Article
Immunology
Fuchuan Wang, Meiying Song, Yuhong Hu, Liu Yang, Xiaoyue Bi, Yanjie Lin, Tingting Jiang, Wen Deng, Shiyu Wang, Fangfang Sun, Zhan Zeng, Yao Lu, Ge Shen, Ruyu Liu, Min Chang, Shuling Wu, Yuanjiao Gao, Hongxiao Hao, Mengjiao Xu, Xiaoxue Chen, Leiping Hu, Gang Wan, Lu Zhang, Minghui Li, Yao Xie
Summary: This study explored the correlation between postpartum hepatitis and changes of plasmacytoid dendritic cells' (pDC) function and frequency in HBeAg-positive pregnant women with chronic HBV infection. The results showed that postpartum hepatitis in HBV infected women mainly occurs at 6-12 weeks postpartum. Antiviral treatment during pregnancy can significantly increase the frequencies of CD83(+) pDCs and CD86(+) pDCs in pregnant women with chronic HBV infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Matthew J. Wiest, Laurie Baert, Chao Gu, Kevin M. Gayler, Hyoungjun Ham, Laurent Gorvel, Mira T. Keddis, Leroy W. Griffing, Hyemee Joo, Jean-Pierre Gorvel, Daniel D. Billadeau, Robert R. Kane, Sangkon Oh
Summary: This study investigated the mechanisms of cytokine expression mediated by TLR7 in pDCs and found that specific intracellular trafficking pathways can regulate the production of IFN alpha and TNF alpha by pDCs. This has important implications for understanding the pathogenesis of autoimmune diseases and developing potential therapeutic approaches.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Fisheries
Sylvie M. A. Quiniou, Jonathan Crider, Kristianna L. Felch, Eva Bengten, Pierre Boudinot
Summary: In this study, we identified the complete repertoire of IFNs and IFN receptor genes in channel catfish. We found 16 type I IFN genes representing six previously defined subgroups, as well as two type II IFN genes and their respective receptors. Our findings provide a comprehensive resource for future research on the innate antiviral immunity of channel catfish.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Immunology
Paoline Laurent, Chao Yang, Andre F. Rendeiro, Benjamin E. Nilsson-Payant, Lucia Carrau, Vasuretha Chandar, Yaron Bram, Benjamin R. tenOever, Olivier Elemento, Lionel B. Ivashkiv, Robert E. Schwartz, Franck J. Barrat
Summary: Lung-infiltrating macrophages play a role in the inflammation and lethality of COVID-19, despite not being infected by the virus. Plasmacytoid dendritic cells (pDCs) in the lungs produce interferons (IFN-I) in response to SARS-CoV-2, leading to macrophage activation. This interaction between pDCs and macrophages may contribute to the severity of the disease.
SCIENCE IMMUNOLOGY
(2022)
Article
Immunology
Tae Jin Yun, Suzu Igarashi, Haoquan Zhao, Oriana A. Perez, Marcus R. Pereira, Emmanuel Zorn, Yufeng Shen, Felicia Goodrum, Adeeb Rahman, Peter A. Sims, Donna L. Farber, Boris Reizis
Summary: Plasmacytoid dendritic cells (pDCs) can recognize live infected cells and produce a unique antiviral immune response, including high amounts of interferons, prolonged and efficient responses to CMV-infected cells, and activation of natural killer cells. Patients with CMV viremia show activated pDCs and increased circulating IFN-I and IFN-III.
SCIENCE IMMUNOLOGY
(2021)
Article
Oncology
Mi He, Bhavesh Soni, Petra C. Schwalie, Tamara Huesser, Caroline Waltzinger, Duvini De Silva, Ylva Prinz, Laura Kruempelmann, Samuele Calabro, Ines Matos, Christine Trumpfheller, Marina Bacac, Pablo Umana, Mitchell P. Levesque, Reinhard Dummer, Maries van den Broek, Stephan Gasser
Summary: TL8-506 in combination with IFN-γ or Poly(I:C) can activate human tumor-associated dendritic cells (DCs), inducing the expression of chemokines and cytokines, and enhancing the immunostimulatory capacity of DCs. This finding provides new insights for the research and development of cancer immunotherapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Dermatology
Jiaqi Zeng, Di Wang, Jialiang Luo, Lei Li, Luyang Lin, Jingyi Li, Wen Zheng, Daming Zuo, Bin Yang
Summary: This study found that the level of MBL is elevated in patients with psoriasis and is positively correlated with disease severity and pDC frequency. In vitro experiments showed that MBL protein can promote the differentiation of pDC and increase the production of inflammatory cytokines and chemokines. Mice deficient in MBL showed reduced accumulation of pDC and decreased secretion of pDC-related cytokines in the early stage of psoriasis. Mechanistic research indicated that the STAT3-IRF8 axis is responsible for MBL-modulated pDC differentiation.
JOURNAL OF DERMATOLOGY
(2022)
Article
Immunology
Amal Hasan, Ebaa Al-Ozairi, Nosiba Y. M. Hassan, Shamsha Ali, Rasheed Ahmad, Nada Al-Shatti, Salem Alshemmari, Fahd Al-Mulla
Summary: Severe COVID-19 is associated with a lower frequency of pDCs compared to other circulating DCs, and lower expression levels of HLA-DR, CD123, or CD11c on DCs.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Ji Xiao, Ping Liu, Yiliang Wang, Yexuan Zhu, Qiongzhen Zeng, Xiao Hu, Zhe Ren, Yifei Wang
Summary: DNA methylation plays a significant role in innate immune responses and antiviral ability, and decitabine, as an efficient DNA methyltransferase inhibitor, has shown promising results. Understanding the regulation of decitabine could lead to the development of therapeutic methods for reducing morbidity and mortality associated with pathogen infections, particularly virus infections.
Article
Immunology
Kerstin H. Mair, Maria Stadler, Mahsa Adib Razavi, Armin Saalmuller, Wilhelm Gerner
Summary: This study demonstrates the expression and function of NKp46 on porcine plasmacytoid dendritic cells (pDCs). It was found that the majority of porcine pDCs express NKp46 and have an active signaling pathway upon NKp46 triggering, leading to cytokine production. However, unlike NK cells, NKp46 on porcine pDCs does not seem to be involved in cytotoxicity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Virology
Jie Min, Wenjun Liu, Jing Li
Summary: This review summarizes the complex regulatory role of IFN-induced ncRNAs in antiviral innate immunity.
Article
Immunology
Oceane Paris, Franck J. D. Mennechet, E. J. Kremer
Summary: This study investigated the interaction between ILCs and adaptive immune response. The researchers found that ILCs uptake HAdVs, leading to phenotypic maturation and cytokine secretion. Moreover, the complex of neutralizing antibodies and host defense proteins altered the cytokine profile generated by ILCs, potentially impacting the efficacy of adenovirus-based vaccines.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Annesa Das, Kuldeep Singh Chauhan, Himanshu Kumar, Prafullakumar Tailor
Summary: The study uncovered the distinct roles of IRF8 in regulating the development of cDC1 and modulating the functionality of pDCs, without affecting development.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Thi Thu Phuong Tran, Tuan Hiep Tran, Eric J. Kremer
Summary: Most adults develop long-lived B- and T-cell responses after exposure to various human adenoviruses (HAdVs), protecting them from re-infections by the same HAdV type. However, certain HAdV types may lead to persistent infections, especially when an individual's T-cell response is compromised. Interestingly, patients with B-cell deficiencies do not seem to be at a greater risk of HAdV disease.
Article
Multidisciplinary Sciences
Meiling Zheng, Zhi Hu, Xiaole Mei, Lianlian Ouyang, Yang Song, Wenhui Zhou, Yi Kong, Ruifang Wu, Shijia Rao, Hai Long, Wei Shi, Hui Jing, Shuang Lu, Haijing Wu, Sujie Jia, Qianjin Lu, Ming Zhao
Summary: This study compares the differences between cutaneous lesions from DLE and SLE patients and healthy controls using single-cell RNA sequencing data. The findings reveal differential immune cell recruitment, cell type, and gene expression, highlighting potential therapeutic targets for lupus erythematosus.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Kangyun Wu, Derek E. Byers, Xiaohua Jin, Eugene Agapov, Jennifer Alexander-Brett, Anand C. Patel, Marina Cella, Susan Gilfilan, Marco Colonna, Daniel L. Kober, Tom J. Brett, Michael J. Holtzman
JOURNAL OF EXPERIMENTAL MEDICINE
(2015)
Article
Biochemistry & Molecular Biology
Zeynep Yurtsever, Dhara A. Patel, Daniel L. Kober, Alvin Su, Chantel A. Miller, Arthur G. Romero, Michael J. Holtzman, Tom J. Brett
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2016)
Article
Pharmacology & Pharmacy
Shenbin Liu, Jing Feng, Jialie Luo, Pu Yang, Thomas J. Brett, Hongzhen Hu
BRITISH JOURNAL OF PHARMACOLOGY
(2016)
Article
Multidisciplinary Sciences
Peter A. Meyer, Stephanie Socias, Jason Key, Elizabeth Ransey, Emily C. Tjon, Alejandro Buschiazzo, Ming Lei, Chris Botka, James Withrow, David Neau, Kanagalaghatta Rajashankar, Karen S. Anderson, Richard H. Baxter, Stephen C. Blacklow, Titus J. Boggon, Alexandre M. J. J. Bonvin, Dominika Borek, Tom J. Brett, Amedeo Caflisch, Chung-I Chang, Walter J. Chazin, Kevin D. Corbett, Michael S. Cosgrove, Sean Crosson, Sirano Dhe-Paganon, Enrico Di Cera, Catherine L. Drennan, Michael J. Eck, Brandt F. Eichman, Qing R. Fan, Adrian R. Ferre-D'Amare, J. Christopher Fromme, K. Christopher Garcia, Rachelle Gaudet, Peng Gong, Stephen C. Harrison, Ekaterina E. Heldwein, Zongchao Jia, Robert J. Keenan, Andrew C. Kruse, Marc Kvansakul, Jason S. McLellan, Yorgo Modis, Yunsun Nam, Zbyszek Otwinowski, Emil F. Pai, Pedro Jose Barbosa Pereira, Carlo Petosa, S. Raman, Tom A. Rapoport, Antonina Roll-Mecak, Michael K. Rosen, Gabby Rudenko, Joseph Schlessinger, Thomas U. Schwartz, Yousif Shamoo, Holger Sondermann, Yizhi J. Tao, Niraj H. Tolia, Oleg V. Tsodikov, Kenneth D. Westover, Hao Wu, Ian Foster, James S. Fraser, Filipe R. N. C. Maia, Tamir Gonen, Tom Kirchhausen, Kay Diederichs, Merce Crosas, Piotr Sliz
NATURE COMMUNICATIONS
(2016)
Article
Biology
Daniel L. Kober, Jennifer M. Alexander-Brett, Celeste M. Karch, Carlos Cruchaga, Marco Colonna, Michael J. Holtzman, Thomas J. Brett
Article
Biochemistry & Molecular Biology
Monica Sala-Rabanal, Zeynep Yurtsever, Kayla N. Berry, Colin G. Nichols, Tom J. Brett
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Review
Biochemistry & Molecular Biology
Daniel L. Kober, Tom J. Brett
JOURNAL OF MOLECULAR BIOLOGY
(2017)
Review
Biochemistry & Molecular Biology
Kayla N. Berry, Daniel L. Kober, Alvin Su, Tom J. Brett
Article
Biochemistry & Molecular Biology
Chamnongsak Ken Chanthamontri, David S. Jordan, Wenjie Wang, Chao Wu, Yanchun Lin, Tom J. Brett, Michael L. Gross, Daisy W. Leung
Article
Biochemistry & Molecular Biology
Shannon I. Ohlemacher, Yiquan Xu, Daniel L. Kober, Mahnoor Malik, Jay C. Nix, Tom J. Brett, Jeffrey P. Henderson
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Cell Biology
Yuetiva Deming, Fabia Filipello, Francesca Cignarella, Claudia Cantoni, Simon Hsu, Robert Mikesell, Zeran Li, Jorge L. Del-Aguila, Umber Dube, Fabiana Geraldo Farias, Joseph Bradley, John Budde, Laura Ibanez, Maria Victoria Fernandez, Kaj Blennow, Henrik Zetterberg, Amanda Heslegrave, Per M. Johansson, Johan Svensson, Bengt Nellgard, Alberto Lleo, Daniel Alcolea, Jordi Clarimon, Lorena Rami, Jose Luis Molinuevo, Marc Suarez-Calvet, Estrella Morenas-Rodriguez, Gernot Kleinberger, Michael Ewers, Oscar Harari, Christian Haass, Thomas J. Brett, Bruno A. Benitez, Celeste M. Karch, Laura Piccio, Carlos Cruchaga
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Article
Cell Biology
Kayla N. Berry, Tom J. Brett
Article
Clinical Neurology
Daniel L. Kober, Melissa D. Stuchell-Brereton, Colin E. Kluender, Hunter B. Dean, Michael R. Strickland, Deborah F. Steinberg, Samantha S. Nelson, Berevan Baban, David M. Holtzman, Carl Frieden, Jennifer Alexander-Brett, Erik D. Roberson, Yuhua Song, Tom J. Brett
Summary: The study using comprehensive biolayer interferometry analysis revealed that TREM2 binds apoE through a protein-mediated mechanism, with slight affinity differences among isoforms; TREM2 and sTREM2 can directly bind mAβ42 and potently inhibit Aβ42 polymerization, suggesting a potential role in preventing AD pathogenesis.
ALZHEIMERS & DEMENTIA
(2021)
Meeting Abstract
Biophysics
Monica Sala-Rabanal, Kayla N. Berry, Colin G. Nichols, Thomas J. Brett
BIOPHYSICAL JOURNAL
(2022)
Meeting Abstract
Clinical Neurology
Fabia Filipello, Yuetiva Deming, Francesca Cignarella, Claudia Cantoni, Simon Hsu, Robert Mikesell, Zeran Li, Jorge Del-Aguila, Umber Dube, Fabiana Geraldo Farias, Joseph Bradley, John Budde, Laura Ibanez, Maria Victoria Fernandez, Kaj Blennow, Henrik Zetterberg, Amanda Heslegrave, Per M. Johansson, Johan Svensson, Bengt Nellgard, Alberto Lleo, Daniel Alcolea, Jordi Clarimon, Lorena Rami, Jose Luis Molinuevo, Marc Suarez-Calvet, Estrella Morenas-Rodriguez, Gernot Kleinberger, Michael Ewers, Oscar Harari, Christian Haass, Thomas J. Brett, Bruno A. Benitez, Celeste Karch, Laura Piccio, Carlos Cruchaga
ANNALS OF NEUROLOGY
(2019)
