Review
Medicine, Research & Experimental
Zhuo Li, Jia Li, Xiao Miao, Wenpeng Cui, Lining Miao, Lu Cai
Summary: AMP-activated protein kinase (AMPK) plays a crucial role in obesity-related renal injury, exerting renal protection by modulating lipid metabolism, autophagy, oxidative stress, and other pathways. Further investigation is needed to explore the mechanisms of AMPK in renal diseases.
Article
Cardiac & Cardiovascular Systems
Tanja Charlotte Frederiksen, Morten Krogh Christiansen, Emelia J. Benjamin, Kim Overvad, Anja Olsen, Christina Catherine Dahm, Henrik Kjaerulf Jensen
Summary: This study examined the association between 5-year weight changes and the risk of incident atrial fibrillation. It found that weight gain over 5 years was significantly associated with a higher risk of atrial fibrillation, while weight loss was not significantly associated with the risk of atrial fibrillation.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Christina A. Fleming, Emer P. O'Connell, Richard G. Kavanagh, Donal P. O'Leary, Maria Twomey, Mark A. Corrigan, Jiang H. Wang, Michael M. Maher, Owen J. O'Connor, Henry P. Redmond
Summary: The study reveals a correlation between body composition and prognosis in colon cancer patients, with low skeletal muscle area and high visceral fat ratio leading to poor outcomes. Changes in the expression of related inflammatory factors may influence the survival rates of colon cancer patients.
Article
Oncology
Katherine K. Clifton, Cynthia X. Ma, Luigi Fontana, Lindsay L. Peterson
Summary: Intermittent fasting (IF) has gained popularity as a potential anticarcinogenic strategy, but its effects on cancer patients remain unclear without high-quality randomized clinical trials. More research is needed to determine the risks and benefits of IF for cancer patients before it can be recommended outside of clinical trials.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Article
Environmental Sciences
Emily Hager, Jiangang Chen, Ling Zhao
Summary: There is growing recognition that environmental exposure to endocrine-disruptive chemicals (EDCs), such as parabens, contributes to the development of breast cancer. Although evidence linking paraben exposure and breast cancer is limited, current findings suggest that parabens may interfere with endocrine and intracrine targets relevant to breast carcinogenesis. Further research is needed to investigate the effects of paraben mixtures and their interaction with other EDCs and signaling pathways in the context of breast cancer development.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Energy & Fuels
Pino Sabia, Giancarlo Sorrentino, Giovanni B. Ariemma, Maria Manna, Raffaele Ragucci, Mara de Joannon
Summary: Despite the rapid growth of renewable energy sources, advanced combustion processes continue to play an irreplaceable role in the energy market. The coupling of appropriate combustion technology with locally available biofuels offers an effective solution to the decarbonization challenge.
Article
Public, Environmental & Occupational Health
D. Liu, J. Yang, S. Wang
Summary: The study found that early-life exposure to famine decreased the risk of overweight and abdominal obesity in adulthood, while exposure to famine during any childhood period reduced the risk of abdominal obesity. Exposure to famine in mid-childhood also decreased the risk of general obesity in both males and females.
Review
Oncology
Junge Bai, Ming Yang, Zheng Liu, Sergey Efetov, Cuneyt Kayaalp, Audrius Dulskas, Darcy Shaw, Xishan Wang
Summary: Colorectal cancer is a major cause of cancer-related death globally, with distant metastatic lesions, primarily in the liver, being found in 20% of patients. Collaboration between interventional radiologists, medical oncologists, and surgeons is crucial for optimal treatment. The effectiveness of primary tumor resection (PTR) in improving overall survival and quality of life is still controversial. This minireview focuses on the treatment options for hepatic colorectal metastatic illness, specifically discussing the advancements and risks of PTR in stage IV CRC patients.
FRONTIERS IN ONCOLOGY
(2023)
Review
Gastroenterology & Hepatology
Pak Kin Wong, In Neng Chan, Hao-Ming Yan, Shan Gao, Chi Hong Wong, Tao Yan, Liang Yao, Ying Hu, Zhong-Ren Wang, Hon Ho Yu
Summary: This study focuses on the application of deep learning technology in radiomics for gastrointestinal cancers, providing comprehensive analysis of challenges and recommendations to advance DLR.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Biology
Andrea M. Guida, Bruno Sensi, Vincenzo Formica, Rolando M. D'Angelillo, Mario Roselli, Giovanna Del Vecchio Blanco, Piero Rossi, Gabriella T. Capolupo, Marco Caricato, Giuseppe S. Sica
Summary: Colorectal carcinoma is the second leading cause of cancer-related deaths, with rectal cancer accounting for approximately one third of new patients. The standard treatment for rectal cancer involves a multimodality approach focusing on local disease control. Total Neoadjuvant Therapy is an emerging strategy to reduce distant metastases and enhance local control, with ongoing studies evaluating its impact on oncological outcomes.
Article
Endocrinology & Metabolism
Eun Ran Kim, Ji Ho Yun, Hyo-Jin Kim, Hyeon Young Park, Yoonseok Heo, Young Suk Park, Do Joong Park, Soo Kyung Koo
Summary: This study investigated the differences in serum hormone and inflammatory cytokine levels before and after surgery in Korean patients with obesity. The results showed that weight loss after surgery led to improvements in clinical parameters and reductions in inflammatory cytokines and hormones. These findings help us understand the mechanism of how bariatric surgery improves glucose metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Diana L. Palacios Ovalle, Susana Rodrigo-Cano, Aranzazu Gonzalez, Carla Soler, Ana I. Catala-Gregori, J. Francisco Merino-Torres, Jose M. Soriano
Summary: This study looked at the relationship between obesity and COVID-19 during the first year of the pandemic, finding that severe COVID-19 patients had higher average BMI values. A new term, COVID obesity, was proposed to define the importance of this anthropometric parameter in relation to the pandemic.
Article
Oncology
Fiona O'Connell, Jacintha O'Sullivan
Summary: Obesity has a significant impact on cancer development, progression, and treatment. It can reduce the efficacy of some treatments but also protect against treatment toxicities, leading to the obesity paradox. The obese tumor microenvironment influences treatment response through various factors, but the specific mechanisms and biological effects are still largely unknown.
Review
Biochemistry & Molecular Biology
Mariella Rosalia, Enrica Chiesa, Erika Maria Tottoli, Rossella Dorati, Ida Genta, Bice Conti, Silvia Pisani
Summary: Antimicrobial resistance, especially in Gram-negative bacteria, poses a significant challenge for antibiotic therapy. Repurposing Tobramycin into nanosized delivery systems has shown promising potential in overcoming AMR. Tobramycin's broad spectrum and fast bactericidal effect make it an attractive candidate for nanomedicine formulation despite its side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Elisabetta Trevellin, Silvia Bettini, Anna Pilatone, Roberto Vettor, Gabriella Milan
Summary: Epidemiological observations, experimental studies and clinical data suggest that obesity is associated with an increased risk of developing various types of cancer. The adipose tissue alterations occurring in obesity could play a significant role in this association. The obesity-altered adipose tissue environment contributes to cancer development, progression, metastasis and chemoresistance through direct and indirect interactions involving different cellular types and molecular mechanisms.
