Article
Pharmacology & Pharmacy
E. Wen, Guang Xin, Shiyi Li, Yuman Dong, Yuda Zhu, Chengyu Wan, Xiuxian Yu, Zeliang Wei, Yilan Wang, Fan Li, Kun Zhang, Hai Niu, Wen Huang
Summary: This study found that Tuftsin alleviates SAP-induced spleen injury by promoting NRP1 expression, mainly through alleviating mitochondrial dysfunction, oxidative stress, ATP depletion, and the expression of pro-inflammatory factors.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Di Zhang, Lei Li, Jun Li, YunLei Wei, Jian Tang, Xiaohua Man, Feng Liu
Summary: Colchicine treatment mitigates the severity of SAP-ALI in rats by inhibiting inflammation, oxidative stress, and cell apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Qian Zhuang, Liqiang Huang, Yue Zeng, Xu Wu, Gan Qiao, Minghua Liu, Lulu Wang, Yejiang Zhou, Yuxia Xiong
Summary: This study found that in SAP rats, the immunoswitching point from excessive inflammatory response to immunosuppression occurs at 48 hours after model construction. This has significant implications for optimizing the timing of immune regulation in SAP.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Tongtian Ni, Ying Chen, Bing Zhao, Li Ma, Yi Yao, Erzhen Chen, Weijun Zhou, Enqiang Mao
Summary: The study suggests that colon fluid resuscitation may help in early controlled fluid resuscitation for severe acute pancreatitis patients, reducing the rate of mechanical ventilation and incidence of hypernatremia, but there is no significant difference in prognosis compared to conventional fluid resuscitation. Further prospective research is needed to evaluate the impact of colon fluid resuscitation on SAP patients.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Shukun Sun, Yu Han, Chuanxin Zhang, Han Liu, Bailu Wang, Shengchuan Cao, Qiuhuan Yuan, Shujian Wei, Yuguo Chen
Summary: ADK inhibition reduces inflammation and necroptotic acinar cell death in severe acute pancreatitis via the adenosine A(2A) receptor/ER stress pathway, providing new clues for potential therapeutic targets for SAP.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Medicine, General & Internal
Hongxin Kang, Yue Yang, Lv Zhu, Xianlin Zhao, Juan Li, Wenfu Tang, Meihua Wan
Summary: Severe acute pancreatitis (SAP) is a life-threatening abdominal disease. Neutrophil extracellular traps (NETs) play an important role in the occurrence and development of SAP, as well as its fatal complications. This review provides insights into the involvement of NETs in SAP and suggests targeting NETs as a promising strategy in SAP treatment.
CHINESE MEDICAL JOURNAL
(2022)
Article
Multidisciplinary Sciences
Shujun Yang, Yaodong Song, Qiaofang Wang, Yanna Liu, Zhongwei Wu, Xiaojia Duan, Yan Zhang, Xiuqian Bi, Yuanzhang Geng, Sanyang Chen, Changju Zhu
Summary: Daphnetin pretreatment significantly alleviated SAP-induced pancreatic and lung tissue damage by inhibiting the activation of the JAK2-STAT3 signaling pathway, reducing inflammatory cytokine concentrations, decreasing cell apoptosis, and inhibiting white blood cell infiltration.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Yaru Huangfu, Xiuxian Yu, Chengyu Wan, Yuda Zhu, Zeliang Wei, Fan Li, Yilan Wang, Kun Zhang, Shiyi Li, Yuman Dong, Yangying Li, Hai Niu, Guang Xin, Wen Huang
Summary: This study found that Xanthohumol (Xn) improved severe acute pancreatitis (SAP) by enhancing autophagic flux through inhibition of the AKT/mTOR pathway, suggesting its potential as a novel therapeutic agent for SAP.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Haiyan Han, Lixin Zhang, Qiang Fu, Biqin Zhang, Jiaxiu Chen
Summary: Obesity may worsen the severity of pancreatitis by increasing serum lipase, non-esterified fatty acids, and myeloperoxidase levels, activating M1 polarization in adipose tissue macrophages, and elevating pro-inflammatory cytokines. Moreover, serum exosomes may modulate the expression of inflammatory factors in THP-1 cells, affecting the development of pancreatitis. These findings contribute to a better understanding of the relationship between obesity and pancreatitis and the underlying mechanisms.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Jiaqi Yao, Bowen Lan, Chi Ma, Yan Liu, Xiaoqi Wu, Kaixuan Feng, Hailong Chen, Qingping Wen
Summary: This study found that Dexmedetomidine can attenuate pancreatic injury, inhibit cell necroptosis and apoptosis, and alleviate oxidative stress caused by severe acute pancreatitis (SAP). It can also mitigate the structural damage to mitochondria and endoplasmic reticulum caused by SAP, and regulate the inflammatory response and tissue damage through inhibiting specific pathways and neutrophil extracellular trap formation. These findings provide experimental evidence for the future clinical application of Dexmedetomidine in SAP treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Engineering, Biomedical
Sebastian Rasch, Senguel Sancak, Johanna Erber, Johannes Wiessner, Dominik Schulz, Christina Huberle, Hana Alguel, Roland M. Schmid, Tobias Lahmer
Summary: Cytokine adsorption may be an effective treatment option for severe acute pancreatitis, stabilizing hemodynamics, reducing levels of pro-inflammatory marker IL-6, and improving renal function.
Review
Immunology
Shiyu Liu, Peter Szatmary, Jing-wen Lin, Qiqi Wang, Robert Sutton, Lu Chen, Tingting Liu, Wei Huang, Qing Xia
Summary: Acute pancreatitis is a common gastrointestinal disease characterized by acute onset of abdominal pain, often leading to organ failure and death. Monocytes, a type of cells in the innate immune system, are highlighted as key contributors and regulators of the inflammatory response and organ failure in acute pancreatitis, with a special focus on lipid modulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Jinxiang Wu, Jintao Zhang, Jiping Zhao, Shihong Chen, Tao Zhou, Jianwei Xu
Summary: This study revealed the role of GSDMD-mediated pyroptosis in SAP-associated lung injury, and demonstrated the potential application of disulfiram as a pyroptosis inhibitor in the treatment of SAP.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Xiaohong Wang, Jing Qian, Yun Meng, Ping Wang, Ruizhi Cheng, Guoxiong Zhou, Shunxing Zhu, Chun Liu
Summary: Salidroside alleviated pancreatic injury and inhibited inflammation by regulating the miR-217-5p/YAF2 axis, which might provide new therapeutic strategies for SAP treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yun Wang, Yanjing Li, Shaojingya Gao, Xi Yu, Yu Chen, Yunfeng Lin
Summary: The use of tetrahedral framework nucleic acids (tFNAs) in treating severe acute pancreatitis (SAP) in mice has proven effective in suppressing inflammation and preventing pathological cell death.
Article
Oncology
Xingcheng Xiong, Jiarui Feng, Xiao Yang, Hanjun Li, Qiao Shi, Jing Tao, Jian Chang
Summary: The circular RNA CDR1as (circCDR1as) is highly expressed in pancreatic cancer tissues, promoting the migration, invasion, and proliferation of pancreatic cancer cells. It mediates E2F3 expression by sponging miR-432-5p, suggesting it could be a novel diagnostic target for pancreatic cancer.
CANCER CELL INTERNATIONAL
(2021)
Article
Biotechnology & Applied Microbiology
Zhendong Qiu, Wenhong Deng, Yupu Hong, Liang Zhao, Man Li, Yongjun Guan, Yingru Su, Chen Chen, Qiao Shi, Jia Yu, Weixing Wang
Summary: Research showed that the knockdown of ATP citrate lyase (ACLY) and Sterol regulatory element binding protein 1 (SREBP1) genes inhibits proliferation, migration, and invasion of colorectal cancer cells, while promoting apoptosis. These findings suggest potential new targets for treating colorectal cancer through modulation of lipid synthesis in cancer cells.
ONCOTARGETS AND THERAPY
(2021)
Article
Immunology
Jiacheng Zhang, Fangchao Mei, Liang Zhao, Teng Zuo, Yupu Hong, Man Li, Jia Yu, Weixing Wang
Summary: The study found that the p38 MAPK inhibitor SB203580 can protect against acute renal injury caused by APIP by blocking the p38 MAPK signaling pathway and inhibiting inflammatory responses.
IMMUNOLOGIC RESEARCH
(2021)
Article
Cell Biology
Xiaoyi Zhang, Jing Tao, Jia Yu, Ning Hu, Xuanzhe Zhang, Guirong Wang, Jiarui Feng, Xingcheng Xiong, Man Li, Dongqi Chai, Hanjun Li, Yuping Rong, Zhigang Tang, Weixing Wang, Zhiyong Peng, Qiao Shi
Summary: It has been found that beta-cell loss contributes to pancreatic endocrine insufficiency following acute pancreatitis, whereas inhibition of Notch activity promotes the differentiation of pancreatic Krt5(+) cells into beta cells, thereby improving glucose homeostasis.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Yongjun Guan, Man Li, Zhendong Qiu, Junhui Xu, Yichao Zhang, Ning Hu, Xuanzhe Zhang, Wenyi Guo, Jingping Yuan, Qiao Shi, Weixing Wang
Summary: This study conducted a comprehensive analysis of DOK family genes based on their expression profile and their relationship with patient survival, immune infiltration, tumor microenvironment, and drug sensitivity. The results showed that DOK family genes are significantly associated with poor prognosis and tumor immunity in UVM, with DOK2 increasing the sensitivity of chemotherapy drugs and DOK4 reducing the sensitivity of multiple chemotherapy drugs.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Oncology
Yichao Zhang, Junhui Xu, Zhendong Qiu, Yongjun Guan, XiaoYi Zhang, Xin Zhang, Dongqi Chai, Chen Chen, Qinyong Hu, Weixing Wang
Summary: STK25 interacts with STRN to regulate energy reserve and EMT via lipid metabolism reprogramming in HCC. High expression of STK25 may be associated with poor prognosis in HCC patients, suggesting it as a potential target for lipid metabolism in cancer therapy.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Lilong Zhang, Man Li, Zhoujun Cui, Dongqi Chai, Yongjun Guan, Chen Chen, Weixing Wang
Summary: This study systematically describes the close association between SLC52A2 protein and various tumors, especially hepatocellular carcinoma. It was found that SLC52A2 expression is related to patient survival and disease progression.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Su Yan, Wenyi Guo, Yanliang Liu, Kai Li, Weixing Wang
Summary: This study explored the application value of FR+ -CTC analysis in the diagnosis of CRC. The results showed that CTC levels were related to cancer stage and metastasis. The sensitivity and specificity of FR+ -CTC analysis in the diagnosis of colorectal cancer were determined. FR+ -CTC analysis has potential in recurrence diagnosis and decision of adjuvant chemotherapy for CRC.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2022)
Correction
Cell Biology
Jun Hui Xu, Yong Jun Guan, Zhen Dong Qiu, Xin Zhang, Liu Liu Zi, Yu Zhou, Chen Chen, Jia Yu, Yi Chao Zhang, Wei Xing Wang
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Cell Biology
Jun Hui Xu, Yong Jun Guan, Zhen Dong Qiu, Xin Zhang, Liu Liu Zi, Yu Zhou, Chen Chen, Jia Yu, Yi Chao Zhang, Wei Xing Wang
Summary: This study analyzed the role of ROS-related genes in hepatocellular carcinoma using bioinformatics methods, constructing a prognostic model and investigating their correlation with immune infiltration, tumor sternness, and drug sensitivity. In vitro experiments demonstrated that STK25 knockdown could increase the proliferation, migration, and invasion capacity of HCC cells. The findings provide insights into the potential therapeutic targets for HCC.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Medicine, Research & Experimental
Ning Hu, Xiaoyi Zhang, Xuanzhe Zhang, Yongjun Guan, Ruyuan He, Enfu Xue, Wenhong Deng, Jia Yu, Weixing Wang, Qiao Shi
Summary: The study revealed that hyperglycemia can induce excessive activation of Notch signaling, leading to pancreatic tissue damage during acute pancreatitis. Inhibiting Notch signaling can reduce the number of M1 macrophages and decrease the production of proinflammatory factors, thus alleviating pancreatic injury.
Article
Gastroenterology & Hepatology
Enfu Xue, Qiao Shi, Shouliang Guo, Xiaoyi Zhang, Chengsi Liu, Bin Qian, Xingzhou Guo, Ning Hu, Fang Jiang, Jing Tao, Weixing Wang
Summary: This study aims to investigate the clinical characteristics of acute pancreatitis (AP) patients with and without diabetes and analyze the risk factors for pancreatic necrosis. The results showed that diabetic patients are more likely to suffer from severe AP, and serum calcium and D-dimer are independent predictors for pancreatic necrosis.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Oncology
Chunlei Li, Lilong Zhang, Yao Xu, Dongqi Chai, Shengchen Nan, Zhendong Qiu, Weixing Wang, Wenhong Deng
Summary: This study systematically describes the close relationship between P3H1 and various tumors, especially hepatocellular carcinoma (LIHC). P3H1 expression is significantly increased in tumors and is associated with survival and progression in many cancers. Decreasing P3H1 expression can significantly inhibit the proliferation, migration, and invasion of liver cancer cells. Furthermore, high P3H1 expression is also associated with immune cell infiltration and immune treatment efficacy.
JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
Xin Zhang, Keshuai Dong, Jiacheng Zhang, Tianrui Kuang, Yiyun Luo, Jia Yu, Jinming Yu, Weixing Wang
Summary: G-proteins, including GNB1, have been shown to play a pro-cancer role in lung cancer and breast cancer, but their function in hepatocellular carcinoma (HCC) is unclear. This study found that GNB1 is overexpressed in HCC and its increased expression is associated with poor prognosis. Further experiments revealed that GNB1 enhances cell proliferation, colony formation, migration, and invasion, and promotes the epithelial-to-mesenchymal transition in HCC cells. The oncogenic role of GNB1 was confirmed in a tumor xenograft model and the P38 signaling pathway was found to be important for its function in HCC.
Article
Gastroenterology & Hepatology
Chengsi Liu, Qiao Shi, Xiaoyi Zhang, Enfu Xue, Hanjun Li, Weixing Wang
Summary: This study found that high blood lipid levels, older age, low blood calcium levels, and the etiology of pancreatitis are associated with fasting hyperglycemia in patients with first-attack acute pancreatitis.
BMC GASTROENTEROLOGY
(2023)
