Article
Endocrinology & Metabolism
Lei Wu, Yan Zhang, Hong Zhao, Guodong Rong, Peijun Huang, Fang Wang, Ting Xu
Summary: This study found that APOE gene polymorphisms are associated with CAD with or without T2DM and have an influence on lipid profiles in both T2DM and CAD patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Wendao Han, Nating Xiong, Renkai Zhong, Zhongyi Pan
Summary: The APOE E2/E3 and E3/E4 genotypes may be risk factors for developing diabetes mellitus in hypertensive patients.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Fei Luo, Mingjie Shi, Junhao Guo, Yisen Cheng, Xusan Xu, Jieqing Zeng, Si Huang, Weijun Huang, Wenfeng Wei, Yajun Wang, Riling Chen, Guoda Ma
Summary: A meta-analysis found no significant association between RETN -420C/G polymorphism and T2DM susceptibility. However, there was high heterogeneity across studies, which may be attributed to variations in age among participants.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Xianqin Yang, Li Ni, Junyu Sun, Xiaolu Yuan, Dezhong Li
Summary: The present meta-analysis revealed a significant association between rs3480 in the FNDC5 gene and susceptibility to T2DM, while rs16835198 does not show such an association.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Li-Mei Li, Bei-Ge Jiang, Liang-Liang Sun
Summary: Diabetes is a highly heterogeneous metabolic disease with different types and clinical manifestations. Distinguishing between types and defining subtypes is a major challenge in precise treatment. T2D is the main type of diabetes, and certain gene variants have been shown to increase the risk of T2D. HNF1 alpha gene mutations can cause different types of diabetes and exhibit high polymorphism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Wei-Wei Chang, Li-Ying Wen, Liu Zhang, Xin Tong, Yue-Long Jin, Gui-Mei Chen
Summary: This study investigated the relationship between the miR-146a rs2910164 polymorphism and the genetic susceptibility of T2DM in the Chinese Han population and conducted a meta-analysis. The results showed that the miR-146a rs2910164 polymorphism was associated with the risk of T2DM in certain age and BMI subgroups, but no significant association was found in the overall meta-analysis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Sherin Bakhashab, Tahani Alsulami, Amani M. T. Gusti, Steve Harakeh, Rajaa Al-Raddadi, Wissam A. Alwazani, Huda F. Alshaibi
Summary: This study identified novel risk alleles and genotypes that contribute to genetic risk for T2DM in the western Saudi population.
Article
Cardiac & Cardiovascular Systems
Yan-Yan Li, Hui Wang, Yang-Yang Zhang
Summary: The meta-analysis showed a significant association between NEUROD1 gene Ala45Thr polymorphism and T2DM, especially in the Asian population, with Thr45 allele carriers being more susceptible to T2DM.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Nutrition & Dietetics
Liana Najjar, Joshua Sutherland, Ang Zhou, Elina Hyppoenen
Summary: A systematic review and meta-analysis were conducted to assess the association between selected variants affecting 25-hydroxyvitamin D concentrations and T1D risk, revealing no significant correlation. Despite some heterogeneity in one of the genetic variants analyzed, overall results did not show any association with T1D susceptibility. Additionally, subgroup analysis for Caucasians also found no association with T1D.
Article
Endocrinology & Metabolism
Xinyuan Zhang, Yao Nie, Zhizhong Gong, Meidong Zhu, Bingjie Qiu, Qiyun Wang
Summary: ApoE, apoC-II/apoC-III, apoE/apoC-II, and apoB/non-HDL-C could be novel biomarkers for the occurrence and severity of DR, while apoA-I and apoA-II are protective factors for DR.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Ha Young Yoon, Min Hye Lee, Yubin Song, Jeong Yee, Gonjin Song, Hye Sun Gwak
Summary: The CC or CT genotype of ABCA1 69C>T polymorphism is associated with an increased risk of type 2 diabetes mellitus, with C allele carriers in the Asian population showing a higher risk compared to those with the TT genotype.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell & Tissue Engineering
Yanju Li, Feiqing Wang, Huiling Liang, Dongxin Tang, Mei Huang, Jianing Zhao, Xu Yang, Yanqing Liu, Liping Shu, Jishi Wang, Zhixu He, Yang Liu
Summary: The meta-analysis included 10 studies with a total of 239 participants, evaluating the efficacy of mesenchymal stem cells (MSCs) therapy in treating diabetes mellitus. The results showed that MSC treatment led to significantly lower HbA1c levels, higher fasting C-peptide levels, and reduced insulin requirement in T1DM patients.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Hao Cheng, Wenbin Zhu, Mou Zhu, Yan Sun, Xiaojie Sun, Di Jia, Chao Yang, Haitao Yu, Chunjing Zhang
Summary: The study found no significant association between the -174G/C polymorphism and T2DM overall, but the association was relatively significant under the dominant model, especially in studies involving subjects of different races. Genotype-phenotype analysis showed that carriers of -174CC and -174CG genotypes had lower circulating IL-6 concentrations compared to -174GG carriers.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Aiyu Shao, Jikang Shi, Zhuoshuai Liang, Lingfeng Pan, Wenfei Zhu, Sainan Liu, Jiayi Xu, Yanbo Guo, Yi Cheng, Yichun Qiao
Summary: This meta-analysis study found that individuals with APOE epsilon 2 genotype may have a protective effect against myocardial infarction, while individuals with APOE epsilon 4 genotype may have an increased risk of myocardial infarction.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Multidisciplinary Sciences
Yan-yan Li, Hui Wang, Yang-yang Zhang
Summary: Through meta-analysis, we found a significant association between MTNR1B gene rs10830963 C/G polymorphism and T2DM in the Chinese population, suggesting that individuals with the G allele might be more susceptible to T2DM.
Article
Energy & Fuels
Paraskevi N. Zaza, Anastasios Sepetis, Pantelis G. Bagos
Summary: This study investigated the energy costs of Greek hospitals and found that different factors have varying contributions to energy costs. By developing two models, the annual energy costs of hospitals can be calculated, helping the Ministry of Health and hospital management in budget planning and environmental improvement.
Review
Genetics & Heredity
Evaggelia Barba, Panagiota I. Kontou, Ioannis Michalopoulos, Pantelis G. Bagos, Georgia G. Braliou
Summary: In this study, a systematic review and meta-analysis were conducted to investigate the genetic association of ITPA polymorphisms with adverse effects in patients treated with AZA/6-MP. The results showed that rs1127354 and rs7270101 were associated with neutropenia and other adverse effects in different populations. Stratification analysis also confirmed the association between neutropenia and these two polymorphisms in ALL patients. These findings suggest that ITPA polymorphisms could serve as predictive biomarkers for adverse effects of thiopurine drugs, providing personalized treatment options for ALL patients.
PHARMACOGENOMICS JOURNAL
(2022)
Article
Genetics & Heredity
Yiannis Goutzelas, Panagiota Kontou, Zissis Mamuris, Pantelis Bagos, Theologia Sarafidou
Summary: This study performed a meta-analysis of gene expression data in adipose tissue to identify differentially expressed genes between obese and non-obese subjects. The results revealed 821 differentially expressed genes and reconstructed a protein-protein interactions network, suggesting their involvement in RNA and energy metabolism pathways.
Article
Environmental Sciences
Anastasios Sepetis, Paraskevi N. Zaza, Fotios Rizos, Pantelis G. Bagos
Summary: The healthcare sector produces a significant amount of waste annually, and it is crucial to have effective waste management systems to protect public health. This study investigated the factors affecting healthcare waste in Greek public hospitals and found that individual-hospital characteristics have an impact on waste generation. The study provides prediction models and suggests specific actions to reduce healthcare waste and associated costs.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Genetics & Heredity
Tzoulia-Maria Tsalazidou-Founta, Evangelia A. Stasi, Maria Samara, Yorgos Mertzanis, Maria Papathanassiou, Pantelis G. Bagos, Spyros Psaroudas, Vasiliki Spyrou, Yorgos Lazarou, Athanasios Tragos, Yannis Tsaknakis, Elpida Grigoriadou, Athanasios Korakis, Maria Satra, Charalambos Billinis
Summary: This study estimated the population size, genetic status, and gene flow of brown bear sub-populations in three National Parks in Greece. The results showed high levels of inbreeding in some sub-populations and a distinct genetic structure in one sub-population. Significant gene flow was also observed between certain sub-populations.
Article
Biology
Ioannis A. Tamposis, Georgios A. Manios, Theodosia Charitou, Konstantina E. Vennou, Panagiota Kontou, Pantelis G. Bagos
Summary: MAGE is an open-source Python package designed for meta-analysis and functional enrichment analysis of gene expression data. It includes various functions for analysis and visualization, and is available as both a standalone version and a webserver.
Article
Genetics & Heredity
Theodosia Charitou, Panagiota Kontou, Ioannis A. Tamposis, Georgios A. Pavlopoulos, Georgia G. Braliou, Pantelis G. Bagos
Summary: This study examines the relationship between drugs, genes, and COVID-19 susceptibility. It suggests that genetic factors may influence the clinical manifestation of COVID-19, especially in patients with comorbidities.
PHARMACOGENOMICS JOURNAL
(2022)
Review
Oncology
Maria Papathanassiou, Ioannis Tamposis, Kalliopi K. K. Exarchou-Kouveli, Panagiota I. I. Kontou, Anna Tzortzi de Paz, Lampros Mitrakas, Maria Samara, Pantelis G. G. Bagos, Vassilios Tzortzis, Panagiotis J. J. Vlachostergios
Summary: The effectiveness or ineffectiveness of immunotherapy after prior use of anti-PD1/PD-L1 or/and anti-CTLA monoclonal antibodies is still largely unknown.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, General & Internal
Georgia V. Kapoula, Konstantina E. Vennou, Pantelis G. Bagos
Summary: This study conducted a systematic review and meta-analysis to assess the association between seasonal influenza vaccination and pneumococcal vaccination with SARS-CoV-2 infection and its clinical outcomes. The results showed that both influenza and pneumococcal vaccination were associated with a lower risk of SARS-CoV-2 infection. However, there was no evidence to support the association between vaccination and harder endpoints such as ICU admission and death.
Article
Education & Educational Research
Zoi Kourti, Christos-Apostolos Michalakopoulos, Pantelis G. G. Bagos, Efrosyni-Alkisti Paraskevopoulou-Kollia
Summary: This study investigates the development of Computational Thinking (CT) skills in preschool age children by assessing their readiness and exploring the perspectives of parents and preschool teachers. The research findings indicate that preschool children show a high level of readiness for CT activities, although parents express concerns. Additionally, the study reveals that the use of personal computers in kindergarten varies among teachers, with their attitudes towards CT introduction being mainly neutral.
EDUCATION SCIENCES
(2023)
Review
Health Care Sciences & Services
Pelagia Soultatou, Stamatis Vardaros, Pantelis G. Bagos
Summary: This article aims to review the evidence generated over the past two decades (2003-2023), identifying the main policy gaps in school health services and health education curricula in Greece and providing a concrete policy plan. The findings suggest that school health services are not school-based but a function of the primary health care system, and health education has a constantly changing position in school curricula. The study also highlights deficiencies in schoolteachers' training, coordination, and leadership. The article provides a set of policy measures towards the reform and integration of school health with health education.
Article
Biochemistry & Molecular Biology
Marina Petsana, Ahmed F. Roumia, Pantelis G. Bagos, Haralabia Boleti, Georgia G. Braliou
Summary: The aim of this study was to retrieve the entire spectrum of Kinetoplastea protein sequences containing the PX module, predict their structures, and identify evolutionary conserved and unique traits. A new Kinetoplastea_PX pHMM was constructed using a combination of protein IDs from two searches. The study identified the unique PX-Pkinase domain architecture in Trypanosoma spp. and suggests the potential use of Kinetoplastea PX-proteins as targets for anti-parasitic drug design.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Maria Papaefthimiou, Panagiota I. Kontou, Pantelis G. Bagos, Georgia G. Braliou
Summary: This study aimed to investigate the effects of stevia leaf extracts or glycosides on oxidative stress markers in diseased rats. The results demonstrated that stevia leaf extracts restored oxidative stress markers to a higher extent compared to pure glycosides. Rats with diabetes mellitus showed the strongest restorative response to stevia leaf extract administration. These findings suggest that stevia leaf extract may have protective effects against various diseases through its antioxidant properties.
Article
Biochemical Research Methods
Evangelos Karatzas, Fotis A. Baltoumas, Eleni Aplakidou, Panagiota Kontou, Panos Stathopoulos, Leonidas Stefanis, Pantelis G. Bagos, Georgios A. Pavlopoulos
Summary: This article introduces Flame (v2.0), a web tool that combines and visualizes results from popular functional enrichment applications. Flame utilizes aGOtool, g: Profiler, WebGestalt, and Enrichr pipelines to present their outputs separately or in combination. It offers interactive plots for intuitive representations and easier interpretation.
Article
Health Care Sciences & Services
Paraskevi N. Zaza, Pantelis G. Bagos
Summary: The funding of public hospitals has been a major concern for health systems in recent decades. This study attempts to estimate the necessary funding for public hospitals based on their characteristics and annual output, regardless of the case mix managed by each hospital. Using data from 121 public hospitals in Greece, the study found that hospital type, number of beds, existence of an intensive care unit, number of employees, total number of inpatients, their days of hospitalization, and total number of laboratory tests are the key factors determining the hospital's operating costs. The significant implication of this model is its potential to serve as a basis for a national system of economic evaluation and resource allocation for public health.
