Article
Immunology
Tirza Gabrielle Ramos de Mesquita, Jose do Espirito Santo Junior, Luan Diego Oliveira da Silva, George Allan Villarouco Silva, Felipe Jules de Araujo, Suzana Kanawati Pinheiro, Herllon Karllos Athaydes Kerr, Lener Santos da Silva, Luciane Macedo de Souza, Samir Assad de Almeida, Krys Layane Guimaraes Duarte Queiroz, Josue Lacerda de Souza, Cilana Chagas da Silva, Hector David Graterol Sequera, Mara Lucia Gomes de Souza, Anderson Nogueira Barbosa, Gemilson Soares Pontes, Marcus Vinitius de Farias Guerra, Rajendranath Ramasawmy
Summary: The immunopathology associated with Leishmaniasis is a consequence of inflammation that may lead to different clinical manifestations depending on host-immune response type, with various pathways influencing disease severity. Comparing immune profiles in patients with cutaneous leishmaniasis caused by L. guyanensis and healthy individuals helps identify specific immune factors related to disease development progression. Multiple biomarker pairs showed high correlation, with cytokines IL-17 and IL-1 beta exhibiting the most positive pair correlation among patients. Prediction of disease progression in Lg-infected individuals may be associated with specific cytokines.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Eloisa Helena Medeiros Cunha, Pedro Henrique Ferreira Marcal, Rafael Silva Gama, Lorena Bruna Pereira de Oliveira, Roberta Olmo Pinheiro, Euzenir Nunes Sarno, Joaquim Pedro Brito-de-Sousa, Marcio Luis Moreira de Souza, Jessica Kathleen Fairley, Thaisa Netto Souza Valente, Cibele Velloso-Rodrigues, Olindo Assis Martins-Filho, Dirce Ribeiro de Oliveira, Lucia Alves de Oliveira Fraga
Summary: The aim of this study was to investigate the association between the TLR4 gene single nucleotide polymorphism (SNP) rs1927914 A/G and the immunological profile of household contacts (HHC) of leprosy patients. The results showed that M. leprae stimuli induced high production of chemokines in HHC(PB), while elevated levels of pro-inflammatory cytokines were observed in HHC(MB). Furthermore, the AA and AG genotypes were associated with prominent secretion of soluble mediators compared to GG.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Pedro Paulo Carneiro, Andreza S. Dorea, Walker N. Oliveira, Luiz Henrique Guimaraes, Claudia Brodskyn, Edgar M. Carvalho, Olivia Bacellar
Summary: Research has shown that the use of TLR2 and TLR4 antagonists can reduce the number of infected cells and internalized parasites in monocytes of CL patients, as well as decrease oxidative burst, IL-1 beta, TNF, and CXCL9 production. Additionally, TNF production in cells from CL lesions also decreased after neutralization of TLR2 and TLR4.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Monica Franca, Luiz H. Guimaraes, Mauricio T. Nascimento, Paulo N. Rocha, Lucas P. Carvalho
Summary: High levels of pro-inflammatory cytokines in cutaneous leishmaniasis patients are associated with tissue damage and ulcer development, but do not influence therapeutic failure in response to pentavalent antimony treatment.
MICROBES AND INFECTION
(2021)
Article
Cell Biology
Gang Wang, Hua-Ling Wu, Yue-Ping Liu, De-Qi Yan, Zi-Lin Yuan, Li Chen, Qian Yang, Yu-Song Gao, Bo Diao
Summary: This study demonstrates that transplantation of human umbilical cord mesenchymal stem cells (huMSCs) is a safe and effective strategy for the treatment of traumatic brain injury (TBI), with good immunoregulatory function.
NEURAL REGENERATION RESEARCH
(2022)
Article
Parasitology
Iara Barreto Neves Oliveira, Clayton Luiz Borges, Rodrigo Saar Gomes, Fatima Ribeiro-Dias
Summary: This article reviews studies on SNPs in immune genes associated with susceptibility or resistance to tegumentary leishmaniasis (TL). The authors highlight the difficulties of these studies and emphasize the importance of future analyses to enhance our understanding of host genetic factors in TL. Understanding the genetic characteristics of the host can contribute to the development of immunotherapy schedules for this disease, which currently lacks effective treatment methods and a human vaccine.
Review
Immunology
Fernanda O. Novais, Camila Farias Amorim, Phillip Scott
Summary: Cutaneous leishmaniasis presents a wide spectrum of clinical manifestations, with severe cases often not responding to anti-parasitic drugs. Host-directed therapies offer a novel approach to improve clinical outcomes and could be a valuable tool in modulating disease severity. It is important to tailor these therapies for specific types of leishmaniasis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Mauricio T. Nascimento, Monica Franca, Augusto M. Carvalho, Camila F. Amorim, Fabio Peixoto, Daniel Beiting, Phillip Scott, Edgar M. Carvalho, Lucas P. Carvalho
Summary: The study found that Notch signaling can protect against pathologic inflammatory response in CL patients, and a specific gamma-secretase inhibitor JLK6 can reduce the in-vitro inflammatory response, potentially serving as an adjuvant treatment for CL patients.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Immunology
Akram Miramin Mohammadi, Malcolm S. Duthie, Steven G. Reed, Amir Javadi, Ali Khamesipour
Summary: The study evaluated antigen-specific immune responses at different stages of cutaneous leishmaniasis and found that cured CL patients had persistent antigen-specific IFN-gamma responses, SLA induced IL-10 secretion, and IFN-gamma responses developed in the late active CL lesion phase.
PARASITE IMMUNOLOGY
(2021)
Article
Allergy
Christian J. Carlsson, Morten A. Rasmussen, Susanne B. Pedersen, Ni Wang, Jakob Stokholm, Bo L. Chawes, Klaus Bonnelykke, Hans Bisgaard
Summary: The study found that upper airway immune mediator levels were altered during episodes of asthma-like symptoms, and levels of TNF-alpha, CCL22, and IL-10 may predict the response to azithromycin treatment.
Article
Biochemistry & Molecular Biology
Fernanda Fortes de Araujo, Matheus Fernandes Costa-Silva, Agnes Antonia Sampaio Pereira, Felipe Dutra Rego, Victoria Hellena Silva Pereira, Jaqueline Paulino de Souza, Luana Oliveira Borges Fernandes, Olindo Assis Martins-Filho, Celia Maria Ferreira Gontijo, Vanessa Peruhype-Magalhaes, Andrea Teixeira-Carvalho
Summary: Interactions between pathogens and host immune responses are critical for immunity and pathology against Leishmania parasites. Proinflammatory responses enhance immune control, while anti-inflammatory responses favor parasite proliferation. Chemokines play a key role in determining cellular composition at inflammatory sites.
Article
Immunology
Feride Eren, Lilly Schwieler, Funda Orhan, Anna Malmqvist, Fredrik Piehl, Simon Cervenka, Carl M. Sellgren, Helena Fatouros-Bergman, Goran Engberg, Sophie Erhardt
Summary: In this study, immune aberrations in schizophrenia were investigated by analyzing a large number of immune-related proteins. It was found that several inflammatory proteins were significantly elevated in the plasma of both first-episode psychosis patients and schizophrenia patients, and these elevations were associated with disease severity. However, only CD5 showed a difference in cerebrospinal fluid.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Biochemistry & Molecular Biology
Xuan Xiang, Yi-Ran Niu, Zi-Hao Wang, Lin-Lin Ye, Wen-Bei Peng, Qiong Zhou
Summary: This review summarizes the biological functions of cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME), particularly in supporting tumor cell proliferation, migration, and invasion. CAFs also play a crucial role in suppressing immune responses by attracting immunosuppressive cells through the secretion of cytokines, chemokines, and metabolites. The review highlights potential therapeutic strategies to alleviate the immunosuppression caused by CAFs and inhibit tumor progression.
CYTOKINE & GROWTH FACTOR REVIEWS
(2022)
Article
Immunology
Kadir Gonzalez, Jose Eduardo Calzada, Thaise Yumie Tomokane, Carmen Maria Sandoval Pacheco, Gabriela Venicia Araujo Flores, Claudia Maria Castro Gomes, Carlos Eduardo Pereira Corbett, Azael Saldana, Marcia Dalastra Laurenti
Summary: This study assessed the in situ immune response during LCL infection in Panamanian patients, revealing a mixed cellular immune response characterized by the presence of pro-inflammatory, anti-inflammatory, and regulatory elements.
PARASITE IMMUNOLOGY
(2021)
Article
Immunology
Bruce K. Patterson, Jose Guevara-Coto, Ram Yogendra, Edgar B. Francisco, Emily Long, Amruta Pise, Hallison Rodrigues, Purvi Parikh, Javier Mora, Rodrigo A. Mora-Rodriguez
Summary: CCR5 and its ligands play a role in COVID-19 pathogenesis, with a focus on immune responses. Elevated B-cells and certain monocytic subsets were observed in COVID-19 patients, while certain T-cell subsets were decreased compared to healthy controls. Various cytokines showed significantly different levels in COVID-19 patients compared to healthy controls, indicating immune dysregulation in the disease process.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Andrology
Natalia de Castro Alves, Soraia de Araujo Diniz, Rodrigo Novaes Viegas, Steyner Franca Cortes, Eduardo Damasceno Costa, Marina Morra Freitas, Olindo Assis Martins-Filho, Marcio Sobreira Silva Araujo, Angela Maria Quintao Lana, Raphael Rocha Wenceslau, Monique de Albuquerque Lagares
Summary: The addition of 5 mM caffeine was found to increase sperm motility and decrease nitrite concentration in frozen-thawed equine sperm, leading to a higher fertility rate in mares inseminated with caffeine-treated semen compared to the control group.
Article
Environmental Sciences
Pamela B. Vilela, Alessandra S. Martins, Maria Clara V. M. Starling, Felipe A. R. de Souza, Giovana F. F. Pires, Ananda P. Aguilar, Maria Eduarda A. Pinto, Tiago A. O. Mendes, Camila C. de Amorim
Summary: This study evaluated the elimination and inactivation of resistance-conferring plasmids (RCPs) in secondary wastewater using solar photo-Fenton, showing enhanced performance compared to the dark Fenton process. Solar photo-Fenton completely removed RCPs and rapidly inactivated target RCPs, demonstrating the potential to improve wastewater quality and reduce the spread of antimicrobial resistance in the environment.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2021)
Article
Parasitology
Denise da Silveira-Lemos, Glaucia Diniz Alessio, Mauricio Azevedo Batista, Patrick Orestes de Azevedo, Joao Luis Reis-Cunha, Tiago Antonio de Oliveira Mendes, Rodrigo de Almeida Lourdes, Marta de Lana, Ricardo Toshio Fujiwara, Olindo Assis Martins Filho, Daniella Castanheira Bartholomeu
Summary: The study used multiple markers to decode the genotype-specific immune response of experimental T. cruzi infection, revealing that different T. cruzi genotypes influence the phenotypic and functional features of host immune response as well as genotype-specific serological reactivity during early and late stages of infection.
Article
Biochemistry & Molecular Biology
Fernanda Rodrigues Nascimento, Jefferson Viktor de Paula Barros Baeta, Andressa Antunes Prado de Franca, Maria Aparecida Braga Rocha E Oliveira, Virginia Ramos Pizziolo, Anesia Aparecida dos Santos, Tiago Antonio de Oliveira Mendes, Gaspar Diaz-Munoz, Marisa Alves Nogueira Diaz
Summary: DPBP has been found to have high in vitro antineoplastic activity against melanoma cells, inducing tumor cell death through apoptosis pathways with high selectivity. Treatment with DPBP reduced tumor volume and did not cause hepatomegaly or nephrotoxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Entomology
R. C. S. Guimaraes, E. F. Marialva, J. A. Feijo, J. W. Pereira-Silva, K. M. Martins-Campos, C. M. F. Gontijo, A. A. S. Pereira, C. M. Rios-Velasquez, F. A. C. Pessoa
Summary: This study evaluated the effects of anthropization processes on the composition of sand fly fauna and natural infection by Trypanosomatids. The results showed that sand flies from different landscapes were infected with Trypanosomatids, and some parasite species may play a role in the transmission of leishmaniasis.
JOURNAL OF MEDICAL ENTOMOLOGY
(2022)
Article
Pharmacology & Pharmacy
Sandra Aparecida dos Reis Louzano, Mariana de Moura e Dias, Lisiane Lopes da Conceicao, Tiago Antonio de Oliveira Mendes, Maria do Carmo Gouveia Peluzio
Summary: The study aimed to investigate the treatment of obesity with antimicrobial and potential probiotics. Results indicated that using ceftriaxone alone or in combination with the potential probiotic reduced body fat, but the negative impact of ceftriaxone on the intestinal microbiota composition may have led to intestinal dysbiosis, destroying villi structure and reducing absorptive surface.
PHARMACOLOGICAL REPORTS
(2022)
Article
Immunology
Barbara B. Esteves, Marcella N. Melo-Braga, Vladimir Gorshkov, Thiago Verano-Braga, Martin R. Larsen, Celia M. F. Gontijo, Patricia F. Quaresma, Helida M. Andrade
Summary: In this study, differential protein expression in Leishmania braziliensis strains causing atypical cutaneous lesions compared to strains causing typical lesions was identified. The atypical strains showed upregulation of proteins related to macrophage survival, antimony resistance, and peroxidase activity. Additionally, potential drug and vaccine targets were identified. These findings contribute to the understanding of atypical cutaneous leishmaniasis and provide new insights for treatment and prevention strategies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Parasitology
Thallyta Maria Vieira, Soraia de Oliveira Silva, Luciana Lima, Gilberto Sabino-Santos, Eduardo Robson Duarte, Sabrina Miranda Lima, Agnes Antonia Sampaio Pereira, Francisco C. Ferreira, Walter Santos de Araujo, Marta Maria Geraldes Teixeira, Renata Luiz Ursine, Celia Maria Ferreira Gontijo, Maria Norma Melo
Summary: This study investigated the occurrence of Leishmania infection in bats in urban and wild areas in an endemic municipality for visceral and cutaneous leishmaniasis in Minas Gerais, Brazil. The results showed an overall infection rate of 4.4%, with most infected bats being frugivorous bats. Additionally, the study reported Artibeus cinereus as a host of Leishmania (Leishmania) amazonensis for the first time.
Article
Biochemistry & Molecular Biology
Fabiana R. Araujo, Bruno M. Bertassoli, Natalia M. Ocarino, Amanda M. S. Reis, Juneo F. Silva, Lorena G. R. Ribeiro, Rogeria Serakides
Summary: In this study, we evaluated the cultures of femoral chondrocytes from offspring of rats with intrauterine growth restriction induced by maternal hyperthyroidism. We found that maternal hyperthyroidism did not alter the chondrocyte morphology or viability, but significantly reduced the percentage of PAS+ areas, decreased the expression of Col2 and Acan genes, and increased the expression of Sox9 gene.
Article
Pathology
Daniele C. de Oliveira Freitas, Fabricio G. Melo, Natalia de Melo Ocarino, Douglas M. Abreu, Fabiana R. Araujo, Rogeria Serakides
Summary: Three young adult cattle presented neoplastic masses in the rostral region of the mandible, leading to tooth displacement and loss. These masses were diagnosed as mandibular ossifying fibroma based on macroscopic, radiographic, and microscopic findings.
JOURNAL OF COMPARATIVE PATHOLOGY
(2022)
Article
Veterinary Sciences
Gabriela S. M. Assuncao, Natalia M. Ocarino, Luiz C. C. Sofal, Rogeria Serakides
Summary: This study aimed to investigate the microscopic alterations in the dental pulp of dogs. The results showed that pulp alterations, including fibrosis, calcification, and necrosis, were present in most of the examined teeth. Premolars were the most affected, while molars were the least affected by these alterations.
JOURNAL OF VETERINARY DENTISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Mariana de Fatima Albuquerque Pereira, Larissa Gabriela Morais de Avila, Gabriela de Cassia Avila Alpino, Bruna Cristina dos Santos Cruz, Lucas Filipe Almeida, Jordana Macedo Simoes, Andressa Ladeira Bernardes, Iasmim Xisto Campos, Andrea de Oliveira Barros Ribon, Tiago Antonio de Oliveira Mendes, Maria do Carmo Gouveia Peluzio
Summary: This study analyzed the microbial community profile of milk kefir and its effects on metabolism, oxidative stress, and the microbiota-gut-brain axis in a mouse model. The results showed that kefir improved gut microbiota, increased production of short-chain fatty acids, and positively influenced brain health. Therefore, kefir has potential benefits for maintaining gut and brain health.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Infectious Diseases
Talita Pereira Vaz, Patricia Flavia Quaresma, Felipe Dutra Rego, Camila Binder Souza, Gilberto Fontes, Celia Maria Ferreira Gontijo
Summary: This study is the first attempt to treat and monitor dogs with canine visceral leishmaniasis (CVL) in natural conditions. The results show that treatment with miltefosine reduces the detection of the parasite in the skin and bone marrow, and the continuous use of allopurinol helps control the disease.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Agronomy
Nathalia Chicon Elert, Higor Azevedo Assis, Leticia Parmanhani Romao, Rogeria Serakides, Natalia de Melo Ocarino, Alfredo Miranda de Goes, Francisco de Paula Careta, Greiciane Gaburro Paneto, Adriana Madeira Alvares da Silva, Jankerle Neves Boeloni
Summary: The objective of this study was to investigate the effect of triiodothyronine (T3) on the chondrogenic differentiation of adipose tissue-derived stem cells (ASCs) in female rats. The results showed that T3 did not alter cell morphology or chondrogenic matrix formation, but at lower doses, it decreased the expression of the Sox9 gene.
Article
Veterinary Sciences
Julia Perinotto Picelli, Simone Scarpin de Sa, Isabel Rodrigues Rosado, Ananda Neves Teodoro, Ana Julia de Souza Lima, Barbara Monteiro Kiellander, Rogeria Serakides, Endrigo Gabellini Leonel Alves
Summary: This report describes a case of pneumothorax secondary to pulmonary bullae in a dog, which was successfully treated with surgical intervention. The clinical signs, diagnosis, and treatment methods of pneumothorax were discussed, highlighting the importance of early therapy and surgical intervention for better outcomes.
ACTA SCIENTIAE VETERINARIAE
(2022)
