Article
Oncology
Mauro Scaravilli, Sonja Koivukoski, Andrew Gillen, Aya Bouazza, Pekka Ruusuvuori, Tapio Visakorpi, Leena Latonen
Summary: The study demonstrates that miR-32 promotes MYC-induced prostate adenocarcinoma and identifies PDK4 as a PC-relevant metabolic target of miR-32-3p. Elevated expression of miR-32 influences prostate tumor growth and phenotype, and regulates the expression of prostate secretome and several PC-related target genes.
Article
Cell Biology
Tao Ding, Yanjun Zhu, Huimin Jin, Ping Zhang, Jianming Guo, Jianghua Zheng
Summary: circ_0057558 promotes cell proliferation and cell cycle control in prostate cancer cells by sponging miR-206 and positively regulating the transcription of miR-206 target gene USP33.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Xiaoyan Liu, Yongjun Li, Zhuo Li, Tian Hou
Summary: The study revealed that miR-155 may serve as a potential diagnostic and therapeutic target for breast cancer. High levels of miR-155 were found in breast cancer tissues and were associated with tumor size, TNM stage, and metastasis status. Inhibitors of miR-155 reduced cell proliferation and suppressed the epithelial-mesenchymal transition process in MCF-7 cells.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Cell Biology
Shuo Wang, Peng Du, Yudong Cao, Jinchao Ma, Xiao Yang, Ziyi Yu, Yong Yang
Summary: Cancer-associated fibroblasts (CAFs) play important roles in promoting tumor growth and metastasis in prostate cancer (PC) through the transfer of exosomes. This study reveals that the exosomal miR-1290 from CAFs enhances PC cell growth and metastasis by inhibiting GSK3 beta/beta-catenin signaling.
CELL DEATH DISCOVERY
(2022)
Article
Oncology
Neda K. Dezfuli, Shamila D. Alipoor, Neda Dalil Roofchayee, Sharareh Seyfi, Babak Salimi, Ian M. Adcock, Esmaeil Mortaz
Summary: The study found that miR-146a expression was significantly downregulated in NSCLC patients, while IL-6 and TGF-beta levels were elevated. The frequencies of immune cells CD3+ CTLA-4+ and Treg cells were also higher in patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Minghua Bai, Chenchen He, Shengjia Shi, Mincong Wang, Jinlu Ma, Pengtao Yang, Yiping Dong, Xingyi Mou, Suxia Han
Summary: This study demonstrates a novel mechanism of the Linc00963/miR-655/TRIM24 competitive endogenous RNA (ceRNA) network in accelerating cell proliferation in castration-resistant prostate cancer (CRPC) in vitro and in vivo. miR-655 inhibits TRIM24 expression and cell proliferation in CRPC cells, while Linc00963 promotes TRIM24 expression and cell proliferation by suppressing miR-655 expression. The findings suggest that Linc00963 could be a potential therapeutic target for CRPC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Priyanka Kulkarni, Pritha Dasgupta, Yutaka Hashimoto, Marisa Shiina, Varahram Shahryari, Z. Laura Tabatabai, Soichiro Yamamura, Yuichiro Tanaka, Sharanjot Saini, Rajvir Dahiya, Shahana Majid
Summary: The study reveals that the interaction between lncTCL6 and miR-155 plays a crucial role in regulating the Src-Akt-EMT network in clear cell renal cell carcinoma, impacting disease progression and metastasis. Patients with higher lncTCL6 expression and lower miR-155 expression have a better survival probability, offering a promising therapeutic target for renal cancer treatment.
Article
Oncology
Hao Zhang, Yang Du, Peng Xin, Xiaojun Man
Summary: In this study, the researchers found that LINC00852 is highly expressed in prostate cancer tissue and its up-regulation can promote the proliferation, migration, and invasion of prostate cancer cells. They also identified that LINC00852 regulates the expression of JARID2 through miR-29a-3p induction. The LINC00852/miR-29a-3p/JARID2 axis could be a potential target for prostate cancer treatment.
Article
Biotechnology & Applied Microbiology
MingLiang Ning, Shaojie Qin, Jia Tian, Yuchen Wang, Qingyuan Liu
Summary: Our research demonstrated that AFAP-AS1 could promote the progression of thyroid cancer by sponging miR-155-5p through regulating the ETS1/ERK pathway. Knock-down of AFAP-AS1 inhibited cell proliferation and accelerated apoptosis in ATC cells. Additionally, AFAP-AS1 negatively regulated miR-155-5p and influenced the ETS1/ERK pathway in ATC.
Article
Medicine, Research & Experimental
Junfeng Wang, Quanyi Wang, Yinan Guan, Yulu Sun, Xiaozhi Wang, Kaylie Lively, Yuzhen Wang, Ming Luo, Julian A. Kim, E. Angela Murphy, Yongzhong Yao, Guoshuai Cai, Daping Fan
Summary: The expression of miR-155 in breast cancer cells is associated with a favorable antitumor immune profile and better patient outcomes. Overexpression of miR-155 in breast cancer cells enhances T cell influx, delays tumor growth, and increases sensitivity to immune checkpoint blockade therapy. The mechanism involves upregulation of CXCL9/10/11 production mediated by SOCS1 inhibition and increased phosphorylated STAT1/STAT3 ratios. Serum miR-155 levels in breast cancer patients correlate with tumor miR-155 levels and tumor immune status.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Multidisciplinary Sciences
Sarathkumar Edachery, Prakash Patil, Rajashekar Mohan, Bhuvanesh Aradhya, Jayaprakash Shetty, Shama Prasada Kabekkodu, Manas Kumar Santra, Sathisha Jayanna Gonchigar, Praveenkumar Shetty
Summary: miR-936 is downregulated in metastatic prostate cancer, leading to the overexpression of its target gene ANXA2. miR-936 directly interacts with coding and 3'UTR regions of ANXA2 mRNA to regulate ANXA2 expression. Overexpression of miR-936 inhibits cell proliferation, migration, and invasion abilities in metastatic prostate cancer cells, and suppresses tumor formation in vivo. Therefore, miR-936 may serve as a targeted therapeutic molecule for metastatic prostate cancer control and prognosis improvement.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
S. Sun, Z. Wang, F. Yao, K. Sun, Z. Li, C. Li
Summary: The study found that microRNA-155 loaded by breast cancer cell-derived exosomes inhibits the generation of white adipose tissue and promotes the formation of brown adipose tissue, leading to cachexia. It was also discovered that this effect is associated with miR-155 targeting UBQLN1.
HUMAN MOLECULAR GENETICS
(2023)
Review
Biochemistry & Molecular Biology
Petra Korac, Mariastefania Antica, Maja Matulic
Summary: miR-7 is an ancient miRNA involved in cell signaling pathways, acting primarily as a tumor suppressor by inhibiting cell proliferation and promoting apoptosis. It also has additional roles in cell regulation and protection, with potential for use in biotherapeutics.
Article
Medicine, Research & Experimental
Lei Du, Yongli Gao
Summary: The study revealed that PGM5-AS1 upregulates GDF10 gene expression by competitively binding to miR-587, thus inhibiting proliferation and accelerating apoptosis of PCa cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biology
Liang Bai, Li Luo, Weicheng Gao, Chenfeng Bu, Jianfeng Huang
Summary: The study revealed that miR-182 is upregulated in prostate cancer and can influence the proliferation and invasion abilities of tumor cells by regulating ST6GALNAC5, while also modulating tumor progression through the PI3K/Akt pathway.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2021)