Article
Cell Biology
Lingjun Dong, Fuxiang Liang, Zhiling Lou, Yangfan Li, Jinsheng Li, Yaling Chen, Jingjing Ding, Bin Jiang, Chuanqiang Wu, Huan Yu, Yafei Liu, Weiping Zhang, Yunbi Lu, Ming Wu
Summary: Nec-1 can alleviate lung ischemia-reperfusion injury by inhibiting necroptosis and apoptosis of epithelial cells, and promoting neutrophil apoptosis, making it a promising medication against primary graft dysfunction after lung transplantation.
Article
Orthopedics
Chen Yu, Xiaoxu Wang, Jian Qin
Summary: Necrostatin-1 (Nec-1) can reduce peripheral nerve lesions and protect Schwann cells and axons by inhibiting necroptosis. It also reduces inflammation and oxidative stress by inhibiting RIP1.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Immunology
Qiao Xu, Junjie Guo, Xiangen Li, Yang Wang, Dan Wang, Kan Xiao, Huiling Zhu, Xiuying Wang, Chien-An Andy Hu, Guolong Zhang, Yulan Liu
Summary: Necroptosis, a newly recognized form of programmed cell death with features of both necrosis and apoptosis, was found to occur in the liver during sepsis, contributing to septic hepatic injury. Inhibition of necroptosis led to reduced hepatic inflammation and damage in a piglet model of LPS-induced sepsis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bing-feng Hu, Qian Gong, Shi-qing Chen, Lin Yue, Wen-xian Ma, Fang Wang, Xiao-wen Feng, Jia-nan Wang, Chao Li, Ming-ming Liu, Xue-fu Wang, Xiao-ming Meng, Jun Li, Jia-gen Wen
Summary: Necroptosis plays a role in gentamicin-induced acute kidney injury, and suppressing necroptosis could be a promising strategy for prevention.
Article
Pharmacology & Pharmacy
Liyuan Cao, Wei Mu
Summary: Necrostatin-1 (Nec-1) is an inhibitor of necroptosis that has been shown to play an important role in various diseases and has the potential to provide protection in diseases such as COVID-19. Research findings indicate that Nec-1 can ameliorate disease development by inhibiting the necroptosis signaling pathway.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jiao Mu, Jiequn Weng, Chaoxian Yang, Teng Guan, Li Deng, Meiyu Li, Guohui Zhang, Jiming Kong
Summary: Nec-1 protects neurons and oligodendrocytes against traumatic and ischemic brain injuries by targeting the BNIP3-induced cell death pathway, making it a novel inhibitor for BNIP3.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Medicine, General & Internal
Xiaohong Xiang, Jiefu Zhu, Gang Zhang, Zhengwei Ma, Man J. Livingston, Zheng Dong
Summary: The study demonstrates that p53 plays a critical role in kidney injury associated with cold storage/transplantation, and inhibiting p53 can improve the histology and function of transplanted kidneys, showing potential as a therapeutic target for kidney transplantation.
FRONTIERS IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Danuta Jantas, Wladyslaw Lason
Summary: Neurodegenerative diseases are common chronic conditions without definitive treatment. Oxidative stress and necroptosis are thought to be closely related to the pathogenesis of neurodegenerative diseases. Multi-potential neuroprotectants with antioxidant and anti-necroptotic properties may be an effective therapeutic strategy.
Article
Biology
Shintaro Ide, Yoshihiko Kobayashi, Kana Ide, Sarah A. Strausser, Koki Abe, Savannah Herbek, Lori L. O'Brien, Steven D. Crowley, Laura Barisoni, Aleksandra Tata, Purushothama Rao Tata, Tomokazu Souma
Summary: The study reveals that proximal tubular cells develop a pro-inflammatory state following injury, which can lead to persistent inflammation and fibrosis. After mild injury, these inflammatory PT cells transiently appear and make the cells vulnerable to ferroptotic stress; while after severe injury, they accumulate and enhance inflammation and fibrosis.
Article
Chemistry, Medicinal
Kunyu Shi, Jifa Zhang, Enda Zhou, Jiaxing Wang, Yuxi Wang
Summary: This article summarizes the recent research progress in RIP1 small-molecule inhibitor development based on different binding modalities, and discusses prospective strategies for designing additional RIP1 therapeutic agents.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jin-Yong Lee, Maki Tokumoto, Masahiko Satoh
Summary: Cadmium exerts its cytotoxicity through the inhibition of MEF2A activity and suppression of GLUT4 expression, leading to reduced cellular glucose concentration and ATP levels. This study provides a crucial breakthrough in understanding the mechanism of Cd toxicity in renal cells.
Article
Pharmacology & Pharmacy
Hend Ashour, Heba A. Hashem, Akef A. Khowailed, Laila A. Rashed, Randa M. Hassan, Ayman S. Soliman
Summary: Inhibition of RIPK1 improves the inflammatory immune response induced by renal IRI, reducing necrosis and cell death. The use of two doses of necrostatin-1 shows more beneficial effects in normalizing renal function.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Review
Cell Biology
Min Chen, Xiangchen Gu
Summary: Endocytosis plays a crucial role in kidney diseases, particularly in renal fibrosis, and is affected by other diseases and factors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Immunology
Mengyuan Liu, Haibo Li, Rongliang Yang, Dan Ji, Xiaobo Xia
Summary: The study found that glutamate excitotoxicity induced necroptosis in RGCs through activation of the RIP1/RIP3/MLKL pathway in vivo and in vitro. Administration of the RIP3 inhibitor GSK872 and RIP1 inhibitor Nec-1 prevented glutamate-induced RGCs loss, retinal damage, neuroinflammation, overproduction of ROS and a decrease in GSH. Furthermore, after suppression of the RIP1/RIP3/MLKL pathway by GSK872 and Nec-1, glutamate-induced upregulation of key proteins involved in NLRP3 inflammasome activation was markedly inhibited.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neurosciences
Xiaocheng Gao, Ping Zhang, Jianping Chen, Lan Zhang, Nan Shang, Jin Chen, Rong Fan, Yanhong Wang, Tao Huang, Qiao Niu, Qinli Zhang
Summary: This study established a zebrafish AD model induced by aluminum and found that Nec-1 was effective in reversing learning and memory deficits caused by aluminum exposure. Nec-1 increased acetylcholine levels and neural cell numbers, and influenced the expression of necroptosis-related genes.
NEUROTOXICITY RESEARCH
(2022)
Article
Peripheral Vascular Disease
Ya-wen Mo, Chun-yan Sun, Li Song, Li-fang Zhou, Ting-ting Zhuang, Mi Zhong, Shu-qian Zheng, Ying-gui Chen, Yuan-han Chen, Shuang-xin Liu, Xin-ling Liang, Xia Fu
Summary: The study showed a positive correlation between blood flow measured by ultrasonic dilution technique and duplex Doppler ultrasound during hemodialysis, indicating the latter can be used to monitor blood flow changes in the brachial and radial arteries for timely interventions to improve fistula patency.
JOURNAL OF VASCULAR ACCESS
(2021)
Article
Cardiac & Cardiovascular Systems
Penghua Hu, Yuanhan Chen, Yanhua Wu, Li Song, Li Zhang, Zhilian Li, Lei Fu, Shuangxin Liu, Zhiming Ye, Wei Shi, Xinling Liang
Summary: A new clinical model was developed and validated to predict the risk of AKI after cardiac surgery in older patients. The model demonstrated high discrimination, good calibration, and clinical utility, outperforming existing scoring systems.
JOURNAL OF CARDIAC SURGERY
(2021)
Article
Geriatrics & Gerontology
Libin Xu, Yanhua Wu, Yuanhan Chen, Ruiying Li, Zhiqiang Wang, Zhilian Li, Guoping Liu, Lei Yu, Wei Shi, Xinling Liang
Summary: The study found that the incidence of AKI in older adults showed a U-shaped curve with age, with a significantly higher incidence in those aged 75 and above. However, AKI risk did not increase with age, and the association between AKI and in-hospital death did not increase in an age-dependent manner in older adults.
Article
Urology & Nephrology
Min He, Yanhua Wu, Zhen Xie, Zhilian Li, Li Hao, Guohui Liu, Qiang He, Yuanjiang Liao, Rizwangul Ghappar, Hongwei Peng, Jinglie Xie, Xiaohong Wei, Yusheng Zhang, Qiongyi Huang, Yuanhan Chen, Xinling Liang
Summary: Pesticide intoxication is a major risk factor for acute kidney injury, with herbicides posing the greatest risk. Severe renal disease is associated with AKI. Different categories of pesticides result in varying degrees of AKI, which significantly increase in-hospital mortality rates.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Urology & Nephrology
Penghua Hu, Li Song, Huaban Liang, Yuanhan Chen, Yanhua Wu, Li Zhang, Zhilian Li, Lei Fu, Yiming Tao, Shuangxin Liu, Zhiming Ye, Xia Fu, Xinling Liang
Summary: A model was developed and validated to predict the chance of renal recovery in cardiac surgery patients with AKI requiring RRT, which included six variables and showed good discrimination and calibration in predicting renal recovery.
Article
Urology & Nephrology
Qingyu Niu, Xinju Zhao, Liangying Gan, Xinling Liang, Zhaohui Ni, Xiaonong Chen, Yuqing Chen, Fan Fan Hou, Li Zuo
Summary: The study found that higher levels of self-reported physical function limitations were associated with increased risk of all-cause mortality and hospitalization in hemodialysis patients.
Article
Urology & Nephrology
Yuanhan Chen, Yanhua Wu, Penghua Hu, Xia Fu, Shuangxin Liu, Li Song, Wei Dong, Xueqing Yu, Xinling Liang
Summary: During the COVID-19 pandemic, the psychological status of patients and medical staff in hemodialysis centers in Guangdong province was not significantly affected. The implementation of comprehensive preventative measures prevented cluster outbreaks of COVID-19 in these centers. This survey may offer guidance for other regions facing a similar situation.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Cell Biology
Ruizhao Li, Xingchen Zhao, Shu Zhang, Wei Dong, Li Zhang, Yuanhan Chen, Zhilian Li, Huan Yang, Ying Huang, Zhiyong Xie, Weidong Wang, Chunling Li, Zhiming Ye, Zheng Dong, Xinling Liang
Summary: RIP3 plays a crucial role in suppressing autophagic degradation by obstructing the TFEB-lysosome pathway in septic AKI, suggesting potential therapeutic targets for the prevention and treatment of the condition.
CELL DEATH & DISEASE
(2021)
Article
Medicine, General & Internal
Wenxue Hu, Guanglan Li, Jieshan Lin, Wei Dong, Feng Yu, Wei Liu, Yanhua Wu, Wenke Hao, Xinling Liang
Summary: The study reveals the presence of M2 macrophage subpopulations in the glomeruli of patients with primary membranous nephropathy, highlighting their association with disease progression and clinicopathological features. Furthermore, M2a and M2c macrophages show distinct tendencies in the pathogenesis of the disease.
FRONTIERS IN MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Zhi-yong Xie, Wei Dong, Li Zhang, Meng-jie Wang, Zhen-meng Xiao, Yu-hua Zhang, Wan-xin Shi, Ying Huang, Yan Yang, Cui-li Li, Lei Fu, Xing-chen Zhao, Rui-zhao Li, Zhi-lian Li, Yuan-han Chen, Zhi-ming Ye, Shuang-xin Liu, Zheng Dong, Xin-ling Liang
Summary: The new drug 11R-VIVIT effectively prevents renal fibrosis in the transition from AKI to CKD by inhibiting NFAT2 activation, reducing tubulointerstitial fibrosis and cell apoptosis.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Physiology
Zhuo Li, Guibao Ke, Li Song, Junlin Huang, Yamei Zhang, Jie Xiao, Shuangxin Liu, Xinling Liang
Summary: This study investigated the factors influencing serum IS concentrations in HD patients. The results showed that male sex, age >= 60 years, ventricular septal thickness, and mitral regurgitation were closely associated with high total serum IS concentrations. Furthermore, elevated IS levels may play a role in the process of mitral regurgitation in HD patients <60 years of age.
KIDNEY & BLOOD PRESSURE RESEARCH
(2022)
Article
Urology & Nephrology
Penghua Hu, Zhiming Mo, Yuanhan Chen, Yanhua Wu, Li Song, Li Zhang, Zhilian Li, Lei Fu, Huaban Liang, Yiming Tao, Shuangxin Liu, Zhiming Ye, Xinling Liang
Summary: The study aimed to construct a clinical model based on preoperative data for predicting acute kidney injury (AKI) following cardiac surgery in patients with normal renal function. The model showed good discrimination and calibration, providing valuable information for decision-making and rational utilization of medical resources.
Article
Biotechnology & Applied Microbiology
Zhuo Li, Zhiwen Lian, Jianchao Ma, Li Zhang, Xingji Lian, Shuangxin Liu, Jianteng Xie, Zhonglin Feng, Ting Lin, Hong Zhang, Xinling Liang
Summary: The axis formed by ITG beta 3, RhoA, and YAP plays a crucial role in podocyte injury induced by high glucose exposure. ITG beta 3 overexpression promotes podocyte injury by inhibiting the RhoA-YAP axis, while ITG beta 3 inhibition mitigates the ability of wound closure and apoptosis in podocytes under high glucose conditions.
Article
Physiology
Mengxi Zhang, Wei Dong, Zhilian Li, Zhenmeng Xiao, Zhiyong Xie, Zhiming Ye, Shuangxin Liu, Ruizhao Li, Yuanhan Chen, Li Zhang, Mengjie Wang, Huaban Liang, Reshalaitigu Baihetiyaer, Rizvangul Apaer, Zheng Dong, Xinling Liang
Summary: Mitochondrial damage in renal tubular epithelial cells is a key feature of endotoxin-induced acute kidney injury. The downregulation of FOXO1 in RTECs is associated with this injury, while overexpression of FOXO1 can improve renal injury and mitochondrial dysfunction, partially through the PGC1-alpha signaling pathway. FOXO1 may be a potential target for preventing and treating endotoxin-induced AKI.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Urology & Nephrology
Ruizhao Li, Zhiyong Xie, Li Zhang, Ying Huang, Jianchao Ma, Wei Dong, Zhilian Li, Yuanhan Chen, Huaban Liang, Yanhua Wu, Xingchen Zhao, Wenjian Wang, Zhiming Ye, Shuangxin Liu, Wei Shi, Xinling Liang
Summary: This study found that amiloride can significantly decrease urinary albumin creatinine ratio (uACR) in patients with DKD, and also reduce serum and urinary suPAR levels. Elevated levels of urinary suPAR were positively associated with uPCR and uACR, indicating its potential as a biomarker for DKD prognosis.
