Article
Multidisciplinary Sciences
Ewa Kilanczyk, Jesus M. Banales, Ewelina Jurewicz, Piotr Milkiewicz, Malgorzata Milkiewicz
Summary: The study revealed an interaction between PDC-E2 and phosphorylated STAT3 under cholestatic conditions, which may play a role in the development of primary biliary cholangitis.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Katharina Hill-Muendel, Donatus Nohr
Summary: Clinical data supporting the efficacy of pharmacological doses of ascorbic acid (AA) in killing cancer cells are still lacking. Inhibition of glycolysis may enhance the anticancer effect of AA by reducing the generation of pyruvate. Experimental results suggest that 2-DG enhances the cytotoxic effect of AA by increasing H2O2 concentration in glycolytic cancer cells, potentially due to lower pyruvate levels as a result of glycolysis inhibition.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Sezin Dagdeviren, Richard T. Lee, Ning Wu
Summary: TXNIP is a versatile protein involved in various cellular functions, such as cellular transport, mitochondrial energy generation, and protein cycling. Recent studies have unveiled its induction by ER stress, activation of NLRP3 inflammasomes, and regulation of glucose transport. Additionally, TXNIP exhibits tumor suppressor role in different cancer types and plays a role in fructose absorption. However, the functional dependence on thioredoxin, the inhibition of glucose transporters without endocytosis, and the regulation of ER stress by TXNIP require further investigation.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Multidisciplinary Sciences
Irati Aiestaran-Zelaia, Maria Jesus Sanchez-Guisado, Marina Villar-Fernandez, Mikel Azkargorta, Lucia Fadon-Padilla, Uxoa Fernandez-Pelayo, Diego Perez-Rodriguez, Pedro Ramos-Cabrer, Antonella Spinazzola, Felix Elortza, Jesus Ruiz-Cabello, Ian J. Holt
Summary: 2-Deoxy-D-glucose (2DG) inhibits glycolysis, stimulates respiration, and restricts viral replication in cultured cells. In the murine heart, 2DG increases the respiratory chain proteome of mitochondria, enhancing oxidative capacity and potentially compensating for the energy deficit caused by glycolysis inhibition.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Chao Xu, Xiang-Fei Li, Liu-Ling Gao, Zhi-Rong Ding, Xiao-Ping Huang, Yuan-You Li, Di-Zhi Xie
Summary: This study characterized the full-length cDNA of thioredoxin-interacting protein (TXNIP) from Megalobrama amblycephala and investigated its roles in high glucose-induced inflammatory response. Txnip expression was found to increase in liver and white muscle under a high-carbohydrate diet, while insulin injection led to a decrease in txnip expression. In vitro studies showed that over-expression of txnip increased il-1 beta and il-6 expression in hepatocytes, while knockdown reduced il-1 beta expression. Metformin treatment increased cell viability and trx expression, and decreased ROS levels and other factors under high glucose conditions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Medicine, Research & Experimental
Sananda Dey, Nensina Murmu, Tanushree Mondal, Ishita Saha, Soumendranath Chatterjee, Rahul Manna, Subhash Haldar, Sandeep K. Dash, Tapasree Roy Sarkar, Biplab Giri
Summary: Chronic exposure to high glucose promotes cancer progression by activating signaling pathways and impairing immune response. 2-DG inhibits cancer progression, decreases inflammation, and modulates immune function, also reducing the risk of infection.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Clara I. Marin-Briggiler, Guillermina M. Luque, Maria G. Gervasi, Natalia Oscoz-Susino, Jessica M. Sierra, Carolina Mondillo, Ana M. Salicioni, Dario Krapf, Pablo E. Visconti, Mariano G. Buffone
Summary: Experimental results show that human sperm exhibit reduced motility and other kinematic parameters under starvation conditions, while treatment with energy recovery restores hyperactivated motility, rapidly increasing ATP and cAMP levels. This suggests that modulating sperm energy levels through such treatment may positively impact human sperm fertilizing ability in vitro.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Zoufang Huang, Vivek P. Chavda, Lalitkumar K. Vora, Normi Gajjar, Vasso Apostolopoulos, Nirav Shah, Zhe-Sheng Chen
Summary: There is a lack of adequate treatment choices for COVID-19, and no established intervention has effectively reduced mortality rate. Recent studies have shown that 2-deoxy-D-glucose (2-DG) could aid in faster recovery and reduce the need for supplemental oxygen in COVID-19 patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Marko Groeger, Koji Matsuo, Emad Heidary Arash, Ashley Pereira, Dounia Le Guillou, Cindy Pino, Kayque A. Telles-Silva, Jacquelyn J. Maher, Edward C. Hsiao, Holger Willenbring
Summary: Researchers have successfully used induced pluripotent stem cells to establish a model of hepatic insulin resistance and identify inflammation as a driver of this metabolic disease. Co-culture of hepatocytes and macrophages derived from the same stem cell line revealed the mechanisms through which inflammation disrupts insulin-mediated regulation of hepatic glucose metabolism, offering potential targets for therapy.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Prakash Kumar Bhagat, Deepika Sharma, Deepanjali Verma, Kirti Singh, Alok Krishna Sinha
Summary: This study reveals the essential role of MAP kinase signaling in Arabidopsis sensitivity to higher concentrations of D-Glc. D-Glc activates MAP kinases MPK3 and MPK6 in a concentration and time-dependent manner. Mutants of mpk3 and mpk6 display low sensitivity to D-Glc, and this sensitivity is further enhanced by the addition of sucrose. The study also provides insights into the interaction between the Glc sensor protein RGS1 and MPK3/MPK6.
Article
Biochemistry & Molecular Biology
Konstantin Potapov, Roman A. Novikov, Pavel N. Solyev, Sergey N. Kochetkov, Alexander A. Makarov, Vladimir A. Mitkevich
Summary: The article highlights the important role of heptose phosphates in immune system activation and the significance of obtaining a substantial amount of heptose phosphates for biological studies through optimizing synthetic methods. By developing a new synthesis approach, efficiency has been improved and the number of steps reduced, potentially offering practical value for further biological screening.
Article
Biochemistry & Molecular Biology
Jingjing Huang, An Staes, Francis Impens, Vadim Demichev, Frank Van Breusegem, Kris Gevaert, Patrick Willems
Summary: Accurate quantification of cysteine oxidation is crucial for decoding protein redox regulation. CysQuant is a novel approach that allows for simultaneous quantification of cysteine oxidation degrees and protein abundancies, and can be widely applied across various mass spectrometry platforms and organisms.
Article
Cell Biology
Lulu Wei, Ranran Wang, Junaid Wazir, Kai Lin, Shiyu Song, Li Li, Wenyuan Pu, Chen Zhao, Yong Wang, Zhonglan Su, Hongwei Wang
Summary: This study aimed to explore the efficiency of 2-DG in blocking Cori cycle activity and its therapeutic effect on cachexia-associated muscle wasting. The results showed that 2-DG significantly ameliorated cancer cachexia-associated muscle wasting and increased mitochondrial bioenergetic capacity.
Review
Biochemistry & Molecular Biology
Beata Pajak, Rafal Zielinski, John Tyler Manning, Stanislava Matejin, Slobodan Paessler, Izabela Fokt, Mark R. Emmett, Waldemar Priebe
Summary: Viral infection triggers metabolic changes in cells, particularly an upregulation of glycolysis. The glycolysis inhibitor 2-DG has been studied as an antiviral drug, but its pharmacokinetic properties limit its application.
Article
Agriculture, Multidisciplinary
Shibin Deng, Heping Cui, Khizar Hayat, Shahzad Hussain, Muhammad Usman Tahir, Yun Zhai, Qiang Zhang, Xiaoming Zhang, Chi-Tang Ho
Summary: Additional DL-methionine did not affect the degradation rate of the methionine-glucose-derived Amadori rearrangement product, but played a role in subsequent reactions, resulting in a decrease in C-6-alpha-dicarbonyl compounds and facilitating the formation of glyoxal and methylglyoxal. The effect of Met addition was dependent on reaction temperature and contributed to the acceleration of browning formation by improving the formation of color precursors glyoxal and methylglyoxal.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
C. Gillet, D. Spruyt, S. Rigutto, A. Dalla Valle, J. Berlier, C. Louis, C. Debier, N. Gaspard, W. J. Malaisse, V. Gangji, J. Rasschaert
Article
Cell & Tissue Engineering
J. L. Berlier, I. Kharroubi, J. Zhang, A. Dalla Valle, S. Rigutto, M. Mathieu, V. Gangji, J. Rasschaert
STEM CELL REVIEWS AND REPORTS
(2015)
Article
Cell & Tissue Engineering
J. L. Berlier, I. Kharroubi, J. Zhang, A. Dalla Valle, S. Rigutto, M. Mathieu, V. Gangji, J. Rasschaert
STEM CELL REVIEWS AND REPORTS
(2015)
Article
Endocrinology & Metabolism
Valerie Gangji, Muhammad S. Soyfoo, Audrey Heuschling, Violaine Afzali, Rodrigo Moreno-Reyes, Joanne Rasschaert, Celine Gillet, Jean-Francois Fils, Jean-Philippe Hauzeur
Article
Orthopedics
Jacques Hernigou, Pascale Vertongen, Esfandiar Chahidi, Theofylaktos Kyriakidis, Jean-Paul Dehoux, Magalie Crutzen, Sebastien Boutry, Lionel Larbanoix, Sarah Houben, Nathalie Gaspard, Dimitrios Koulalis, Joanne Rasschaert
INTERNATIONAL ORTHOPAEDICS
(2018)
Article
Rheumatology
Ahmad Awada, Charles Nicaise, Sabrina Ena, Liliane Schandene, Joanne Rasschaert, Iuliana Popescu, Valerie Gangji, Muhammad S. Soyfoo
ANNALS OF THE RHEUMATIC DISEASES
(2014)
Article
Biochemistry & Molecular Biology
Monica Garcia, Zeynep Dogusan, Fabrice Moore, Shintaro Sato, Gunther Hartmann, Decio L. Eizirik, Joanne Rasschaert
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2009)
Article
Endocrinology & Metabolism
Myrielle Mathieu, Sabrina Rigutto, Aude Ingels, Delphine Spruyt, Nadia Stricwant, Ilham Kharroubi, Valentina Albarani, Marc Jayankura, Joanne Rasschaert, Enrico Bastianelli, Valerie Gangji
Article
Cell & Tissue Engineering
Jessica L. Berlier, Sabrina Rigutto, Antoine Dalla Valle, Jessica Lechanteur, Muhammad S. Soyfoo, Valerie Gangji, Joanne Rasschaert
Article
Virology
Christine Weyn, Jean-Marie Vanderwinden, Joanne Rasschaert, Yvon Englert, Veronique Fontaine
Article
Endocrinology & Metabolism
Antoine Dalla Valle, Pascale Vertongen, Delphine Spruyt, Jessica Lechanteur, Valerie Suain, Nathalie Gaspard, Jean-Pierre Brion, Valerie Gangji, Joanne Rasschaert
FRONTIERS IN ENDOCRINOLOGY
(2019)
Article
Rheumatology
P. Sidiras, D. Spruyt, V Gangji, V Imbault, T. Sokolova, P. Durez, D. Communi, J. Rasschaert, V Badot
Summary: The study found that anti-CarP antibodies were detected in a cohort of Belgian RA patients. In seronegative RA patients, the presence of anti-CarP antibodies was associated with higher disease activity and disability. Additionally, anti-CarP antibodies were also detected in primary SS patients and JIA patients.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2021)
Letter
Allergy
Amaryllis Haccuria, Alain Van Muylem, Andrei Malinovschi, Joanne Rasschaert, Myrna Virreira, Nicolas Bruffaerts, Marijke Hendrickx, Alain Michils
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Article
Endocrinology & Metabolism
Celine Gillet, Antoine Dalla Valle, Nathalie Gaspard, Delphine Spruyt, Pascale Vertongen, Jessica Lechanteur, Sabrina Rigutto, Elena-Raluca Dragan, Audrey Heuschling, Valerie Gangji, Joanne Rasschaert