Article
Endocrinology & Metabolism
Dong Chen, Yawen Tan, Zhichao Li, Wujiao Li, Lei Yu, Wei Chen, Yuchen Liu, Lisa Liu, Liangfeng Guo, Weiren Huang, Yongsheng Zhao
Summary: Researchers established patient-derived PTC organoids as a promising new preclinical model for personalized therapy, demonstrating preservation of biological characteristics and genomic heterogeneity from the originating tumors and patient-specific drug responses.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Oncology
Hwa Young Ahn, Ra-Yeong Song, Hye Shin Ahn, Hee Sung Kim
Summary: The study found that the majority of PTC patients exhibited positive expression of ERs or PR, but the expression rates of hormone receptors or overexpression of EGFR were not associated with PTC recurrence.
CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Huimin Chu, Bo Hu, Xinyu Su
Summary: The study revealed that SERPINE2 forms a positive feedback loop with EGF/EGFR to regulate the proliferation, invasion, and migration of TPC cells, suggesting that SERPINE2 could be a potential therapeutic target for papillary thyroid carcinoma.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Julien Solinc, Jessica Raimbault-Machado, France Dierick, Lamiaa El Bernoussi, Ly Tu, Raphael Thuillet, Nathalie Mougenot, Benedicte Hoareau-Coudert, Virginie Monceau, Catherine Pavoine, Fabrice Atassi, David Sassoon, Giovanna Marazzi, Richard P. Harvey, Peter Schofield, Daniel Christ, Marc Humbert, Christophe Guignabert, Florent Soubrier, Sophie Nadaud
Summary: This study demonstrates the significant role of the platelet-derived growth factor receptor alpha (PDGFR alpha) pathway in progenitor cell-dependent vascular remodeling and neomuscularization associated with pulmonary arterial hypertension (PAH). Inhibition of PDGFR alpha activity reduces pulmonary vessel neomuscularization, while constitutive activation of PDGFR alpha leads to neomuscularization and PH development. These findings suggest that PDGFR alpha blockers may be a promising therapeutic strategy for reducing vascular remodeling in PAH patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medical Laboratory Technology
Yaru Lu, Hui Liu, Bo Dong, Jingyu Yang, Lu Kou, Qin Qin
Summary: The aim of this study was to investigate the relationship between plasma platelet-derived growth factor (PDGF)-BB levels and single nucleotide polymorphisms (SNP) of the PDGF-B gene, as well as their correlation with the onset and stability of coronary heart disease (CHD). The study found that high plasma PDGF-BB levels were a risk factor for CHD and were related to its instability. Furthermore, the SNP of the PDGF-B gene was not associated with CHD.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Hematology
Julian Leberzammer, Stijn M. Agten, Xavier Blanchet, Rundan Duan, Hans Ippel, Remco T. A. Megens, Christian Schulz, Maria Aslani, Johan Duchene, Yvonne Doring, Natalie J. Jooss, Pengyu Zhang, Richard Brandl, Konstantin Stark, Wolfgang Siess, Kerstin Jurk, Johan W. M. Heemskerk, Tilman M. Hackeng, Kevin H. Mayo, Christian Weber, Philipp von Hundelshausen
Summary: The study explored the molecular mechanisms of CXCL12 in arterial thrombosis, revealing that inhibition of CXCR4 can attenuate platelet aggregation and limit arterial thrombosis. Mechanistically, CXCL12 activates Btk leading to platelet aggregation, while the interaction between CXCL12 and CCL5 can inhibit this process. A novel peptide was found to inhibit CXCL12-induced platelet aggregation without prolonging bleeding time.
Article
Neurosciences
Jelena Medved, William M. Wood, Michael D. van Heyst, Amin Sherafat, Ju-Young Song, Sagune Sakya, Dennis L. Wright, Akiko Nishiyama
Summary: Oligodendrocyte precursor cells play a crucial role in brain development and have the potential to be targeted for the treatment of brain tumors.
Article
Chemistry, Multidisciplinary
Ana L. Graca, Manuel Gomez-Florit, Hugo Osorio, Marcia T. Rodrigues, Rui M. A. Domingues, Rui L. Reis, Manuela E. Gomes
Summary: This study produced and characterized platelet-derived EVs and investigated their effects on different cell types. The EVs were found to regulate stem cell differentiation, promote angiogenesis, and modulate macrophage polarization, suggesting their potential as therapeutic tools in tissue engineering and regenerative medicine.
Article
Biochemistry & Molecular Biology
Susan Y. S. Li, Rebecca Johnson, Leon C. D. Smyth, Mike Dragunow
Summary: This review provides an updated overview of the actions of platelet-derived growth factors on neurovascular function, their role in regulating perivascular cell types, and their clinical relevance and therapeutic potential for neurological diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Microbiology
Minmin Zhou, Shaobo Wang, Jiao Guo, Yang Liu, Junyuan Cao, Xiaohao Lan, Xiaoying Jia, Bo Zhang, Gengfu Xiao, Wei Wang
Summary: PDGFR beta was identified as a potential therapeutic target against JEV infection, with the inhibitor imatinib showing protection against JEV-induced lethality by reducing viral load in the brain and preventing histopathological changes.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Wanting Niu, Teck Chuan Lim, Abdulmonem Alshihri, Ravikumar Rajappa, Lishan Wang, Motoichi Kurisawa, Myron Spector
Summary: This study demonstrated the high viability of bone marrow mesenchymal stem cells (bMSCs) in Gelatin-hydroxyphenyl propionic acid (Gtn-HPA) covalent cross-linking gelation. The incorporation of platelet-derived growth factor (PDGF)-BB directly into the gel or released from polyelectrolyte complex nanoparticles (PCNs) stimulated bMSC migration and proliferation effectively. Stromal cell-derived factor (SDF)-1 alpha enhanced migration and proliferation when released from PCNs, highlighting the potential of using Gtn-HPA/PDGF-BB as an injectable therapeutic agent for musculoskeletal tissue defects.
Article
Medicine, General & Internal
Sorina Martin, Theodor Mustata, Oana Enache, Oana Ion, Andreea Chifulescu, Anca Sirbu, Carmen Barbu, Adrian Miron, Cosmin Giulea, Florin Andrei, Simona Fica
Summary: The study analyzed the inflammatory markers and platelet indices in patients with papillary thyroid cancer (PTC) compared to those with benign thyroid pathology, finding higher levels in PTC patients. Fibrinogen and platelet count were identified as potential independent predictors for the presence of PTC when compared to benign thyroid disorders.
Article
Immunology
Qiang Wang, Hong Huang, Peng Chen, Xiao Xiao, Xiaolei Luo, Yanyun Wang, Siyu Long, Linbo Gao, Lin Zhang
Summary: The rs8101923 G allele is significantly associated with a higher risk of papillary thyroid carcinoma (PTC), and it is related to increased enhancer activities and gene expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rimma Sergeevna Kamentseva, Marianna Viktorovna Kharchenko, Gulnara Vladikovna Gabdrahmanova, Michael Alexandrovich Kotov, Vera Vladislavovna Kosheverova, Elena Sergeevna Kornilova
Summary: This study compared the effects of EGF, TGF-α, and AREG on physiological responses in endometrial MSCs and HeLa cells, and investigated the internalization and degradation of EGFR stimulated by these ligands. The study found that while EGF and TGF-α stimulated cell proliferation and prevented differentiation in enMSCs in an EGFR-dependent manner, AREG had no effect. Additionally, differences were observed in the degradation and recovery of EGFR in different cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
James A. Fagin, Gnana P. Krishnamoorthy, Inigo Landa
Summary: This review outlines the genomic simplicity of differentiated cancers derived from thyroid follicular cells and explores the impact of oncogenic drivers on tumor phenotypes. The activation of key nodes in the receptor tyrosine kinase-RAS-BRAF pathway by oncoproteins in thyroid cancer leads to constitutive MAPK signaling with varying degrees of activity based on their specific biochemical mechanisms. The magnitude of MAPK signaling determines important aspects of thyroid cancer biology, including differentiation state, invasiveness, and tumor microenvironment. Genomic lesions, chromatin accessibility disruption, cell cycle dysfunction, and progressive immunosuppression in the tumor microenvironment contribute to disease progression.
NATURE REVIEWS CANCER
(2023)