Article
Medicine, Research & Experimental
Carlotta Boscaro, Giovanni Eugenio Ramaschi, Lucia Trevisi, Andrea Cignarella, Chiara Bolego
Summary: miR-206 can interfere with GPER-mediated signaling and cell motility, and has the potential to act as pathway-selective antagonists in estrogen-dependent EOC.
Article
Biochemistry & Molecular Biology
Jiahong Tan, Chunyan Song, Daoqi Wang, Yigang Hu, Dan Liu, Ding Ma, Qinglei Gao
Summary: High-grade serous ovarian cancer (HGSOC) with high expression of hormone receptors, including androgen receptor (AR), estrogen receptor alpha (ER), and progesterone receptor (PR), is associated with longer progression-free survival (PFS), overall survival (OS), and platinum-free interval (PFI). Correlation analysis shows significant positive correlations between hormone receptor expression and survival, indicating that AR, ER, and PR could serve as feasible prognostic biomarkers for HGSOC through immunohistochemical analysis. Co-expression of AR, ER, and PR has an improved predictive performance with an area under the curve (AUC) value of 0.945.
BIOSCIENCE REPORTS
(2021)
Article
Oncology
Lili Zhang, Huixiao Chen, Fengxi He, Shiqian Zhang, Aihua Li, Aifeng Zhang, Anqi Zhang
Summary: miR-320a plays an important role in ovarian cancer progression and infiltration, promoting the proliferation, migration, and invasion of EOC cells by targeting RASSF8.
FRONTIERS IN ONCOLOGY
(2021)
Review
Endocrinology & Metabolism
Xue-Ling Xu, Zheng-Yuan Huang, Kun Yu, Jun Li, Xiang-Wei Fu, Shou-Long Deng
Summary: This review focuses on the role of ER alpha and ER beta in polycystic ovary syndrome (PCOS), ovarian cancer, and premature ovarian failure (POF), as well as the major challenges of existing therapies. It provides a reference for the treatment of estrogen target tissue ovarian diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shuangyu Guo, Bo Zhang, Wen Qi, Xiaolian Cao, Yixuan Xu, Xueting Zhang, Xu Li, Liting Zhou, Lin Ye
Summary: The study revealed that MEHP promotes proliferation, migration, and invasion of neuroblastoma cells through ER alpha by upregulating the expression levels of PCNA, MMP-2, and MMP-9, while downregulating TIMP-2.
Article
Biotechnology & Applied Microbiology
Fengjie Li, Zhen Liang, Yongqin Jia, Panyang Zhang, Kaijian Ling, Yanzhou Wang, Zhiqing Liang
Summary: The decreased expression of miR-324-3p inhibits ovarian cancer (OC) proliferation, and this inhibition can be reversed by the upregulated kinase WNK2, which promotes OC cell proliferation and invasion through the activation of the RAS pathway.
Article
Obstetrics & Gynecology
Weiyi Huang, Lili Chen, Pengming Sun
Summary: ERR alpha has been shown to play a significant role in the tumourigenesis and development of ovarian cancer. Higher expression of ERR alpha in late-stage and high-grade ovarian cancer tissues correlates with increased invasion and metastasis capabilities in vitro. Up-regulating ERR alpha enhances invasion and metastasis, while down-regulation weakens these capabilities. The expression level of ERR alpha is positively correlated with both wound sealing rate and cell invasiveness.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Environmental Sciences
Chen Sang, Yu Song, Tong-wang Jin, Shuo Zhang, Linyan Fu, Yi Zhao, Xinxin Zou, Zhe Wang, Hui Gao, Sijin Liu
Summary: The study found that BPA can stimulate proliferation and metastasis of ovarian cancer cells by upregulating various proteins through the ER alpha signaling pathway. These results provide new insights into the carcinogenic effects of BPA on ovarian cancer.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Cell Biology
Dinesh Kumar, Saket Awadesbhai Patel, Md. Khurshidul Hassan, Nachiketa Mohapatra, Niharika Pattanaik, Manjusha Dixit
Summary: IQGAP2 functions as a tumor suppressor in breast cancer by enhancing apoptosis, reducing epithelial-mesenchymal transition, and negatively regulating oncogenic properties of breast cancer cells. The interaction between IQGAP1 and IQGAP2 suggests the possibility of IQGAP2 sequestering IQGAP1 to inhibit ERK activation. Targeting IQGAP2 could be a potential therapeutic intervention for breast cancer.
CELL DEATH & DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Marta Justyna Koziel, Agnieszka Wanda Piastowska-Ciesielska
Summary: Ovarian cancer, a common cancer in women, is believed to be influenced by hormonal imbalance. Estrogens, a group of hormones with important roles in physiological and pathological processes, are involved in regulating proliferation, invasiveness, and the epithelial to mesenchymal transition in ovarian cancer. Estrogen signaling also plays a role in the biology of the tumor microenvironment. This review provides information on estrogen receptors, estrogens, and their association with the tumor microenvironment, as well as changes in estrogen receptor expression following exposure to various environmental chemicals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Vajihe Azimian-Zavareh, Zeinab Dehghani-Ghobadi, Marzieh Ebrahimi, Kian Mirzazadeh, Irina Nazarenko, Ghamartaj Hossein
Summary: The study found that Wnt5A can regulate the expression of its receptors, affecting cell proliferation, migration, invasion, and multicellular aggregates formation. Moreover, Wnt5A can also modulate integrin expression levels, potentially associated with ovarian cancer cell proliferation, migration, and fibronectin attachment.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Yali Fan, Jiandong Wang, Ziwei Fang, Stuart R. Pierce, Lindsay West, Allison Staley, Katherine Tucker, Yajie Yin, Wenchuan Sun, Weimin Kong, Varun Prabhu, Joshua E. Allen, Chunxiao Zhou, Victoria L. Bae-Jump
Summary: ONC201 shows promising anti-tumor potential in ovarian cancer by suppressing cell proliferation and inducing apoptosis through multiple pathways. It also inhibits adhesion and invasion in cancer cells. Additionally, it can suppress tumor growth and decrease serum VEGF production, which is accelerated by obesity.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Tianshui Sun, Fangfang Bi, Zhuonan Liu, Qing Yang
Summary: In ovarian cancer patients, TMEM119 is overexpressed and associated with poor survival. Experimental results indicate TMEM119 promotes proliferation, invasion, and migration of ovarian cancer cells. Additionally, TMEM119 may exert oncogenic effects by regulating PDGFRB expression and activating the PI3K/AKT signaling pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Guna He, Xiaomei Liu, Lingyu Liu
Summary: This study aimed to elucidate the mechanism of miR-26b in ovarian cancer (OC) cell proliferation and epithelial-mesenchymal transition (EMT) through the suppression of ER alpha. The findings showed that miR-26b was poorly expressed in OC tissues and cells. Over-expression of miR-26b exerted inhibitory effects on cell proliferation, migration, invasion, and EMT, while silencing miR-26b had the opposite effect. The study also demonstrated that miR-26b could negatively regulate ER alpha and that over-expression of miR-26b led to down-regulation of ER alpha and suppression of OC tumor growth and EMT. In conclusion, miR-26b inhibits OC cell proliferation and EMT through the negative modulation of ER alpha, offering a potential strategy for OC treatment.
Article
Medicine, Research & Experimental
Jiangtao Yu, Xiaoli Hu, Xiuxiu Chen, Qiangyong Zhou, Qi Jiang, Zhengzheng Shi, Haiyan Zhu
Summary: CNOT7 plays an important role in biological processes and has potential for treating malignant tumors. This study aimed to investigate the functions and mechanism of CNOT7 in ovarian cancer. Results showed that CNOT7 overexpression in A2780 and SKOV3 cells could be partially or completely eliminated by treatment with the AKT inhibitor LY294002.