Journal
MOLECULAR IMMUNOLOGY
Volume 55, Issue 1, Pages 87-93Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2012.08.003
Keywords
Chemokines; Atypical chemokine receptors; Inflammation; GPCR
Categories
Funding
- Ministero dell'Istruzione dell'Universita e della Ricerca
- Minister della Salute (Ricerca Finalizzata)
- Italian Association for Cancer Research (AIRC)
- Regione Lombardia
- Fondazione Cariplo
- European Community [HEALTH-F4-2011-281608]
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The atypical chemokine receptor D6 was initially called silent on the basis of lack of conventional signaling events that lead to directional cell migration. It has emerged that D6 is able to bind and drive to degradative compartments most inflammatory CC chemokines and that is able to convey G-protein independent signaling events to optimize its scavenging activity. We here summarize the knowledge available today on D6 structural and signaling properties and its essential role for the control of inflammatory cells traffic and proper development of the adaptive immune response. (C) 2012 Elsevier Ltd. All rights reserved.
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