Article
Radiology, Nuclear Medicine & Medical Imaging
Ivica J. Bratanovic, Chengcheng Zhang, Zhengxing Zhang, Hsiou-Ting Kuo, Nadine Colpo, Jutta Zeisler, Helen Merkens, Carlos Uribe, Kuo-Shyan Lin, Francois Benard
Summary: ProBOMB2, a bombesin derivative radiolabeled with Ga-68 and Lu-177, showed excellent tumor uptake in a preclinical model of human prostate cancer. Ga-68-ProBOMB2 and Lu-177-ProBOMB2 are promising radiotracers with limited pancreas uptake, good tumor uptake, and favorable pharmacokinetics for imaging and therapy of GRPR-expressing tumors.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Heesu Ahn, Ji-Hee Kim, Kyo Chul Lee, Ji-Ae Park, Jung Young Kim, Yoon-jin Lee, Yong Jin Lee
Summary: Early diagnosis of radiation-induced pulmonary fibrosis (RIPF) is important in lung cancer patients after radiation therapy. Our group synthesized a GRPR-targeted PET imaging probe, [Cu-64]Cu-NODAGA-galacto-BBN, and found that it can accurately predict and monitor the therapeutic efficacy of RIPF.
MOLECULAR PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Ibolya Kalman-Szabo, Judit P. Szabo, Viktoria Arato, Noemi Denes, Gabor Opposits, Istvan Joszai, Istvan Kertesz, Zita Kepes, Aniko Fekete, Dezso Szikra, Istvan Hajdu, Gyorgy Trencsenyi
Summary: This study investigated the GRPR specificity of the newly synthesized [Sc-44]Sc-NODAGA-AMBA and its potential as a valuable radiotracer in the imaging of GRPR-positive PCa through in vitro and in vivo experiments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Wen Liang Lu, Houfang Kuang, Jianyou Gu, Xiaojun Hu, Bo Chen, Yingfang Fan
Summary: The study aims to develop a fluorescent probe for intraoperative imaging of perineural invasion (PNI) in pancreatic cancer, to assist in precise tumor excision. The probe specifically targets GAP-43-positive neural cells in an in vitro PNI model. Small animal imaging systems and surgical navigation systems can remove the tumor with R0 precision.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jacopo Gomena, Balazs Vari, Rita Olah-Szabo, Beata Biri-Kovacs, Szilvia Bosze, Adina Borbely, Adam Soos, Ivan Randelovic, Jozsef Tovari, Gabor Mezo
Summary: Targeted tumour therapy using gastrin-releasing peptide receptor (GRP-R) has shown promise for cancer imaging, diagnosing, and treatment. We developed peptide-drug conjugates (PDCs) containing the cytotoxic drug daunorubicin, which selectively delivered the drug to prostate and breast cancer cells with high stability and efficacy. Our PDCs displayed significant anti-proliferative activity, efficient uptake by multiple cancer cell lines, and a safe profile with consistent reduction of tumour volume in vivo. These findings highlight the importance of GRP-R binding PDCs for targeted cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Moritz-Valentin Schreck, Caroline Burgard, Alexander Schmidtke, Ina Hierlmeier, Tobias Stemler, Stephan Maus, Florian Rosar, Martin Jung, Andreas Speicher, Samer Ezziddin, Jason P. Holland, Mark D. Bartholomae
Summary: The study developed a novel GRPr antagonistic probe using a metal chelator that forms positively charged metal complexes. The results showed that the metal-labeled conjugate had high affinity similar to a potent antagonist. Small-animal PET imaging demonstrated high radioactivity accumulation in GRPr-expressing tumors and pancreas. The probe successfully visualized an estrogen receptor-positive tumor in a breast cancer patient.
MOLECULAR PHARMACEUTICS
(2023)
Review
Oncology
Rosalba Mansi, Berthold A. Nock, Simone U. Dalm, Martijn B. Busstra, Wytske M. van Weerden, Theodosia Maina
Summary: Recent medical advancements have focused on personalized medicine, with nuclear medicine methodologies playing an important role. Using smart peptide carriers, such as analogs of the amphibian 14-peptide bombesin (BBN), clinically attractive radionuclides can be delivered to malignant lesions to minimize damage to healthy tissues.
Article
Chemistry, Analytical
Liqiang Yan, Cuiping Zhou, Hong Yang
Summary: The analysis of Tricarbonylchloro(glycinato)ruthenium (CORM-3) is of great significance due to its anti-inflammatory and heart-protecting properties in clinical diseases and its role in studying the metabolic mechanism of endogenous carbon monoxide. A small molecule fluorescent probe was developed to detect CORM-3, which showed enhanced near-infrared fluorescence and a large Stokes shift. The probe achieved a detection limit of 0.11 mu M and a linear range of 0 - 175 mu M, and was successfully used for high-resolution fluorescence imaging in living cells and Zebrafish.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Review
Endocrinology & Metabolism
Terry W. Moody, Lingaku Lee, Irene Ramos-Alvarez, Tatiana Iordanskaia, Samuel A. Mantey, Robert T. Jensen
Summary: GPCRs are potential therapeutic targets in cancer treatment, especially in CNS/neural tumors. The activation of GPCRs on tumors can stimulate growth effects, making them promising targets for targeted therapy. More effective treatments are needed for CNS/neural tumors like gliomas, neuroblastomas, and medulloblastomas.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Chemistry, Medicinal
Truc T. Huynh, Ellen M. van Dam, Sreeja Sreekumar, Cedric Mpoy, Benjamin J. Blyth, Fenella Muntz, Matthew J. Harris, Buck E. Rogers
Summary: This study investigated the therapeutic efficacy of a copper-based therapeutic agent [Cu-67]Cu-SAR-BBN in a pre-clinical mouse model. The results demonstrated significant tumor growth inhibition and increased median survival in the treatment group.
Article
Biochemistry & Molecular Biology
Ying Chen, Il Minn, Steven P. Rowe, Alla Lisok, Samit Chatterjee, Mary Brummet, Sangeeta Ray Banerjee, Ronnie C. Mease, Martin G. Pomper
Summary: We have synthesized a series of near-infrared imaging agents targeting PSMA for use in fluorescence-guided surgery. The compounds were designed to improve pharmacokinetics by altering the linker between the PSMA-targeting urea moiety and the fluorophore. These compounds show potential for FGS in prostate, renal or other PSMA-expressing cancers.
Article
Multidisciplinary Sciences
Jingbo Qiao, Junquan Liu, Jillian C. Jacobson, Rachael A. Clark, Sora Lee, Li Liu, Zhiqiang An, Ningyan Zhang, Dai H. Chung
Summary: Gastrin-releasing peptide receptor (GRP-R) monoclonal antibody (mAb-1) demonstrated effective anti-tumor effects on neuroblastoma cells and may serve as a novel immunotherapy for high-risk neuroblastoma patients.
Article
Multidisciplinary Sciences
Keiko Takanami, Daisuke Uta, Ken Ichi Matsuda, Mitsuhiro Kawata, Earl Carstens, Tatsuya Sakamoto, Hirotaka Sakamoto
Summary: Estrogens selectively enhance histamine-evoked itch in females by affecting the spinal GRP/GRPR system. Estradiol does not affect pain sensitivity but decreases touch sensitivity in female rats.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Physical
Xiaoqiong Huang, Lei Xu, Xiaoran Yu, Yiming Li, Ziqing Huang, Ruogu Xu, Wenyi Zeng, Zhengchuan Zhang, Weichang Li, Feilong Deng
Summary: Treatment for chronic diabetic wounds remains a clinical challenge. A multifunctional hydrogel with two-stage sequential release upon NIR stimulation, antibacterial activity and pro-angiogenic efficacy has been developed. This hydrogel consists of covalently crosslinked bilayer structure with peptide-functionalized gold nanorods embedded in each layer.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Medicinal
Edyta Proniewicz, Grzegorz Burnat, Helena Domin, Izabela Maluch, Marta Makowska, Adam Prahl
Summary: The article discusses the application of alanine-scanning technique combined with various spectroscopic methods to study the role of individual amino acid residues in the adsorption process of a peptide fragment on metal nanoparticles. By analyzing spectral profiles and conducting bioactivity studies, conclusions were drawn on the specific interactions between peptides and metal nanoparticles as well as peptide-G protein-coupled receptors (GPCRs).
JOURNAL OF MEDICINAL CHEMISTRY
(2021)