Journal
MOLECULAR MEDICINE REPORTS
Volume 11, Issue 3, Pages 2248-2254Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2014.2957
Keywords
renal cell carcinoma; microRNA; miR-451a
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Funding
- National Natural Science Foundation of China [81101922]
- Medical Scientific Research Foundation of Guangdong Province of China [A2012584, A2013606]
- Science and Technology Development Fund Project of Shenzhen [JCYJ20130402114702124]
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MicroRNAs (miRNAs) are an important class of small, non-coding RNA molecules that regulate gene expression at the transcriptional or post-transcriptional level. They are involved in apoptosis, proliferation and migration and are known to have an important role in many types of cancer. Aberrant expression of miRNA-451a (miR-451a) has previously been reported in tumors, however its role in renal cell carcinoma (RCC) is currently unknown. The aim of the present study was to investigate the role of miR-451a in RCC. The expression of miR-451a was analyzed in 50 paired RCC and normal tissues by quantitative polymerase chain reaction. Furthermore, the effects of miR-451a on cell migration, proliferation and apoptosis were evaluated, using migration scratch, MTT and flow cytometric assays. The present study demonstrated that miR-451a was upregulated in RCC, as compared with paired normal tissues (P<0.05). Downregulation of miR-451a using a synthesized inhibitor, significantly suppressed cell migration and proliferation, and induced apoptosis of renal cancer cells in vitro, as compared with a negative control (P<0.05). In the present study, it was determined that miR-451a may have an important role as a tumor enhancer in RCC. These results imply that miR-451a may be a promising therapeutic target for the treatment of RCC.
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