Totipotency and lineage segregation in the human embryo

Nonstochastic Reprogramming from a Privileged Somatic Cell State

(2014) Shangqin Guo et al.   CELL

The impact of culture on epigenetic properties of pluripotent stem cells and pre-implantation embryos

(2013) Kirsten R. McEwen et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells

(2013) Wei Xie et al.   CELL

Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer

(2013) Masahito Tachibana et al.   CELL

Genetic and Epigenetic Variations in iPSCs: Potential Causes and Implications for Application

(2013) Gaoyang Liang et al.   Cell Stem Cell

Towards an understanding of the regulatory mechanisms of totipotency

(2013) Takashi Ishiuchi et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Cell cycle regulation in human embryonic stem cells: links to adaptation to cell culture

(2013) Tomas Barta et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Evolution of aneuploidy up to Day 4 of human preimplantation development

(2013) A. Mertzanidou et al.   HUMAN REPRODUCTION

Smad2 Is Essential for Maintenance of the Human and Mouse Primed Pluripotent Stem Cell State

(2013) Masayo Sakaki-Yumoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Derivation of novel human ground state naive pluripotent stem cells

(2013) Ohad Gafni et al.   NATURE

Establishment of totipotency does not depend on Oct4A

(2013) Guangming Wu et al.   NATURE CELL BIOLOGY

Defining the Genomic Signature of Totipotency and Pluripotency during Early Human Development

(2013) Amparo Galan et al.   PLoS One

Spontaneously Differentiated GATA6-Positive Human Embryonic Stem Cells Represent an Important Cellular Step in Human Embryonic Development; They Are Not Just an Artifact of In Vitro Culture

(2013) Jun Ho Lee et al.   STEM CELLS AND DEVELOPMENT

TGF-β family signaling in stem cells

(2012) Masayo Sakaki-Yumoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Recurrent Variations in DNA Methylation in Human Pluripotent Stem Cells and Their Differentiated Derivatives

(2012) Kristopher L. Nazor et al.   Cell Stem Cell

Cyclin-Dependent Kinase Inhibitor p21 Controls Adult Neural Stem Cell Expansion by Regulating Sox2 Gene Expression

(2012) M. Ángeles Marqués-Torrejón et al.   Cell Stem Cell

Developmental fate and lineage commitment of singled mouse blastomeres

(2012) C. Lorthongpanich et al.   DEVELOPMENT

The roles of FGF and MAP kinase signaling in the segregation of the epiblast and hypoblast cell lineages in bovine and human embryos

(2012) E. W. Kuijk et al.   DEVELOPMENT

Maternal Cdx2 is dispensable for mouse development

(2012) S. Blij et al.   DEVELOPMENT

Analysis of human embryos from zygote to blastocyst reveals distinct gene expression patterns relative to the mouse

(2012) Kathy K. Niakan et al.   DEVELOPMENTAL BIOLOGY

DMSO is a strong inducer of DNA hydroxymethylation in pre-osteoblastic MC3T3-E1 cells

(2012) Roman Thaler et al.   Epigenetics

Human trophectoderm cells are not yet committed

(2012) C. De Paepe et al.   HUMAN REPRODUCTION

Microarray analysis reveals abnormal chromosomal complements in over 70% of 14 normally developing human embryos

(2012) A. Mertzanidou et al.   HUMAN REPRODUCTION

Further evidence that culture media affect perinatal outcome: findings after transfer of fresh and cryopreserved embryos

(2012) E. C. Nelissen et al.   HUMAN REPRODUCTION

Genetic and epigenetic instability in human pluripotent stem cells

(2012) H.T. Nguyen et al.   HUMAN REPRODUCTION UPDATE

Effect of vitrification on promoter methylation and the expression of pluripotency and differentiation genes in mouse blastocysts

(2012) Xue-Ming Zhao et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Tracking the progression of the human inner cell mass during embryonic stem cell derivation

(2012) Thomas O'Leary et al.   NATURE BIOTECHNOLOGY

Genetic and epigenetic stability of human pluripotent stem cells

(2012) Riikka J. Lund et al.   NATURE REVIEWS GENETICS

Human placentation from nidation to 5 weeks of gestation. Part I: What do we know about formative placental development following implantation?

(2012) J.L. James et al.   PLACENTA

Human placentation from nidation to 5 weeks of gestation. Part II: Tools to model the crucial first days

(2012) J.L. James et al.   PLACENTA

Nuclear Reprogramming: Kinetics of Cell Cycle and Metabolic Progression as Determinants of Success

(2012) Sebastian Thomas Balbach et al.   PLoS One

Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment

(2012) P. Home et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs Regulate p21Waf1/Cip1 Protein Expression and the DNA Damage Response in Human Embryonic Stem Cells

(2012) Dasa Dolezalova et al.   STEM CELLS

Lengthened G1 Phase Indicates Differentiation Status in Human Embryonic Stem Cells

(2012) Ashley Calder et al.   STEM CELLS AND DEVELOPMENT

Intercellular Interactions, Position, and Polarity in Establishing Blastocyst Cell Lineages and Embryonic Axes

(2012) R. O. Stephenson et al.   Cold Spring Harbor Perspectives in Biology

Dynamic blastomere behaviour reflects human embryo ploidy by the four-cell stage

(2012) Shawn L. Chavez et al.   Nature Communications

Transcriptomic Signature of Trophoblast Differentiation in a Human Embryonic Stem Cell Model1

(2011) Melanie Marchand et al.   BIOLOGY OF REPRODUCTION

Maintaining embryonic stem cell pluripotency with Wnt signaling

(2011) S. Y. Sokol   DEVELOPMENT

Waves of early transcriptional activation and pluripotency program initiation during human preimplantation development

(2011) R. Vassena et al.   DEVELOPMENT

Human hypoblast formation is not dependent on FGF signalling

(2011) Mila Roode et al.   DEVELOPMENTAL BIOLOGY

Trophectoderm Lineage Determination in Cattle

(2011) Debra K. Berg et al.   DEVELOPMENTAL CELL

Isolated mouse inner cell mass is unable to reconstruct trophectoderm

(2011) Katarzyna Szczepanska et al.   DIFFERENTIATION

E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming

(2011) Torben Redmer et al.   EMBO REPORTS

XCI in preimplantation mouse and human embryos: first there is remodelling…

(2011) I. M. van den Berg et al.   HUMAN GENETICS

Nuclear reprogramming in zygotes

(2011) Chanchao Lorthongpanich et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

HLA-G Expression in Human Embryonic Stem Cells and Preimplantation Embryos

(2011) A. Verloes et al.   JOURNAL OF IMMUNOLOGY

Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development

(2011) Ikuhiro Okamoto et al.   NATURE

Human oocytes reprogram somatic cells to a pluripotent state

(2011) Scott Noggle et al.   NATURE

Human Embryonic Stem Cells Derived from Embryos at Different Stages of Development Share Similar Transcription Profiles

(2011) Gnanaratnam Giritharan et al.   PLoS One

Prenatal environmental exposures, epigenetics, and disease

(2011) Frederica Perera et al.   REPRODUCTIVE TOXICOLOGY

Reprogramming within hours following nuclear transfer into mouse but not human zygotes

(2011) Dieter Egli et al.   Nature Communications

Cell Polarity Regulator PARD6B Is Essential for Trophectoderm Formation in the Preimplantation Mouse Embryo1

(2010) Vernadeth B. Alarcon   BIOLOGY OF REPRODUCTION

Derivation of Pre-X Inactivation Human Embryonic Stem Cells under Physiological Oxygen Concentrations

(2010) Christopher J. Lengner et al.   CELL

Conserved and Divergent Roles of FGF Signaling in Mouse Epiblast Stem Cells and Human Embryonic Stem Cells

(2010) Boris Greber et al.   Cell Stem Cell

Developmental control of the early mammalian embryo: competition among heterogeneous cells that biases cell fate

(2010) Alexander W Bruce et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Initiation of trophectoderm lineage specification in mouse embryos is independent of Cdx2

(2010) G. Wu et al.   DEVELOPMENT

Maternally and zygotically provided Cdx2 have novel and critical roles for early development of the mouse embryo

(2010) Agnieszka Jedrusik et al.   DEVELOPMENTAL BIOLOGY

Individual blastomeres of 16- and 32-cell mouse embryos are able to develop into foetuses and mice

(2010) Andrzej K. Tarkowski et al.   DEVELOPMENTAL BIOLOGY

The primitive endoderm lineage of the mouse blastocyst: Sequential transcription factor activation and regulation of differentiation by Sox17

(2010) Jérôme Artus et al.   DEVELOPMENTAL BIOLOGY

Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal

(2010) K. K. Niakan et al.   GENES & DEVELOPMENT

Effect of in vitro culture of human embryos on birthweight of newborns

(2010) J. C. Dumoulin et al.   HUMAN REPRODUCTION

Genome-wide microarray evidence that 8-cell human blastomeres over-express cell cycle drivers and under-express checkpoints

(2010) Ann A. Kiessling et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Making the blastocyst: lessons from the mouse

(2010) Katie Cockburn et al.   JOURNAL OF CLINICAL INVESTIGATION

Extrinsic regulation of pluripotent stem cells

(2010) Martin F. Pera et al.   NATURE

Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage

(2010) Connie C Wong et al.   NATURE BIOTECHNOLOGY

Random X Inactivation and Extensive Mosaicism in Human Placenta Revealed by Analysis of Allele-Specific Gene Expression along the X Chromosome

(2010) Joana Carvalho Moreira de Mello et al.   PLoS One

Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo

(2010) S. A. Morris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs

(2010) J. Hanna et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Embryonic gene activation in in vitro produced embryos of the domestic cat (Felis catus)

(2010) R Waurich et al.   REPRODUCTION

Meta-analysis of the heterogeneity of X chromosome inactivation in human pluripotent stem cells

(2010) Tal Bruck et al.   Stem Cell Research

Inhibition of Notch Signaling in Human Embryonic Stem Cell-Derived Neural Stem Cells Delays G1/S Phase Transition and Accelerates Neuronal Differentiation In Vitro and In Vivo

(2010) Lodovica Borghese et al.   STEM CELLS

X Chromosome Inactivation Is Initiated in Human Preimplantation Embryos

(2009) Ilse M. van den Berg et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Oct-4 controls cell-cycle progression of embryonic stem cells

(2009) Jungwoon Lee et al.   BIOCHEMICAL JOURNAL

Uncovering Early Response of Gene Regulatory Networks in ESCs by Systematic Induction of Transcription Factors

(2009) Akira Nishiyama et al.   Cell Stem Cell

Optimal Timing of Inner Cell Mass Isolation Increases the Efficiency of Human Embryonic Stem Cell Derivation and Allows Generation of Sibling Cell Lines

(2009) Alice E. Chen et al.   Cell Stem Cell

Cdk4/CyclinD1 Overexpression in Neural Stem Cells Shortens G1, Delays Neurogenesis, and Promotes the Generation and Expansion of Basal Progenitors

(2009) Christian Lange et al.   Cell Stem Cell

The regulation of TGF  signal transduction

(2009) A. Moustakas et al.   DEVELOPMENT

Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo

(2009) J. Nichols et al.   DEVELOPMENT

The maternal-to-zygotic transition: a play in two acts

(2009) W. Tadros et al.   DEVELOPMENT

The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass

(2009) Noriyuki Nishioka et al.   DEVELOPMENTAL CELL

Gene expression profiles of human inner cell mass cells and embryonic stem cells

(2009) Renee A. Reijo Pera et al.   DIFFERENTIATION

Trophoblast Stem Cells: Models for Investigating Trophectoderm Differentiation and Placental Development

(2009) Gordon C. Douglas et al.   ENDOCRINE REVIEWS

DNA methylation in the IGF2 intragenic DMR is re-established in a sex-specific manner in bovine blastocysts after somatic cloning

(2009) Claudia Gebert et al.   GENOMICS

Human embryonic stem cell lines derived from single blastomeres of two 4-cell stage embryos

(2009) Mieke Geens et al.   HUMAN REPRODUCTION

In vitro post-meiotic germ cell development from human embryonic stem cells

(2009) B. Aflatoonian et al.   HUMAN REPRODUCTION

A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A

(2009) Xin Zhang et al.   JOURNAL OF CELL BIOLOGY

Cyclin D2 and the CDK substrate p220NPATare required for self-renewal of human embryonic stem cells

(2009) Klaus A. Becker et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mitochondrial gene replacement in primate offspring and embryonic stem cells

(2009) Masahito Tachibana et al.   NATURE

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

(2009) Akiko Doi et al.   NATURE GENETICS

Chromosome instability is common in human cleavage-stage embryos

(2009) Evelyne Vanneste et al.   NATURE MEDICINE

A Continuum of Cell States Spans Pluripotency and Lineage Commitment in Human Embryonic Stem Cells

(2009) Shelley R. Hough et al.   PLoS One

Transcriptome Profiling of Human Pre-Implantation Development

(2009) Pu Zhang et al.   PLoS One

MicroRNA 92b Controls the G1/S Checkpoint Gene p57 in Human Embryonic Stem Cells

(2009) Srikumar Sengupta et al.   STEM CELLS

Derivation of Human Embryonic Stem Cell Lines From Biopsied Blastomeres on Human Feeders With Minimal Exposure to Xenomaterials

(2009) Dusko Ilic et al.   STEM CELLS AND DEVELOPMENT

Stem Cells and Early Lineage Development

(2008) Janet Rossant   CELL

NANOG Is a Direct Target of TGFβ/Activin-Mediated SMAD Signaling in Human ESCs

(2008) Ren-He Xu et al.   Cell Stem Cell

Blastomeres of the mouse embryo lose totipotency after the fifth cleavage division: Expression of Cdx2 and Oct4 and developmental potential of inner and outer blastomeres of 16- and 32-cell embryos

(2008) Aneta Suwińska et al.   DEVELOPMENTAL BIOLOGY

Role of Cdx2 and cell polarity in cell allocation and specification of trophectoderm and inner cell mass in the mouse embryo

(2008) A. Jedrusik et al.   GENES & DEVELOPMENT

Cell identity in the preimplantation mammalian embryo: an epigenetic perspective from the mouse

(2008) M. E. Torres-Padilla   HUMAN REPRODUCTION

Markers that define stemness in ESC are unable to identify the totipotent cells in human preimplantation embryos

(2008) G. Cauffman et al.   HUMAN REPRODUCTION

The four blastomeres of a 4-cell stage human embryo are able to develop individually into blastocysts with inner cell mass and trophectoderm

(2008) H. Van de Velde et al.   HUMAN REPRODUCTION

Combinatorial Signals of Activin/Nodal and Bone Morphogenic Protein Regulate the Early Lineage Segregation of Human Embryonic Stem Cells

(2008) Zhao Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oct4/Sox2-Regulated miR-302 Targets Cyclin D1 in Human Embryonic Stem Cells

(2008) D. A. Greer Card et al.   MOLECULAR AND CELLULAR BIOLOGY

Marked differences in differentiation propensity among human embryonic stem cell lines

(2008) Kenji Osafune et al.   NATURE BIOTECHNOLOGY

Expression and functional analysis of G1 to S regulatory components reveals an important role for CDK2 in cell cycle regulation in human embryonic stem cells

(2008) I Neganova et al.   ONCOGENE

Revealing the dynamics of gene expression during embryonic genome activation and first differentiation in the rabbit embryo with a dedicated array screening

(2008) R. D. Léandri et al.   PHYSIOLOGICAL GENOMICS

A Novel and Critical Role for Oct4 as a Regulator of the Maternal-Embryonic Transition

(2008) Kira Foygel et al.   PLoS One

X-chromosome inactivation and epigenetic fluidity in human embryonic stem cells

(2008) S. S. Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide expression profiling reveals distinct clusters of transcriptional regulation during bovine preimplantation development in vivo

(2008) W. A. Kues et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Self-Renewal and Pluripotency by Sox2 in Human Embryonic Stem Cells

(2008) Helen Fong et al.   STEM CELLS

Control of Early Fate Decisions in Human ES Cells by Distinct States of TGFβ Pathway Activity

(2008) Boris Greber et al.   STEM CELLS AND DEVELOPMENT

Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos

(2007) Noriyuki Nishioka et al.   MECHANISMS OF DEVELOPMENT