This study reveals the underlying mechanism for mode coupling and propagation in a strongly-coupled few-period long-period fiber grating (LPG), based on the idea that it can be considered as cascaded and phase-matched Mach-Zehnder interferometers. The proposed mechanism and analysis method can also be applied to conventional LPGs, opening up new possibilities for design and fabrication of other types of LPGs such as mode converters, multichannel, phase-shift, and high-order LPGs.
IEEE PHOTONICS TECHNOLOGY LETTERS
(2023)
Article
Engineering, Electrical & Electronic
Chengliang Zhu, Shuai Huang, Chengfeng Tang, Gang Yang, Yong Zhao, Hongpu Li
Summary: A miniature temperature-independent curvature sensor was proposed and prepared using a phase-shifted long-period fiber grating fabricated from deeply tapered conventional single-mode fibers. A demonstration of a sensor made from a phase-shifted deeply tapered long-period grating with a length of 3.4 mm and a maximum curvature sensitivity of 12.05 nm/m(-1) was successful. The proposed curvature sensor has the characteristics of temperature independence, high sensitivity, high reliability, miniature size, and low cost, making it potentially useful in structural health monitoring, especially in the medical industry and shape reconstruction.
IEEE SENSORS JOURNAL
(2023)
Article
Engineering, Electrical & Electronic
Chengliang Zhu, Shuai Huang, Xinyue Meng, Yong Zhao, Hongpu Li
Summary: Deeply-tapered long-period fiber gratings (DT-LPFGs) have been fabricated using the cylindrical-lens-assisted CO2 laser technique. The DT-LPFG demonstrates high coupling efficiency and low polarization-dependence, making it suitable for the production of ultrashort yet strong LPFGs and highly sensitive transverse load sensors.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2023)
Article
Optics
Zhang Meng, Naruya Mochzuki, Shiryu Oiwa, Hua Zhao, Peng Wang, Chengliang Zhu, Hongpu Li
Summary: In this study, a full C-band covered and DWDM channelized OAM mode generator is proposed and experimentally demonstrated. The generator utilizes a broadband helical long-period fiber grating (HLPG) combined with a phase-only sampled multichannel fiber Bragg grating (MFBG). The demonstrated generator shows high conversion efficiency, wide bandwidth, and uniformity between channels, and has potential applications in various fields.
Article
Optics
Hua Zhao, Jiannan Xu, Yuanyuan Hao, Jiayang Xu, Huali Lu, Hui Hao, Ting Zhao, Pengfei Li, Peng Wang, Hongpu Li
Summary: In this study, it is demonstrated theoretically and experimentally that the convolutional neural network (CNN) combined with residual blocks and regression methods can accurately and quickly reconstruct the OAM spectrum of hybrid OAM modes, regardless of the consistency of the order indices in both azimuthal and radial directions. The mean errors of recognized parameters for hybrid OAM modes in a 4-mode fiber (4MF) and a 6-mode fiber (6MF) are smaller than 0.003 and 0.008, respectively. This is the first time that all OAM modes in 4MFs or 6MFs can be accurately and quickly recognized using the deep learning method.
Proceedings Paper
Engineering, Mechanical
Zhaoming Tang, Binbin Lu, Jia Yang
Summary: This paper studies the abnormal heating of the main hydraulic tank and the failure of maintaining the supercharged pressure of the fuel tank in a certain type of aircraft's main hydraulic source. It uses fault tree analysis method to analyze the fault phenomenon and carries out fault troubleshooting from both static and dynamic aspects. Finally, it is concluded that the cause of the abnormal heating of the main hydraulic tank is the fault of the safety valve.
INTERNATIONAL CONFERENCE ON MECHANICAL DESIGN AND SIMULATION (MDS 2022)
(2022)
