Article
Cell Biology
Xiaoqing Wan, Jiaxin Hou, Shurong Liu, Yanli Zhang, Wenqing Li, Yanru Zhang, Yi Ding
Summary: Resistance to anthracyclines, such as doxorubicin, is commonly observed in ER alpha-positive breast cancer patients. EMT plays a role in chemotherapy-induced drug resistance, with ER alpha-positive cells showing lower sensitivity to doxorubicin compared to ER alpha-negative cells. The regulation of E-cadherin expression in response to doxorubicin treatment varies depending on ER alpha status, with potential implications for treatment strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Sihai Lu, Yaju Tang, Ru Yao, Rui Xu, Hui Zhang, Jie Liu, Yan Gao, Qiang Wei, Xiaoe Zhao, Jianpeng Liu, Bin Han, Meng-Hao Pan, Baohua Ma
Summary: This study suggests that FSH mediates meiotic arrest of oocytes in goat follicles through the promotion of 17-beta-estradiol synthesis and the expression of ER beta. Additionally, the E-2/ER signaling pathway prevents meiotic recovery of oocytes by inhibiting NPR2 expression and cGMP synthesis.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Neurosciences
Alev Selek, Zehra Seda Unal Halbutogullari, Cigdem Inci Aydemir, Berrin Cetinarslan, Zeynep Canturk, Ilhan Tarkun, Gulay Erman, Cansu Subasi, Karaoz Erdal
Summary: This study investigates the potential of using an aromatase inhibitor as a substitute for testosterone in treating prolactinomas. The findings reveal that the aromatase inhibitor can inhibit cell proliferation and induce apoptosis in prolactinoma cells, as well as reduce prolactin and estrogen levels.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Candice B. Herber, Chaoshen Yuan, Anthony Chang, Jen-Chywan Wang, Isaac Cohen, Dale C. Leitman
Summary: This study suggests that 2',3',4'-THC may act as a new class of ERα modulators that are not direct agonists or antagonists. By altering the activity of ERα on gene regulation and cell proliferation, 2',3',4'-THC has a reprogramming effect, unlike antagonists that compete with E2 for binding to ERα. Adding a reprogramming drug to MHT may offer a new strategy to overcome the adverse proliferative effects of estrogen in MHT.
MOLECULAR MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Lena Steppe, Benjamin Thilo Krueger, Miriam Eva Angelica Tschaffon, Verena Fischer, Jan Tuckermann, Anita Ignatius, Melanie Haffner-Luntzer
Summary: Biomechanical stimulation by whole-body low-magnitude high-frequency vibration has shown to have anabolic effects on bone metabolism. Specifically, osteoblast lineage-specific ER alpha plays a critical role in LMHFV-induced effects on fracture healing, with WNT and Cox2/PGE(2) signaling pathways involved in the mechanotransduction process.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Oncology
Jianling Xie, Eric P. Kusnadi, Luc Furic, Luke A. Selth
Summary: Estrogen and androgen receptors are key drivers in breast and prostate cancer, regulating mRNA translation to influence cellular protein production and enhance cancer cell growth. Targeting mRNA translation could be a potential strategy for treating breast and prostate cancer.
Review
Biochemistry & Molecular Biology
Kenta Yoh, Kazuhiro Ikeda, Kuniko Horie, Satoshi Inoue
Summary: Estrogen is an essential hormone that primarily functions in the female reproductive system and has pleiotropic effects in various tissues and organs. Low estrogen levels, such as in postmenopausal women, can lead to disorders like cardiovascular disease, dementia, metabolic syndrome, osteoporosis, sarcopenia, and frailty. Estrogen receptors (ERs) and estrogen-related receptors (ERRs) play crucial roles in muscle physiology, including muscle mass maintenance, exercise physiology, and regeneration, particularly in relation to mitochondrial function and metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Diana Kata, Ilona Grof, Zsofia Hoyk, Eszter Ducza, Maria A. Deli, Istvan Zupko, Imre Foldesi
Summary: In this study, a complex fluorescent immunocytochemical analysis revealed the colocalization of aromatase with the nuclear stain in GFAP-positive astrocytes in cell cultures and adult rat brain, suggesting a unique mechanism in astrocytes that may regulate certain CNS functions via estradiol production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Maki Fukami, Tsutomu Ogata
Summary: Estrogens play important roles in pubertal development, reproductive function, bone turnover, and metabolic conditions. Mutations in genes related to estrogen synthesis and action can lead to congenital disorders. Clinical studies on these disorders provide insights into the functions of estrogens in the human body.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Anastasia Psarra, Maria A. Theodoropoulou, Martin Erhardt, Marina Mertiri, Christiana Mantzourani, Sofia Vasilakaki, Victoria Magrioti, Andrea Huwiler, George Kokotos
Summary: This study synthesized various alpha-ketoheterocycles and identified one alpha-ketobenzothiazole and one alpha-ketobenzoxazole that can suppress the generation of PGE(2) at a nanomolar level in stimulated mesangial cells.
Article
Endocrinology & Metabolism
Aylin Del Moral-Morales, Juan Carlos Gonzalez-Orozco, Ana Maria Hernandez-Vega, Karina Hernandez-Ortega, Karla Mariana Pena-Gutierrez, Ignacio Camacho-Arroyo
Summary: A study found that in human Glioblastomas (GBM), the pro-oncogenic actions of 17 beta-estradiol (E2) are mediated by EZH2, which promotes proliferation, migration, and invasion of GBM cells. Although E2 does not modify EZH2 expression, gene silencing and pharmacological inhibition of EZH2 can block these pro-oncogenic actions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Medicinal
Lilan Xin, Jian Min, Hebing Hu, Yuanyuan Li, Chuanqian Du, Baohua Xie, Yan Cheng, Xiaofei Deng, Xiangping Deng, Kang Shen, Jian Huang, Chun -Chi Chen, Rey-Ting Guo, Chune Dong, Hai -Bing Zhou
Summary: In this study, a novel class of dual-targeting selective estrogen receptor degraders (SERDs) based on a three-dimensional oxabicycloheptene sulfonamide (OBHSA) scaffold equipped with aromatase inhibitor (AI) activity were identified. These compounds showed excellent ERa degradation activity, ARO inhibitory activity, and antiproliferative activity against drug-resistant breast cancer cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Lisa Z. Fang, Victoria Linehan, Maria Licursi, Christian O. Alberto, Jacob L. Power, Matthew P. Parsons, Michiru Hirasawa
Summary: Hypothalamic inflammation can exacerbate obesity and fatty liver by stimulating appetite-promoting neurons.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Philipp Wartenberg, Imre Farkas, Veronika Csillag, William H. Colledge, Erik Hrabovszky, Ulrich Boehm
Summary: Sex steroid hormones act on hypothalamic kisspeptin neurons to regulate reproductive neural circuits in the brain, with a network of aromatase neurons identified in the hypothalamus and amygdala. By birth, this network becomes sexually dimorphic, with aromatase neurons in the arcuate nucleus converting testosterone to estrogen to regulate kisspeptin neuron activity. The study highlights a novel mechanism whereby aromatase neurons regulate the activity of distinct neuronal populations expressing estrogen receptors.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Na-Lee Ka, Ga Young Lim, Seung-Su Kim, Sewon Hwang, Juhyeong Han, Yun-Hee Lee, Mi-Ock Lee
Summary: This study revealed a novel function of type I interferons in inducing aromatase expression in adipose tissues surrounding breast cancer, which potentiates the growth of estrogen receptor-positive breast cancer. The findings provide insights into the crosstalk between type I interferons and estrogen signaling in the progression of ER-positive BC.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ke Zhu, Jianxun Yi, Yajuan Xiao, Yumei Lai, Pingping Song, Wei Zheng, Hongli Jiao, Jie Fan, Chuanyue Wu, Di Chen, Jingsong Zhou, Guozhi Xiao
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Multidisciplinary Sciences
Chuanyue Wu, Hongli Jiao, Yumei Lai, Wei Zheng, Ka Chen, Hong Qu, Weimin Deng, Pingping Song, Ke Zhu, Huiling Cao, Deborah L. Galson, Jie Fan, Hee-Jeong Im, Yujie Liu, Ju Chen, Di Chen, Guozhi Xiao
NATURE COMMUNICATIONS
(2015)
Review
Endocrinology & Metabolism
Hongli Jiao, E. Xiao, Dana T. Graves
CURRENT OSTEOPOROSIS REPORTS
(2015)
Article
Genetics & Heredity
Shibing Yu, Rohit Sharma, Daibang Nie, Hongli Jiao, Hee-Jeong Im, Yumei Lai, Zhongfang Zhao, Ke Zhu, Jie Fan, Di Chen, Qingde Wang, Guozhi Xiao
Article
Biochemistry & Molecular Biology
Lu Zheng, Ke Zhu, Hongli Jiao, Zhongfang Zhao, Lixiao Zhang, Mo Liu, Weimin Deng, Di Chen, Zhi Yao, Guozhi Xiao
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2013)
Article
Biochemistry & Molecular Biology
Wanjin Tang, Fan Yang, Yang Li, Benoit de Crombrugghe, Hongli Jiao, Guozhi Xiao, Chi Zhang
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Guozhi Xiao, Hongqiang Cheng, Huiling Cao, Ka Chen, Yizeng Tu, Shibing Yu, Hongli Jiao, Shengyong Yang, Hee-Jeong Im, Di Chen, Ju Chen, Chuanyue Wu
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Endocrinology & Metabolism
Ke Zhu, Hongli Jiao, Shuai Li, Huiling Cao, Deborah L. Galson, Zhongfang Zhao, Xi Zhao, Yumei Lai, Jie Fan, Hee-Jeong Im, Di Chen, Guozhi Xiao
JOURNAL OF BONE AND MINERAL RESEARCH
(2013)
Article
Cell & Tissue Engineering
Hongli Jiao, Brian E. Walczak, Ming-Song Lee, Madeleine E. Lemieux, Wan-Ju Li
Summary: Cellular reprogramming can reverse aging of cells by altering the activities of regulatory networks associated with inflammation and proliferation. The expression of GATA6 in reprogrammed cells is attenuated, leading to an increase in sonic hedgehog signaling and FOXP1 expression, which ameliorates cellular hallmarks of aging. GATA6 is identified as a critical regulator of aging-related activities in MSCs, controlling the downstream pathways to modulate cellular senescence.
Article
Immunology
Shu Li, Hongli Jiao, Xu Yu, Amie J. Strong, Yiming Shao, Yongtao Sun, Marcus Altfeld, Yichen Lu
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2007)
Article
Chemistry, Medicinal
LJ Chen, XQ Yang, HL Jiao, BL Zhao
CHEMICAL RESEARCH IN TOXICOLOGY
(2004)
Article
Biotechnology & Applied Microbiology
Y Wang, HL Jiao, JZ Zhang, RQ He
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
(2004)
Article
Chemistry, Medicinal
LJ Chen, XQ Yang, HL Jiao, BL Zhao
CHEMICAL RESEARCH IN TOXICOLOGY
(2003)
Article
Biochemistry & Molecular Biology
HL Jiao, P Ye, BL Zhao
FREE RADICAL BIOLOGY AND MEDICINE
(2003)