Article
Biophysics
Jinya Du, Shuangshuang Yang, Yuchun Qiao, Huiting Lu, Haifeng Dong
Summary: The emergence of photoacoustic imaging (PAI) has greatly expanded the application of biomolecules bioimaging, especially in near-infrared (NIR) PAI which shows great potential in biomedical applications. Comparing different imaging modalities and focusing on the strategies used to improve contrast and performance in NIR-PAI are essential for enhancing imaging accuracy. Challenges and prospects in accelerating the development of PAI are identified to attract more researchers in this field.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biochemical Research Methods
Feng Li, Zihua Zeng, Dale Hamilton, Youli Zu, Zheng Li
Summary: The aptamer radiotracer demonstrates specific binding to tumor cells and can be used for tumor-specific PET imaging by chelating a Cu-64 isotope and DOTA-PEGylated aptamer sequence to target EpCAM. In vivo studies in xenograft mice showed rapid and specific tumor uptake of the aptamer radiotracer, highlighting its potential for accurate tumor staging and therapy evaluation.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Zhuoran Ma, Feifei Wang, Weizhi Wang, Yeteng Zhong, Hongjie Dai
Summary: This study utilized artificial neural networks to transform fluorescence images in the shorter-wavelength NIR window to images resembling NIR-IIb window, achieving high signal-to-background ratio in vivo lymph node imaging with human-approved molecular probes. Translation of PD-L1 or EGFR imaging greatly enhanced tumor-to-normal tissue ratio and improved tumor margin localization, showcasing the potential of deep learning in enhancing noninvasive NIR imaging and microscopy. Deep learning equipped NIR imaging could facilitate basic biomedical research and clinical diagnostics and imaging-guided surgery.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Multidisciplinary
Jiangao Li, Hanlin Ou, Jing Li, Xiaodi Yang, Congwu Ge, Dan Ding, Xike Gao
Summary: A facile molecular design strategy based on large pi-extended donor-acceptor (L-pi-D-A) structure is reported for achieving semiconducting polymers (SPs) with highly efficient in vitro and in vivo photoacoustic imaging (PAI) and photothermal therapy (PTT) capabilities.
SCIENCE CHINA-CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Julia Ackermann, Jan Stegemann, Tim Smola, Eline Reger, Sebastian Jung, Anne Schmitz, Svenja Herbertz, Luise Erpenbeck, Karsten Seidl, Sebastian Kruss
Summary: Optical nanosensors based on single-wall carbon nanotubes are able to capture the dynamics of biochemical processes. A one-step phase separation approach has been developed to isolate monochiral (6,4)-SWCNTs from mixed SWCNT samples, enabling high-resolution imaging in the near-infrared spectrum using standard Si-based cameras. (6,4)-SWCNTs modified with (GT)(10)-ssDNA become highly sensitive to the neurotransmitter dopamine, allowing for fast and high-resolution imaging of dopamine release from cells.
Article
Engineering, Civil
Ewa M. Nowara, Tim K. Marks, Hassan Mansour, Ashok Veeraraghavan
Summary: Imaging photoplethysmography (iPPG) has the potential to enhance driver safety systems by detecting driver fatigue and early heart failure in a non-invasive manner. However, iPPG faces challenges in the driving context due to illumination and motion. This paper proposes two innovations to overcome these challenges: using narrow-band near-infrared video recordings to reduce illumination variations, and introducing a novel optimization algorithm called AutoSparsePPG that improves performance compared to existing methods.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2022)
Review
Engineering, Environmental
Lu Li, Xue Han, Mingfeng Wang, Chenglong Li, Tao Jia, Xiuhua Zhao
Summary: NIR absorbing organic photothermal agents have low cytotoxicity and are promising candidates for clinical application in deep-tissue cancer treatment. Imaging-guided PTT and combination therapy methods have shown to be optimizable and have potential for development amidst current challenges.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biochemical Research Methods
Mebin B. George, Benjamin Lew, Steven Blair, Zhongmin Zhu, Zuodong Liang, Indrajit Srivastava, Austin Chang, Hyungsoo Choi, Kyekyoon Kim, Shuming Nie, Sunil Singhal, Viktor Gruev
Summary: We developed a bioinspired endoscopic system that can image multiple tumor-targeted probes, quantify volumetric ratios, and detect tumors. Our optimized endoscope achieves a 60% improvement in NIR spatial resolution compared to a leading FDA-approved endoscope. The system can help assess multiple tumor-targeted probe concepts during surgical procedures.
JOURNAL OF BIOMEDICAL OPTICS
(2023)
Article
Chemistry, Multidisciplinary
Sai S. Sunku, Dorri Halbertal, Rebecca Engelke, Hyobin Yoo, Nathan R. Finney, Nicola Curreli, Guangxin Ni, Cheng Tan, Alexander S. McLeod, Chiu Fan Bowen Lo, Cory R. Dean, James C. Hone, Philip Kim, D. N. Basov
Summary: Graphene-based heterostructures present a variety of phenomena tunable by electrostatic local gates. While monolayer graphene exhibits tunable surface plasmon polaritons, bilayer graphene may display unique plasmonic effects such as plasmon amplification and domain wall plasmons. These effects are highly sensitive to displacement fields and have potential applications in nano-optics.
Article
Acoustics
Zhen Jiang, Yuanmeng Ding, Jonathan F. Lovell, Yumiao Zhang
Summary: This review summarizes NIR-II organic contrast agents reported in the past decade for photoacoustic and fluorescence imaging, and discusses the rational design of NIR-II fluorophores to improve imaging contrast and resolution. A wide variety of applications using NIR-II dyes have been realized, including imaging of tumors, lymphatics, brains, intestines, and others. Targeted imaging and activable imaging with improved resolution and sensitivity have been demonstrated by innovative chemical modification of NIR-II dyes.
Article
Chemistry, Analytical
Zhao Wang, Weiwei Wang, Pengzhan Wang, Xinjian Song, Zhiqiang Mao, Zhihong Liu
Summary: The article presents a highly sensitive NIR fluorescence probe DDAO-PN for in vivo detection of ONOO- in inflammation. The probe demonstrates rapid response and high sensitivity in detecting ONOO-, which has the potential to advance research on inflammation-related diseases.
ANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Hangqi Luo, Shuai Gao
Summary: Phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), is widely used for cancer treatment, but conventional PTT/PDT lack disease recognition ability, resulting in limited therapeutic effects. Integrating fluorescence imaging with PTT/PDT can reveal tumor locations in real-time, enabling early diagnosis and precision treatment. The use of NIR-II fluorescence imaging with PTT/PDT can significantly improve tumor theranostics accuracy and minimize damage to normal tissues.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Gwanho Yoon, Kwan Kim, Se-Um Kim, Seunghoon Han, Heon Lee, Junsuk Rho
Summary: Printable metalenses made of a silicon nanocomposite offer high refractive index and thermal stability, suitable for intricate nanofabrication and rapid large-scale manufacturing. By optimizing the composition of the nanocomposite, the focusing efficiency of the metalenses can be further increased.
Review
Chemistry, Inorganic & Nuclear
Caiping Ding, Tianbing Ren
Summary: Near infrared (NIR) fluorescent probes have advantageous features including low background interference, strong tissue penetration, and minimal tissue damage. This paper provides a summary and discussion on the various types and properties of fluorophores used in the design of NIR fluorescent probes. It also discusses the latest research achievements in detecting and imaging reactive oxygen species, reactive nitrogen, and active sulfur in cells or in vivo. Additionally, a concise overview of the future development of NIR molecular fluorescence probes is proposed based on existing research, offering a reference for current research directions.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Medicine, General & Internal
Hirotoshi Yasui, Yuko Nishinaga, Shunichi Taki, Kazuomi Takahashi, Yoshitaka Isobe, Misae Shimizu, Chiaki Koike, Tetsuro Taki, Aya Sakamoto, Keiko Katsumi, Keisuke Ishii, Kazuhide Sato
Summary: The research shows that NIR-PIT targeting GPR87 has potential therapeutic effects in treating thoracic cancers, offering a new treatment option.
Review
Pharmacology & Pharmacy
M. J. Fowler, J. D. Cotter, B. E. Knight, E. M. Sevick-Muraca, D. I. Sandberg, R. W. Sirianni
ADVANCED DRUG DELIVERY REVIEWS
(2020)
Article
Computer Science, Interdisciplinary Applications
Banghe Zhu, Sunkuk Kwon, John C. Rasmussen, Maritoni Litorja, Eva M. Sevick-Muraca
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2020)
Article
Surgery
John C. Rasmussen, Banghe Zhu, John R. Morrow, Melissa B. Aldrich, Aaron Sahihi, Stuart A. Harlin, Caroline E. Fife, Thomas F. O'Donnell, Eva M. Sevick-Muraca
Summary: Near-infrared fluorescence lymphatic imaging showed that lymphatic anatomy and contractile function deteriorate with the severity of venous insufficiency in comparison to normal health subjects. Lymphatic abnormalities in venous insufficiency resemble those in early cancer-acquired lymphedema.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2021)
Review
Oncology
Melissa B. Aldrich, John C. Rasmussen, Caroline E. Fife, Simona F. Shaitelman, Eva M. Sevick-Muraca
Article
Immunology
Alexandre E. Malek, Caroline E. Fife, John C. Rasmussen, Ron J. Karni, John R. Morrow, Audrey Wanger, Eva M. Sevick-Muraca, Luis Ostrosky-Zeichner
Summary: Cutaneous tuberculosis caused by skin inoculation of Mycobacterium tuberculosis is rare but can occur in healthcare settings. This case report describes an unusual case of primary cutaneous tuberculosis of the thumb following a needlestick injury, with progression to necrotic granuloma, lymphatic dysfunction, and axillary web syndrome.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Meeting Abstract
Oncology
Melissa B. Aldrich, Meghan E. McWain, Wenyaw Chan, John C. Rasmussen, Sarah DeSnyder, Eva M. Sevick-Muraca, Simona F. Shaitelman
Meeting Abstract
Oncology
Wintana Balema, Janelle Morton, Richard Larson, Fred C. Velasquez, Eva Sevick-Muraca, Wendy A. Woodward
Meeting Abstract
Oncology
Anna R. Vang, Simona F. Shaitelman, Eva M. Sevick-Muraca, Chan Wen-yaw, John C. Rasmussen, Sarah D. DeSnyder, Melissa B. Aldrich
Editorial Material
Nanoscience & Nanotechnology
Eva M. Sevick-Muraca
NATURE NANOTECHNOLOGY
(2022)
Article
Oncology
Carolina Mantilla-Rojas, Fred C. Velasquez, Janelle E. Morton, Leticia C. Clemente, Edwin R. Parra, Carlos Torres-Cabala, Eva M. Sevick-Muraca
Summary: This study demonstrates that combining vaccination and checkpoint blockade immunotherapy delivered through the lymphatics can improve anti-tumor responses in non-immunogenic melanoma models. This method may potentially benefit more patients by directing immune responses within the regional lymph node environment.
Article
Oncology
Melissa B. Aldrich, John C. Rasmussen, Sarah M. DeSnyder, Wendy A. Woodward, Wenyaw Chan, Eva M. Sevick-Muraca, Elizabeth A. Mittendorf, Benjamin D. Smith, Michael C. Stauder, Eric A. Strom, George H. Perkins, Karen E. Hoffman, Melissa P. Mitchell, Carlos H. Barcenas, Lynn E. Isales, Simona F. Shaitelman
Summary: This study investigated the use of near-infrared fluorescence lymphatic imaging (NIRF-LI) surveillance to predict early onset of peripheral lymphatic dysfunction as a predictor of breast cancer-related lymphedema (BCRL). The results showed that dermal backflow can predict the development of BCRL months before arm swelling occurs, enabling early treatment to prevent edema and irreversible tissue changes.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Anna R. Vang, Simona F. Shaitelman, John C. Rasmussen, Wenyaw Chan, Eva M. Sevick-Muraca, Melissa B. Aldrich
Summary: Breast cancer-related lymphedema (BCRL) occurs in approximately 40% of patients after axillary lymph node dissection (ALND), radiation therapy (RT), or chemotherapy. First-line palliative treatment involves the use of compression garments and specialized massage. Reparative microsurgeries are a second-line treatment, but both compression and surgical therapy are most effective in the early stages of LE development. Identifying patients at the highest risk for BCRL would allow for earlier and more effective treatment.
Article
Computer Science, Interdisciplinary Applications
Banghe Zhu, Eva M. Sevick-Muraca, Ryan D. Nguyen, Manish N. Shah
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2020)
Article
Medicine, Research & Experimental
Kay T. Pham, Duraisamy Balaguru, Varaha S. Tammisetti, Carlos J. Guevara, John C. Rasmussen, Rodrick C. Zvavanjanja, Robert Hanfland, Eva M. Sevick-Muraca, Melissa B. Aldrich
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2020)
Article
Physiology
John C. Rasmussen, Sunkuk Kwon, Amanda Pinal, Alexander Bareis, Fred C. Velasquez, Christopher F. Janssen, John R. Morrow, Caroline E. Fife, Ron J. Karni, Eva M. Sevick-Muraca
PHYSIOLOGICAL REPORTS
(2020)