Article
Biochemistry & Molecular Biology
Xinxin Huang, Juncheng Hao, Yan Qin Tan, Tao Zhu, Vijay Pandey, Peter E. Lobie
Summary: Patients with epithelial ovarian cancer are often diagnosed at an advanced stage, leading to poor overall prognosis. This review summarizes the functional significance of CXCL/CXCR chemokines in modulating EOC progression and discusses the current status and prospects of CXCR/CXCL-based theranostic strategies in EOC management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Ameng Shi, Ting Wang, Miao Jia, Lei Dong, Haitao Shi
Summary: The study revealed that the SDF-1/CXCR7 axis is crucial in promoting migration, invasion, and EMT in gastric cancer cells, suggesting that targeting CXCR7 suppression could be a potential strategy for inhibiting gastric cancer metastasis.
FRONTIERS IN GENETICS
(2021)
Article
Fisheries
Zhaosheng Sun, Yuting Qin, Danjie Liu, Bangjie Wang, Zhao Jia, Junya Wang, Qian Gao, Jun Zou, Yue Pang
Summary: Chemokines are soluble peptides that guide cell migration in development and immune defense. The CXC chemokine system in lamprey has been found to have diversified, showing variations in gene organization and expression patterns in different tissues, indicating an evolutionary adaptation in jawless fish.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Neurosciences
Yu Wu, Zhuwei Zhang, Xiaoou Sun, Jing Wang, Haitao Shen, Xue Sun, Zhong Wang
Summary: This study found that inhibition of SDF-1/CXCR4 complex formation can rescue the inflammatory response and alleviate neurobehavioral dysfunction after intracerebral hemorrhage (ICH). Pharmacological inhibition with AMD3100 reduced the upregulation of SDF-1/CXCR4 and decreased levels of TNF-alpha and IL-1 beta. These findings suggest that SDF-1/CXCR4 may serve as a therapeutic target for ICH.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Oncology
Hyun Min Koh, Chang Lim Hyun, Bo Gun Jang, Hyun Ju Lee
Summary: High expression of CXCR3 is associated with better survival in gastric cancer patients, as well as with younger age, lower tumor grade, absence of lymph node metastasis, and lower TNM stage.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Rongzhang He, Xingyu Zheng, Jian Zhang, Bo Liu, Qijie Wang, Qian Wu, Ziyan Liu, Fangfang Chang, Yabin Hu, Ting Xie, Yongchen Liu, Jun Chen, Jing Yang, Shishan Teng, Rui Lu, Dong Pan, You Wang, Liting Peng, Weijin Huang, Velislava Terzieva, Wenpei Liu, Youchun Wang, Yi-Ping Li, Xiaowang Qu
Summary: The study found that spike-specific CXCR3(+) T-FH cells play a crucial role in antibody maintenance and recall responses after SARS-CoV-2 infection and vaccination, exhibiting a more durable response and better ability to induce antibody secretion.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Immunology
Lin Gao, Yan-Mei Jiao, Ping Ma, Lijun Sun, Hongxin Zhao, An-Liang Guo, Xing Fan, Chao Zhang, Jin-Wen Song, Ji-Yuan Zhang, Fengmin Lu, Fu-Sheng Wang
Summary: This study aimed to investigate the characteristics and distribution of HIV-infected cells in semen, in order to improve strategies for exposure prevention and assisted reproduction for HIV-infected partners. The results showed that HIV-infected spermatozoa were mainly CD4 negative, and p24-positive cells in semen were predominantly spermatozoa. Additionally, the study confirmed that motile spermatozoa could carry HIV into peripheral blood mononuclear cells of healthy men.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Anatomy & Morphology
Jiaqian Feng, Tao Han, Yuexing Zhang, Bing Zhang, Dexiang Huang, Tianming Wang, Jingwen Yang
Summary: The study revealed the elevated expression of MsCXCR1 in head kidney, spleen, and liver of largemouth bass infected with N. seriolae, indicating its involvement in immune response and potential impact on digestive function of the species.
Article
Biotechnology & Applied Microbiology
Zhao Zhu, Guoxiu Zhang, Dahuan Li, Xiaojun Yin, Tianzhong Wang
Summary: In septic myocardial injury, SP1 regulates inflammation and cell apoptosis through CXCR4 and the NF-kB signaling pathway.
Article
Clinical Neurology
Lei Zhu, Fugui Yang, Guangxue Wang, Qinchuan Li
Summary: The study demonstrated that CXCR4 promotes lung cancer brain metastasis (LCBM) by regulating the PI3K/Akt signal pathway, and inhibiting CXCR4 can prevent LCBM.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Lei Zhu, Fugui Yang, Guangxue Wang, Qinchuan Li
Summary: This study revealed that CXCR4 promotes lung cancer brain metastasis by regulating the PI3K/Akt signal pathway. We also demonstrated that inhibiting CXCR4 could lead to prevention of brain metastasis. This study provides further rationale for clinical therapy that targets CXCR4/PI3K/AKT.
WORLD NEUROSURGERY
(2022)
Article
Neurosciences
Cheng Ju, Fangyu Yuan, Lu Wang, Caixia Zang, Jingwen Ning, Meiyu Shang, Jingwei Ma, Gen Li, Yang Yang, Qiuzhu Chen, Yueqi Jiang, Fangfang Li, Xiuqi Bao, Dan Zhang
Summary: This study investigated the role of CXCR2 in oligodendrocyte precursor cell (OPC) differentiation and remyelination. The results showed that inhibiting CXCR2 enhanced OPC differentiation and remyelination by promoting myelin protein formation. Furthermore, the study revealed that PDE10A is a downstream protein of CXCR2 that regulates OPC differentiation. Inhibition of CXCR2 resulted in reduced PDE10A expression, while inhibition of PDE10A did not affect CXCR2. Inhibition of PDE10A promoted OPC differentiation, while overexpression of PDE10A down-regulated OPC differentiation. The study also found that inhibition of CXCR2/PDE10A activated the cAMP/ERK1/2 signaling pathway, leading to up-regulation of key transcription factors and ultimately promoting remyelination and myelin protein biosynthesis.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Cell & Tissue Engineering
Sung-Tai Wei, Yen-Chih Huang, Jung-Ying Chiang, Chia-Ching Lin, Yu-Jung Lin, Woei-Cherng Shyu, Hui-Chen Chen, Chia-Hung Hsieh
Summary: The study revealed that CXCR7 promotes the osteogenic and chondrogenic differentiation of MSCs and MSC-mediated immunomodulation by regulating multiple signaling pathways and anti-inflammatory soluble factors. MSCs with enhanced CXCR7 function significantly improved arthritic symptoms in a collagen-induced arthritis model.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Nanoscience & Nanotechnology
Peng Zhao, Jun Wang, Behnaz Karkheiran, Samira Alesaeidi, Ehsan Nourbakhsh, Mohammad Saeed Kahrizi, Asal Mir
Summary: This study developed a new nano-liposome that can modulate the tumor microenvironment and enhance the efficacy of immune checkpoint inhibitors, leading to improved anti-tumor immune response.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Andrea Vecchione, Tatiana Jofra, Jolanda Gerosa, Kimberly Shankwitz, Roberta Di Fonte, Giuseppe Galvani, Elio Ippolito, Maria Pia Cicalese, Andrew R. Schultz, Howie R. Seay, Mariagrazia Favellato, Giulia Milardi, Angela Stabilini, Francesca Ragogna, Pauline Grogan, Eleonora Bianconi, Andrea Laurenzi, Amelia Caretto, Rita Nano, Raffaela Melzi, Nichole Danzl, Emanuele Bosi, Lorenzo Piemonti, Alessandro Aiuti, Todd Brusko, Constantinos Petrovas, Manuela Battaglia, Georgia Fousteri
Summary: The study found significantly reduced frequency of Tfr cells in the spleen and pancreatic lymph nodes of T1D patients, while no significant differences were observed in the frequency and phenotype of blood Tfr cells. Adoptive transfer of Tfr cells in a mouse model of T1D delayed disease development, indicating an important role for Tfr cells in maintaining peripheral tolerance and regulating autoreactive Tfh cells.
Article
Biotechnology & Applied Microbiology
Rongxue Zhang, Yuan Zhu, Yang Li, Wanzhu Liu, Lei Yin, Siqi Yin, Cheng Ji, Yuyan Hu, Qiongni Wang, Xinru Zhou, Jingyan Chen, Wenrong Xu, Hui Qian
BIOTECHNOLOGY LETTERS
(2020)
Article
Biotechnology & Applied Microbiology
Wei Li, Jianling Liu, Bin Zhang, Qingli Bie, Hui Qian, Wenrong Xu
ONCOTARGETS AND THERAPY
(2020)
Article
Immunology
Gaoying Wang, Mbobda Defo Marius Joel, Jintao Yuan, Jingyan Wang, Xiu Cai, Dickson Kofi Wiredu Ocansey, Yongmin Yan, Hui Qian, Xu Zhang, Wenrong Xu, Fei Mao
INFLAMMOPHARMACOLOGY
(2020)
Article
Biology
Dickson K. W. Ocansey, Li Zhang, Yifei Wang, Yongmin Yan, Hui Qian, Xu Zhang, Wenrong Xu, Fei Mao
BIOLOGICAL REVIEWS
(2020)
Article
Oncology
Meng Shao, Jiayin Zhang, Jiahui Zhang, Hui Shi, Yu Zhang, Runbi Ji, Fei Mao, Hui Qian, Wenrong Xu, Xu Zhang
CANCER CELL INTERNATIONAL
(2020)
Review
Oncology
Zhaofeng Liang, Wenhao Guo, Shikun Fang, Yue Zhang, Ling Lu, Wenrong Xu, Hui Qian
Summary: circRNAs, with their covalently closed loop structure, high stability, tissue specificity, and functional diversity, have been identified as potential biomarkers for bladder cancer. They have been shown to function in regulating gene transcription, acting as miRNA sponges, and encoding proteins.
FRONTIERS IN ONCOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Xu Zhang, Hongbo Zhang, Jianmei Gu, Jiayin Zhang, Hui Shi, Hui Qian, Dongqing Wang, Wenrong Xu, Jianming Pan, Helder A. Santos
Summary: Extracellular vesicles (EVs) have shown great potential as a cell-free strategy for cancer therapy, with the ability to be modified and engineered to enhance their therapeutic efficiency and safety. Recent advances have focused on strategies to scale up production, improve cargo-loading, and enhance tumor-targeting of engineered EVs.
ADVANCED MATERIALS
(2021)
Review
Engineering, Biomedical
Peipei Wu, Bin Zhang, Dickson Kofi Wiredu Ocansey, Wenrong Xu, Hui Qian
Summary: Extracellular vesicles play a crucial role in disease treatment and diagnosis, with engineered design enhancing their therapeutic capability and diagnostic imaging potential.
Article
Cell Biology
Xinye Han, Peipei Wu, Linli Li, Hassan Mohamud Sahal, Cheng Ji, Jiahui Zhang, Yi Wang, Qichen Wang, Hui Qian, Hui Shi, Wenrong Xu
Summary: DF-Ex can reverse the damage caused by high glucose in HUVECs and accelerate diabetic cutaneous wound healing; DF-Ex exerts its effects by activating the Akt/beta-catenin pathway; This research provides a new treatment strategy for diabetic cutaneous wound healing.
Article
Cell Biology
Yan Wang, Huiting Wang, Ruiqi Zheng, Peipei Wu, Zixuan Sun, Jingyan Chen, Leilei Zhang, Chenxiao Zhang, Hui Qian, Jiajia Jiang, Wenrong Xu
Summary: In this study, circ-ITCH was found to suppress GC metastasis by acting as a sponge for miR-199a-5p and increasing Klotho expression, providing potential biomarkers and targets for the diagnosis and therapy of GC.
Review
Cell & Tissue Engineering
Qian Jin, Peipei Wu, Xinru Zhou, Hui Qian, Wenrong Xu
Summary: Exosomes, small extracellular vesicles secreted by cells, play crucial roles in intercellular communication in the CNS, contributing to CNS development and homeostasis as well as potentially influencing the progression of neurological disorders. Additionally, exosomes may serve as diagnostic biomarkers and therapeutic tools for these disorders, showing promise in the field of neurological research.
STEM CELLS INTERNATIONAL
(2021)
Article
Oncology
Hui Shi, Yaoxiang Sun, Hongru Ruan, Cheng Ji, Jiahui Zhang, Peipei Wu, Linli Li, Chihan Huang, Yuanwang Jia, Xu Zhang, Wenrong Xu, Jiajia Jiang, Hui Qian
Summary: The study found that the anti-cancer drug DIM at therapeutic concentrations upregulated the expression of tumor-related factors in GC-MSCs and promoted the proliferation, invasion, and migration of gastric cancer cells, leading to tumor growth. This mechanism provides a new insight into anti-cancer drug resistance and suggests the need to adjust the chemotherapy regimen to minimize the side effects of drugs on targeted TME cells.
FRONTIERS IN ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Benshuai You, Yang Yang, Zixuan Zhou, Yongmin Yan, Leilei Zhang, Jianhua Jin, Hui Qian
Summary: EVs have shown cardioprotective effects in heart disease by activating beneficial signaling pathways. Engineering approaches have been developed to improve the therapeutic efficiency of EVs, but further optimization is needed to achieve better cardiac repair outcomes.
Review
Pharmacology & Pharmacy
Fengtian Sun, Yuntong Sun, Feng Wu, Wenrong Xu, Hui Qian
Summary: This review introduces the novel cell-free strategy of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) and their applications in the treatment of diabetes mellitus (DM) and diabetic complications. The major characteristics of MSC-EVs are summarized, and the recent advances in the use of engineered MSC-EVs for treating hyperglycemia-induced tissue damage are discussed. Additionally, the potential applications of engineered MSC-EVs in the therapy of DM-related diseases are presented, and the opportunities and challenges for clinical translation of MSC-EVs, particularly engineered MSC-EVs, are evaluated.
Article
Oncology
Cheng Ji, Jiahui Zhang, Zixuan Zhou, Hui Shi, Wanzhu Liu, Fengtian Sun, Chenxiao Zhang, Leilei Zhang, Zixuan Sun, Hui Qian
Summary: The study proposed the therapeutic use of platelet-rich plasma-stimulated mesenchymal stem cells (PRP-MSCs) for acute kidney injury (AKI), showing significant improvement in kidney damage and reduced levels of blood urea nitrogen and creatinine in both in vivo and in vitro studies. The results suggest that PRP can enhance the therapeutic effect of MSCs through a paracrine pathway, offering a promising treatment option for AKI.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
