Article
Medicine, General & Internal
Carlotta Scarafia, Martina Masciovecchio, Stefano Canosa, Andrea Roberto Carosso, Gianluca Gennarelli, Alberto Revelli, Chiara Benedetto
Summary: The study found that in women with ovarian endometriosis, ICSI can be performed without harming oocytes or affecting the outcome. Additionally, there is no advantage in removing endometrioma before ICSI.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Chia Lin Chang
Summary: The decline in fertility in aging women, especially those with poor ovarian response (POR) or primary ovarian insufficiency (POI), is a major concern. Researchers have explored alternative approaches, including adjunct interventions and mechanical procedures, to improve fertility outcomes. However, the molecular mechanisms underlying fertility decline in aging women are not yet fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Xiaoyun Gong, Yunian Zhang, Yuejie Zhu, Peng Wang, Zhihui Wang, Chen Liu, Manli Zhang, Xiaolin La
Summary: This study developed a nomogram based on POSEIDON criteria to predict live birth in patients with poor ovarian response. Age, BMI, AMH, normal fertilized oocytes, and basal FSH were identified as independent factors predicting live birth in these patients. The nomogram model showed good predictive accuracy in both the training and validation sets.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Jia Liu, Dekang Lv, Xiaobin Wang, Ruicong Wang, Xiaodong Li
Summary: This study systematically analyzed the survival-related AS signal in ovarian serous cystadenocarcinoma and established a new comprehensive prognostic model based on seven AS events. The models were highly efficient in distinguishing patient survival and showed higher prediction ability than mRNA signature, which could be used as potential predictor and therapeutic target for patients with OV.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Blazej Chermula, Greg Hutchings, Wieslawa Kranc, Malgorzata Jozkowiak, Karol Jopek, Boguslawa Stelmach, Paul Mozdziak, Leszek Pawelczyk, Hanna Piotrowska-Kempisty, Robert Z. Spaczynski, Bartosz Kempisty
Summary: The immune system plays a crucial role in recognizing and eliminating abnormal cells in addition to defending against pathogens. Immune cells in the ovary regulate processes like follicular selection and ovulation. Analysis of gene expression in cumulus cells can identify molecular markers and provide insights into their functions.
Article
Endocrinology & Metabolism
Rong Luo, Jiahui Wang, Yu Yang, Cen Xu, Minyan Yang, Dandan Zhu, Jia Wang, Ping Zhang, Hongshan Ge
Summary: This study aimed to assess the impact of vitamin D levels on embryo quality and pregnancy outcomes in patients with normal ovarian reserve undergoing the first IVF/ICSI cycle. The findings suggest that serum vitamin D level is not associated with embryo quality and pregnancy outcomes for these patients. Further studies are needed to elucidate the relationships between vitamin D levels and IVF outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Reproductive Biology
Di Zhang, Dan Zou, Yue Deng, Lihua Yang
Summary: Ovarian cancer is a highly lethal gynecological tumor, and effective biomarkers are crucial for improving its prognosis. This study analyzed the relationship between alternative splicing events and the prognosis of OC, constructed multiple prognostic models, and found that SFs and AS events can impact the prognosis of OC patients.
JOURNAL OF OVARIAN RESEARCH
(2021)
Review
Plant Sciences
Xiao-Xiao Liu, Qian-Huan Guo, Wei-Bo Xu, Peng Liu, Kang Yan
Summary: Plants use diverse strategies and complex regulations to adapt to changing environmental conditions. In addition to direct gene transcription regulation, alternative splicing plays a crucial role in coping with various stresses.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Biology
Woon Shu Yuan, Muhammad Azrai Abu, Mohd Faizal Ahmad, Marjanu Hikmah Elias, Abdul Kadir Abdul Karim
Summary: Despite the inconsistent findings and lack of rigorous trials, our review found that DHEA supplementation can have beneficial effects on ovarian cumulus cells in improving oocyte quality for women of advanced age or with poor ovarian responders. However, there is no significant difference in stimulation and pregnancy outcomes between the DHEA supplementation group and the control group.
Article
Endocrinology & Metabolism
Fangyuan Li, Ruihui Lu, Cheng Zeng, Xin Li, Qing Xue
Summary: This study developed a predictive model to estimate the individual probability of clinical pregnancy failure for poor ovarian responders (PORs) undergoing IVF/ICSI. The model was constructed based on characteristics associated with pregnancy failure, and showed satisfactory performance in both the training and validation groups.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Nina Rogenhofer, Udo Jeschke, Viktoria von Schoenfeldt, Sven Mahner, Christian J. Thaler
Summary: This study reveals the seasonal fluctuations of cholecalciferol (D3) and anti-Muellerian hormone (AMH) concentrations, and their association with ART outcomes. D3 and AMH concentrations are highest between August and October, which may affect ovarian stimulation and fertilized oocyte numbers in ART cycles.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Review
Plant Sciences
Varvara Dikaya, Nabila El Arbi, Nelson Rojas-Murcia, Sarah Muniz Nardeli, Daniela Goretti, Markus Schmid
Summary: Alternative splicing in plants is closely linked to their ability to perceive environmental stimuli, particularly temperature, which strongly influences plant development and morphology.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Oncology
Shijie Yao, Cheng Yuan, Yuying Shi, Yuwen Qi, Radhakrishnan Sridha, Mengyuan Dai, Hongbing Cai
Summary: This study explores the correlation between alternative splicing (AS) and prognosis in ovarian cancer (OV) and establishes a prognostic model and nomogram for OV. It provides potential biomarkers and targets for the treatment of OV and suggests the possibility of interfering with AS in the comprehensive treatment of OV.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Review
Oncology
Antoine Bernard, Romain Boidot, Frederique Vegran
Summary: This article presents the role and mechanism of alternative splicing in cancer cells and immune cells. Alternative splicing is an important mechanism that can generate multiple proteins from a single gene. In normal cells, alternative splicing is involved in the regulation of cellular behavior. However, in cancer, alternative splicing is dysregulated and contributes to the characteristics of tumor cells.
Article
Biochemistry & Molecular Biology
Elli Anagnostou, Alexia Kafkoutsou, Despina Mavrogianni, Ekaterini Domali, Evangelia Dimitroulia, Dimitris Mathiopoulos, Peter Drakakis, Dimitris Loutradis
Summary: This study evaluated the impact of two polymorphisms in a Greek population of women undergoing IVF/ICSI program and found that the FSH 13-211 G>T polymorphism is rare in the infertile Greek population. Statistically significant differences were observed in LH levels for some polymorphisms. The study concluded that the polygenic combination of the Asn680Ser and FSH 13 subunit-211 G>T gene polymorphisms may provide additional predictive value for ovarian response to exogenous gonadotropins.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2021)
Article
Endocrinology & Metabolism
G. Isik, M. Oktem, I. Guler, E. Oktem, C. Ozogul, S. Saribas, A. Erdem, M. Erdem
Summary: The experimental study showed that G-CSF improved the thin endometrium by increasing endometrial thickness, promoting cell proliferation, enhancing angiogenesis, and reducing DNA fragmentation.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Erhan Demirdag, Ismail Guler, Ilknur Selvi, Munire Funda Cevher Akdulum, Sultan Canan, Ahmet Erdem, Mehmet Erdem
Summary: This study aimed to evaluate the impact of surgical removal of ovarian endometrioma on IVF outcomes, showing that the surgery may affect ovarian reserve and lead to higher cancellation rates, but pregnancy outcomes are similar. Patients with lower than expected ovarian response may benefit from endometrioma surgery in subsequent IVF cycles.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Obstetrics & Gynecology
Erhan Demirdag, Ismail Guler, Munire Funda Cevher Akdulum, Esin Sahin, Ozlem Erdem, Ahmet Erdem, Mehmet Erdem
Summary: The aim of the study was to identify the incidence of chronic endometritis (CE) in recurrent implantation failure (RIF) patients undergoing IVF treatment and compare IVF outcomes after antibiotic therapy. Furthermore, comparison was made between IVF outcomes of RIF patients with CE and without CE, as well as with patients undergoing their first IVF cycle.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Marine & Freshwater Biology
Jonathan Daly, Rebecca J. Hobbs, Nikolas Zuchowicz, Justine K. O'Brien, Jessica Bouwmeester, Line Bay, Kate Quigley, Mary Hagedorn
Summary: Maintaining genetic diversity and biodiversity is crucial for the health and adaptability of ecosystems. Assisted Gene Flow (AGF) is a management approach that involves transferring adaptive genes between populations to restore declining and at-risk habitats. This study demonstrates that cryopreserved sperm can be used for intrapopulation and interpopulation crosses to support AGF. The concentration of motile sperm in post-thaw samples is an important factor for successful fertilization. Coral reefs with high species and genetic diversity and coral cover are suitable for preserving biodiversity through cryopreservation.
Article
Obstetrics & Gynecology
Ilknur Mutlu, Erhan Demirdag, Funda Cevher, Ahmet Erdem, Mehmet Erdem
Summary: The study showed that using dual trigger with a GnRH agonist and a standard dosage of hCG in poor ovarian responders undergoing IVF has significantly improved the number of retrieved and mature oocytes, fertilisation rates, implantation rates, clinical pregnancy rates, and live birth rates compared to using only hCG trigger. These findings suggest the potential benefits of dual trigger in improving IVF outcomes in poor ovarian responders.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Review
Obstetrics & Gynecology
J. A. Wessel, N. A. Danhof, R. van Eekelen, M. P. Diamond, R. S. Legro, K. Peeraer, T. M. D'Hooghe, M. Erdem, T. Dankert, B. J. Cohlen, C. Thyagaraju, B. W. J. Mol, M. Showell, M. van Wely, M. H. Mochtar, R. Wang
Summary: This study conducted an individual participant data meta-analysis to compare the effectiveness and safety of gonadotrophins, letrozole, and clomiphene citrate in ovarian stimulation with intrauterine insemination (IUI-OS) for couples with unexplained infertility, and explored treatment-covariate interactions for important baseline characteristics in couples undergoing IUI.
HUMAN REPRODUCTION UPDATE
(2022)
Article
Environmental Sciences
Rebecca J. Hobbs, Justine K. O'Brien, Line K. Bay, Andrea Severati, Rebecca Spindler, E. Michael Henley, Kate M. Quigley, Carly J. Randall, Madeleine J. H. van Oppen, Virginia Carter, Nikolas Zuchowicz, Mary Hagedorn, Jonathan Daly
Summary: In order to support the resilience and adaptation of coral reef ecosystems, active restoration or intervention programs will be necessary in the future. Selective propagation of corals ex situ can assist in conserving keystone species and their ecosystems, and cross-disciplinary research and communication between science and industry are crucial to success.
FRONTIERS IN MARINE SCIENCE
(2022)
Review
Agriculture, Dairy & Animal Science
Zara M. Anastas, Phillip G. Byrne, Justine K. O'Brien, Rebecca J. Hobbs, Rose Upton, Aimee J. Silla
Summary: Integrating reproductive technologies can enhance the propagation and genetic management of threatened amphibian species. Advances in cold storage and cryopreservation of amphibian sperm, coupled with assisted fertilisation technologies, are being applied to an increasing number of threatened species globally.
Article
Agriculture, Dairy & Animal Science
Aimee J. Silla, Rebecca J. Hobbs, Deon J. Gilbert, Damian Goodall, Marissa L. Parrott, Adam Lee, Justine K. O'Brien, Phillip G. Byrne
Summary: The integration of reproductive technologies into conservation breeding programs can contribute to the propagation and genetic management of threatened amphibian species. This study reports on the successful use of hormone-induced spawning, hormone-induced sperm-release, and sperm cryopreservation in the critically endangered Baw Baw frog, Philoria frosti. These reproductive technologies can assist in achieving propagation targets and managing genetic diversity more effectively.
Article
Obstetrics & Gynecology
Erhan Demirdag, Ismail Guler, Munire Funda Cevher Akdulum, Esin Sahin, Ayse Duygu Tufan, Ahmet Erdem, Mehmet Erdem
Summary: This study found no significant difference in pregnancy outcomes between natural cycles and artificial cycles for frozen-thawed embryo transfer. Suitable endometrial preparation is crucial for successful pregnancy rates, and the choice between NC and AC protocols should be based on menstrual regularity and clinical experience.
TURKISH JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Medicine, General & Internal
Erhan Demirdag, Ismail Guler, M. Funda Cevher Akdulum, Cengiz Karakaya, Esin Sahin, Ahmet Erdem, Mehmet Erdem
Summary: This study aimed to evaluate the impact of hCG day serum LH levels on IVF outcomes in patients undergoing GnRH antagonist protocols. The results showed that lower hCG day LH levels may lead to poorer pregnancy outcomes, especially in older and poor responders. However, lower hCG day LH levels may not affect IVF outcomes in antagonist cycles.
GAZI MEDICAL JOURNAL
(2022)
Article
Developmental Biology
Rebecca J. Hobbs, Rose Upton, Leesa Keogh, Karen James, James Baxter-Gilbert, Martin J. Whiting
Summary: Assisted reproductive technologies for threatened herpetofauna have made significant advancements in population and genetic management. The use of complex diluents significantly improved post-thaw total motility, with different effects observed under fast and slow freezing rates.
REPRODUCTION FERTILITY AND DEVELOPMENT
(2022)
Article
Medicine, General & Internal
Rabia Tural, Cengiz Karakaya, Mehmet Erdem, Zeynep Aykol, Recep Onur Karabacak, Mustafa Kavutcu
Summary: This study found that in IVF patients, the cumulus cell GST enzyme activity significantly increased in the high responder group, while MDA levels significantly decreased, indicating that oxidative stress has an effect on oocyte status and quality.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Ilknur Selvi, Mehmet Erdem, Erhan Demirdag, Funda Cevher, Cengiz Karakaya, Ahmet Erdem
Summary: In patients with previous cycle cancellations due to uterine peristalsis, using letrozole for endometrial preparation significantly improves clinical pregnancy rate and live birth rate in FET cycles.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Computer Science, Artificial Intelligence
Cagdas Kurt, O. Ayhan Erdem
TURKISH JOURNAL OF ELECTRICAL ENGINEERING AND COMPUTER SCIENCES
(2020)