Journal
SCIENCE OF THE TOTAL ENVIRONMENT
Volume 505, Issue -, Pages 454-463Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.scitotenv.2014.10.039
Keywords
Methyl siloxanes; General industries; Plasma; Abdominal fat; Accumulation
Categories
Funding
- Chinese Academy of Sciences [XDB14010201]
- National Natural Science Foundation of China [41023005, 2132100]
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We investigated human exposure to methyl siloxanes in three general industries (building, automobile, and textile industries) and residential areas in China. Usage volumes of methyl siloxanes per capita in these industries were 2-5 orders of magnitudes higher than those in residential areas. Methyl siloxane concentrations in indoor air and dust samples from industrial facilities were 1-3 orders of magnitudes higher than those in residential houses. Both cyclic (D4-D6) and linear (L5-L16) siloxanes were detected in plasma of industrial workers (1.00-252 ng/mL, detection frequencies = 3.7-71%, n = 528), while only cyclic compounds (D4-D6) were detected in plasma of general population (n = 519) with much lower concentrations (1.10-7.50 ng/mL) and detection frequencies (1.7-3.7%). During the occupational exposure, anti-dust mask can reduce 30% of intake of cyclic siloxanes and 74% of intake of linear siloxanes, respectively. In addition, PM-10 could elevate intake of linear siloxanes. Calculated fat-plasma partition ratios of methyl siloxanes (D4-D6, L6-L11) in the present study were 5.3-241 mL/g. Linear rather than cyclic siloxanes had an apparent accumulation in abdominal fat. Population's half-lives of L8-L10 in abdominal fat of general population were approximately 1.49-1.80 years. (C) 2014 Elsevier B.V. All rights reserved.
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