Synthesis of deuterium-enriched sorafenib derivatives and evaluation of their biological activities

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(2018) María Reig et al.   JOURNAL OF HEPATOLOGY

FDA approves first deuterated drug

(2017) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Recent advances in hepatocellular carcinoma therapy

(2017) Rinku Dutta et al.   PHARMACOLOGY & THERAPEUTICS

Deuterated Drugs

(2015) Robert H. Howland   JOURNAL OF PSYCHOSOCIAL NURSING AND MENTAL HEALTH SERVICES

Hepatocellular carcinoma: clinical frontiers and perspectives

(2014) Jordi Bruix et al.   GUT

Using Deuterium in Drug Discovery: Leaving the Label in the Drug

(2013) Thomas G. Gant   JOURNAL OF MEDICINAL CHEMISTRY

Large deuterium isotope effects and their use: a historical review

(2011) Peter Krumbiegel   ISOTOPES IN ENVIRONMENTAL AND HEALTH STUDIES

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

(2010) Sonja J. Heidorn et al.   CELL

Sorafenib Overcomes TRAIL Resistance of Hepatocellular Carcinoma Cells through the Inhibition of STAT3

(2010) K.-F. Chen et al.   CLINICAL CANCER RESEARCH

Sorafenib

(2009) Gillian M. Keating et al.   DRUGS

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE