Article
Genetics & Heredity
Gokul Gopinathan, Xianghong Luan, Thomas G. H. Diekwisch
Summary: The nonmineralized state of the mammalian periodontal ligament is controlled by an epigenetic regulation of the RUNX2 and OSX key mineralization gene promoters.
Article
Multidisciplinary Sciences
Anna J. Korzekwa, Anna Kononiuk, Wladyslaw Kordan, Aleksandra Orzolek
Summary: Metalloproteinases (MMPs) play key roles in various developmental processes and are involved in stem cell biology. This study aimed to investigate the effects of retinoic acid (RA) on MMPs in antler stem cells (ASCs). The results showed that RA increased the expression and output of MMP-3 and TIMP-3 in ASCs, while it had no significant effect on the expression and output of MMP-1 and TIMP-1. The expression profiles of MMPs and TIMPs varied during the differentiation of ASCs into different lineages. These findings provide valuable insights into the physiological and differentiation processes of stem cells.
Article
Ecology
Stefano Mattioli, Francesco Ferretti, Sandro Nicoloso, Luca Corlatti
Summary: Heterogeneity in resource availability and quality can lead to spatial patterns in sexually selected traits, as observed in a nonmigratory population of red deer. The study found significant fine-scale spatial variations in body mass, antler mass, and antler allocation, matching differences in land cover. The results highlight the role of environmental heterogeneity in shaping spatial variations of key life-history traits within populations.
ECOLOGY AND EVOLUTION
(2021)
Article
Biochemistry & Molecular Biology
Lucy Peters, Jisca Huisman, Loeske E. B. Kruuk, Josephine M. Pemberton, Susan E. Johnston
Summary: Sexually selected traits exhibit large variation and rapid evolution in the animal kingdom, yet genetic variation persists within populations despite directional selection. Understanding the genetic architecture of sexually selected traits, such as antler morphology in red deer, can shed light on evolutionary drivers and constraints at the genomic level. The study on red deer antler traits revealed high repeatability, heritability, and polygenic architecture, suggesting that genetic covariances among traits and pleiotropy may contribute to the maintenance of genetic variation in antler morphology.
Review
Orthopedics
Mesalie Feleke, Samuel Bennett, Jiazhi Chen, Xiaoyong Hu, Desmond Williams, Jiake Xu
Summary: The deer antler serves as a unique model for studying organ regeneration in mammals, with potential applications in regenerative medicine and bone remodeling. Understanding the process and defining the antler stem cells could lead to improved clinical outcomes in the field of regenerative medicine.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Article
Orthopedics
Zhenwei Zhou, Tiancheng Wang, Yuyan Jia, Tingting Wang, Enjing Luo, Jinghong Zhong, Jingcheng Zhang, Jianyu Wang, Yuchi Wei, Daqing Zhao, Baojin Yao
Summary: Deer antler extract (DAE) enhances renal function by maintaining renal homeostasis, combating renal fibrosis, and reducing renal inflammation. It also strengthens the bone system by promoting osteoblast differentiation and regulating bone regeneration and the bone marrow microenvironment. DAE promotes bone trabecular formation and increases bone mineral density.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Multidisciplinary Sciences
Yanxia Chen, Zhenxiang Zhang, Jingjing Zhang, Xiaxia Chen, Yuqin Guo, Changzhong Li
Summary: Through RNA sequencing analysis, we identified miRNAs that play important roles in the development of velvet antler in C. elaphus kansuensis. These findings provide new insights into the regulatory mechanisms mediated by miRNAs.
Article
Zoology
Peter Smolko, Peter Garaj, Tibor Lebocky, L'ubomir Butora, Tibor Pataky, Zuzana Janakova, Martin Babic, Alexandra Veselovska, Jakub Kubala, Rudolf Kropil
Summary: The size of antlers in polygynous male cervids is influenced by genetic potential, nutrition, and environmental conditions. This study found that the availability of calcium, phosphorus, and nitrogen in soils is related to the hunting value of antlers, while deer density has a negative impact on antler size.
Article
Food Science & Technology
Wang Pan, Juan Du, Liping An, Guangyu Xu, Guangxin Yuan, Yu Sheng, Jingbo Sun, Manli Wang, Nanxi Zhao, Xiao Guo, Hongyu Li, Xiao Han
Summary: This study aimed to investigate the effect of velvet antler extract (VAE) on the prevention of osteoporosis and the modulation of gut microbiota in ovariectomized (OVX) mice. Results showed that VAE increased serum markers of bone metabolism, improved bone structure, and modulated gut microbiota in OVX mice. These findings suggest that VAE has therapeutic potential for the treatment of osteoporosis.
FOOD SCIENCE & NUTRITION
(2023)
Article
Agriculture, Dairy & Animal Science
Yanxia Chen, Zhenxiang Zhang, Wenjie Jin, Zhaonan Li, Changhong Bao, Caixia He, Yuqin Guo, Changzhong Li
Summary: This study conducted an integrated analysis of the transcriptome and proteome of antler cartilage tissues at different growth stages, revealing candidate genes and proteins related to rapid growth and regeneration in velvet antler. The findings suggest that gene13546 and its coding protein protein13546 annotated in the Wnt signaling pathway may play important roles in the rapid growth of antler. This study provides further insights into the molecular mechanisms controlling antler development.
Article
Zoology
Jose Angel Gomez, Javier Perez-Barberia, Andres Jose Garcia, Jamil Cappelli, Louis Chonco, Francisco Ceacero, Martina Perez-Serrano, Tomas Landete-Castillejos
Summary: Body weight, age, and antler weight have effects on the casting date and growth period of antlers. Heavier and older males cast their antlers earlier and grow them faster. The date of the end of antler growth also influences casting date, with longer growth period leading to later casting.
JOURNAL OF MAMMALOGY
(2022)
Article
Medicine, General & Internal
Ying-Kai Hung, Shang-Tse Ho, Ching-Yun Kuo, Ming-Ju Chen
Summary: The study demonstrated that velvet antler extracts could enhance the integrity of colonic epithelial cell barriers and promote repair through specific mechanisms. Future animal studies are needed for further confirmation.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Genetics & Heredity
Zhenxiang Zhang, Caixia He, Changhong Bao, Zhaonan Li, Wenjie Jin, Changzhong Li, Yanxia Chen
Summary: A variety of cell growth factors regulate antler growth, which involves the rapid proliferation and differentiation of tissue cells. The unique development process of deer antlers has potential value in biomedical research, particularly in studying cartilage tissue development and repair. The molecular mechanisms underlying rapid antler growth are still not well understood. In this study, high-throughput sequencing was used to analyze miRNA expression patterns in antler growth centers at different stages. Differentially expressed miRNAs were identified, and their target genes were annotated. The results revealed that certain miRNAs, especially ppy-miR-1, mmu-miR-200b-3p, and novel miR-94, may play crucial roles in the rapid growth of antlers.
Article
Zoology
M. Franchini, T. Peric, L. Frangini, A. Prandi, A. Comin, M. Rota, S. Filacorda
Summary: Hair cortisol is a suitable parameter to measure the physiological chronic stress response in roe deer. The cortisol concentrations in roe deer are higher in response to increased red deer density, indicating direct interspecific competition. Habitat suitability, however, does not significantly affect cortisol levels in roe deer.
JOURNAL OF ZOOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Zhenxiang Zhang, Zhaonan Li, Changhong Bao, Caixia He, Wenjie Jin, Changzhong Li, Xiaoan Li, Yanxia Chen
Summary: This study compared the differences in metabolite composition and abundance in antler bases between red deer and sika deer from a metabolomics perspective. The results showed that there was no significant difference in endogenous metabolites between the antler bases of different deer species, indicating that they may have similar medicinal value.
ANIMAL PRODUCTION SCIENCE
(2023)
Article
Oncology
Barbara Kocsis-Deak, Kristof Arvai, Bernadett Balla, Balint Tobias, Andrea Kohanka, Balazs Jaray, Janos Horanyi, Janos Podani, Istvan Takacs, Zsuzsanna Putz, Janos Kosa, Peter Lakatos
PATHOLOGY & ONCOLOGY RESEARCH
(2020)
Article
Multidisciplinary Sciences
Mihaly Kondrak, Andrea Kopp, Csilla Uri, Anita Sos-Hegedus, Edina Csakvari, Matyas Schiller, Endre Barta, Istvan Cernak, Zsolt Polgar, Janos Taller, Zsofia Banfalvi
Article
Plant Sciences
Tamas Pocs, Gaik Ee Lee, Janos Podani, Elizabeth Pesiu, Judit Havasi, Hung Yung Tang, Andi Maryani A. Mustapeng, Monica Suleiman
Article
Biodiversity Conservation
Denes Schmera, Janos Podani, Pierre Legendre
ECOLOGICAL INDICATORS
(2020)
Article
Food Science & Technology
Daniel Szemethy, Bendeguz Mihalik, Krisztian Frank, Tibor Nagy, Dora ujvary, Szilvia Kusza, Laszlo Szemethy, Endre Barta, Viktor Steger
Summary: Quality control plays a crucial role in maintaining customer confidence in the food supply chain, with strict regulations on food safety in the EU but often undefined composition requirements and standard control methods. The increasing wild boar population is becoming a larger part of venison or game meat production. Research aimed to develop a rapid, reliable PCR-based genetic tool for species identification in food quality control labs, using InDel markers specifically for wild boar detection.
FOOD ANALYTICAL METHODS
(2021)
Article
Ecology
Janos Podani, Tibor Kalapos, Barbara Barta, Denes Schmera
Summary: In biological data analysis, common solutions to missing data include deleting data, data imputation, and restricting analysis. This study introduces a modified PCA method called InDaPCA, which avoids artificial data imputation and has shown biologically meaningful results in applications.
ECOLOGICAL INFORMATICS
(2021)
Article
Multidisciplinary Sciences
Krisztian Frank, Nora a. Bana, Norbert Bleier, Laszlo Sugar, Janos Nagy, Julia Wilhelm, Zsofia Kalman, Endre Barta, Laszlo Orosz, Peter Horn, Viktor Steger
Article
Plant Sciences
Balint Czuppon, Janos Podani
Summary: This study analyzed sister groups at the root of large plant clades and found asymmetry in species richness, as well as some striking phenomena in the distribution of species within the clades.
Article
Biochemistry & Molecular Biology
Zsuzsanna Szucs, Eva Pinti, Iren Haltrich, Orsolya Palne Szen, Tibor Nagy, Endre Barta, Gabor Mehes, Laszlo Bidiga, Olga Torok, Aniko Ujfalusi, Katalin Koczok, Istvan Balogh
Summary: Duchenne muscular dystrophy (DMD) is the most common inherited muscle dystrophy, typically affecting males. This study presents an ultra-rare manifestation of DMD in a female patient.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Miklos Laczik, Edina Erdos, Lilla Ozgyin, Zsuzsanna Hevessy, Eva Csosz, Gergo Kallo, Tibor Nagy, Endre Barta, Szilard Poliska, Istvan Szatmari, Balint Laszlo Balint
Summary: Isogenic B-lymphoblastoid cell lines (LCLs) are widely used for studying mutations due to their genetic stability. However, we have found that these cell lines exhibit phenotypic variability accompanied by genetic variation. In this study, we provide comprehensive datasets using next generation sequencing techniques to analyze the genomic, transcriptomic, protein-DNA interaction, and proteomic changes in LCLs. These datasets are shared with the scientific community for further investigations following the FAIR principles.
Article
Multidisciplinary Sciences
Monika Gonczi, Joao M. C. Teixeira, Susana Barrera-Vilarmau, Laura Mediani, Francesco Antoniani, Tamas Milan Nagy, Krisztina Feher, Zsolt Raduly, Viktor Ambrus, Jozsef Tozser, Endre Barta, Katalin E. Kover, Laszlo Csernoch, Serena Carra, Monika Fuxreiter
Summary: The context-dependent higher-order assembly of Mef2D controls muscle lineage development by simultaneously interacting with the basal machinery and myogenic factors. The study found that the alternatively spliced acidic beta-domain enhances the transcription of Mef2D. The beta-domain can serve as an interaction element for higher-order assembly, forming nuclear condensates and solid-like aggregates. These findings suggest that the beta-domain fine-tunes Mef2D assembly and provides a platform for myogenic regulatory factors and transcriptional apparatus during muscle development.
NATURE COMMUNICATIONS
(2023)
Article
Ecology
Janos Podani, Denes Schmera, Simonetta Bagella
Summary: Ecological variables can be measured on different scales, but existing methods cannot calculate correlations between all pairwise combinations of these variables, limiting the application of standard multivariate techniques.
METHODS IN ECOLOGY AND EVOLUTION
(2023)
Article
Ecology
Carlo Ricotta, Janos Podani, Denes Schmera, Giovanni Bacaro, Simona Maccherini, Sandrine Pavoine
Summary: In this study, an additive diversity decomposition method is proposed to partition the diversity structure of a given community into three components: functional diversity, functional redundancy, and species dominance. These components can be used to portray the community structure in a ternary diagram. The value of this diversity decomposition is demonstrated through the analysis of actual abundance data on plant assemblages in grazed and ungrazed grasslands in Tuscany, Italy.
METHODS IN ECOLOGY AND EVOLUTION
(2023)
Article
Medicine, Research & Experimental
Gergely Imre, Bertalan Takacs, Erik Czipa, Andrea Bakne Drubi, Gabor Jaksa, Dora Latinovics, Andrea Nagy, Reka Karkas, Liza Hudoba, Balint Mark Vasarhelyi, Gabriella Pankotai-Bodo, Andras Blastyak, Zoltan Hegedus, Peter German, Balazs Balint, Khaldoon Sadiq Ahmed Abdullah, Anna Georgina Kopasz, Anita Kovacs, Laszlo G. Nagy, Farkas Sukosd, Lajos Pinter, Thomas Rulicke, Endre Barta, Istvan Nagy, Lajos Haracska, Lajos Mates
Summary: DNA transposon-based gene delivery vectors are a promising new branch of gene therapy. By comparing piggyBac and Sleeping Beauty systems, the two transposons currently used in clinical trials, we treated a mouse model of tyrosinemia type I with liver-targeted gene delivery using both vectors. Using a new sequencing method, we identified approximately one million transposon insertion sites and found that piggyBac integrations are mainly clustered in hot regions, while Sleeping Beauty integrations are closer to random distribution.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2023)
Review
Plant Sciences
Janos Podani
ACTA SOCIETATIS BOTANICORUM POLONIAE
(2020)