Review
Medicine, Research & Experimental
Hui-Hui Shen, Tao Zhang, Hui-Li Yang, Zhen-Zhen Lai, Wen-Jie Zhou, Jie Mei, Jia-Wei Shi, Rui Zhu, Feng-Yuan Xu, Jin Li, Jiang-Feng Ye, Ming-Qing Li
Summary: Menstruation is a cyclic physiological phenomenon controlled by ovarian hormones, and a proper understanding of normal endometrial physiology is crucial for regulating menstrual disorders. Autophagy in the endometrium, regulated by ovarian hormones, plays a key role in immune cell infiltration, tissue repair, and infection prevention during menstruation. Abnormal autophagy levels and dysregulated immune system function are associated with the pathogenesis and progression of endometriosis, suggesting the potential value of autophagy as a target for the treatment of menstrual-related and endometrium-related disorders.
Article
Medicine, General & Internal
Jane B. Maoga, Muhammad A. Riaz, Agnes N. Mwaura, Georgios Scheiner-Bobis, Ezekiel Mecha, Charles O. A. Omwandho, Ivo Meinhold-Heerlein, Lutz Konrad
Summary: Matrix metalloproteinases (MMPs) play an important role in menstruation and endometriosis. The expression of MT2-MMP and MT3-MMP proteins varies in different types of endometrial tissues.
Article
Medicine, General & Internal
Anna C. Loeffelmann, Alena Hoerscher, Muhammad A. Riaz, Felix Zeppernick, Ivo Meinhold-Heerlein, Lutz Konrad
Summary: In endometriosis, the localization of claudin-10 is impaired, but the epithelial phenotype remains preserved. Claudin-10 is highly expressed in endometriosis and adenomyosis, but there are differences in its localization between the two conditions.
Article
Multidisciplinary Sciences
V Jansa, T. Klancic, M. Pusic, M. Klein, E. Vrtacnik Bokal, H. Ban Frangez, T. Lanisnik Rizner
Summary: Endometriosis is a common gynecological disease that affects fertility and quality of life, with diagnosis currently relying on surgical laparoscopy. This study identified potential diagnostic biomarkers through proteomic analysis and developed a classification model for distinguishing between patients with and without endometriosis-related infertility. Further research is warranted to explore the pathophysiology and potential applications of these biomarkers in blood samples.
SCIENTIFIC REPORTS
(2021)
Article
Surgery
Tomohide Hori, Hideki Harada, Michihiro Yamamoto, Masahiro Yamada, Takefumi Yazawa, Ben Sasaki, Masaki Tani, Hikotaro Katsura, Asahi Sato, Yudai Sasaki, Hidekazu Yamamoto
Summary: Ectopic endometrium in the appendix is rare and can cause acute appendicitis. Symptoms may be related to periodic menstruation, but the sensitivity to hormones varies among patients. Treatment should be individualized, and surgical intervention may be necessary for recurrent symptoms.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2021)
Article
Obstetrics & Gynecology
N. L. Yuwono, A. Alonso, J. Abbott, S. Houshdaran, C. E. Henry, R. Rodgers, C. E. Ford, K. Warton
Summary: The study found that circulating cell-free DNA from the endometrium does not increase during menstruation and is not elevated in endometriosis. The research did not identify cirDNA as a potential diagnostic biomarker for endometriosis.
HUMAN REPRODUCTION
(2022)
Article
Biochemistry & Molecular Biology
Jane B. Maoga, Muhammad A. Riaz, Agnes N. Mwaura, Ezekiel Mecha, Charles O. A. Omwandho, Georgios Scheiner-Bobis, Ivo Meinhold-Heerlein, Lutz Konrad
Summary: This study found changes in MT1-MMP in patients with endometriosis and adenomyosis, suggesting that MT1-MMP is regulated differently in these two diseases.
Article
Agriculture, Dairy & Animal Science
Inkyu Yoo, Soohyung Lee, Yugyeong Cheon, Hakhyun Ka
Summary: This study investigated the expression, localization, and regulation of MMP2, MMP8, MMP9, MMP12, and MMP13 in the pig endometrium during the estrous cycle and pregnancy. The results showed that expression levels of these MMPs changed during different reproductive stages, suggesting their important role in endometrial remodeling and processing bioactive molecules in pigs.
Article
Orthopedics
Omid Sadatpour, Mohammad Taha Ebrahimi, Maryam Akhtari, Nooshin Ahmadzadeh, Mahdi Vojdanian, Ahmadreza Jamshidi, Elham Farhadi, Mahdi Mahmoudi
Summary: The study found that A(2A)AR activation cannot reduce MMP8 expression in patients' macrophages, while it can in healthy macrophages. The effect of A(2A)AR activation on BMP2 and MMP9 expression did not reach statistical significance in either healthy macrophages or the patients' group. Additionally, a significant positive correlation was discovered between MMP8 expression and patient scores on the BASFI.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Multidisciplinary Sciences
Rebeca Alvarino, Cristina Gil-Mouce, Manuel A. Botana, Sandra Gegunde, Jesus Gonzalez-Jartin, Mercedes R. Vieytes, Amparo Alfonso, Luis M. Botana
Summary: This study describes the changes in cyclophilin B concentrations across the menstrual cycle and reveals the association of luteinizing and follicle stimulating hormones with cyclophilin D. These findings suggest a role of these proteins in the cyclic inflammatory events that affect the female reproductive system.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Konstantin A. Toniyan, Elena Yu. Gorbacheva, Valery V. Boyarintsev, Irina V. Ogneva
Summary: Endometriosis of the cervix is a rare form of genital endometriosis, characterized by tissue appearance on the vaginal part of the cervix resembling uterine cavity mucous membrane tissue. This study compared cytoskeletal proteins, H3 histone modifications, and DNA methylation in the eutopic endometrium and endometriosis foci on the cervix. The patient exhibited elevated levels of estradiol, interleukin-1 beta, and interleukin-8. Results showed reduced tubulin and stable microtubule marker content in the ectopic endometrium, along with increased alpha-actinin-1 content and gene expression. Additionally, DNA methylation levels were significantly reduced with an accumulation of the intermediate product 5-hydroxymethylcytosine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medical Laboratory Technology
Anuja Pant, Kareena Moar, Taruna K. Arora, Pawan Kumar Maurya
Summary: Endometriosis is a severe reproductive disorder affecting a significant percentage of women. The current diagnostic approaches are invasive, leading to delayed treatment. Finding sensitive and specific biomarkers for early diagnosis is a research priority. Non-invasive detection of biomarkers may provide early diagnosis, and future advancements in science and technology may result in a potent remedy for endometriosis.
CLINICA CHIMICA ACTA
(2023)
Article
Cell Biology
Roman Eremichev, Maria Kulebyakina, Nataliya Alexandrushkina, Peter Nimiritsky, Nataliya Basalova, Olga Grigorieva, Mane Egiazaryan, Daniyar Dyikanov, Vsevolod Tkachuk, Pavel Makarevich
Summary: Healing of most tissues in the human body occurs via formation of scar tissue, rather than restoration of lost structures. The endometrium is a unique mucous membrane in the human body that heals without scarring after various injuries, possibly due to tissue-specific features of its stromal cells and the effects of soluble factors secreted during menstruation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Obstetrics & Gynecology
A. Nenicu, K. Yordanova, Y. Gu, M. D. Menger, M. W. Laschke
Summary: The study found that there were no differences in growth, microvessel density, and cell proliferation between endometriotic lesions forming from menstrual and non-menstrual tissue fragments in non-ovariectomized mice. However, lesion formation from non-menstrual tissue fragments was suppressed in ovariectomized mice, which could be reversed by estrogen supplementation. On the other hand, endometriotic lesions from menstrual tissue fragments showed smaller volume in ovxthornE2 mice, indicating reduced hormone sensitivity.
HUMAN REPRODUCTION
(2021)
Article
Medicine, General & Internal
Julia Vallve-Juanico, Ashley F. George, Sushmita Sen, Reuben Thomas, Min-Gyoung Shin, Divyashree Kushnoor, Joshua J. Vasquez, Kim Chi Vo, Juan C. Irwin, Nadia R. Roan, Alexis J. Combes, Linda C. Giudice
Summary: This study utilized mass cytometry and high dimensional analyses to study immune cell phenotypes, abundance, activation states, and functions in women with and without endometriosis in different cycle phases and disease stages. The findings revealed a greater inflammatory phenotype of endometrial macrophages in endometriosis and systemic aberrant functionality of the myeloid system.
Article
Obstetrics & Gynecology
Pauline Coudyzer, Pascale Lemoine, Chrystelle Po, Benedicte F. Jordan, Patrick Van der Smissen, Pierre J. Courtoy, Patrick Henriet, Etienne Marbaix
HUMAN REPRODUCTION
(2015)
Article
Cell Biology
Benedicte Delire, Valerie Lebrun, Charlotte Selvais, Patrick Henriet, Amelie Bertrand, Yves Horsmans, Isabelle A. Leclercq
Article
Developmental Biology
Mylah Villacorte, Anne-Sophie Delmarcelle, Manon Lernoux, Mahe Bouquet, Pascale Lemoine, Jennifer Bolsee, Lieve Umans, Susana Chuva de Sousa Lopes, Patrick Van der Smissen, Takako Sasaki, Guido Bommer, Patrick Henriet, Samuel Refetoff, Frederic P. Lemaigre, An Zwijsen, Pierre J. Courtoy, Christophe E. Pierreux
Article
Multidisciplinary Sciences
Manuel Johanns, Pascale Lemoine, Virginie Janssens, Giuseppina Grieco, Soren K. Moestrup, Rikke Nielsen, Erik I. Christensen, Pierre J. Courtoy, Herve Emonard, Etienne Marbaix, Patrick Henriet
SCIENTIFIC REPORTS
(2017)
Article
Cell & Tissue Engineering
Mustapha Najimi, Silvia Berardis, Hoda El-Kehdy, Valerie Rosseels, Jonathan Evraerts, Catherine Lombard, Adil El Taghdouini, Patrick Henriet, Leo van Grunsven, Etienne Marc Sokal
STEM CELL RESEARCH & THERAPY
(2017)
Article
Oncology
Benedicte Delire, Patrick Henriet, Pascale Lemoine, Isabelle A. Leclercq, Peter Starkel
Article
Chemistry, Multidisciplinary
Andra C. Dumitru, Louise Conrard, Cristina Lo Giudice, Patrick Henriet, Maria Veiga-da-Cunha, Sylvie Derclaye, Donatienne Tyteca, David Alsteens
CHEMICAL COMMUNICATIONS
(2018)
Article
Endocrinology & Metabolism
Guillaume E. Courtoy, Patrick Henriet, Etienne Marbaix, Matthieu de Codt, Mathieu Luyckx, Jacques Donnez, Marie-Madeleine Dolmans
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2018)
Editorial Material
Urology & Nephrology
Pierre J. Courtoy, Patrick Henriet
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2018)
Article
Biochemistry & Molecular Biology
Pauline Coudyzer, Pascale Lemoine, Benedicte F. Jordan, Bernard Gallez, Christine Galant, Michelle Nisolle, Pierre J. Courtoy, Patrick Henriet, Etienne Marbaix
Article
Biochemistry & Molecular Biology
Melanie Carquin, Helene Pollet, Maria Veiga-da-Cunha, Antoine Cominelli, Patrick Van der Smissen, Francisca N'kuli, Herve Emonard, Patrick Henriet, Hideaki Mizuno, Pierre J. Courtoy, Donatienne Tyteca
JOURNAL OF LIPID RESEARCH
(2014)
Article
Cell Biology
Antoine Cominelli, Mathias Halbout, Francisca N'Kuli, Pascale Lemoine, Pierre J. Courtoy, Etienne Marbaix, Donatienne Tyteca, Patrick Henriet
Article
Biochemistry & Molecular Biology
Charlotte Thieffry, Marie Van Wynendaele, Asena Aynaci, Mauriane Maja, Caroline Dupuis, Axelle Loriot, Etienne Marbaix, Patrick Henriet
Summary: The study showed that AG-205 affects gene expression in endometrial cells, but not through PGRMC1 or other MAPRs. AG-205 lacks specificity and its mechanisms of action are unclear, raising the risk for endometrial pathologies related to hormone imbalance.
Article
Biochemistry & Molecular Biology
Charlotte Thieffry, Marie Van Wynendaele, Lucie Samain, Donatienne Tyteca, Christophe Pierreux, Etienne Marbaix, Patrick Henriet
Summary: The expression of PGRMC1 in the uterine endometrium varies throughout the menstrual cycle, increasing during the proliferation phase and decreasing during the secretory phase. However, the localization and distribution of PGRMC1 expression varies within the tissue samples. There is no significant difference in PGRMC1 mRNA levels between patients with or without endometriosis for any phase of the menstrual cycle.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)