Article
Cell Biology
Michael St Paul, Samuel D. Saibil, SeongJun Han, Kavita Israni-Winger, Scott C. Lien, Rob C. Laister, Azin Sayad, Susanne Penny, Rodabe N. Amaria, Lauren E. Haydu, Carlos R. Garcia-Batres, Meghan Kates, David T. Mulder, Celine Robert-Tissot, Matthew J. Gold, Charles W. Tran, Alisha R. Elford, Linh T. Nguyen, Trevor J. Pugh, Devanand M. Pinto, Jennifer A. Wargo, Pamela S. Ohashi
Summary: Metabolic programming plays a crucial role in the anti-tumor properties of T cells. By utilizing metabolomics, it was found that pantothenate and its metabolite CoA drive T cell polarization, bioenergetics, and anti-tumor immunity, enhancing the efficacy of anti-tumor therapy. Pre-treatment plasma pantothenic acid levels were positively correlated with the response to anti-PD1 therapy in melanoma patients.
Article
Biotechnology & Applied Microbiology
Martina Damo, Brittany Fitzgerald, Yisi Lu, Mursal Nader, Ivana William, Julie F. Cheung, Kelli A. Connolly, Gena G. Foster, Elliot Akama-Garren, Da-Yae Lee, Greg P. Chang, Vasilena Gocheva, Leah M. Schmidt, Alice Boileve, Josephine H. Wilson, Can Cui, Isabel Monroy, Prashanth Gokare, Peter Cabeceiras, Tyler Jacks, Nikhil S. Joshi
Summary: A new method called NINJA has been developed to control the expression of neoantigens, allowing for studies of immune responses, particularly in anti-tumor immunity. This approach bypasses central and peripheral tolerance mechanisms, inducing strong T cell responses in peripheral tissues.
NATURE BIOTECHNOLOGY
(2021)
Article
Immunology
Kerstin M. Gergely, Juergen Podlech, Sara Becker, Kirsten Freitag, Steffi Krauter, Nicole Buescher, Rafaela Holtappels, Bodo Plachter, Matthias J. Reddehase, Niels A. W. Lemmermann
Summary: The study demonstrates that combining ACT and TherVac in HCT recipients significantly improves antiviral control, and the enhancement of antiviral protection through vaccination is strictly epitope-specific.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Samyuktha Ramesh, Soohyung Park, Wonpil Im, Melissa J. Call, Matthew E. Call
Summary: The B cell receptor (BCR) and T cell receptor (TCR) share a common core transmembrane (TM) structure, which is vital for optimal receptor assembly and stability in the cell membrane.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Pathology
Lisa G. Lanigan, Blake E. Hildreth, Wessel P. Dirksen, Jessica K. Simmons, Chelsea K. Martin, Jillian L. Werbeck, Nandu K. Thudi, Tracey L. Papenfuss, Prosper N. Boyaka, Ramiro E. Toribio, Jerrold M. Ward, Katherine N. Weilbaecher, Thomas J. Rosol
Summary: The study found that the expression of the HTLV-1 oncogene Tax in mice leads to osteolytic tumors. Mechanisms of bone-invasive malignancies were identified, and related cell lines were established for further research.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Cell Biology
Xiaojuan Zhou, Xian Jia, Zhe Huang, Chao Yang, Jiali Li, Wangnan Xie, Xiaoyu He, Wei Ying, Chenfeng Liu, Yun Liu, Kunyu Liao, Yazhen Hong, Xiao Lei Chen, Tianying Zhang, Ningshao Xia, Wen-Hsien Liu, Guo Fu, Changchun Xiao
Summary: This study identifies a group of CD8+ T cells reactive to both MHC class I and II molecules in MHC class II-deficient mice. These CD8+ T cells undergo negative selection in wild-type animals, but develop into mature CD8+ T cells in the absence of MHC class II. When encountering MHC class II in the periphery, they cause autoimmune diseases. However, these CD8+ T cells are able to efficiently control MHC class II-expressing tumors in adoptive T cell therapy.
Article
Biochemistry & Molecular Biology
Emma J. Keller, Nina Dvorina, Trine N. Jorgensen
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by dysregulated T and B lymphocytes. Type I interferons (IFN-I) play important roles in SLE, affecting B cell differentiation, autoantibody production, and development of glomerulonephritis. However, the specific effects of IFN-I on T cells and the role of different T cell subsets in SLE are not well understood. This study used a mouse model of lupus to investigate the role of T cell-specific IFN-I stimulation. The results suggest that IFN-I specifically affects CD8+ T cells and may contribute to both pathogenic and immunosuppressive responses in lupus-like autoimmunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Wenyan Li, Yanjun Jia, Yanping Wang, Qin Zhao, Lu Yang, Ting Zeng, Linlin Niu, Rongxin Dai, Yanan Li, Xiaodong Zhao, Junfeng Wu
Summary: This study reveals the selective impact of WASp deficiency on the TCR diversity of different memory T cell subsets, with a greater effect on the TCRV beta diversity of CD4(+) effector memory T cells than CD8(+) central memory T cells. Additionally, it is found that the limitation of TCRV beta diversity in CD4(+) effector memory T cells and CD8(+) central memory T cells in WAS is intrinsic and not severe.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Valerie Janelle, Jean-Sebastien Delisle
Summary: T cells play a crucial role in immunotherapy, but their efficacy can be limited by physiological constraints and external factors. Ex vivo manipulation of T cells offers opportunities to improve therapeutic potential, but also poses risks of inducing dysfunctional features that may impact treatment outcomes. Ongoing research focuses on strategies to prevent or reverse T-cell dysfunction and enhance the effectiveness of adoptive cell therapies.
Article
Biochemistry & Molecular Biology
Sun-Hye Shin, Kyung-Ah Cho, Hee-Soo Yoon, So-Yeon Kim, Hee-Yeon Kim, Yael Pewzner-Jung, Sung-Ae Jung, Woo-Jae Park, Anthony H. Futerman, Joo-Won Park
Summary: This study revealed that CerS2 null mice showed milder symptoms and lower Th2 responses after OVA exposure. CerS2 null CD4+ T cells exhibited impaired Th2 and increased Th17 responses along with higher TCR signal strength post TCR stimulation, suggesting that CerS2 and very-long chain SLs could be therapeutic targets for Th2-related diseases like asthma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xiaolan Guo, Haobin Li, Xiuqiong Meng, ZhiBin Zhao, Rongxin Zhang, Lijing Wang, Jiangchao Li
Summary: CD8 + effector cells play a crucial role in immune surveillance and adaptive immunity against cancer cells. Knockout of the Shkbp1 gene increases the number and enhances the function of CD8 + T cells in the spleen. This study suggests that Shkbp1 may be a potential target in cancer immunotherapy.
MOLECULAR IMMUNOLOGY
(2023)
Article
Immunology
Deborah K. Johnson, Wyatt Magoffin, Sheldon J. Myers, Jordan G. Finnell, John C. Hancock, Taylor S. Orton, Stephen P. Persaud, Kenneth A. Christensen, K. Scott Weber
Summary: CD4(+) T cells are important for suppressing and eliminating cancer cells, and their activation is influenced by CD4 expression and TCR affinity. The coreceptor CD4 inhibits TCR activation through various mechanisms. TCR-pMHCII affinity and construct format impact IL-2 production and tetramer staining for each TCR.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jatin Machhi, Pravin Yeapuri, Yaman Lu, Emma Foster, Rupesh Chikhale, Jonathan Herskovitz, Krista L. Namminga, Katherine E. Olson, Mai Mohamed Abdelmoaty, Ju Gao, Rolen M. Quadros, Tomomi Kiyota, Liang Jingjing, Bhavesh D. Kevadiya, Xinglong Wang, Yutong Liu, Larisa Y. Poluektova, Channabasavaiah B. Gurumurthy, R. Lee Mosley, Howard E. Gendelman
Summary: Alzheimer's disease is characterized by pathological deposition of misfolded self-protein amyloid beta, leading to neuroinflammation. Effector T cells induced by self-antigens accelerate disease progression, suggesting a potential therapeutic target in controlling AD pathology.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Immunology
Guangyao Tian, Mingqian Li, Guoyue Lv
Summary: This article reviews the recent advances in TCR sequencing techniques and computational tools, as well as the recent discovery in overall TCR profile and antigen-specific T cells tracking in transplantation. The challenges and potential of using TCR sequencing-based assays to profile alloreactive TCR repertoire as the fingerprint for immune monitoring and prediction of rejection and tolerance are further discussed.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Kimberly A. Morrissey, Marcin Wegrecki, T. Praveena, Victoria L. Hansen, Lijing Bu, Komagal Kannan Sivaraman, Samuel Darko, Daniel C. Douek, Jamie Rossjohn, Robert D. Miller, Jerome Le Nours
Summary: The study describes a unique population of γμTCRs found exclusively in non-eutherian mammals, with restricted diversity in the Vγ and Vμj domains and highly diverse unpaired Vμ domain. Crystal structures of two distinct γμTCRs reveal the structural basis of the association and suggest a major antigen recognition determinant in the CDR3μ loop of the Vμ domain. This defines the molecular basis underlying the assembly of a third TCR lineage, the γμTCR.
Article
Biochemical Research Methods
Anne Wiemhoefer, Anita Stargardt, Wouter A. van der Linden, Maria C. Renner, Ronald E. van Kesteren, Jan Stap, Marcel A. Raspe, Birgitta Tomkinson, Helmut W. Kessels, Huib Ovaa, Herman S. Overkleeft, Bogdan Florea, Eric A. Reits
MOLECULAR & CELLULAR PROTEOMICS
(2015)
Article
Oncology
Elina Timosenko, Hemza Ghadbane, Jonathan D. Silk, Dawn Shepherd, Uzi Gileadi, Lauren J. Howson, Robert Laynes, Qi Zhao, Robert L. Strausberg, Lars R. Olsen, Stephen Taylor, Francesca M. Buffa, Richard Boyd, Vincenzo Cerundolo
Article
Multidisciplinary Sciences
Niels R. Reinders, Yvonne Pao, Maria C. Renner, Carla M. da Silva-Matos, Tessa R. Lodder, Roberto Malinow, Helmut W. Kessels
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Neurosciences
Nicolas Gutierrez-Castellanos, Carla M. Da Silva-Matos, Kuikui Zhou, Cathrin B. Canto, Maria C. Renner, Linda M. C. Koene, Ozgecan Ozyildirim, Rolf Sprengel, Helmut W. Kessels, Chris I. De Zeeuw
Article
Biology
Maria C. Renner, Eva H. H. Albers, Nicolas Gutierrez-Castellanos, Niels R. Reinders, Aile N. van Huijstee, Hui Xiong, Tessa R. Lodder, Helmut W. Kessels
Article
Psychiatry
J. Zhao, R. W. H. Verwer, S-F Gao, X-R Qi, P. J. Lucassen, H. W. Kessels, D. F. Swaab
JOURNAL OF PSYCHIATRIC RESEARCH
(2018)
Article
Clinical Neurology
Sylvie L. Lesuis, Lianne Hoeijmakers, Aniko Korosi, Susanne R. de Rooij, Dick F. Swaab, Helmut W. Kessels, Paul J. Lucassen, Harm J. Krugers
ALZHEIMERS RESEARCH & THERAPY
(2018)
Article
Neurosciences
Secil Uyaniker, Sophie J. F. van der Spek, Niels R. Reinders, Hui Xiong, Ka Wan Li, Koen Bossers, August B. Smit, Joost Verhaagen, Helmut W. Kessels
FRONTIERS IN CELLULAR NEUROSCIENCE
(2019)
Article
Biochemical Research Methods
Aile N. van Huijstee, Helmut W. Kessels
JOURNAL OF NEUROSCIENCE METHODS
(2020)
Article
Clinical Neurology
Till S. Zimmer, Bastian David, Diede W. M. Broekaart, Martin Schidlowski, Gabriele Ruffolo, Anatoly Korotkov, Nicole N. van der Wel, Peter C. van Rijen, Angelika Muhlebner, Wim van Hecke, Johannes C. Baayen, Sander Idema, Liesbeth Francois, Jonathan van Eyll, Stefanie Dedeurwaerdere, Helmut W. Kessels, Rainer Surges, Theodor Rueber, Jan A. Gorter, James D. Mills, Erwin A. van Vliet, Eleonora Aronica
Summary: Neuronal dysfunction caused by iron accumulation and reactive oxygen species may play a significant role in the epileptogenic process, while alterations in iron metabolism in the epileptic brain have not been extensively studied. Through clinical and animal experiments, as well as in vitro cell culture, the study revealed the mechanisms of iron in epilepsy pathology and antioxidant metabolism.
ACTA NEUROPATHOLOGICA
(2021)
Article
Cell Biology
Kim Dore, Zachary Carrico, Stephanie Alfonso, Marc Marino, Karin Koymans, Helmut W. Kessels, Roberto Malinow
Summary: The study found that increased PSD-95 can protect synapses from the toxic effects of A beta, suggesting that low levels of PSD-95 may be a molecular sign of synapse vulnerability to A beta. Inhibition of PSD-95 depalmitoylation pharmacologically may offer a therapeutic avenue against Alzheimer's disease.
Article
Oncology
Eugene Shenderov, Matheswaran Kandasamy, Uzi Gileadi, Jili Chen, Dawn Shepherd, James Gibbs, Gennaro Prota, Jonathan D. Silk, Jonathan W. Yewdell, Vincenzo Cerundolo
Summary: The NY-ESO-1 T cell receptor (TCR) transgenic mouse model provides a unique opportunity for studying TCR response avidity against this tumor-specific antigen, with the potential to accelerate clinical development of tumor vaccines and cell therapies targeted at NY-ESO-1.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Jonathan D. Silk, Rachel J. M. Abbott, Katherine J. Adams, Alan D. Bennett, Sara Brett, Terri Cornforth, Katherine L. Crossland, David J. Figueroa, Junping Jing, Caitriona O'Connor, Annette Pachnio, Lea Patasic, Carlos E. Peredo, Adriano Quattrini, Laura L. Quinn, Alistair G. Rust, Joseph P. Sanderson, Dylan Steiner, Barbara Tavano, Preetha Viswanathan, Guy E. Wiedermann, Ryan Wong, Bent K. Jakobsen, Cedrik M. Britten, Andrew B. Gerry, Joanna E. Brewer
Summary: Coexpressing dnTGF-beta RII with high-affinity TCRs can alleviate the inhibitory effect of exogenous TGF-beta on human T cells expressing the TCRs.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Behavioral Sciences
Fabrizio Grieco, Briana J. Bernstein, Barbara Biemans, Lior Bikovski, C. Joseph Burnett, Jesse D. Cushman, Elsbeth A. van Dam, Sydney A. Fry, Bar Richmond-Hacham, Judith R. Homberg, Martien J. H. Kas, Helmut W. Kessels, Bastijn Koopmans, Michael J. Krashes, Vaishnav Krishnan, Sreemathi Logan, Maarten Loos, Katharine E. McCann, Qendresa Parduzi, Chaim G. Pick, Thomas D. Prevot, Gernot Riedel, Lianne Robinson, Mina Sadighi, August B. Smit, William Sonntag, Reinko F. Roelofs, Ruud A. J. Tegelenbosch, Lucas P. J. J. Noldus
Summary: The reproducibility crisis in the field of behavioral neuroscience, particularly in biomedical research, is influenced by various environmental factors and human interference. Automated home-cage monitoring systems have been developed to reduce human interference and provide continuous measures of spontaneous behavior for analysis across multiple time scales. These systems address technical issues related to behavioral data acquisition and offer advantages such as opportunities for within-subject analyses and circadian activity assessments.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Oncology
Victoria E. Anderson, Sara S. Brilha, Anika M. Weber, Annette Pachnio, Guy E. Wiedermann, Sumaya Dauleh, Tina Ahmed, George R. Pope, Laura L. Quinn, Roslin Y. Docta, Adriano Quattrini, Siobhan Masters, Neil Cartwright, Preetha Viswanathan, Luca Melchiori, Louise V. Rice, Alexandra Sevko, Claire Gueguen, Manoj Saini, Barbara Tavano, Rachel J. M. Abbott, Jonathan D. Silk, Bruno Laugel, Joseph P. Sanderson, Andrew B. Gerry
Summary: In this study, T cells were engineered to express an affinity-enhanced HLA class I-restricted TCR and CD8α coreceptor. The coexpression of these receptors enhanced the activation, effector functions, and cytotoxic activity of CD4(+) T cells, as well as improved dendritic cell activation. These findings suggest that adding the CD8α coreceptor to TCR-engineered T cells could improve the depth and durability of antitumor responses.
JOURNAL OF IMMUNOTHERAPY
(2023)