Article
Biochemistry & Molecular Biology
Jacqueline Georgy, Yvonne Arlt, Jens M. Moll, Meryem Ouzin, Hendrik T. Weitz, Lothar Gremer, Dieter Willbold, Joachim Groetzinger, Felix Thives-Kurenbach, Juergen Scheller, Doreen M. Floss
Summary: This study identified key amino acid residues in the p40 subunit of IL-12/IL-23 that are crucial for binding to IL-12Rβ1, providing insights into the structural basis of cytokine-cytokine receptor interactions and offering potential for the development of novel therapeutic strategies.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Immunology
Dennis M. de Graaf, Ruth X. Wang, Jesus Amo-Aparicio, J. Scott Lee, Alexander S. Dowdell, Isak W. Tengesdal, Carlo Marchetti, Sean P. Colgan, Leo A. B. Joosten, Charles A. Dinarello
Summary: IL-38 is a recently discovered cytokine that is primarily produced by B lymphocytes and functions to suppress inflammation. Studies have shown that a deficiency of IL-38 may contribute to the worsening of ulcerative colitis and Crohn's disease, and this is likely due to the disinhibition of the NLRP3 inflammasome and increased production of pro-inflammatory cytokines.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yumei Rong, Ge Hong, Na Zhu, Yang Liu, Yong Jiang, Tianjun Liu
Summary: Combining photodynamic therapy (PDT) with a novel photosensitizer LD4 for treating ulcerative colitis (UC) in rat models can improve survival rates, modulate expression of inflammatory factors, protect intestinal epithelial integrity, rebuild intestinal microflora balance, and reprogram protein expression profiles. AOC(1) emerges as a potential target in this efficient UC treatment approach using LD4-PDT.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Yong Zhang, Zhengxia Zha, Wenhua Shen, Dan Li, Naixin Kang, Zhong Chen, Yanli Liu, Guoqiang Xu, Qiongming Xu
Summary: The study demonstrated that anemoside B4 ameliorated TNBS-induced colitis symptoms by inhibiting tissue damage, inflammatory cell infiltration, pro-inflammatory cytokine production, apoptosis, and slowed proliferation in colon. Quantitative proteomic analyses revealed that anemoside B4 significantly altered 56 proteins in TNBS-induced rats, with a focus on proteins related to TCA cycle and respiratory electron transport chain. S100A9, one of the most significantly down-regulated proteins, was associated with NF-kappa B and MAPK signaling pathways in UC pathogenesis.
Review
Gastroenterology & Hepatology
Bram Verstockt, Azucena Salas, Bruce E. Sands, Clara Abraham, Haim Leibovitzh, Markus Neurath, Niels Vande Casteele
Summary: IL-12 and IL-23 play a crucial role in intestinal homeostasis and inflammation, and are implicated in the pathogenesis of inflammatory bowel disease. Monoclonal antibodies targeting IL-12 and/or IL-23 have been developed for the treatment of Crohn's disease and ulcerative colitis. This Review summarizes the biological characteristics of IL-12 and IL-23, discusses their role in intestinal homeostasis and inflammation, and highlights the development of drugs targeting IL-12 and/or IL-23.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Respiratory System
Chenli Chang, Gongqi Chen, Wenliang Wu, Dian Chen, Shengchong Chen, Jiali Gao, Yuchen Feng, Guohua Zhen
Summary: This study found that IL-25 can alleviate airway neutrophilia in asthma by inhibiting macrophage M1 polarization and the expression of IL-12 and IL-23. This discovery may provide new therapeutic strategies, especially for patients with severe or non-eosinophilic asthma.
RESPIRATORY RESEARCH
(2023)
Article
Medicine, Research & Experimental
Razieh Mohammad Jafari, Sevda Shayesteh, Moein Ala, Hasan Yousefi-Manesh, Amir Rashidian, Seyed Mohammadreza Hashemian, Majid Sorouri, Ahmad Reza Dehpour
Summary: Dapsone has shown anti-inflammatory effects and reduced levels of TNF-alpha and INF-gamma in an animal model of CD. It works through the TLR4/NF-κB pathway to attenuate inflammation by reducing tissue edema, inhibiting inflammatory cell infiltration, and maintaining the histologic architecture of the colon.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Mei-Mei Wu, Qiu-Mei Wang, Bao-Yuan Huang, Chu-Tian Mai, Chun-Li Wang, Tian-Tian Wang, Xiao-Jun Zhang
Summary: Restoring immune balance by targeting macrophage polarization with Dioscin is a promising therapeutic strategy for UC. Dioscin ameliorates colitis in mice by inhibiting M1 and promoting M2 macrophage polarization through modulation of mTOR signals. This protection is achieved by inhibiting aerobic glycolysis and promoting fatty acid oxidation in macrophages.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Oncology
Kevin James Baker, Elizabeth Brint, Aileen Houston
Summary: IL-36 cytokines play a crucial role in the pathogenesis of inflammatory diseases and malignancies. This study demonstrates that IL-36 gene expression increases with the development of colorectal cancer and decreased IL-36 receptor expression is associated with better patient outcome. The IL-36/IL-17/IL-23 axis is found to be influential in IL-36-mediated colon tumorigenesis.
BRITISH JOURNAL OF CANCER
(2023)
Article
Pharmacology & Pharmacy
Karuppusamy Arunachalam, Amilcar Sabino Damazo, Antonio Macho, Monica Steffi Matchado, Eduarda Pavan, Fabiana de Freitas Figueiredo, Darley Maria Oliveira, Carrie A. Duckworth, Parimelazhagan Thangaraj, Marco Leonti, Domingos Tabajara de Oliveira Martins
Summary: Canthin-6-one has anti-inflammatory and antioxidant effects on colitis, reducing intestinal damage and improving inflammatory markers. It has the potential therapeutic benefit for inflammatory bowel disease by regulating molecular immune mediators.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Plant Sciences
Cailan Li, Meigui Liu, Li Deng, Dandan Luo, Runfang Ma, Qiang Lu
Summary: This study firstly indicated that OBB had a superior therapeutic effect than BBR against TNBS-elicited colitis in rats. The protective effect of OBB might be closely related to the modulation of Keap1/Nrf2/NF-kappa B mediated inflammatory response and oxidant stress. The evidences highlight the potentiality of OBB as a prospective candidate for the amelioration of colitis.
Article
Biochemistry & Molecular Biology
Noriko Kawamoto-Miyamoto, Hiroshi Hosoda, Kazuyuki Miyoshi, Koji Nomoto
Summary: Lactic acid bacteria (LAB) cultured on food grade medium showed smaller cell size and higher yield, and exhibited a stronger ability to induce IL-12(p40) production. Furthermore, the concentration of glutamate in the medium influenced the cell size, yield, and the ability to induce IL-12 production. Therefore, regulating the concentration of glutamate is crucial for efficient culturing of functional LAB.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Shuguang Yan, Hailiang Wei, Rui Jia, Meijia Zhen, Shengchuan Bao, Wenba Wang, Fanrong Liu, Jingtao Li
Summary: Wumeiwan has a preventive effect on ulcerative colitis by inhibiting pro-inflammatory cytokines, promoting anti-inflammatory factors, and affecting macrophage polarization, thereby protecting mice from DSS-induced colitis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Xi Jing, Anna A. Korchagina, Sergey A. Shein, Wayne T. Muraoka, Ekaterina Koroleva, Alexei V. Tumanov
Summary: IL-23 contributes to intestinal inflammation in C. jejuni infected mice by promoting IL-17 and IFN gamma production by innate lymphoid cells. Reduced levels of pro-inflammatory cytokines and immune cell accumulation in the colon were observed in IL-23(-/-) mice, independent from bacterial clearance. Flow cytometry analysis revealed a decrease in IL-17 and IFN gamma production by group 1 and 3 innate lymphoid cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Jingyi Hu, Yiheng Tong, Zhaofeng Shen, Yanan Li, Cheng Cheng, Ryan Au, Feng Xu, Yajun Liu, Lei Zhu, Hong Shen
Summary: Ulcerative colitis (UC) is a chronic inflammatory disease of the intestine, and dysbiosis of gut microbiota is one of its main pathogenic mechanisms. This study found that Gegen Qinlian decoction (GD) could inhibit the expansion of pathogenic Escherichia coli (E. coli) by activating PPAR-gamma signaling pathway, which contributes to the improvement of UC symptoms.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Maya M. Jeyaraman, Rasheda Rabbani, Leslie Copstein, Wasan Sulaiman, Farnaz Farshidfar, Hessam Kashani, Sheikh M. Z. Qadar, Qingdong Guan, Becky Skidmore, Elissavet Kardami, John Ducas, Samer Mansour, Ryan Zarychanski, Ahmed M. Abou-Setta
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2017)
Editorial Material
Cell Biology
Qingdong Guan, Xiaoling Gao, Junhui Wang, Yu Sun, Sudhanshu Shekhar
MEDIATORS OF INFLAMMATION
(2017)
Review
Cell Biology
Qingdong Guan, Jiguo Zhang
MEDIATORS OF INFLAMMATION
(2017)
Article
Biochemical Research Methods
Qingdong Guan, Peyman Ezzati, Victor Spicer, Oleg Krokhin, Donna Wall, John A. Wilkins
CLINICAL PROTEOMICS
(2017)
Article
Cell & Tissue Engineering
Qingdong Guan, Yun Li, Tanner Shpiruk, Swaroop Bhagwat, Donna A. Wall
Article
Gastroenterology & Hepatology
Qingdong Guan, Carolyn R. Weiss, Shuhe Wang, Gefei Qing, Xi Yang, Richard J. Warrington, Charles N. Bernstein, Zhikang Peng
INFLAMMATORY BOWEL DISEASES
(2018)
Editorial Material
Cell Biology
Qingdong Guan, Cheng Xiao, Minggang Zhang
MEDIATORS OF INFLAMMATION
(2018)
Editorial Material
Immunology
Cheng Xiao, Qingdong Guan, Yong Tan, Lifei Hou, Wuxiang Xie
JOURNAL OF IMMUNOLOGY RESEARCH
(2018)
Article
Hematology
Ahmed Y. Ali, Qingdong Guan, Xun Wu, Sen Hou, Versha Banerji, James B. Johnston, Donna Wall, David Szwajcer, Spencer B. Gibson, Aaron J. Marshall
BRITISH JOURNAL OF HAEMATOLOGY
(2019)
Article
Allergy
Qingdong Guan, Bin Yang, Richard J. Warrington, Steven Mink, Chrystyna Kalicinsky, Allan B. Becker, Elinor Simons, Zhikang Peng
Editorial Material
Cell Biology
Qingdong Guan, Cheng Xiao, Minggang Zhang
MEDIATORS OF INFLAMMATION
(2019)
Review
Immunology
Qingdong Guan
JOURNAL OF IMMUNOLOGY RESEARCH
(2019)
Article
Medicine, Research & Experimental
Qingdong Guan, Richard Warrington, Sem Moreno, Gefei Qing, Carolyn Weiss, Zhikang Peng
Review
Cardiac & Cardiovascular Systems
Maya M. Jeyaraman, Rasheda Rabbani, Leslie Copstein, Wasan Sulaiman, Farnaz Farshidfar, Hessam H. Kashani, Sheikh M. Z. Qadar, Qingdong Guan, Becky Skidmore, Elissavet Kardami, John Ducas, Samer Mansour, Ryan Zarychanski, Ahmed M. Abou-Setta
CANADIAN JOURNAL OF CARDIOLOGY
(2017)
Article
Medicine, Research & Experimental
Sabine Ivison, Mehrnoush Malek, Rosa Garcia, Raewyn Broady, Anne Halpin, Manon Richaud, Rollin F. Brant, Szu- Wang, Mathieu Goupil, Qingdong Guan, Peter Ashton, Jason Warren, Amr Rajab, Simon Urschel, Deepali Kumar, Mathias Streitz, Birgit Sawitzki, Stephan Schlickeiser, Janetta J. Bijl, Donna A. Wall, Jean-Sebastien Delisle, Lori J. West, Ryan R. Brinkman, Megan K. Levings