Article
Chemistry, Medicinal
Marzena Wyskocka-Gajda, Lukasz Przypis, Monika Olesiejuk, Tomasz Krawczyk, Anna Kuznik, Krzysztof Nawara, Masafumi Minoshima, Fuminori Sugihara, Kazuya Kikuchi, Nikodem Kuznik
Summary: Investigation into iron(III) chelates with N,O-aminophenol showed high versatility and tuning potential, with functionalization with galactose providing a bioresponsive character sensitive to enzyme activity. The resulting complexes exhibited extremely high relaxivity and could change relaxivity by over 80% through enzymatic hydrolysis. MRI and cytotoxicity studies confirmed the bioresponsive character and good biocompatibility of these iron-based chelates.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Bo Song, Xinyue Zhang, Xinyi Wen, Qi Liu, Hua Ma, Weihua Guo, Mingqian Tan, Lei Jia, Jingli Yuan
Summary: The study developed a novel bioconjugate, Tf-Eu-Gd, with intense long-lived luminescence, high MR relaxivity, and good biocompatibility. As a probe, Tf-Eu-Gd can specifically accumulate in cancer cells overexpressing Tf receptors for TGL and MR imaging of tumors.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Physical
Hao Zhang, Zhijia Lv, Dongzhi Xue, Tianqi Zhang, Longhai Jin, Yue Cao, Shuai Zhang, Yinghui Wang, Hongjie Zhang
Summary: A TME-responsive theranostic nanoagent was fabricated using a layer-by-layer synthesis method, which can achieve enhanced chemotherapy within tumor cells without collateral damage to normal tissues. The nanoagent efficiently kills tumor cells in both in vitro and in vivo experiments.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Xiaoqing Wei, Dan Mu, Yingping Li, Jingya Zhao, Shaobing Zhou
Summary: Researchers have developed a magnetic exosome that responds to bacteria associated with tumors, enabling sensitive tumor imaging. The magnetic exosome can rapidly respond in the tumor microenvironment and release iron oxide nanoparticles for dynamic MRI of tumors. After MRI, the iron oxide nanoparticles can be eliminated through renal clearance to avoid potential toxicity.
Article
Nanoscience & Nanotechnology
Vidumin Dahanayake, Trevor Lyons, Brendan Kerwin, Olga Rodriguez, Christopher Albanese, Erika Parasido, Yichien Lee, Edward Van Keuren, Luxi Li, Evan Maxey, Tatjana Paunesku, Gayle Woloschak, Sarah L. Stoll
Summary: The study focused on enhancing the relaxivity of a manganese and iron-oxo cluster grafted within porous polystyrene nanobeads with increased surface area. The synthesis of the cluster-nanocarrier under miniemulsion conditions resulted in porous nanobeads approximately 70 nm in diameter, leading to higher relaxivity. The stability assessment and synchrotron X-ray fluorescence microscopy showed promising results for in vivo applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Applied
Hamed Nosrati, Marziyeh Salehiabar, Faezeh Mozafari, Jalil Charmi, Nuri Erdogan, Mohammadreza Ghaffarlou, Fatemeh Abhari, Hossein Danafar, Ali Ramazani, Yavuz Nuri Ertas
Summary: Early diagnosis and treatment of cancer is crucial, and theranostic systems play a significant role in this aspect. In this study, bi-functional nanoparticles were developed as dual MRI/CT contrast agent and carrier of natural anticancer drug. These nanoparticles showed good performance in both MRI and CT imaging contrast, while also demonstrating high biocompatibility and anticancer activity.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chi-Feng Chiang, Yuan-Hung Hsu, Wen-Yuan Hsieh, Tzu-Hsin Liao, Chih-Lung Chen, Yung-Chu Chen, Po-Chin Liang, Shian-Jy Wang
Summary: This study evaluated the safety and clinical validity of IOP Injection as an MRI contrast agent in diagnosing hepatocellular carcinoma (HCC). It was found that IOP-enhanced MRI had a sensitivity of 100% for detecting HCC, and it could also visualize subtle vascular invasion.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Nanoscience & Nanotechnology
Li-Hua Deng, Hai Jiang, Fu-Lin Lu, Han-Wei Wang, Yu Pu, Chang-Qiang Wu, Hong-Jie Tang, Ye Xu, Tian-Wu Chen, Jiang Zhu, Cheng-Yi Shen, Xiao-Ming Zhang
Summary: By using PEGylated SPIO nanoparticles as MRI contrast agents, different nanocrystal sizes and PEG coatings can be utilized to achieve T-1, T-2, or T-1-T-2 dual-mode imaging at different magnetic field intensities.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Mike Jeon, Mackenzie Halbert, Zachary R. Stephen, Miqin Zhang
Summary: Gadolinium-based chelates are commonly used contrast agents for MRI, but their toxicity and potential retention in patients' bodies have raised safety concerns. Iron oxide nanoparticles have emerged as a promising alternative due to their non-toxic and biodegradable nature, but their development as T-1 contrast agents is complex and challenging. Progress is being made in exploring IONPs as safe and improved alternatives, but there are still many hurdles to overcome before they can be used clinically.
ADVANCED MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Yaning Zhao, Congcong Cui, Jiahui Zhan, Guangshan Xuan
Summary: The study successfully prepared folate-chitosan/chitosan-diethylenetriaminepentaacetic acid-gadolinium nanoparticles, which exhibited good magnetic properties and specific targeting effect towards folate-overexpressing tumor cells.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Nanoscience & Nanotechnology
Yongjie Xiong, Yi Qu, Zhe Min, Jun Wu, Suming Zhang, Zheng Xue
Summary: This study developed a novel MRI contrast agent by coupling ultrasmall superparamagnetic iron oxide nanoparticles with a functional protein. The contrast agent successfully penetrated biological membranes and bound to Aβ deposits, allowing for the visualization of Aβ deposits in Alzheimer's disease animal models by MRI.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Xiaoming Wang, Shiwei Guo, Zhiqian Li, Qiang Luo, Yan Dai, Hu Zhang, Yun Ye, Qiyong Gong, Kui Luo
Summary: The concept of non-metallic MRI contrast agents has emerged to address the potential toxicity of metal-based contrast agents. Paramagnetic nitroxides are being studied for their stability and imaging mechanisms similar to metal-based agents, with the challenge of lower relaxivity and rapid in vivo metabolism. Macromolecular nitroxides contrast agents have been shown to increase stability and improve water relaxation, with the potential for expanding application in tumor, liver, kidney, and cardiovascular imaging.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Anna Koudrina, Erin M. McConnell, Joseph A. Zurakowski, Greg O. Cron, Suzan Chen, Eve C. Tsai, Maria C. DeRosa
Summary: The study successfully prepared a fibrin-targeting MRI contrast agent, Gd(III)-NOTA-FA, which can specifically accumulate at the location of blood clots, enhancing contrast capabilities.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Biomedical
Shuai Guo, Wei Xiong, Jiaoyang Zhu, Jie Feng, Ruilong Zhou, Qingdeng Fan, Qianqian Zhang, Zongheng Li, Jing Yang, Huimin Zhou, Peiwei Yi, Yanqiu Feng, Sugeun Yang, Xiaozhong Qiu, Yikai Xu, Zheyu Shen
Summary: In this study, a STING pathway-activatable contrast agent was developed for magnetic resonance imaging (MRI)-guided tumor immunoferroptosis synergistic therapy. The effectiveness and biosafety of this therapy were demonstrated by in vivo investigations, and the mechanisms of action were studied using various indicators.
Article
Chemistry, Multidisciplinary
Jianxian Ge, Cang Li, Ning Wang, Ruru Zhang, Mohammad Javad Afshari, Can Chen, Dandan Kou, Dandan Zhou, Ling Wen, Jianfeng Zeng, Mingyuan Gao
Summary: Polyethylene glycol (PEG) is commonly used to enhance the biocompatibility and blood circulation time of iron oxide nanoparticles (IONPs) as MRI contrast agents. However, the surface effect induced by PEGylation can impact the relaxometric properties of IONPs and subsequently affect imaging results. In this study, three diphosphonate PEGs with different molecular weights were used to replace the hydrophobic oleate ligands of IONPs, and the relationship between PEG chain length and relaxometric properties of IONPs was investigated.
Article
Oncology
Grazia Carbotti, Amin Reza Nikpoor, Paola Vacca, Rosaria Gangemi, Chiara Giordano, Francesco Campelli, Silvano Ferrini, Marina Fabbi
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2017)
Review
Cell Biology
Marina Fabbi, Grazia Carbotti, Silvano Ferrini
MEDIATORS OF INFLAMMATION
(2017)
Letter
Oncology
G. Barisione, M. Fabbi, G. Cutrona, L. De Cecco, S. Zupo, B. Leitinger, M. Gentile, M. Manzoni, A. Neri, F. Morabito, M. Ferrarini, S. Ferrini
BLOOD CANCER JOURNAL
(2017)
Article
Multidisciplinary Sciences
Cecilia Marini, Silvia Bruno, Francesco Fiz, Cristina Campi, Roberta Piva, Giovanna Cutrona, Serena Matis, Alberto Nieri, Maurizio Miglino, Adalberto Ibatici, Anna Maria Orengo, Anna Maria Massone, Carlo Emanuele Neumaier, Daniela de Totero, Paolo Giannoni, Matteo Bauckneht, Michele Pennone, Claudya Tenca, Elena Gugiatti, Alessandro Bellini, Anna Borra, Elisabetta Tedone, Hulya Efeturk, Francesca Rosa, Laura Emionite, Michele Cilli, Davide Bagnara, Valerio Brucato, Paolo Bruzzi, Michele Piana, Franco Fais, Gianmario Sambuceti
SCIENTIFIC REPORTS
(2017)
Article
Cell Biology
Giovanna Cutrona, Claudio Tripodo, Serena Matis, Anna Grazia Recchia, Carlotta Massucco, Marina Fabbi, Monica Colombo, Laura Emionite, Sabina Sangaletti, Alessandro Gulino, Daniele Reverberi, Rosanna Massara, Simona Boccardo, Daniela de Totero, Sandra Salvi, Michele Cilli, Mariavaleria Pellicano, Martina Manzoni, Sonia Fabris, Irma Airoldi, Francesca Valdora, Silvano Ferrini, Massimo Gentile, Ernesto Vigna, Sabrina Bossio, Laura De Stefano, Angela Palummo, Giovanni Iaquinta, Martina Cardillo, Simonetta Zupo, Giannamaria Cerruti, Adalberto Ibatici, Antonino Neri, Franco Fais, Manlio Ferrarini, Fortunato Morabito
SCIENCE TRANSLATIONAL MEDICINE
(2018)
Review
Biochemistry & Molecular Biology
Paolo Giannoni, Franco Fais, Giovanna Cutrona, Daniela de Totero
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Oncology
Grazia Carbotti, Andrea Petretto, Elisabeth Naschberger, Michael Stuerzl, Stefania Martini, Maria Cristina Mingari, Gilberto Filaci, Silvano Ferrini, Marina Fabbi
Article
Oncology
Adriana Amaro, Michela Croce, Silvano Ferrini, Gaia Barisione, Marina Gualco, Patrizia Perri, Ulrich Pfeffer, Martine J. Jager, Sarah E. Coupland, Carlo Mosci, Gilberto Filaci, Marina Fabbi, Paola Queirolo, Rosaria Gangemi
Article
Oncology
Beatrice Dozin, Grazia Carbotti, Silvio Roncella, Paola Ferro, Paolo Dessanti, Pier Aldo Canessa, Silvano Ferrini, Marina Fabbi
Summary: This study suggests that a high level of IFN-gamma in pleural effusion may be associated with better survival in malignant pleural mesothelioma patients and could potentially serve as a prognostic biomarker. Larger prospective studies are needed to confirm these findings.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Oncology
Grazia Carbotti, Beatrice Dozin, Stefania Martini, Chiara Giordano, Francesca Scordamaglia, Michela Croce, Gilberto Filaci, Silvano Ferrini, Marina Fabbi
Summary: Malignant mesothelioma (MM) is a rare and aggressive tumor associated with asbestos exposure and involves cytokines such as IL-6 and IL-27. Recent studies suggest that IL-27 may play a role in immune resistance mediated by PD-L1 in MM.
Article
Biochemistry & Molecular Biology
Paolo Giannoni, Marco Grosso, Giuseppina Fugazza, Mario Nizzari, Maria Cristina Capra, Rita Bianchi, Roberto Fiocca, Sandra Salvi, Fabrizio Montecucco, Maria Bertolotto, Franco Fais, Mario Salio, Emanuela Barisione, Daniela de Totero
Summary: Hypersensitivity pneumonitis (HP) is an interstitial lung disease caused by inhalation of various antigens, while fibrotic HP (fHP) may be associated with idiopathic pulmonary fibrosis and have a worse prognosis. A fibroblastic cell line derived from a patient with fHP was established and characterized, showing features similar to myofibroblasts, and could potentially serve as a tool to model the disease in vitro. Preliminary assessment of pirfenidone demonstrated consistent inhibition of cell growth.
Article
Medicine, General & Internal
Marina Fabbi, Delfina Costa, Daniela Russo, Laura Arenare, Gabriele Gaggero, Simona Signoriello, Giovanni Scambia, Carmela Pisano, Nicoletta Colombo, Nunzia Simona Losito, Gilberto Filaci, Anna Spina, Daniela Califano, Giosue Scognamiglio, Angiolo Gadducci, Delia Mezzanzanica, Marina Bagnoli, Silvano Ferrini, Vincenzo Canzonieri, Paolo Chiodini, Francesco Perrone, Sandro Pignata
Summary: By investigating the expression of ADAM17 in ovarian cancer tissues, this study aimed to identify prognostic factors for advanced ovarian cancer patients undergoing first-line therapy. The results showed that high expression of ADAM17 was associated with worse prognosis, especially in patients with no residual disease at baseline.
Article
Oncology
Paolo Giannoni, Cecilia Marini, Giovanna Cutrona, Katia Todoerti, Antonino Neri, Adalberto Ibatici, Gianmario Sambuceti, Simona Pigozzi, Marco Mora, Manlio Ferrarini, Franco Fais, Daniela de Totero
Summary: The expression of CD16 on circulating CLL monocytes is directly correlated with the extent of bone erosion in CLL patients. Treatment of healthy monocytes with CLL-conditioned medium upregulates the expression of CD16, RANK, and RANKL, with CD16 being the most significantly upregulated. Monocytes polarized toward the M2 phenotype show high CD16 expression and a propensity to differentiate into osteoclasts, providing a potential explanation for the increased levels of bone erosion in CLL patients.
Review
Medicine, Research & Experimental
P. Giannoni, G. Cutrona, D. de Totero
CURRENT MOLECULAR MEDICINE
(2017)