Journal
MOLECULAR GENETICS AND GENOMICS
Volume 282, Issue 5, Pages 453-462Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00438-009-0477-z
Keywords
ZIP1; Homologous recombination; Recombination hotspot; Chromosome segregation; Non-disjunction; YAC DNA
Funding
- Israel Science Foundation (ISF)
- US-Israel Binational Science Foundation
- Austrian science foundation [F3405, I031-B]
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Synapsis of homologs during meiotic prophase I is associated with a protein complex built along the bivalents-the synaptonemal complex (SC). Mutations in the SC-component gene ZIP1 diminish SC formation, leading to reduced recombination levels and low spore viability. Here we show that in SK1 strains heterozygous for a deletion of ZIP1 in certain regions meiotic interference are impaired with no decrease in recombination levels. The extent of synapsis is over all reduced and NDJ levels of a large endogenous chromosome and of artificial chromosomes (YACs) rise to twice the level of wild type strains. A substantial proportion of mis-segregating YACs had undergone crossing over. This demonstrates that different functions of Zip1 display differential sensitivities to changes in expression levels.
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