Article
Biology
Mengyao Wu, Tak-Ho Lo, Liping Li, Jia Sun, Chujun Deng, Ka-Ying Chan, Xiang Li, Steve Ting-Yuan Yeh, Jimmy Tsz Hang Lee, Pauline Po Yee Lui, Aimin Xu, Chi-Ming Wong
Summary: This study found that adhesion G protein-coupled receptor F1 (Adgrf1) regulates hepatic lipid metabolism by controlling the expression of stearoyl-coA desaturase 1 (Scd1). The downregulation of Adgrf1 expression in the livers of obese subjects may serve as a protective mechanism to prevent the excessive accumulation of fat. These findings not only reveal a new mechanism for the progression of non-alcoholic fatty liver disease (NAFLD), but also propose a novel therapeutic approach to combat NAFLD by targeting Adgrf1.
Article
Medicine, Research & Experimental
Yu-Shi Liu, Ming-Hao Yuan, Cun-Yan Zhang, Hong-Mei Liu, Juan-Ru Liu, Ai-Ling Wei, Qiang Ye, Bin Zeng, Mei-Feng Li, Yi-Ping Guo, Li Guo
Summary: The study demonstrated that PLR flavonoids and puerarin can alleviate alcohol-induced hepatic steatosis in zebrafish larvae by regulating alcohol and lipid metabolism, which is closely related to the AMPKα-ACC signaling pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Zhiyuan Xue, Lianggong Zhao, Donghan Wang, Xinyue Chen, Dan Liu, Xiaohua Liu, Shilan Feng
Summary: The study demonstrates that HPS-80-1 has excellent gastric mucosal protective activity, mainly due to the high content of glucose in the backbone and anti-inflammatory, antioxidant groups. These findings provide a scientific basis for further utilization of polysaccharides from Radix Hedysari.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Food Science & Technology
Li Zeng, Fangwei Zhong, Zhiliang Chen, Gengxi Li, Qi Zhu
Summary: Research has shown that Polygonatum sibiricum polysaccharides have a protective effect on obesity and nonalcoholic fatty liver disease induced by a high-fat diet. This is achieved by regulating lipid metabolism, reducing body weight, and alleviating inflammation and oxidative stress caused by lipid accumulation.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Biochemistry & Molecular Biology
Zihao He, Tingting Guo, Zheng Cui, Jingya Xu, Zhijing Wu, Xiawen Yang, Huiping Hu, Hao Mei, Jing Zhou, Yu Zhang, Kaiping Wang
Summary: This study demonstrates for the first time the direct role of Angelica sinensis polysaccharide (ASP) in lipid metabolism and reveals the underlying mechanism of its lipid-lowering and antioxidant effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Food Science & Technology
Zifang Wu, Sujuan Rao, Jiaying Li, Ning Ding, Jianzhao Chen, Li Feng, Shuo Ma, Chengjun Hu, Haonan Dai, Lijun Wen, Qingyan Jiang, Jinping Deng, Ming Deng, Chengquan Tan
Summary: This study demonstrates that dietary AMP supplementation enhances food intake and energy expenditure in male mice, and improves lipid metabolism. These findings highlight the physiological importance of AMP supplementation in preventing energy metabolic disorders.
FOOD & NUTRITION RESEARCH
(2022)
Article
Immunology
Liang Bian, Huaguo Chen, Xin Zhou
Summary: Mori Fructus polysaccharide (MFP) can treat acute alcoholic liver injury by regulating various lipid metabolic pathways, which can help improve the pathological changes in the liver.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Xingchun Wang, Bangfeng Zhao, Hang Sun, Hui You, Shen Qu
Summary: This study aimed to evaluate the effects of sitagliptin on intrahepatic lipid (IHL) content in patients with nonalcoholic fatty liver disease (NAFLD). The results showed that sitagliptin improved glucose metabolism abnormalities but did not directly reduce IHL in patients with NAFLD.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chian-Jiun Liou, Shu-Ju Wu, Szu-Chuan Shen, Li-Chen Chen, Ya-Ling Chen, Wen-Chung Huang
Summary: Acacetin reduces lipid accumulation, improves hepatocyte steatosis, and regulates lipid metabolism and inflammation in obese mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Jiarong Wang, Wei Jiang, Jiao Xin, Weiju Xue, Congjian Shi, Jiagen Wen, Yan Huang, Chengmu Hu
Summary: The study found that CAV1 can inhibit oxidative stress through the AMPK/Nrf2/HO-1 pathway to protect the liver from injury exacerbated by NAFLD/APAP. Upregulation of CAV1 may have clinical benefits in reducing hepatotoxicity aggravated by NAFLD/APAP.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Food Science & Technology
Jae-Hyuk Byun, Ji Eun Shin, Yeung-Joon Choi, Se-Young Choung
Summary: TGPN significantly improved alcoholic fatty liver by decreasing liver index and lipid levels, increasing adiponectin level, and reducing liver fat accumulation. It activated AMP-activated protein kinase and its downstream pathway, promoting lipid metabolism and decreasing liver function markers, ultimately reducing liver cell damage.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Chia-Jung Liao, Po-Shuan Huang, Hui-Tzu Chien, Tzu-Kang Lin, Chau-Ting Yeh, Kwang-Huei Lin
Summary: The typical modern lifestyle contributes to the development of metabolic disorders. Thyroid hormones play an important role in liver lipid metabolism and have potential applications in the management of non-alcoholic fatty liver disease (NAFLD).
Article
Pharmacology & Pharmacy
Xiaojiaoyang Li, Junde Ge, Yajing Li, Yajie Cai, Qi Zheng, Nana Huang, Yiqing Gu, Qi Han, Yunqian Li, Rong Sun, Runping Liu
Summary: The study found that saikosaponin A (SSa) and saikosaponin D (SSd) from Radix Bupleuri can improve nonalcoholic fatty liver disease by modulating glycerolipid metabolism and regulating specific genes. These components also activate certain transcription factors, such as peroxisome proliferator-activated receptor alpha, to regulate fatty acid synthesis and degradation. The results provide critical evidence for the discovery of innovative therapies based on SSa and SSd.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Gastroenterology & Hepatology
Cheng Chang, Huicong Li, Ruilin Zhang
Summary: Non-alcoholic fatty liver disease (NAFLD) is a growing metabolic disease worldwide. Zebrafish, with their genetic and metabolic similarity to mammals, as well as unique advantages such as high fecundity and optical transparency, have become an emerging model for studying liver and metabolic diseases. In this review, we summarize the tools and models used in zebrafish NAFLD research, including dietary feeding, chemical treatments, and genetic manipulations. We also discuss how zebrafish models contribute to our understanding of NAFLD pathogenesis, toxicology, and drug evaluation.
LIVER INTERNATIONAL
(2023)
Review
Gastroenterology & Hepatology
Stanislav Kotlyarov
Summary: In recent years, there has been increased interest in NAFLD due to its high prevalence and clinical significance. NAFLD is closely related to the metabolic syndrome and research is actively exploring the connections between metabolic abnormalities and the innate immune system. A better understanding of these connections will improve the diagnosis and management of patients, as well as shed light on the association between NAFLD and other diseases like atherosclerosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)