Article
Rheumatology
Ruth E. Costello, Belay B. Yimer, Polly Roads, Meghna Jani, William G. Dixon
Summary: The study found an association between the use of glucocorticoids and incident hypertension in patients with rheumatoid arthritis, especially at doses >= 7.5 mg. Clinicians should consider cardiovascular risk when prescribing glucocorticoids, and ensure regular monitoring and treatment of blood pressure.
Article
Medical Laboratory Technology
Luping Gong, Yinxin Zhou, Shanjun Shi, Lina Ying, Yan Li, Mingcai Li
Summary: IL-41 expression is increased in the serum of RA patients and positively correlated with disease-related parameters. IL-41 may serve as a potential new diagnostic biomarker for RA.
CLINICA CHIMICA ACTA
(2023)
Article
Immunology
Aleksandra Stojanovic, Mirjana Veselinovic, Yanan Zong, Vladimir Jakovljevic, Iva Pruner, Aleksandra Antovic
Summary: This study identified elevated levels of circulating EVs of different cell origins in female patients with established rheumatoid arthritis (RA), which were associated with the inflammatory burden and coagulation activation in the disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Jian-Fang Xie, Jia Wang, Huan-Huan Bai, Jiao-Jiao He, Rui-Huan Jia, Xia Wang, Wen-Qi Zhang, Xiang-Cong Zhao, Xian-Cheng Zhang, Guang-Ying Liu, Xiao-Feng Li
Summary: This study suggests that serum OPN levels are higher in patients with active and refractory RA compared to healthy controls. In active RA patients, there is an increase in Th2 cells and a decrease in Th1 and T-reg cells. As the disease condition worsens, OPN levels increase while the counts of Th1 and T-reg cells decrease. Patients with high disease activity show the lowest counts of Th1 and T-reg cells and the highest OPN levels. The serum OPN level is significantly negatively correlated with the counts of T-reg cells in CD4(+) T lymphocyte subsets.
ADVANCES IN THERAPY
(2022)
Article
Peripheral Vascular Disease
Takeko Kawabata, Takuro Kubozono, Satoko Ojima, Shin Kawasoe, Yuichi Akasaki, Anwar Ahmed Salim, Yoshiyuki Ikeda, Masaaki Miyata, Toshihiro Takenaka, Mitsuru Ohishi
Summary: This study investigated the relationship between blood pressure control status with or without antihypertensive drugs and arterial stiffness. The researchers found that even with antihypertensive drugs, poor blood pressure control is independently associated with increased arterial stiffness.
HYPERTENSION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Anniina Tynjala, Valma Harjutsalo, Fanny Jansson Sigfrids, Per-Henrik Groop, Daniel Gordin
Summary: This study investigated the association between long-term glycemic variability and arterial stiffness in patients with type 1 diabetes. The results showed that the variability of HbA1c was significantly correlated with arterial stiffness. Importantly, this association was independent of the HbA1c mean.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Immunology
Wanlin Li, Chenghui Liao, Jing Du, Jing Hu, Lu Wang, Xun Song, Zhendan He, Xiaohua Xiao, Liang Ye
Summary: Two isoforms of TSLP, lTSLP and sTSLP, exist in rheumatoid arthritis (RA), with lTSLP being predominant in active RA and sTSLP in inactive RA and healthy controls. lTSLP expression is associated with disease activity and proinflammatory cytokine expression. lTSLP promotes the expression of proinflammatory cytokines in PBMCs of RA, while inhibiting the expression of anti-inflammatory cytokines.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Sung-Eun Choi, Haimuzi Xu, Ji-Hyoun Kang, Dong-Jin Park, Sun-Seog Kweon, Young-Hoon Lee, Hye-Yeon Kim, Jung-Kil Lee, Min-Ho Shin, Shin-Seok Lee
Summary: RHR is positively associated with the radiographic severity of knee joints but not hand joints in patients with musculoskeletal diseases like osteoarthritis. Adjusted for various factors, RHR shows positive correlations with total, osteophyte, JSN, and tibial attrition scores in knee joints and JSN and subchondral cyst scores in hand joints.
SCIENTIFIC REPORTS
(2021)
Article
Pediatrics
Nicolas L. Madsen, Jessica E. Haley, Ryan A. Moore, Philip R. Khoury, Elaine M. Urbina
Summary: The study found that increased arterial stiffness in youth is associated with diastolic dysfunction, independent of cardiovascular disease risk factors. This suggests that improving arterial stiffness during adolescence may help prevent the development of heart failure.
FRONTIERS IN PEDIATRICS
(2021)
Article
Endocrinology & Metabolism
Amra Jujic, Peter M. Nilsson, Naeimeh Atabaki-Pasdar, Anna Dieden, Tiinamaija Tuomi, Paul W. Franks, Jens Juul Holst, Signe Sorensen Torekov, Susana Ravassa, Javier Diez, Margaretha Persson, Emma Ahlqvist, Olle Melander, Maria F. Gomez, Leif Groop, Martin Magnusson
Summary: This study revealed that elevated fasting GIP levels are associated with increased IMTmeanCCA, while GLP-1 levels are associated with decreased IMTmaxBulb in an elderly Swedish population, highlighting diverging cardiovascular effects of these two incretin hormones.
Article
Immunology
Shu-Lin Chen, Qiang Xu, Chang-Song Lin
Summary: A study found that the therapeutic drugs for rheumatoid arthritis (RA) are associated with thyroid function, with methotrexate being linked to decreased levels of total thyroxine (TT4) and glucocorticoids being linked to decreased levels of total triiodothyronine (TT3).
INFLAMMOPHARMACOLOGY
(2023)
Article
Rheumatology
Hieronymus T. W. Smeele, Esther Roder, Annemarie G. M. G. J. Mulders, Eric A. P. Steegers, Radboud J. E. M. Dolhain
Summary: This study is the first to show that the use of TNFi during pregnancy is associated with increased birth weight in offspring of women with well-controlled RA. Further research is needed to explore the underlying mechanism of TNF inhibition on birth weight and its long-term consequences for the offspring.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Medicine, General & Internal
Giovanni Cioffi, Ombretta Viapiana, Luigi Tarantini, Federica Ognibeni, Giovanni Orsolini, Angelo Fassio, Davide Gatti, Maurizio Rossini, Alessandro Giollo
Summary: Inflammatory arthritis patients with cancer have specific asymptomatic cardiovascular abnormalities such as left ventricular diastolic dysfunction and reduced vascular elasticity, which are independent of age and hypertension. This study highlights the close association between cancer and cardiovascular abnormalities in RA/PsA/AS adults without a history of cardiovascular disease. Older age, hypertension, and specific cardiovascular abnormalities like left ventricular diastolic dysfunction and abnormally high ascending aortic stiffness index (AOSI) are factors associated with cancer in these patients.
INTERNAL AND EMERGENCY MEDICINE
(2021)
Article
Biology
Kai-Hsiang Chang, Chih-Hsien Wang, Bang-Gee Hsu, Jen-Pi Tsai
Summary: This study investigated the relationship between serum OPN and aortic stiffness in peritoneal dialysis patients, and found that there was a correlation between the two, with OPN being an independent predictor of AS.
Article
Cell Biology
Zhicheng Yang, Weixi Liu, Ting Yan, Ruiping Liu
Summary: The study revealed that HLA-DPB1 rs9277535 polymorphism is associated with a decreased risk of rheumatoid arthritis in the Chinese population, particularly among women and those at least 55 years old. Additionally, certain genotypes were linked to inflammatory markers and levels of HLA-DPB1 plasma and mRNA in RA patients.
Article
Immunology
Marco Falcone, George L. Daikos, Giusy Tiseo, Dimitrios Bassoulis, Cesira Giordano, Valentina Galfo, Alessandro Leonildi, Enrico Tagliaferri, Simona Barnini, Spartaco Sani, Alessio Farcomeni, Lorenzo Ghiadoni, Francesco Menichetti
Summary: This study aimed to compare the outcomes of patients with MBL-producing Enterobacterales bloodstream infections treated with CAZ-AVI + ATM or other active antibiotics. The results showed that CAZ-AVI + ATM was associated with lower 30-day mortality, lower clinical failure at day 14, and shorter length of stay.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Hematology
Dario Nieri, Tommaso Neri, Greta Barbieri, Sara Moneta, Giovanna Morelli, Desire Mingardi, Stefano Spinelli, Lorenzo Ghiadoni, Marco Falcone, Giusy Tiseo, Francesco Menichetti, Maria Franzini, Laura Caponi, Aldo Paolicchi, Roberta Pancani, Francesco Pistelli, Laura Carrozzi, Alessandro Celi
Summary: This study found that CCL2 levels are associated with coagulation derangement and respiratory impairment in patients with severe COVID-19, suggesting a potential role for CCL2 in the thromboinflammatory events characterizing this disease.
THROMBOSIS RESEARCH
(2021)
Article
Multidisciplinary Sciences
Alina Sirbu, Greta Barbieri, Francesco Faita, Paolo Ferragina, Luna Gargani, Lorenzo Ghiadoni, Corrado Priami
Summary: Clinical decision support systems based on predictive models can improve the management of COVID-19 patients by selecting six clinical variables with the highest predictive power using genetic algorithms.
SCIENTIFIC REPORTS
(2021)
Letter
Emergency Medicine
Federico Coccolini, Enrico Cicuttin, Camilla Cremonini, Dario Tartaglia, Bruno Viaggi, Akira Kuriyama, Edoardo Picetti, Chad Ball, Fikri Abu-Zidan, Marco Ceresoli, Bruno Turri, Sumita Jain, Carlo Palombo, Xavier Guirao, Gabriel Rodrigues, Mahir Gachabayov, Fernando Machado, Lostoridis Eftychios, Souha S. Kanj, Isidoro Di Carlo, Salomone Di Saverio, Vladimir Khokha, Andrew Kirkpatrick, Damien Massalou, Francesco Forfori, Francesco Corradi, Samir Delibegovic, Gustavo M. Machain Vega, Massimo Fantoni, Demetrios Demetriades, Garima Kapoor, Yoram Kluger, Shamshul Ansari, Ron Maier, Ari Leppaniemi, Timothy Hardcastle, Andras Vereczkei, Evika Karamagioli, Emmanouil Pikoulis, Mauro Pistello, Boris E. Sakakushev, Pradeep H. Navsaria, Rita Galeiras, Ali I. Yahya, Aleksei V. Osipov, Evgeni Dimitrov, Krstina Doklestic, Michele Pisano, Paolo Malacarne, Paolo Carcoforo, Maria Grazia Sibilla, Igor A. Kryvoruchko, Luigi Bonavina, Jae Il Kim, Vishal G. Shelat, Jacek Czepiel, Emilio Maseda, Sanjay Marwah, Mircea Chirica, Giandomenico Biancofiore, Mauro Podda, Lorenzo Cobianchi, Luca Ansaloni, Paola Fugazzola, Charalampos Seretis, Carlos Augusto Gomez, Fabio Tumietto, Manu Malbrain, Martin Reichert, Goran Augustin, Bruno Amato, Alessandro Puzziello, Andreas Hecker, Angelo Gemignani, Arda Isik, Alessandro Cucchetti, Mirco Nacoti, Doron Kopelman, Cristian Mesina, Wagih Ghannam, Offir Ben-Ishay, Sameer Dhingra, Raul Coimbra, Ernest E. Moore, Yunfeng Cui, Martha A. Quiodettis, Miklosh Bala, Mario Testini, Jose Diaz, Massimo Girardis, Walter L. Biffl, Matthias Hecker, Ibrahima Sall, Ugo Boggi, Gabriele Materazzi, Lorenzo Ghiadoni, Junichi Matsumoto, Wietse P. Zuidema, Rao Ivatury, Mushira A. Enani, Andrey Litvin, Majdi N. Al-Hasan, Zaza Demetrashvili, Oussama Baraket, Carlos A. Ordonez, Ionut Negoi, Ronald Kiguba, Ziad A. Memish, Mutasim M. Elmangory, Matti Tolonen, Korey Das, Julival Ribeiro, Donal B. O'Connor, Boun Kim Tan, Harry Van Goor, Suman Baral, Belinda De Simone, Davide Corbella, Pietro Brambillasca, Michelangelo Scaglione, Fulvio Basolo, Nicola De'Angelis, Cino Bendinelli, Dieter Weber, Leonardo Pagani, Cinzia Monti, Gianluca Baiocchi, Massimo Chiarugi, Fausto Catena, Massimo Sartelli
Summary: The COVID-19 pandemic has presented the world with unprecedented challenges, prompting us to learn valuable lessons and strengthen global health cooperation for future preparedness against similar events.
WORLD JOURNAL OF EMERGENCY SURGERY
(2021)
Article
Biology
Kristen M. Meiburger, Francesco Marzola, Guillaume Zahnd, Francesco Faita, Christos P. Loizou, Nolann Laine, Catarina Carvalho, David A. Steinman, Lorenzo Gibello, Rosa Maria Bruno, Ricarda Clarenbach, Martina Francesconi, Andrew N. Nicolaides, Herve Liebgott, Aurelio Campilho, Reza Ghotbi, Efthyvoulos Kyriacou, Nassir Navab, Maura Griffin, Andrie G. Panayiotou, Rachele Gherardini, Gianfranco Varetto, Elisabetta Bianchini, Constantinos S. Pattichis, Lorenzo Ghiadoni, Jose Rouco, Maciej Orkisz, Filippo Molinari
Summary: This study presents technical outlooks on computerized carotid intima-media thickness (CIMT) measurements and provides considerations for the development and comparison of these methods. A multi-center database of 500 images was collected and three manual segmentations and seven computerized methods were employed to measure the CIMT. The computerized methods showed comparable results with previous studies and demonstrated promising segmentation outcomes. The entire database has been made publicly available for further research and comparison.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Giulia Elena Mandoli, Chiara Borrelli, Matteo Cameli, Sergio Mondillo, Lorenzo Ghiadoni, Claudia Taddei, Claudio Passino, Michele Emdin, Alberto Giannoni
Summary: Obstructive and central apneas have negative impacts on cardiac structure and function, with obstructive apneas promoting progressive cardiac alterations leading to heart failure. Early identification of these effects and detection of initial cardiac dysfunction in patients with apneas are becoming increasingly relevant. Speckle tracking echocardiography is recognized as an effective method for early detection of cardiac dysfunction, but more research is needed on apnea-related alterations in heart failure progression.
HEART FAILURE REVIEWS
(2022)
Article
Emergency Medicine
Gianni Turcato, Alessandro Cipriano, Arian Zaboli, Naria Park, Alessandro Riccardi, Massimo Santini, Roberto Lerza, Giorgio Ricci, Antonio Bonora, Lorenzo Ghiadoni
Summary: Repeat head CT in patients on DOACs with MTBI after an initial negative CT scan is a common clinical practice. In this study, researchers assessed the incidence of delayed ICH and its association with clinical and risk factors presented on patient arrival in the ED. The results showed that delayed ICH is an uncommon event at the 24-hour control CT and does not affect patient outcome.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Multidisciplinary Sciences
Elisa Ferrari, Luna Gargani, Greta Barbieri, Lorenzo Ghiadoni, Francesco Faita, Davide Bacciu
Summary: We propose a clinical data analysis workflow based on Bayesian Structure Learning (BSL). This workflow incorporates prior medical knowledge into the learning process and provides explainable results in the form of causal connections among analyzed features. Evaluation on a COVID-19 dataset shows that the proposed framework gives a schematic overview of the multi-factorial processes contributing to the outcome and rediscovers established cause-effect relationships. Furthermore, the approach yields a highly interpretable tool that accurately predicts the outcome using a small number of features.
Article
Acoustics
Federica Poli, Catherine Fortier, Hakim Khettab, Francesco Faita, Saverio Vitali, Giacomo Aringhieri, Lorenzo Ghiadoni, Stefano Taddei, Laurence Amar, Aurelien Lorthioir, Pierre Boutouyrie, Rosa Maria Bruno
Summary: Ultrahigh-frequency ultrasound is a useful tool for studying human small muscular arteries and understanding arterial aging. The Carotid Studio software is a valid and reproducible tool for analyzing UHFUS scans of digital arteries.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Nicola Riccardo Pugliese, Alessio Balletti, Silvia Armenia, Nicolo De Biase, Francesco Faita, Alessandro Mengozzi, Francesco Paneni, Frank Ruschitzka, Agostino Virdis, Lorenzo Ghiadoni, Stefano Taddei, Bryan Williams, Francesco Antonini-Canterin, Stefano Masi
Summary: This study evaluated the ventricular-arterial coupling in heart failure patients and found that abnormal ventricular-arterial coupling is directly correlated with the severity of heart failure and worse functional capacity. Furthermore, heart failure patients with preserved ejection fraction have worse ventricular-arterial coupling.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Emergency Medicine
Gianni Turcato, Alessandro Cipriano, Naria Park, Arian Zaboli, Giorgio Ricci, Alessandro Riccardi, Greta Barbieri, Sara Gianpaoli, Grazia Guiddo, Massimo Santini, Norbert Pfeifer, Antonio Bonora, Ciro Paolillo, Roberto Lerza, Lorenzo Ghiadoni
Summary: This study showed that post-traumatic intracranial hemorrhage (ICH) risk in patients with mild traumatic brain injury (MTBI) on oral anticoagulant therapy (OAT) is associated with clinical risk factors such as post-traumatic amnesia, post-traumatic transitory loss of consciousness, greater trauma dynamic, GCS less than 15, and evidence of trauma above the clavicles. The absence of concussion and neurological alteration at admission significantly reduces the likelihood of ICH. The use of a machine-learning-based CART model can help stratify patients and guide decision-making in this population.
BMC EMERGENCY MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Maria Cristina Vedovati, Greta Barbieri, Chiara Urbini, Erika D'Agostini, Simone Vanni, Chiara Papalini, Giacomo Pucci, Ludovica Anna Cimini, Alessandro Valentino, Lorenzo Ghiadoni, Cecilia Becattini
Summary: This study aimed to validate and improve existing clinical models for predicting prognosis in hospitalized patients with acute COVID-19. Results showed that most scores had acceptable discrimination in predicting in-hospital death at 30 days, with REMS and 4C scores having high negative predictive values and ROX-index having the best positive predictive value. Simple predictors such as age and PaO2/FiO2 ratio can also be useful as standalone predictors.
RESPIRATORY MEDICINE
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
C. Giacomelli, L. Russo, L. Marchetti, T. Marzo, M. Calvello, D. La Mendola, A. Cattaneo, C. Martini, M. L. Trincavelli
Article
Geriatrics & Gerontology
Simona Cintoli, Claudia Radicchi, Marianna Noale, Stefania Maggi, Giuseppe Meucci, Gloria Tognoni, Ubaldo Bonuccelli, Alessandro Sale, Nicoletta Berardi, Lamberto Maffei
Summary: The study aimed to test the effects of physical and cognitive training on neuropsychiatric symptoms and quality of life in patients with mild cognitive impairment.
Results showed that after 7 months of training, participants in the training group exhibited a significant reduction in neuropsychiatric symptoms and a significant increase in quality of life compared to the control group.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Peripheral Vascular Disease
Maria Lorenza Muiesan, Enrico Agabiti Rosei, Claudio Borghi, Nicola De Luca, Lorenzo Ghiadoni, Guido Grassi, Stefano Perlini, Giacomo Pucci, Massimo Salvetti, Massimo Volpe, Claudio Ferri
Summary: A survey conducted in Italy revealed differences in the awareness, management, and treatment of hypertensive emergencies and urgencies among physicians, highlighting the need for further dissemination of updated scientific information and improved collaboration with the general practitioner healthcare system.
HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION
(2021)