Article
Biochemistry & Molecular Biology
Mengnan Ma, Huiming Wang, Yi Zhang, Jinbi Zhang, Jingge Liu, Zengxiang Pan
Summary: The study identified that ssc-circINHA-001 plays a role in resisting GC apoptosis by enhancing INHBA expression through adsorbing miR-214-5p, miR-7144-3p, and miR-9830-5p. Low expression of ssc-circINHA-001 increases free miRNAs, inhibits INHBA expression, and leads to GC apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yong Wang, Yunxia Guo, Chunhui Duan, Junjie Li, Shoukun Ji, Huihui Yan, Yueqin Liu, Yingjie Zhang
Summary: In this study, a new lncRNA (lncGSAR) was identified and its effects on proliferation and steroid hormone secretion in ovine granulosa cells (GCs) were investigated. The results showed that lncGSAR can activate the SCAP/SREBP signaling pathway by sponging miR-125b to regulate steroid hormone secretion in GCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Zhifu Cui, Xiaoxu Shen, Xianxian Zhang, Fugui Li, Felix Kwame Amevor, Qing Zhu, Yan Wang, Diyan Li, Gang Shu, Yaofu Tian, Xiaoling Zhao
Summary: The study investigated the role of the INHA gene in egg production in chickens, finding that polymorphism in the 3' UTR of the gene can influence miRNA binding efficiency and subsequently affect gene function.
CELL AND TISSUE RESEARCH
(2021)
Article
Oncology
Peter Svajdler, Peter Vasovcak, Marian Svajdler, Monika Sedivcova, Veronika Urban, Michal Michal, Roman Mezencev
Summary: This study identified a specific germline mutation in the CHEK2 gene that is associated with an increased risk of developing adult-type granulosa cell tumors. Female carriers of this mutation were found to have a significantly higher proportion of ovarian adult-type granulosa cell tumors compared to the general population. These findings suggest potential avenues for the development of targeted interventions for this type of tumor.
Article
Biochemistry & Molecular Biology
Chirukandath Sidhanth, Sadhanandhan Bindhya, Aboo Shabna, Shyama Krishnapriya, Pacharla Manasa, Rohit Pravin Nagare, Thanda Joshua, Smarkan Sneha, Kanchan Murhekar, Trivadi Sundaram Ganesan
Summary: The interaction between LASP-1 and ErbB2 may play an important role in the pathogenesis of ovarian cancer, with their binding and phosphorylation being independent of the kinase activity of ErbB2.
BIOCHEMICAL JOURNAL
(2022)
Article
Obstetrics & Gynecology
Haiyan Liang, Dongkui Xu, Xianhong Tong, Bin Ling, Wenhui Wang, Dingqing Feng, Jing Liang
Summary: The study investigates the dose- and time-dependent interactions between TNF-alpha and human granulosa cells. The results reveal a biphasic effect of TNF-alpha on ovarian endocrine and follicular development.
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Abdul Rehman, Ejaz Ahmad, Usman Arshad, Amjad Riaz, Muhammad Saleem Akhtar, Tanveer Ahmad, Jawaria Ali Khan, Imran Mohsin, Zhendan Shi, Abdul Sattar
Summary: The study aimed to determine the dose-dependent effects of active immunization against inhibin alpha-subunit on ovarian dynamics and reproductive performance in Beetal goats during the non-breeding season. Results showed that the small dose (G-AIINHA-0.5) group had greater follicle size and post-breeding P-4 concentrations compared to the control group (G-CON-0), indicating improved reproductive performance. Recommended dose for enhancing reproductive performance during the non-breeding season was determined to be G-AIINHA-0.5.
ANIMAL REPRODUCTION SCIENCE
(2021)
Article
Oncology
Shinya Kusumoto, Masako Kurashige, Kenji Ohshima, Shinichiro Tahara, Takahiro Matsui, Satoshi Nojima, Satoshi Hattori, Eiichi Morii
Summary: The study found that inhibin-alpha expressing OCCC tumor cells in ovarian tumors exhibit distinct features, including lower proliferation, immaturity, and acceleration of malignant progression.
Article
Multidisciplinary Sciences
Yongkang Yang, Haiquan Lu, Chelsey Chen, Yajing Lyu, Robert N. Cole, Gregg L. Semenza
Summary: Hypoxia-inducible factor-1 (HIF-1) recruits TRIM28 and DNA-dependent protein kinase (DNA-PK) to release paused RNA polymerase II (Pol II), stimulating gene transcriptional elongation. The study reveals the molecular mechanism of HIF-1 in gene transcription and suggests the potential anticancer effects of drugs targeting DNA-PK in breast cancer.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Hamed Alhusaini, Mahmoud A. Elshenawy, Ahmed Badran, Ayman Elshentenawy, Ahmed Mohieldin, Ahmed Mostafa Gad, Ayman Omar, Amgad Shaheen, Tusneem Elhassan, Hussein Soudy
Summary: This study reports the clinical characteristics and long-term outcomes of adult-type ovarian granulosa cell tumour (AOGCT), and identifies the factors affecting relapse and survival. The presence of ascites and elevated preoperative CA 125 levels were associated with a higher risk of recurrence and poor prognosis.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Lu Deng, Jiaoqin Wang
Summary: The purpose of this study was to investigate the function and interaction of Hsc70 and KCNA5 in PCOS. The results showed that Hsc70 expression was upregulated in PCOS and overexpression of Hsc70 promoted granulosa cell proliferation while inhibiting apoptosis. KCNA5 expression was downregulated in PCOS and knockdown of KCNA5 promoted cell proliferation. Hsc70 promotes granulosa cell proliferation by interacting with KCNA5.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Biology
Maryam Damavandi, Parisa Farrokh, Saeed Zavareh
Summary: The study found that ovarian vitrification has adverse effects on follicle growth and the epigenetics of granulosa cells. Improvement is needed for vitrification methods in the future.
Article
Agriculture, Dairy & Animal Science
S. -Q. Zhao, Y. Gao, Y. Zhang, X. -P. Yang, Z. Yang
Summary: The study revealed a correlation between melatonin and biological clock genes in cultured Bactrian camel ovarian granulosa cells, with the expression of clock genes being regulated by melatonin. The findings suggest that the rhythmic regulation of ovarian granulosa cells is consistent with the central circadian clock.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2021)
Article
Pediatrics
Senay Kurtulus, Bulent Demir, Nilufer Aylanc
Summary: Juvenile granulosa cell tumor (JGCT) is a rare malignancy of childhood, accounting for 5% of granulosa cell tumors. It often presents with isosexual precocious puberty or abdominal mass complaints. Treatment includes surgical resection and chemotherapy.
JOURNAL OF PEDIATRIC SURGERY CASE REPORTS
(2022)