Article
Biochemistry & Molecular Biology
Wonchul Lim, Bu-Nam Jeon, Young-Joo Kim, Ki-Hwan Kim, Hyeonseok Ko
Summary: The study found that FBI-1 plays a negative role in epithelial-to-mesenchymal transition in lung cancer, suggesting it as a potential therapeutic target and diagnostic indicator for early stage of lung cancer metastasis.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ching-Chung Ko, Yao-Yu Hsieh, Pei-Ming Yang
Summary: Epithelial-to-mesenchymal transition (EMT) is a biological process that promotes cancer cell dissemination and drug resistance. This study revealed that overexpression of MIR31HG in pancreatic ductal adenocarcinoma (PDAC) patients is associated with poorer disease-free survival, as well as upregulation of genes related to TGF beta signaling and EMT. In vitro experiments further demonstrated that TGF beta induces MIR31HG expression and knockdown of MIR31HG reverses TGF beta-induced EMT phenotypes and cancer cell migration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Griselda Awanis, Salonee Banerjee, Robert Johnson, Sathuwarman Raveenthiraraj, Aya Elmeligy, Derek Warren, Jelena Gavrilovic, Anastasia Sobolewski
Summary: Tunneling nanotubes (TNTs) play a crucial role in intercellular communication and tumor progression. This study investigates the molecular mechanisms underlying TNT formation and identifies potential targets for inhibiting TNT formation as a novel approach for cancer treatment.
LIFE SCIENCE ALLIANCE
(2023)
Article
Chemistry, Medicinal
Manman Ma, Xiaohua Wang, Xiaohui Liu, Yang Han, Yanhui Chu, Yanzhong Guan, Haifeng Liu
Summary: A novel tT beta RII variant, Z-tT beta RII, was designed by fusing the PDGF beta receptor-specific affibody Z(PDGF beta R) to the N-terminus of tT beta RII. Z-tT beta RII exhibited superior specific fibrotic liver-targeting potential and stronger anti-fibrotic effects in vitro and in vivo. It also showed no significant sign of potential side effects in other vital organs in liver fibrotic mice, making it a potential candidate for targeted therapy for liver fibrosis.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Albena Momchilova, Roumen Pankov, Galya Staneva, Stefan Pankov, Plamen Krastev, Evgenia Vassileva, Rusina Hazarosova, Nikolai Krastev, Bozhil Robev, Biliana Nikolova, Adriana Pinkas
Summary: Resveratrol regulates sphingolipid metabolism in lung cancer cells, leading to changes in CER and S1P levels, and showing anti-cancer effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Zhuo Chen, Hanjie Yu, Xiangqin Chen, Wentian Chen, Wanghua Song, Zheng Li
Summary: TGF-beta superfamily members play important roles in various diseases, and glycosylation modification is involved in the regulation of TGF-beta signaling pathway. There is a complex mutual regulation between glycosylation and TGF-beta signaling, which affects biological processes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Cell Biology
Dorival Mendes Rodrigues-Junior, Chrysoula Tsirigoti, Sai Kiang Lim, Carl-Henrik Heldin, Aristidis Moustakas
Summary: This review summarizes the impact of extracellular vesicles (EVs) on the transforming growth factor beta (TGF-beta) signaling pathway in cancer. The cargo of EVs, including various molecules associated with TGF-beta pathway, can influence tumorigenesis, metastatic spread, immune evasion, and response to treatment. Additionally, TGF-beta-related molecules in circulating EVs show potential as useful biomarkers for prognosis, diagnosis, and treatment response in cancer patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zixuan Liu, Mingming Chen, Yini Sun, Xu Li, Liu Cao, Xiaochun Ma
Summary: Heparin-binding protein (HBP), secreted by neutrophils, plays a role in the pathophysiology of sepsis. Our studies showed that HBP binds to transforming growth factor-beta receptor type 2 (TGF-beta-R2) and triggers acute lung injury and vascular leakage through the TGF-beta/SMAD2/3 signaling pathway. The role of HBP and TGF-beta-R2 in HBP-related acute lung injury at the blood-gas barrier was also defined.
Article
Cell Biology
Chencheng Han, Hong Li, Zhifei Ma, Guozhang Dong, Qianyun Wang, Siwei Wang, Panqi Fang, Xiang Li, Hao Chen, Tongyan Liu, Lin Xu, Jie Wang, Jun Wang, Rong Yin
Summary: The study identified MIR99AHG as a noncoding tumor suppressor gene in LUAD, which suppressed cell proliferation and metastasis by promoting autophagy and synergistically delaying LUAD progression with miR-99a.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Panagiotis Papoutsoglou, Dorival Mendes Rodrigues-Junior, Anita Moren, Andrew Bergman, Fredrik Ponten, Cedric Coulouarn, Laia Caja, Carl-Henrik Heldin, Aristidis Moustakas
Summary: Activation of the TGF beta pathway modulates the expression of genes involved in cell growth arrest, motility, and embryogenesis by inducing the expression of long noncoding RNA MIR100HG. MIR100HG depletion attenuates TGF beta signaling and cell cycle arrest, while its overexpression has an inverse impact on TGF beta signaling responses. MIR100HG forms ribonucleoprotein complexes with the RNA-binding protein HuR to promote TGF beta 1 cytokine secretion and controls the magnitude of TGF beta signaling in carcinomas.
Article
Chemistry, Inorganic & Nuclear
Mohammad Usman, Rais Ahmad Khan, Mohammad Rashid Khan, Mohammad Abul Farah, Ibtisam I. BinSharfan, Walaa Alharbi, Jilani. P. Shaik, Narasimha Reddy Parine, Ali Alsalme, Sartaj Tabassum
Summary: Copper compounds show potential as next-generation metal anticancer drugs, with a newly synthesized polymer displaying high DNA binding propensity and selective cytotoxicity against A549 cancer cells. In vitro studies also revealed the polymer's ability to cleave DNA and its impact on gene expression in various cell lines.
DALTON TRANSACTIONS
(2021)
Article
Medicine, Research & Experimental
Masaki Takahashi, Yoshifumi Hashimoto, Yoshikazu Nakamura
Summary: Transforming growth factor beta (TGF-beta) is a cytokine that plays important roles in various diseases, and inhibiting the TGF-beta 1 isoform using RNA aptamer may be a promising approach for cancer therapy.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Cell Biology
Xiuqin Jia, Ming Xin, Juanjuan Xu, Xindong Xiang, Xuan Li, Yuhan Jiao, Lulin Wang, Jingjing Jiang, Feng Pang, Xianzhen Zhang, Jian Zhang
Summary: In this study, the FGFRs inhibitor FIIN-2 was found to inhibit the proliferation, colony formation, and migration of platinum-resistant LUAD cells while inducing mitochondria-mediated apoptosis. Furthermore, FIIN-2 was shown to enhance autophagy flux in these cells, suggesting its potential as a treatment strategy for LUAD, especially in combination with autophagy inhibitors.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Fuensanta Gomez-Bernal, Juan Carlos Quevedo-Abeledo, Maria Garcia-Gonzalez, Yolanda Fernandez-Cladera, Agustin F. Gonzalez-Rivero, Antonia de Vera-Gonzalez, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study aimed to investigate the relationship between serum levels of transforming growth factor beta 1 (TGF-β1) and disease characteristics, activity, damage, or severity in patients with systemic lupus erythematosus (SLE). The results showed that TGF-β1 serum levels were associated with disease severity and activity, with ocular and cardiovascular manifestations positively correlated, while gastrointestinal and musculoskeletal involvements negatively correlated with circulating TGF-β1 levels.
Article
Oncology
Kota Ishioka, Hiroyuki Yasuda, Junko Hamamoto, Hideki Terai, Katsura Emoto, Tae-Jung Kim, Shigemichi Hirose, Takashi Kamatani, Sachiyo Mimaki, Daisuke Arai, Keiko Ohgino, Tetsuo Tani, Keita Masuzawa, Tadashi Manabe, Taro Shinozaki, Akifumi Mitsuishi, Toshiki Ebisudani, Takahiro Fukushima, Mari Ozaki, Shinnosuke Ikemura, Ichiro Kawada, Katsuhiko Naoki, Morio Nakamura, Takashi Ohtsuka, Hisao Asamura, Katsuya Tsuchihara, Yuichiro Hayashi, Ahmed E. Hegab, Susumu S. Kobayashi, Takashi Kohno, Hideo Watanabe, David M. Ornitz, Tomoko Betsuyaku, Kenzo Soejima, Koichi Fukunaga
Summary: In this study, FGF9 was found to play a crucial role in the transdifferentiation of lung adenocarcinoma to small cell lung cancer. The upregulation of FGF9 was confirmed to induce neuroendocrine differentiation in established human lung adenocarcinoma cells, providing direct evidence for FGF9-mediated SCLC transdifferentiation and proposing the FGF9-FGFR axis as a therapeutic target for transdifferentiated SCLC.