Article
Environmental Sciences
Xuanfeng Zhu, Min Sun, Hongmei Guo, Gan Lu, Jianhua Gu, Lingling Zhang, Licheng Shi, Jia Gao, Dandan Zhang, Wenjun Wang, Jiannan Liu, Xia Wang
Summary: This study demonstrates that verbascoside can exert cardioprotective effects in septic heart injury by inhibiting oxidative stress, inflammation, and apoptosis, as well as promoting mitochondrial biogenesis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Multidisciplinary Sciences
Hiroaki Hiraiwa, Daisuke Kasugai, Masayuki Ozaki, Yukari Goto, Naruhiro Jingushi, Michiko Higashi, Kazuki Nishida, Toru Kondo, Kenji Furusawa, Ryota Morimoto, Takahiro Okumura, Naoyuki Matsuda, Shigeyuki Matsui, Toyoaki Murohara
Summary: This study retrospectively analyzed data from septic shock patients and found that visually-assessed right ventricular dysfunction was associated with in-hospital mortality, lethal arrhythmia, and hemodynamic indicators, suggesting prognostic value in predicting patient outcomes.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, Research & Experimental
Amira Mohamed Taha, Abdelrahman Mohamed Mahmoud, Mohamed M. Ghonaim, Ateeba Kamran, Jehad Feras Alsamhori, Majd M. Albarakat, Abhigan Babu Shrestha, Vikash Jaiswal, Russel J. Reiter
Summary: Septic cardiomyopathy is a complication of sepsis with high mortality rates. Despite extensive research, there is currently no effective pharmacological agent for this condition. Melatonin, with its diverse functions in the body, has emerged as a potential treatment for sepsis-induced cardiomyopathy due to its anti-oxidant, anti-inflammatory, anti-apoptotic, and cardioprotective roles.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell Biology
Federico Carbone, Luca Liberale, Alberto Preda, Thomas Hellmut Schindler, Fabrizio Montecucco
Summary: The onset of cardiomyopathy in sepsis is a common feature that affects its pathophysiology and clinical care. However, there is a lack of consensus in the definition of sepsis-induced cardiomyopathy, and the wide range of ultrasonographic findings may not fully reflect the understanding of the condition. This review explores the current state of research on sepsis-related cardiomyopathy, highlighting the shortcomings in its definition and discussing the dynamic changes in cardiac performance in response to different hemodynamic clusters. The review also addresses the molecular mechanisms leading to myocardial dysfunction and their similarities to myocardial hibernation.
Review
Immunology
Shuang Liu, Wei Chong
Summary: Sepsis is an abnormal systemic inflammatory response to infection that can lead to fatal multiorgan dysfunction syndrome. Sepsic cardiomyopathy is a common complication of sepsis with unclear pathogenesis. Epigenetics and long non-coding RNAs play important roles in regulating septic cardiomyopathy. Mitochondria are important targets in septic cardiomyopathy, and intervention measures to prevent mitochondrial damage are significant for improving prognosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Bettina Kronsteiner, Max Haberbusch, Philipp Aigner, Anne-Margarethe Kramer, Patrick M. Pilz, Bruno K. Podesser, Attila Kiss, Francesco Moscato
Summary: To understand the cardiac responses to vagus nerve stimulation (VNS), an ex-vivo Langendorff-perfused rabbit heart model with intact vagal innervation was used. This model demonstrated nerve excitability for about 5 hours ex-vivo. The charges required for HR reduction were lower in the ex-vivo model compared to in-vivo experiments, indicating the feasibility of this model to study the cardiac effects of VNS.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Zheng Lin, Hai-Han Liao, Zi-Ying Zhou, Nan Zhang, Wen-Jing Li, Qi-Zhu Tang
Summary: This study investigates the role of RIP2 in lipopolysaccharide-induced septic cardiomyopathy and finds that RIP2 induces an inflammatory response by regulating the TAK1/I kappa B alpha/ NF-kappa B signaling pathway. Inhibition of RIP2 shows potential as a treatment strategy for inhibiting inflammation, alleviating cardiac dysfunction, and improving survival.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Critical Care Medicine
Hongli Xiao, Guoxing Wang, Yan Wang, Zhimin Tan, Xuelian Sun, Jie Zhou, Meili Duan, Deyuan Zhi, Ziren Tang, Chenchen Hang, Guoqiang Zhang, Yan Li, Caijun Wu, Fengjie Li, Haiyan Zhang, Jing Wang, Yun Zhang, Xinchao Zhang, Wei Guo, Wenjie Qi, Miaorong Xie, Chunsheng Li
Summary: The study investigated the use of presepsin-guided strategy to shorten antibiotic treatment duration for septic patients without increasing the risk of death, recurrent infection, and organ failure aggravation. The results showed that patients in the presepsin group had more days without antibiotics, shorter hospital stays, and lower hospitalization costs compared to the control group. There were no significant differences in mortality, recurrent infection, multidrug-resistant bacteria, and SOFA score between the two groups.
Article
Cardiac & Cardiovascular Systems
Hua-Xi Zou, Bai-Quan Qiu, Ze-Yu Zhang, Tie Hu, Li Wan, Ji-Chun Liu, Huang Huang, Song-Qing Lai
Summary: This study analyzed the expression of autophagy-related genes in septic cardiomyopathy (SCM) based on human septic heart transcriptomes, identifying key genes and functional pathways. Furthermore, these key genes were associated with abnormal immune infiltration and showed potential as biomarkers. Finally, the study predicted drugs that could potentially play a protective role in SCM by regulating autophagy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Pediatrics
Gabrielle Norrish, Ella Field, Juan P. Kaski
Summary: Hypertrophic cardiomyopathy, caused by sarcomeric protein gene variants, is a common cause of childhood cardiomyopathy with good short-term outcomes but high long-term morbidity and mortality risks. Management focuses on symptom relief and complication prevention, but potential disease-modifying therapies offer promise for improving outcomes in young patients.
FRONTIERS IN PEDIATRICS
(2021)
Article
Genetics & Heredity
Feng Lu, Feng Hu, Baiquan Qiu, Hongpeng Zou, Jianjun Xu
Summary: This study identified STAT3, SOCS3, CCL2, IL1R2, JUNB, S100A9, OSMR, ZFP36, and HAMP as potentially important genes in septic cardiomyopathy using bioinformatics analysis and experimental verification.
FRONTIERS IN GENETICS
(2022)
Article
Anesthesiology
Junyi Wang, Xinjing Gao, Zhengzhong He, Jinxiang Wang, Guowu Xu, Tong Li
Summary: This study evaluated the effects of reducing heart rate using Esmolol on cardiac function in patients with sepsis-induced cardiomyopathy (SIC). The results showed that Esmolol achieved the target heart rate within 24 hours without impairing myocardial contractility, and also led to a decrease in short-term mortality.
BMC ANESTHESIOLOGY
(2023)
Article
Multidisciplinary Sciences
Martin Groeber, Savvas Stafilidis, Arnold Baca
Summary: Stretch-induced residual force enhancement (rFE) is associated with increased performance in a stretch-shortening cycle (SSC), particularly important for movements at greater muscle-tendon unit lengths.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Maria Carmela Filomena, Daniel L. Yamamoto, Pierluigi Carullo, Roman Medvedev, Andrea Ghisleni, Nicoletta Piroddi, Beatrice Scellini, Roberta Crispino, Francesca D'Autilia, Jianlin Zhang, Arianna Felicetta, Simona Nemska, Simone Serio, Chiara Tesi, Daniele Catalucci, Wolfgang A. Linke, Roman Polishchuk, Corrado Poggesi, Mathias Gautel, Marie-Louise Bang
Summary: MYPN gene mutations cause cardiac diseases, and MYPN knockout mice rapidly develop severe cardiac dilation and dysfunction in response to aortic constriction, with accompanying fibrosis and altered protein levels associated with cardiac function.
Article
Physiology
Xiang-Long Meng, Mu-Ming Yu, Yan-Cun Liu, Yu-Lei Gao, Xin-Sen Chen, Song-Tao Shou, Yan-Fen Chai
Summary: This study confirms the preventive effect of a rutin-enriched diet on cardiac apoptosis and cardiac injury induced by CLP in a mouse model.
FRONTIERS IN PHYSIOLOGY
(2022)