Article
Immunology
Ricardo Wesley Alberca, Eliane Gomes, Momtchilo Russo
Summary: This study explored the immunomodulatory effect of CpG-ODN on allergic sensitization to OVA with alum, focusing on dendritic cells expressing the MyD88 molecule and the suppressive IL-10 cytokine. CpG-ODN inhibited allergic sensitization and consequent lung allergic inflammation signaling through MyD88 pathway on dendritic cells. IL-10 was found to be dispensable for the inhibition of allergic lung Th2 responses by CpG-ODN.
Article
Biochemistry & Molecular Biology
Marta Fortunato, Giada Amodio, Silvia Gregori
Summary: Tolerogenic dendritic cells (tolDC) play a central role in immune homeostasis and peripheral tolerance. We developed a protocol to generate genetically engineered tolDC overexpressing IL-10 (DCIL-10) and found that they can modulate cytotoxic CD8(+) T cell responses by reducing proliferation and activation, and inducing anergic CD8(+) T cells without signs of exhaustion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Masashi Kanayama, Yuta Izumi, Megumi Akiyama, Toyoki Hayashi, Koji Atarashi, Axel Roers, Taku Sato, Toshiaki Ohteki
Summary: Emergency myelopoiesis is a hematopoietic response against systemic infections, but the role of lymphocytes in this process has not received much attention. This study found that a unique B cell subset expressing myeloid markers emerged in the bone marrow during emergency myelopoiesis, and these cells preferentially expressed IL-10, which stimulated hematopoietic progenitors for enhanced myeloid differentiation. Blocking IL-10 significantly suppressed emergency myelopoiesis and hindered microbial clearance in a model of cecal ligation and puncture. These findings suggest the importance of adaptive immune cells in boosting emergency myelopoiesis.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Engineering, Biomedical
Farshid Eslami-kaliji, Mohsen Sarafbidabad, Abbas Kiani-Esfahani, Seyede Zohreh Mirahmadi-Zare, Kianoush Dormiani
Summary: The unsaturated fatty acid 10-hydroxy-2-decanoic acid (10-HDA) was found to induce a tolerogenic immunophenotype in dendritic cells cultured on specific biomaterials by reducing the activity of TLR4 signaling pathways. This discovery suggests that 10-HDA may serve as a potential antagonist for TLR4, offering implications for autoimmune diseases and combating the rejection of biomaterials implantation or allograft transplantation.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Multidisciplinary Sciences
Anett Mazlo, Ramona Kovacs, Noemi Miltner, Marta Toth, Zoltan Vereb, Krisztina Szabo, Ildiko Bacskai, Kitti Pazmandi, Agota Apati, Tamas Biro, Krisztian Bene, Eva Rajnavolgyi, Attila Bacsi
Summary: Findings suggest that MSCl cells promote differentiation of CTLA-4 expressing DCs through the production of all-trans retinoic acid, leading to the activation and polarization of allogeneic, naive T cells by semi-matured DCs in a CTLA-4 dependent manner. Understanding the molecular mechanisms behind MSC-mediated modulation of DC differentiation may expand the clinical application of MSCs in cell-free therapies.
Article
Immunology
Patricia Ramos-Ramirez, Carina Malmhall, Omar Tliba, Madeleine Radinger, Apostolos Bossios
Summary: Adiponectin/AdipoR1 axis promotes IL-10 release by Tregs, mainly in Helios(-) Tregs, and the effect was amplified by T2 inflammation in Helios(+) Tregs. This suggests a potential role of adiponectin in regulating Treg function in human inflammatory conditions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Wei Zhang, Eun-Koung An, Juyoung Hwang, Jun-O Jin
Summary: The study found that LPS can directly stimulate pDCs via the TLR4/MD2 pathway and promote the activation of pDCs and cDCs. cDCs may contribute to the enhancement of IFN-alpha production in pDCs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Wojciech Dawicki, Hui Huang, Yanna Ma, Jennifer Town, Xiaobei Zhang, Chris D. Rudulier, John R. Gordon
Summary: CD40 signaling in DC10 plays a crucial role in promoting IL-10 expression and robust induction of tolerance, including activation of induced Treg.
Article
Biochemistry & Molecular Biology
Anette Christ, Pieter G. Goossens, Erwin Wijnands, Han Jin, Bart Legein, Tammy Oth, Aaron Isaacs, Monika Stoll, Joris Vanderlocht, Esther Lutgens, Mat J. A. P. Daemen, Martin Zenke, Erik A. L. Biessen
Summary: Hyperlipidemia significantly affects the activation and immune response of pDCs, particularly in response to pathogen-derived signals.
Article
Immunology
Maarten K. Nijen Twilhaar, Lucas Czentner, Rianne G. Bouma, Katarzyna Olesek, Joanna Grabowska, Aru Zeling Wang, Alsya J. Affandi, Saskia C. Belt, Hakan Kalay, Cornelus F. van Nostrum, Yvette van Kooyk, Gert Storm, Joke M. M. den Haan
Summary: TLR-containing GM3 liposomes are effective vectors to induce DC maturation and T cell priming. Incorporation of PGPC or MDP does not enhance immune responses. These findings provide guidance for the optimal selection of liposomal components to stimulate anti-cancer immune responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Spencer E. E. Brightman, Angelica Becker, Rukman R. R. Thota, Martin S. S. Naradikian, Leila Chihab, Karla Soria Zavala, Ryan Q. Q. Griswold, Joseph S. S. Dolina, Ezra E. W. Cohen, Aaron M. M. Miller, Bjoern Peters, Stephen P. P. Schoenberger
Summary: CD4(+) T cells have important roles in immune responses, either directly or through accessory cells such as CD8(+) T lymphocytes. While the role of NeoAg-specific CD8(+) T cells in cancer has been extensively studied, the role of NeoAg-specific CD4(+) T cells is less well understood.
Article
Multidisciplinary Sciences
Akimichi Inaba, Zewen Kelvin Tuong, Tian X. X. Zhao, Andrew P. P. Stewart, Rebeccah Mathews, Lucy Truman, Rouchelle Sriranjan, Jane Kennet, Kourosh Saeb-Parsy, Linda Wicker, Frank Waldron-Lynch, Joseph Cheriyan, John A. A. Todd, Ziad Mallat, Menna R. R. Clatworthy
Summary: Activation of B cells expressing CD25 can be enhanced by low-dose recombinant IL-2, leading to increased secretion of IL-10. Administration of low dose IL-2 to patients results in an increase in IL-10-producing B cells. Single-cell RNA sequencing reveals enrichment of regulatory B cell gene signature in plasma cell populations from IL-2-treated patients, with significant down-regulation of the transcriptional repressor BACH2. BACH2 suppression leads to increased B cell IL-10, suggesting its role in promoting an immunoregulatory phenotype in B cells through IL-2 modulation.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Truc Thi Huong Dinh, Phawida Tummamunkong, Panuwat Padungros, Pranpariya Ponpakdee, Lawan Boonprakong, Wilasinee Saisorn, Asada Leelahavanichkul, Patipark Kueanjinda, Patcharee Ritprajak
Summary: Host-Candida interaction has been studied, focusing on non-albicans Candida species like C. krusei. The study investigated the impact of beta-glucans from different Candida species on DC responses. C. krusei beta-glucan stimulated BMDCs to produce IL-10, impacting T cell responses. Dectin-1 ligation played a role in the interactions between DCs and cell wall beta-glucans, leading to distinct DC responses.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Alanna Kelly, John Leech, Sarah Doyle, Rachel McLoughlin
Summary: Our study reveals that Staphylococcus aureus manipulates the host immune response in the nasal cavity by promoting immunosuppression, allowing for bacterial survival. Regulatory cytokines IL-10 and IL-27 play a central role in this suppressive response, resulting in reduced protective T cell responses. Furthermore, S. aureus induces IL-27 production to enhance IL-10 production and prolong bacterial colonisation, showcasing a complex host-pathogen interaction during nasal colonisation.
Article
Immunology
Nu Z. N. Nguyen, Vuvi G. Tran, Jiyeon Baek, Younghee Kim, Eun H. Youn, Seung W. Na, Sang J. Park, Su-Kil Seo, Byungsuk Kwon
Summary: Invasive candidiasis has high mortality rates in immunocompromised patients. IL-33 regulates innate immune response to Candida albicans infection in vivo, initiating a defense mechanism by stimulating IL-23 production in dendritic cells and GM-CSF secretion by NK cells.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Parasitology
Maria Eugenia Ancarola, Antonio Marcilla, Michaela Herz, Natalia Macchiaroli, Matias Perez, Sebastian Asurmendi, Klaus Brehm, Carolina Poncini, Mara Rosenzvit, Marcela Cucher
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2017)
Letter
Immunology
Silvia A. Repetto, Paula Ruybal, Estela Batalla, Carlota Lopez, Vanesa Fridman, Mariela Sierra, Marcelo Radisic, Pablo M. Bravo, Marikena G. Risso, Stella M. Gonzalez Cappa, Catalina D. Alba Soto
CLINICAL INFECTIOUS DISEASES
(2018)
Article
Immunology
Silvia A. Repetto, Paula Ruybal, Estela Batalla, Carlota Lopez, Vanesa Fridman, Mariela Sierra, Marcelo Radisic, Pablo M. Bravo, Marikena G. Risso, Stella M. Gonzalez Cappa, Catalina D. Alba Soto
CLINICAL INFECTIOUS DISEASES
(2018)
Article
Infectious Diseases
Lucas D. Caeiro, Catalina D. Alba-Soto, Mariana Rizzi, Maria Elisa Solana, Giselle Rodriguez, Agustina M. Chidichimo, Matias E. Rodriguez, Daniel O. Sanchez, Gabriela V. Levy, Valeria Tekiel
PLOS NEGLECTED TROPICAL DISEASES
(2018)
Article
Immunology
Lucas N. Alberca, Maria L. Sbaraglini, Juan F. Morales, Roque Dietrich, Maria D. Ruiz, Agustina M. Pino Martinez, Cristian G. Miranda, Laura Fraccaroli, Catalina D. Alba Soto, Carolina Carrillo, Pablo H. Palestro, Alan Talevi
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2018)
Article
Immunology
Camila Ledo, Cintia D. Gonzalez, Carolina V. Poncini, Marta Mollerach, Marisa I. Gomez
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2018)
Article
Cell Biology
Agustina M. Pino-Martinez, Cristian G. Miranda, Estela I. Batalla, Stella M. Gonzalez-Cappa, Catalina D. Alba Soto
JOURNAL OF LEUKOCYTE BIOLOGY
(2019)
Article
Immunology
Agata C. Cevey, Federico N. Penas, Catalina D. Alba Soto, Gerardo A. Mirkin, Nora B. Goren
FRONTIERS IN IMMUNOLOGY
(2019)
Editorial Material
Microbiology
Catalina Alba Soto
REVISTA ARGENTINA DE MICROBIOLOGIA
(2019)
Article
Chemistry, Medicinal
Maria L. Sbaraglini, Carolina L. Bellera, Juan Quarroz Braghini, Yesica Areco, Cristian Miranda, Carolina Carrillo, Jazmin Kelly, Bruno Buchholz, Ricardo J. Gelpi, Alan Talevi, Catalina D. Alba Soto
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Medicine, Research & Experimental
Gonzalo Ezequiel Pineda, Barbara Rearte, Maria Florencia Todero, Andrea Cecilia Bruballa, Alan Mauro Bernal, Romina Jimena Fernandez-Brando, Martin Amadeo Isturiz, Elsa Zotta, Catalina Dirney Alba-Soto, Marina Sandra Palermo, Maria Victoria Ramos
Summary: The absence of IL-10 has a protective role in an experimental model of HUS by reducing PMN recruitment into the kidney and renal damage, as well as increasing mice survival.
Article
Immunology
Jessica Rodriguez-Duran, Juan Pablo Gallardo, Catalina Dirney Alba Soto, Karina Andrea Gomez, Mariana Potenza
Summary: This study investigates the role of a hypothetical calcium-binding protein named TcCAL1 in the in vitro life cycle of the pathogen Typanosoma cruzi. The results suggest that TcCAL1 plays a significant role in the differentiation of parasites and their invasion of mammalian cells. This research highlights the importance of studying kinetoplastid-specific proteins with unknown functions in pathogen parasites.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Alicia Grijalva, Lucia Gallo Vaulet, Roberto Nicolas Aguero, Analia Toledano, Marikena Guadalupe Risso, Juan Quarroz Braghini, David Sosa, Paula Ruybal, Silvia Repetto, Catalina Dirney Alba Soto
Summary: This study explored the association between IL-10 gene polymorphisms and CCC through a case-control study and meta-analysis. The results showed that the TT genotype of -819 rs1800871 was associated with an increased risk of CCC, suggesting its potential as a predictive biomarker for disease progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Manuel A. A. Llanos, Lucas N. N. Alberca, Maria D. Ruiz, Maria L. Sbaraglini, Cristian Miranda, Agustina Pino-Martinez, Laura Fraccaroli, Carolina Carrillo, Catalina D. D. Alba Soto, Luciana Gavernet, Alan Talevi
Summary: In this study, a set of classifiers capable of identifying polyamine analogs with anti-trypanosomal activity was developed, along with a multi-template homology model of the polyamine transporter. These models were used in a virtual screening campaign to discover anti-trypanosomal compounds, and the selected drugs were confirmed to inhibit the growth and viability of the parasite.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
(2023)
Article
Immunology
Carolina V. Poncini, Stella M. Gonzalez-Cappa
EUROPEAN JOURNAL OF IMMUNOLOGY
(2017)