Article
Chemistry, Medicinal
Yingjun Cui, Mengyi Zhang, Honglei Xu, Tingrong Zhang, Songming Zhang, Xiuhe Zhao, Peng Jiang, Jing Li, Baijun Ye, Yuanjun Sun, Mukuo Wang, Yangping Deng, Qing Meng, Yang Liu, Qiang Fu, Jianping Lin, Liang Wang, Yue Chen
Summary: Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a common complication in COVID-19. The natural macrocyclic peptide CTL-A has been identified as a potential elastase inhibitor for preventing ALI/ARDS. The first total synthesis of CTL-A was achieved in 24 steps, and preliminary structure-activity relationships were elucidated. In vivo studies using an ALI mouse model demonstrated that CTL-A effectively alleviated acute lung injury, outperforming the approved elastase inhibitor sivelestat. The findings highlight the potential of CTL-A as a candidate for COVID-19 pathogenesis.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Immunology
Yali Sun, Xianfei Ding, Yuqing Cui, Hongyi Li, Dong Wang, Huoyan Liang, Shaohua Liu, Xiaojuan Zhang, Haixu Wang, Tongwen Sun
Summary: This study demonstrates that the administration of Sivelestat in septic rats can improve survival, gut microbiota composition, and associated metabolites, providing new options for sepsis treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Angelique Rivot, Natacha Jugniot, Samuel Jacoutot, Nicolas Vanthuyne, Philippe Massot, Philippe Mellet, Sylvain R. A. Marque, Gerard Audran, Pierre Voisin, Marie Delles, Gilles Devouassoux, Eric Thiaudiere, Abderrazzak Bentaher, Elodie Parzy
Summary: The study suggests using OMRI in mice to evaluate protease activity in the lungs, finding an increase in proteolysis in LPS-induced inflammation. This preclinical detection method may open new avenues for diagnosis and in vivo antiprotease testing.
Article
Urology & Nephrology
Aykut Colakerol, Serhat Suzan, Mustafa Zafer Temiz, Serkan Gonultas, Serdar Aykan, Sule Ozsoy, Suat Hayri Kucuk, Emrah Yuruk, Engin Kandirali, Atilla Semercioz
Summary: The study investigated the impact of extracorporeal shock wave lithotripsy (ESWL) on rat kidney damage, revealing significant tissue inflammation and damage in the early stage, with the use of the NE inhibitor sivelestat significantly reducing the ESWL-induced kidney injury.
Article
Chemistry, Physical
Zhuo Zhang, Jun Xie, Ningli Shan, Hao Wang, Baichun Hu, Jian Wang, Haotian Zhang, Chao Ma
Summary: This study identified thiamphenicol (TAP) as a potential inhibitor of neutrophil elastase (NE) through virtual screening and experimental validation. In a mouse model of acute lung injury (ALI), TAP was found to improve symptoms without causing the side effects associated with glucocorticoids.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Genetics & Heredity
Junting Weng, Danjuan Liu, Bingbing Shi, Min Chen, Shuoyun Weng, Rongjie Guo, Xiaoping Zhou
Summary: This study investigated the therapeutic effects of the neutrophil elastase inhibitor Sivelestat sodium (SIV) in treating lipopolysaccharide (LPS)-induced acute lung injury (ALI) by improving endoplasmic reticulum stress (ERS). The results showed that SIV could improve ALI and suppress the LPS-induced ERS response.
Article
Pharmacology & Pharmacy
Sayantan Sengupta, Nipun Abhinav, Sabita Singh, Joytri Dutta, Ulaganathan Mabalirajan, Karthigeyan Kaliyamurthy, Pulok Kumar Mukherjee, Parasuraman Jaisankar, Arun Bandyopadhyay
Summary: Chronic obstructive pulmonary disease (COPD) and asthma are major global health issues. This study found that the fruit extract of Sonneratia apetala has the potential to inhibit neutrophil elastase, thereby preventing the progression of lung emphysema.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Yanjun Wu, Hongmei Huang, Jiayun Wu, Yiru Qin, Na Zhao, Baowei Chen, Qiying Nong, Yongshun Huang, Ligang Hu
Summary: This study investigates the mechanism of lead-induced myocardial injury and finds that neutrophil degranulation plays a significant role in this process. The findings suggest that lead exposure can initiate early myocardial injury by promoting neutrophil degranulation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Medicine, Research & Experimental
Pei-Shan Sung, Yu-Chun Peng, Shao-Ping Yang, Cheng-Hsun Chiu, Shie-Liang Hsieh
Summary: A study found that CLEC5A interacts with Pseudomonas aeruginosa's LPS, leading to the formation of neutrophil extracellular traps (NETs) and lung inflammation. Blocking CLEC5A can reduce Pseudomonas aeruginosa-induced NETosis and lung injury, and co-administration with ciprofloxacin improves survival rate in mice.
Article
Immunology
Tuo Pan, Tayierjiang Tuoerxun, Xi Chen, Cheng-Jin Yang, Chen-Yu Jiang, Yi-Fan Zhu, Ze-Shi Li, Xin-Yi Jiang, Hai-Tao Zhang, He Zhang, Ya-Peng Wang, Wei Chen, Li-Chong Lu, Min Ge, Yong-Qing Cheng, Dong-Jin Wang, Qing Zhou
Summary: This study aimed to evaluate the effect of sivelestat on pulmonary protection in patients with acute lung injury (ALI) after emergent cardiovascular surgery. The results showed that sivelestat could significantly decrease the incidence of pneumonia, shorten mechanical ventilation time, and improve pulmonary function. Therefore, sivelestat may be considered to improve postoperative outcomes in ALI patients after emergent cardiovascular surgery.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Lu Chen, Min Li, Yingyi Lin, Yanzhen Li, Min Liang, Kai Zeng
Summary: The research investigates the mechanism of neutrophil elastase in dexmedetomidine alleviating sepsis-related renal injury in rats. It reveals that dexmedetomidine and neutrophil elastase can improve the color and morphology of renal tissue, reduce inflammatory cell infiltration, and alleviate renal tubular injury. By inhibiting the inflammatory response, neutrophil elastase actively reduces sepsis-related renal injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shin Ohta, Akihiko Tanaka, Tomoko Okazaki, Hatsuko Mikuni, Tomoki Uno, Yoshitaka Uchida, Tomoyuki Kimura, Yosuke Fukuda, Megumi Jinno, Kuniaki Hirai, Yoshito Miyata, Hideki Inoue, Tetsuya Homma, Mayumi Yamamoto, Shintaro Suzuki, Hironori Sagara
Summary: This study found that transferring fetal lung cells into a mouse model inhibited the progression of lung emphysema and improved the motility of the mice.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Claudius Wagner, Anita Balazs, Jolanthe Schatterny, Zhe Zhou-Suckow, Julia Duerr, Carsten Schultz, Marcus A. Mall
Summary: Elevated levels of MMP-9 and NE are associated with bronchiectasis and lung function decline in CF patients. However, the role of MMP-9 in CF-like lung disease in mice is not significant.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Jiangwei Ni, Ge Li, Ningfeng Dai, Zijiao Quan, Haibin Tong, Yu Liu
Summary: This study found that Esculin, a compound derived from traditional Chinese medicine, has a protective effect against acute lung injury (ALI). In a lipopolysaccharide (LPS)-challenged ALI mouse model, Esculin significantly reduced lung pathological injury, decreased proinflammatory cytokine levels, and inhibited NF-kappa B signaling activation. Esculin also impaired neutrophil migration and chemotaxis by interacting with beta 2 integrin, thereby blocking neutrophil adhesion and aggregation. These findings demonstrate the potential of Esculin as a novel therapeutic compound.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Chun-Lian Wang, Yan Wang, Qi-Lan Jiang, Yang Zeng, Qing-Ping Yao, Xing Liu, Tao Li, Jun Jiang
Summary: The study aimed to investigate the effects of recombinant DNase I and sivelestat on the elimination of NETs and their impact on IRI in hindlimbs. The results showed that both DNase I and moderate doses of sivelestat could eliminate IRI-induced NETs, improve hindlimb perfusion and angiogenesis, prevent muscle fibrosis, and enhance motor function. Appropriate administration mode and dosage are crucial for the prevention of IRI by eliminating NETs, with topical administration of DNase I being more effective and intravenous administration of sivelestat being more beneficial. These findings provide a better treatment strategy for IRI in clinical practice.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Oncology
Ken Yoshida, Hideya Yamazaki, Tadashi Takenaka, Tadayuki Kotsuma, Shunsuke Miyake, Mari Mikami Ueda, Mineo Yoshida, Koji Masui, Yasuo Yoshioka, Yasuo Uesugi, Taiju Shimbo, Nobuhiko Yoshikawa, Hiroto Yoshioka, Kazumasa Aramoto, Yoshifumi Narumi, Shigetoshi Yamada, Keiji Tatsumi, Eiichi Tanaka
Article
Otorhinolaryngology
Masaaki Higashino, Ryo Kawata, Koutetsu Lee, Shuji Nishikawa, Shimpei Ichihara, Yasuo Uesugi
AURIS NASUS LARYNX
(2014)
Article
Biology
Ken Yoshida, Tadashi Takenaka, Hironori Akiyama, Hideya Yamazaki, Mineo Yoshida, Koji Masui, Tadayuki Kotsuma, SungJae Baek, Yasuo Uesugi, Taiju Shimbo, Nobuhiko Yoshikawa, Takumi Arika, Yukihiro Koretsune, Yasuo Yoshioka, Yoshifumi Narumi, Eiichi Tanaka
JOURNAL OF RADIATION RESEARCH
(2014)
Article
Oncology
Nobuhiko Yoshikawa, Taisuke Inomata, Taiju Shimbo, Masatsugu Takahashi, Yasuo Uesugi, Hiroshi Juri, Yoshifumi Narumi
Article
Medicine, Research & Experimental
Nobuhiko Yoshikawa, Taisuke Inomata, Taiju Shinbo, Masatsugu Takahashi, Yasuo Uesugi, Yoshihumi Narumi
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2010)
Article
Medicine, Research & Experimental
Taiju Shimbo, Taisuke Inomata, Masatsugu Takahashi, Toshiaki Tatsumi, Yasuo Uesugi, Isamu Narabayashi, Hiroshi Sonobe
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2007)
Article
Radiology, Nuclear Medicine & Medical Imaging
M Tanikake, T Shimizu, I Narabayashi, M Matsuki, K Masuda, K Yamamoto, Y Uesugi, S Yoshikawa
Article
Radiology, Nuclear Medicine & Medical Imaging
K Sueyoshi, I Narabayashi, K Doi, M Takahashi, T Komori, Y Tatsu, T Tatsumi, K Utunomiya, Y Uesugi, I Adachi, T Shimizu
CLINICAL NUCLEAR MEDICINE
(2000)
Article
Otorhinolaryngology
A Sakakura, Y Yamamoto, Y Uesugi, K Nakai, I Hayashi, K Makimoto, H Takenaka, I Narabayashi
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES
(2000)
Article
Oncology
Taisuke Inomata, Isamu Narabayashi, Yuki Inada, Taiju Shimbo, Masatsugu Takahashi, Toshiaki Tatsumi, Yasuo Uesugi, Shinji Kariya, Akihito Nishioka, Yasuhiro Ogawa
