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Chemistry, Medicinal
Jae Hoon Kim, Jung Sunwoo, Ji Hye Song, Yu-Bin Seo, Won Tae Jung, Kyu-Yeol Nam, YeSeul Kim, Hye Jung Lee, JungHa Moon, Jin-Gyu Jung, Jang Hee Hong
Summary: The interaction between atorvastatin and omega-3 fatty acids was evaluated in a phase 1 trial, and it was found that co-administration of the two drugs affected their concentrations, indicating a drug-drug interaction.
Article
Infectious Diseases
Richard J. Everts, Sharon J. Gardiner, Mei Zhang, Ronald Begg, Stephen T. Chambers, John Turnidge, Evan J. Begg
Summary: This study evaluated the effects of probenecid on the pharmacokinetics and pharmacodynamics of oral cephalexin in healthy volunteers. Results showed that probenecid increased cephalexin plasma concentrations and prolonged half-life, enhancing the likelihood of reaching PK/PD targets. Co-administration of probenecid may expand the clinical benefits of oral cephalexin.
JOURNAL OF INFECTION
(2021)
Article
Pharmacology & Pharmacy
Shanshan Nie, Kaifeng Chen, Chengxian Guo, Qi Pei, Chan Zou, Liangyuan Yao, Hongbo Yuan, Xia Zhao, Ran Xie, Xu He, Jie Huang, Guoping Yang
Summary: This study reveals the impact of CYP4F2 rs2074900 SNP on ticagrelor pharmacokinetics (PK) and provides new insights into the pharmacogenetics of ticagrelor.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Junlin Cheng, Jun Long, Jingjing Zhang, Le Han, Yunfang Hu, Jianghui Liu, Runze Qiu, Zhibin Zhu, Hongwei Fan
Summary: This study aimed to evaluate the safety, tolerance, and pharmacokinetics of Sal B injection in healthy Chinese volunteers. The results showed that single doses up to 300 mg and 250 mg for 5 consecutive days of Salvianolic acid B injections showed excellent safety and tolerability.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Anesthesiology
Stanislas Grassin-Delyle, Michaela Semeraro, Elodie Lamy, Saik Urien, Ileana Runge, Frantz Foissac, Naim Bouazza, Jean-Marc Treluyer, Monica Arribas, Ian Roberts, Haleema Shakur-Still
Summary: The study showed significant differences in pharmacokinetics between intramuscular and oral administration of TXA in healthy volunteers, with intramuscular absorption being rapid and complete, making it a potentially effective alternative to intravenous TXA. Adverse events were mild and transient, mainly consisting of local reactions and low-intensity pain.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Gastroenterology & Hepatology
Edward Gane, Man-Fung Yuen, Dong Joon Kim, Henry Lik-Yuen Chan, Bernadette Surujbally, Vedran Pavlovic, Sudip Das, Miriam Triyatni, Remi Kazma, Joseph F. Grippo, Simon Buatois, Annabelle Lemenuel-Diot, Ben-Fillippo Krippendorff, Henrik Mueller, Yuchen Zhang, Hyung Joon Kim, Apinya Leerapun, Tien Huey Lim, Young-Suk Lim, Tawesak Tanwandee, Won Kim, Wendy Cheng, Tsung-Hui Hu, Cynthia Wat
Summary: The study evaluated the safety and efficacy of RO7062931 in healthy volunteers and patients with chronic hepatitis B. Supradose-proportional increases in plasma exposure and urinary excretion of RO7062931 were observed at the same dosage. Patients exhibited dose-dependent reductions in HBsAg levels when treated with RO7062931.
Article
Pharmacology & Pharmacy
Zoe Kane, Roberto Picetti, Alison Wilby, Joseph F. Standing, Stanislas Grassin-Delyle, Ian Roberts, Haleema Shakur-Still
Summary: The study suggests that intramuscular administration of TXA may achieve targeted exposure and capture variability in pharmacokinetics. Well-designed clinical trials are recommended to validate these findings.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Microbiology
Isabela Ribeiro, Bethania Blum, Jayme Fernandes, Glaucia Santina, Makoto Asada, Michael Everson, Edgar Schuck, Ethel Feleder, Eric Evene, Virginie Gualano
Summary: The study evaluated the pharmacokinetics and safety interactions of BNZ and E1224 in healthy volunteers. The results showed changes in RVZ concentration parameters when both compounds were coadministered, but both compounds were well tolerated and no clinically relevant safety interactions were observed.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Jiayu Li, Pei Hu, Li Zhou, Fumiko Nagahama, Rui Chen
Summary: This study found ethnic differences in the pharmacokinetics of granisetron patches between Chinese and Caucasian populations, but analysis of a population pharmacokinetic model showed no significant differences in pharmacokinetic parameters between the two groups. Therefore, this study provides valuable insights for optimizing dosage across Chinese and Caucasian populations.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Siva Rama Raju Kanumuri, Jessica Mamallapalli, Robyn Nelson, Christopher R. McCurdy, Carol A. Mathews, Chengguo Xing, Abhisheak Sharma
Summary: This study examined the clinical pharmacokinetics of kava in healthy volunteers, finding higher exposure after single-dosing and longer duration of exposure after multiple doses.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Infectious Diseases
Andre Daher, Douglas Pereira Pinto, Lais Bastos da Fonseca, Heliana Martins Pereira, Diego Medeiros Dias da Silva, Leticia de Sa Fernandes Vallim da Silva, Alessandra Lanzillotta Esteves, Juliana J. Soares Medeiros, Jorge Souza Mendonca
Summary: This article presents the results of three bioequivalence studies that provide pharmacokinetic data on chloroquine and primaquine using up-to-date analytical methods. The results show that the tested formulations are bioequivalent, and the individual data provided may contribute to optimizing the treatment of vivax malaria.
Article
Pharmacology & Pharmacy
Myeong-Bae Shin, Sung-Ah Kim, Sooyoung Lee, Wang-Seob Shim, Kyung-Tae Lee, Seung-Kwon Lee, Sung-Vin Yim, Bo-Hyung Kim
Summary: Fermentation of red ginseng produces fermented red ginseng with increased downstream ginsenosides which have beneficial pharmacological effects and are easily absorbed by the human body. A clinical trial showed higher systemic exposure of ginsenosides, particularly CK and Rh2, after administration of fermented red ginseng compared to regular red ginseng.
Article
Clinical Neurology
Michelle B. Offit, Hadi Mohammad Khanli, Tianxia Wu, Tanya J. Lehky
Summary: Electrical impedance myography (EIM) is a reproducible measure of muscle physiology. This study aimed to obtain EIM data from healthy volunteers (HVs), perform reliability tests on EIM outcome measures, and compare findings with muscle ultrasound variables.
Article
Health Care Sciences & Services
Gonjin Song, Jee-Eun Chung, Jeong Yee, Kyung-Eun Lee, Kyungsoo Park, Hye-Sun Gwak
Summary: The study found that plasma exposure to valsartan is significantly decreased in carriers of SLCO1B1*1B and the rs4149153 T allele of SLCO1B3, possibly due to increased hepatic uptake.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Endocrinology & Metabolism
Zhenlei Wang, Xinghai Li, Ying Jin, Runhan Liu, Xiangjie Di, Yi Zhou, Ying Wang, Lei Fan, Yuanwei Chen, Yongsheng Wang, Li Zheng
Summary: HP501 has shown acceptable safety and tolerability in both healthy volunteers and hyperuricemic patients, and it effectively reduces hyperuricemia. Further development of this drug is warranted.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medical Laboratory Technology
Laura Barisoni, J. Charles Jennette, Robert Colvin, Sheela Sitaraman, Alexander Bragat, Jeff Castelli, Dan Walker, Pol Boudes
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2012)
Meeting Abstract
Endocrinology & Metabolism
Laura Barisoni, Charles Jennette, Robert Colvin, Alexander Bragat, Jeff Castelli, Sheela Sitaraman, Pol Boudes
MOLECULAR GENETICS AND METABOLISM
(2011)
Meeting Abstract
Endocrinology & Metabolism
Kathy Nicholls, Dominique P. Germain, Claudio Feliciani, Suma Shankar, Fatih Ezgu, Salim G. Janmohamed, Shiona M. Laing, Rosemary O. Schroyer, Alex C. Bragat, Sheela Sitaraman, Pol F. Boudes
MOLECULAR GENETICS AND METABOLISM
(2013)
Article
Endocrinology & Metabolism
R. Giugliani, S. Waldek, D. P. Germain, K. Nicholls, D. G. Bichet, J. K. Simosky, A. C. Bragat, J. P. Castelli, E. R. Benjamin, P. F. Boudes
MOLECULAR GENETICS AND METABOLISM
(2013)
Article
Genetics & Heredity
Dominique P. Germain, Roberto Giugliani, Derralynn A. Hughes, Atul Mehta, Kathy Nicholls, Laura Barisoni, Charles J. Jennette, Alexander Bragat, Jeff Castelli, Sheela Sitaraman, David J. Lockhart, Pol F. Boudes
ORPHANET JOURNAL OF RARE DISEASES
(2012)
Article
Pharmacology & Pharmacy
Charles Frost, Andrew Shenker, Stanford Jhee, Zhigang Yu, Jessie Wang, Alexander Bragat, Janice Pursley, Frank LaCreta
CLINICAL PHARMACOLOGY-ADVANCES AND APPLICATIONS
(2018)
Article
Pharmacology & Pharmacy
Franklin K. Johnson, Paul N. Mudd, Alexander Bragat, Mathews Adera, Pol Boudes
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT
(2013)
Meeting Abstract
Peripheral Vascular Disease
O Vesterqvist, W Liao, JA Manning, AC Bragat, CL Delaney, VM Campese
JOURNAL OF HYPERTENSION
(2000)