Article
Biochemistry & Molecular Biology
Pedro Felipe Malacarne, Justus Bezzenberger, Melina Lopez, Timothy Warwick, Niklas Mueller, Ralf P. Brandes, Flavia Rezende
Summary: In this study, it was found that there is crosstalk between EETs and prostaglandins in the vascular system, and the lack of EET production sensitizes vessels to vasoconstriction. These findings have important implications for understanding vascular function and the development of related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Paula Accialini, Cyntia Aban, Tomas Etcheverry, Mercedes Negri Malbran, Gustavo Leguizamon, Vanesa Herlax, Sabina Mate, Mariana Farina
Summary: Anandamide plays a crucial role in regulating placental molecules that contribute to the onset of labor at term, affecting prostaglandins levels and NOS activity differently based on the localization of CB1 receptors. The differential actions of anandamide suggest its role as a modulator of the signals that regulate labor.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Peripheral Vascular Disease
Majid Ali, Zainab Hussein, Janice M. Marshall
Summary: Prevalence of cardiovascular disease is higher in South Asians than white Europeans. Offspring of hypertensive parents have greater risk of hypertension. Endothelium-dependent dilatation is blunted in young South Asian women.
JOURNAL OF HYPERTENSION
(2022)
Article
Biochemistry & Molecular Biology
S. Contreras-Duarte, C. Cantin, M. Farias, A. Leiva
Summary: This study evaluated the effects of MSPD on GDM and how these pathologies together affect fetoplacental endothelial function. Results showed increased TC and TG in MSPD and GDM-MSPD groups, decreased eNOS activity, increased hCat1 protein and L-arginine transport, and higher Arginase II protein and activity in GDM-MSPD compared to MPD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Review
Cell Biology
Angel Bago, Miguel A. Iniguez, Juan M. Serrador
Summary: NO and CyPG play important roles in regulating cellular response to oxidative stress, particularly in inflammation and immune responses. They both promote redox-based post-translational modification of proteins, such as S-nitrosylation and S-glutathionylation induced by NO, and adduct formation mediated by cyclopentenones. A key aspect of their action is the susceptibility of actin and actin-binding proteins to covalent PTM, which is essential for cellular activation and migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ana C. Palei, Joey P. Granger, Frank T. Spradley
Summary: This review provides an overview of NOS isoforms and biochemistry, as well as the role of NO in blood pressure control during normal pregnancy, with a focus on the impact of placental malperfusion on NO bioavailability and the development of PE. The article also discusses strategies for targeting the NOS system therapeutically in treating PE. Throughout, the importance of experimental animal studies in understanding NOS biology and finding ways to prevent or alleviate PE is emphasized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Charles E. Norton, Rebecca L. Shaw, Ron Mittler, Steven S. Segal
Summary: This study found that endothelial cells (ECs) are more resistant to oxidative stress than smooth muscle cells (SMCs) in cerebral arteries. The endothelium protects SMCs by reducing calcium ion entry through TRPC3 channels. These findings provide insights into the cellular response to acute oxidative stress in the cerebral vascular supply.
Article
Multidisciplinary Sciences
Lin Qin, Shaik Althaf Hussain, Narendra Maddu, Chinna Padamala Manjuvani, Bangeppagari Manjunatha, Sudhakara Gujjala, Venkata Subba Reddy Gangireddygari, Yingying Fan
Summary: The study investigated the lipid composition and biochemical profile of plasma and erythrocyte membranes in diabetes and alcoholic diabetes in rats. The results showed that STZ-induced diabetic rats exhibited hepatic damage, leading to increased plasma lipid peroxidation, nitrate, and nitrite levels. Diabetic rats treated with alcohol also showed decreased activities of antioxidants. The findings suggest that nitric oxide scavenging levels increased in diabetic hepatopathy rats, potentially protecting against oxidative stress and free radicals.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Review
Pharmacology & Pharmacy
Elizabeth C. Cottrell
Summary: Hypertension in pregnancy is common and poses risks for mothers and babies. Current treatments are limited, so new approaches are needed. Dietary nitrate supplementation has shown potential benefits for hypertension, but more research is needed.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maciej W. Socha, Martyna Stankiewicz, Krzysztof Zolniezewicz, Oskar Puk, Mateusz Wartega
Summary: This study aimed to clarify the changes in nitric oxide (NO) metabolism during the course of preeclampsia (PE). By measuring the concentrations of stable NO metabolites, nitrite and nitrate (NOx), it was found that NOx concentrations were significantly lower in PE patients compared to the control group, suggesting that impairment of NO metabolism may play an important role in the pathogenesis of PE.
Article
Pharmacology & Pharmacy
Miaojuan Fan, Tongtong Pan, Wei Jin, Jian Sun, Shujun Zhang, Yali Du, Xinwei Chen, Qiong Chen, Wenxin Xu, Siew Woh Choo, Guanghui Zhu, Yongping Chen, Jie Zhou
Summary: The study revealed elevated expression of FGF4 in GDM patients, with rFGF4 treatment effectively normalizing adverse metabolic phenotypes and reducing neural tube defects in GDM mice. The findings suggest FGF4 as a potential diagnostic factor and therapeutic target for GDM.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Livius d'Uscio, Zvonimir S. Katusic
Summary: The study revealed an age-related increase in APP expression in vascular endothelium, which is believed to be an adaptive response aimed at protecting and maintaining eNOS function. Endothelial dysfunction was exacerbated in aged eAPP(-/-) mice compared to age-matched WT mice, suggesting a crucial role of APP in controlling endothelial function during aging.
Article
Endocrinology & Metabolism
Justin B. Echouffo-Tcheugui, Jun Guan, Ravi Retnakaran, Baiju R. Shah
Summary: In a large observational study, it was found that gestational diabetes mellitus (GDM) is associated with an increased risk of heart failure (HF), even after adjusting for relevant cardiometabolic risk factors. Additionally, GDM was also found to increase the odds of peripartum cardiomyopathy.
Article
Ophthalmology
Silvia Sgambellone, Silvia Marri, Serafina Villano, Emanuela Masini, Gustavo Provensi, Elena Bastia, Corinna Galli, Stefania Brambilla, Francesco Impagnatiello, Laura Lucarini
Summary: This study demonstrates that repeated ocular dosing of NCX 470 improves ocular hemodynamics and retinal cell dysfunction caused by ischemia/reperfusion via nitric oxide- and bimatoprost-mediated mechanisms. These findings suggest new therapeutic opportunities to reduce visual field loss in glaucoma.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2023)
Review
Cell Biology
Bernardo J. Krause
Summary: This review highlights the importance of endothelial nitric oxide synthase in placental development and function, as well as its impact on preeclampsia and other pregnancy-related diseases. Recent evidence suggests that eNOS regulation is influenced by a complex network of processes, involving mechanisms such as mechano-sensing, epigenetic modifications, and other pathways.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Reproductive Biology
Sabrina L. Roberti, Romina Higa, Hugo Sato, Dalmiro Gomez Ribot, Evangelina Capobianco, Alicia Jawerbaum
REPRODUCTIVE TOXICOLOGY
(2020)
Article
Developmental Biology
Tomas Etcheverry, Paula Accialini, Marcos Palligas, Florencia Loureiro, Nora Saraco, Nora Martinez, Mariana Farina
Summary: The study revealed that the endocannabinoid anandamide disrupts syncytialization process, which may have an impact on pregnancy outcomes.
Article
Dentistry, Oral Surgery & Medicine
Gabriela Martin, Georgette Arce Brisson, Binwen Chen, Cecilia Noemi de Caso, Ana Cecilia Boetto, Maria Ines Jacobo, Romina Higa, Silvia Marta Braschi, Silvio Marchegiani, Andres Monsalvo, Ya Shen, Markus Haapasalo
Summary: The study assessed the minimum thickness of root canal wall in C-shaped teeth after instrumentation, using CBCT and micro-CT scans. Results showed good agreement between CBCT and micro-CT measurements in ten cases, but significantly shorter distances to root surface were revealed by micro-CT in two teeth.
AUSTRALIAN ENDODONTIC JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Sabrina Lorena Roberti, Cintia Romina Gatti, Daiana Fornes, Romina Higa, Alicia Jawerbaum
Summary: Maternal diabetes increases the risk of embryo resorptions and impairs embryo development. A diet enriched in polyunsaturated fatty acids (PUFAs) can prevent decidual alterations in diabetic rats during the early postimplantation period, protecting pregnancies from adverse effects on decidual function and remodeling.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Developmental Biology
Romina Higa, Fredrick J. Rosario, Theresa L. Powell, Thomas Jansson, Alicia Jawerbaum
Summary: MTOR functions as a folate sensor in embryos, and its inhibition can lead to developmental delays. Folate supplementation can rescue these effects. Maternal folic acid supplementation can prevent certain developmental impairments induced by MTOR inhibition, but not all.
Article
Biochemistry & Molecular Biology
Daniel Musikant, Romina Higa, Cristina E. Rodriguez, Martin M. Edreira, Oscar Campetella, Alicia Jawerbaum, Maria S. Leguizam
Summary: In infections caused by Trypanosoma cruzi, different strains of the parasite can modulate the levels of circulating matrix metalloproteinases (MMPs), affecting their activity in blood. Furthermore, the virulence factor trans-sialidase is involved in regulating MMP-2 activity by removing sialic acid residues from cell surfaces and triggering specific signaling pathways. This novel pathogenic mechanism may be exploited by other pathogens expressing similar sialidases to regulate the MMP network.
Article
Reproductive Biology
Ivana Linenberg, Daiana Fornes, Romina Higa, Alicia Jawerbaum, Evangelina Capobianco
Summary: Maternal treatment with Idebenone in pregestational diabetic F0 rats ameliorates the pro-oxidant/proinflammatory environment that affects the placentas of F2 fetuses, although it does not prevent F1 rats from developing GDM.
REPRODUCTIVE TOXICOLOGY
(2021)
Review
Physiology
Romina Higa, Maria Laura Leonardi, Alicia Jawerbaum
Summary: Maternal diabetes increases the risk of cardiovascular diseases in offspring from fetal stage to adult life, with metabolic, pro-oxidant, and proinflammatory alterations in the fetal heart being the initial steps in adverse fetal programming of cardiovascular disease. Studies discuss potential mechanisms including epigenetic changes, cardiac metabolism alterations, effects of pro-oxidant and proinflammatory environment, extracellular matrix remodeling, and signaling pathways, as well as potential actions to prevent cardiovascular impairments in offspring of mothers with diabetes.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Daiana Fornes, Florencia Heinecke, Cintia Romina Gatti, Sabrina Lorena Roberti, Veronica White, Alicia Jawerbaum, Evangelina Capobianco
Summary: The study demonstrated that paternal diabetes can lead to fetal overgrowth and sex-dependent effects on placental lipid metabolism regulation. Specifically, male fetuses showed increased lipid accumulation and mRNA expression of enzymes involved in lipid oxidation and transport pathways in the placenta.
JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Developmental Biology
Evangelina Capobianco, Irune Pirrone
Summary: The alarming increase in the prevalence of metabolic pathologies has raised worldwide concerns. Recent studies have focused on the programming of metabolic diseases by paternal exposure. This review aims to explore the evidence of fetoplacental developmental alterations and metabolic pathologies in offspring, considering paternal metabolic disorders and unhealthy exposures, as well as identifying potential paternal interventions to reduce negative health outcomes in the offspring.
Meeting Abstract
Developmental Biology
Cintia Romina Gatti, Sabrina Lorena Roberti, Maria Florencia Heinecke, Romina Higa, Alicia Jawerbaum
Meeting Abstract
Developmental Biology
Romina Higa
Meeting Abstract
Developmental Biology
Maria Laura Leonardi, Hugo Sato, Sabrina Roberti, Alicia Jawerbaum, Romina Higa
Meeting Abstract
Developmental Biology
Sabrina Lorena Roberti, Cintia Romina Gatti, Romina Higa, Alicia Jawerbaum