Article
Chemistry, Physical
Abdelmalik Brik, Mustapha El Kadiri, Taha El Assimi, Paolo Dambruoso, Redouane Beniazza, Geraldine Gouhier, Abdelkrim El Kadib, Mohammed Lahcini
Summary: A novel solid catalyst CS@PIL@Bi based on chitosan grafted with phosphonium ionic liquid (CS@PIL) supporting bismuth (Bi) was synthesized via a two-step process. The resulting catalyst showed remarkable efficiency and recyclability in the one-step Pietro Biginelli condensation reaction.
MOLECULAR CATALYSIS
(2023)
Article
Chemistry, Organic
Jeremy R. Tuck, Robert J. Tombari, Noah Yardeny, David E. Olson
Summary: In this study, arylazo-1,2,3-triazoles were successfully synthesized using azide-alkyne click chemistry, showcasing high thermal stabilities and near-quantitative bidirectional photoconversion.
Article
Polymer Science
Burcu Alkan, Ozgun Daglar, Serter Luleburgaz, Begum Gungor, Ufuk Saim Gunay, Gurkan Hizal, Umit Tunca, Hakan Durmaz
Summary: A novel one-pot cascade reaction was proposed for the synthesis and simultaneous modification of polyesters, utilizing the Passerini three-component reaction. The study emphasized the significance of temperature in achieving high molecular weight polymers and efficient reactions.
Review
Chemistry, Applied
Farid Ahmed, Hai Xiong
Summary: This review summarizes the latest developments in chemosensors based on click generated triazoles for a range of metal cations, anions, and neutral analytes, highlighting the need for continuous research accumulation in this rapidly growing field to meet demand.
Article
Chemistry, Organic
Mohammad Sadegh Asgari, Saeed Bahadorikhalili, Aram Ghaempanah, Parviz Rashidi Ranjbar, Rahmatollah Rahimi, Alireza Abbasi, Bagher Larijani, Mohammad Mahdavi
Summary: In this study, novel amide linked 1,2,3-triazoles containing aryloxy derivatives were synthesized efficiently via copper-catalyzed one-pot sequential reaction, with high isolated yields.
TETRAHEDRON LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Hassan Farhid, Hanieh Mohammadi Araghi, Ahmad Shaabani, Behrouz Notash
Summary: A sustainable, economical, and straightforward synthetic route utilizing higher-order multicomponent reactions (MCRs) is developed for the unification of biologically significant quinoxaline-pseudopeptide-triazole pharmacophores. The strategy involves a one-pot, six-component, tandem cyclocondensation/Ugi/click reaction sequence, which efficiently produces complex pharmaceutically desirable compounds from easily accessible precursors. This procedure offers advantages including benign reaction conditions, energy efficiency, operational simplicity, pot economy, high bond-forming economy, high atom economy, and excellent overall yields.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Rasheed A. A. Adigun, Frederick P. P. Malan, Mohammed O. O. Balogun, Natasha October
Summary: In response to the resistance of malaria parasite towards quinoline-based antimalarial drugs, a study has employed quinoline-containing compounds combined with dihydropyrimidinone (DHPM) analogues as resistance reversal agents (RAs) to investigate their antimalarial activities. By using click chemistry, the study linked DHPM and quinoline compounds which offered synthetic advantages over amide coupling. Among the synthesized compounds, 4 hybrids with the 7-chloroquinoline moiety showed potent antimalarial activity below 1 μM while mefloquine-containing compounds showed lower activity compared to chloroquine (CQ) and the 7-chloroquinoline hybrids.
STRUCTURAL CHEMISTRY
(2023)
Article
Chemistry, Organic
Zi-Qi Geng, Chunhui Zhao, Hao-Dong Qian, Si-Jia Li, Hao Peng, Hao Xu
Summary: A Cu/Ag relay catalyzed cascade reaction was used to synthesize chiral triazole-fused pyrazine scaffolds. This method utilized a novel N,N,P-ligand and showed high efficiency, functional group tolerance, excellent enantioselectivities, and a broad substrate scope using readily available starting materials.
Article
Biochemistry & Molecular Biology
Jaydeep A. Mokariya, Anirudhdha G. Kalola, Pratibha Prasad, Manish P. Patel
Summary: An environmentally friendly and high yielding one-pot protocol has been developed for the click reaction of N-propargyl-3-formylindole, chloroacetic acid/ester, and sodium azide using CuI catalyst under simultaneous ultrasound and microwave irradiation. The protocol aims to eliminate the handling of organic azides, making the click process user-friendly and safe. The synthesized compounds show inhibitory action against various pathogenic strains, with some exhibiting excellent potency against E.Coli and P. Aeruginosa.
MOLECULAR DIVERSITY
(2022)
Article
Chemistry, Organic
Cong Guan, Jiabin Yin, Jian Ji, Jinhua Liu, Xiang Wu, Tong Zhu, Shunying Liu
Summary: A regioselective electrochemical C-H amination method using easily accessible ethers has been developed to synthesize N (2)-substituted 1,2,3-triazole. Multiple substituents, including heterocycles, were well-tolerated, and 24 examples were obtained in moderate to good yields. Control experiments and DFT calculations revealed that the electrochemical synthesis occurs through a N-tosyl 1,2,3-triazole radical cation process, promoted by single-electron transfer from the lone pair electrons of the aromatic N-heterocycle, and the desulfonation is responsible for the high N (2)-regioselectivity.
Review
Chemistry, Organic
Aslihan Ayvaz, Sinem Gorkem Demirbas, Ahmet Demirbas, Neslihan Demirbas
Summary: Due to the increasing environmental pollution and its detrimental impact on the ecosystem, scientists have developed new chemical strategies using eco-friendly chemicals, solvents, catalysts, and alternative energy sources. Deep eutectic solvents (DESs) are low-melting mixtures primarily consisting of quaternary ammonium salt and hydrogen-bond acceptors. DESs have advantages such as low toxicity, easy preparation, low cost, biodegradability, low vapor pressure, and recyclability.
CURRENT ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Applied
Parviz Movaheditabar, Mohammad Javaherian, Valiollah Nobakht
Summary: A new curcumin-based bidentate linker ligand, CurOAc, and its corresponding zinc-organic framework, Zn-CurOAc, were designed, synthesized and characterized. Zn-CurOAc showed excellent catalytic performance in the one-pot three-component Biginelli condensation reaction.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Jose Laxio Arenas, Pascal Retailleau, Jean-Michel Gillet, Nour-Eddine Ghermani, Sandrine Ongeri, Benoit Crousse
Summary: The 5-fluoro triazole amino acid scaffold prepared by halogen exchange was successfully incorporated into peptides. The X-ray diffraction results revealed an important localization of the 5-fluoro triazole motif on one side of the negative potential surface, with the fluorine atom showing a cylindrical shape in its electron density deformation.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Wei-Bao He, Sai-Jie Zhao, Jing-Yang Chen, Jun Jiang, Xiang Chen, Xinhua Xu, Wei-Min He
Summary: A practical method for the synthesis of 4-thiocyanato-1H-pyrazoles was established through an electrochemical cascade reaction of hydrazines, 1,3-diones and NH4SCN under metal-, chemical oxidant- and external electrolyte-free conditions. Importantly, both a gram-scale synthesis of 4-thiocyanato-1H-pyrazoles and five one-pot sequential transformations starting from hydrazine were successfully achieved.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Menghan Cui, Changhui Su, Rong Wang, Qing Yang, Chunxiang Kuang
Summary: This novel and green route involves the direct synthesis of vinyl triazole derivatives with alkynes and triazoles promoted by an inorganic base under transition metal-free conditions, showing great catalytic activity for the anti-Markovnikov stereoselective hydroamination of alkynes. Good yields with excellent functional group tolerance are successfully achieved for a range of substrates, making it an advanced concept for the synthesis of alkenyl triazole with a versatile and cost-efficient approach.
Article
Biochemistry & Molecular Biology
Mahdi Abbas-Mohammadi, Mahdi Moridi Farimani, Peyman Salehi, Samad Nejad Ebrahimi, Ali Sonboli, Celine Kelso, Danielle Skropeta
Summary: In this study, a molecular networking approach was used to analyze the chemical profile of a medicinal plant extract with AChE activity. A total of 44 compounds were identified, with glycosylated flavonoid querciturone showing the highest affinity and several compounds showing stronger activity against AChE than the clinically used drug donepezil.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Chemistry, Applied
Dara Dastan, Baram Ahmed Hamah-Ameen, Peyman Salehi, Hiva Ghaderi, Mansour Miran
Summary: The essential oils from leaves, flowers, immature and mature fruits of Ferula pseudalliacea, a wild plant in Iran, demonstrated antibacterial and antioxidant activities. They showed inhibition against several bacteria and had potential applications in the food and medicine industry.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Physical
Faezeh Fathi, Samad N. Ebrahimi, Peyman Salehi, Atefeh Safari, Zeinab Shahsavari, Javad Hadian, Luis Carlos Matos, Rita C. Alves, Maria Beatriz Prior Pinto Oliveira
Summary: This study formulated a multi-component nanoemulsion with significant antibacterial activity, which could potentially be used as a natural preservative in the food, agriculture, and cosmetic industries.
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Minoo Dabiri, Hassan Esmaielie Tavil, Noushin Farajinia Lehi, Siyavash Kazemi Movahed, Aram Mnachekanian Salmasi, Sepideh Souri
Summary: An effective and recyclable catalyst based on tungstate ion immobilization on magnetic ionic liquid modified graphene oxide (WO4@Fe3O4/GO-IL) was synthesized, characterized, and demonstrated to have catalytic activity in the selective oxidation of sulfides. The catalyst was easily recovered and successfully reused using an external magnet for multiple reaction cycles without significant reduction in activity or selectivity.
JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
(2022)
Article
Chemistry, Multidisciplinary
Sedigheh Sadat Naeimi, Peyman Salehi, Morteza Bararjanian
Summary: The synthesis of prolinamide derivatives of (R)-tetrahydropapaverine and their application as organocatalysts in asymmetric Aldol reaction were reported. Catalyst 2 showed the best catalytic activity in the reaction between cyclohexanone and 4-nitrobenzaldehyde, achieving up to 90% enantiomeric excess. Unlike the anti-stereoselectivity observed in the presence of L-proline alone, the hybridization with (R)-tetrahydropapaverine resulted in the formation of syn products as the major compounds.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Medicinal
Majid Nami, Peyman Salehi, Morteza Bararjanian, Nazanin Seighal Delshad, Bahareh Heidari, Mona Khoramjouy, Soraya Shahhosseini, Mehrdad Faizi
Summary: A series of novel triazole compounds containing derivatives of norsufentanil were synthesized and evaluated for their affinity and anti-nociceptive activity. Compound 3h exhibited the highest affinity and potency among all the selected compounds.
MEDICINAL CHEMISTRY RESEARCH
(2022)
Article
Chemistry, Physical
Neda Salarinejad, Minoo Dabiri, Siyavash Kazemi Movahed
Summary: Pd/N-RGO nanohybrid was used as a catalyst for efficient C-H acyloxylation and halogenation reactions. The introduction of nitrogen into the graphene lattice enhanced the catalytic activities of palladium, and the catalyst showed no significant palladium leaching, allowing for its successful recovery and reuse without any noticeable decrease in catalytic activity.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2022)
Article
Chemistry, Medicinal
Zohreh Mousavimanesh, Mostafa Shahnani, Amirmohammad Faraji-Shovey, Morteza Bararjanian, Ahmad Shahir Sadr, Alireza Ghassempour, Peyman Salehi
Summary: Noscapine, a compound derived from opium poppy, shows potential for enantioselective separation of various compounds due to its distinctive chiral structure and chemistry. Researchers have synthesized a new noscapine derivative chiral stationary phase (ND-CSP) with better enantioresolution performance, stability, reproducibility, and loading capacity. This stationary phase provides a considerable surface coverage and has been successfully used for the enantioseparation of different compounds.
Article
Chemistry, Physical
Niloofar Savadkouhi, Peyman Salehi, Houri Sepehri, Ladan Delphi, Hasan Rafati
Summary: In this study, PEGylated derivatives of noscapine with enhanced solubility were synthesized and their anticancer activities were evaluated. The results showed that increasing the PEG chain length improved the water solubility and cytotoxicity of the derivatives. These new PEGylated compounds may have the potential to be developed as novel anticancer drugs.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Medicinal
Zahra Hasanpour, Peyman Salehi, Atousa Aliahmadi, Mahdieh Hoseinpour, Hossein Behboodi, Dan Staerk, Morteza Bararjanian
Summary: In this study, new 1,2,3-triazole-tethered analogs of N-northebaine were synthesized and their anti-bacterial properties were evaluated. Compounds 5b, 5j, and 5m showed strong activities against Staphylococcus aureus, surpassing the parent compound. These compounds and thebaine were also found to have potential as wound healing agents based on their cytotoxicity, proliferation, and anti-hemolytic activities. Compound 5j showed no inhibition of cell line growth and exhibited no hemolysis activity at different doses.
MEDICINAL CHEMISTRY RESEARCH
(2023)
Article
Plant Sciences
Kaveh Rasoolijokari, Peyman Salehi, Atousa Aliahmadi, Bahareh Heidari, Morteza Bararjanian
Summary: A series of 12 novel 1,2,3-triazole penicillin G derivatives were synthesized and evaluated for their antimicrobial activity. Compounds 5a and 5b showed the highest potency in inhibiting the growth of Staphylococcus aureus.
PHYTOCHEMISTRY LETTERS
(2023)
Review
Pharmacology & Pharmacy
Mona Kamelan Zargar Zarin, Wim Dehaen, Peyman Salehi, Amir Ata Bahmani Asl
Summary: Morphine and codeine, commonly used opioids, have significant side effects, necessitating the development of derivatives. Biological studies on semi-synthetic derivatives of both morphine and codeine have shown their significance in the development of potent opioids.
Article
Chemistry, Multidisciplinary
Mohadeseh Karbasi, Peyman Salehi, Atousa Aliahmadi, Morteza Bararjanian, Farzaneh Zandi
Summary: New N-substituted alpha-aminonitrile derivatives were synthesized from menthol via consecutive succinic ester formation, propargylation, 1,3-dipolar Huisgen cycloaddition, and Strecker reaction. The structures of the synthesized compounds were confirmed using spectroscopic techniques. These novel compounds showed strong inhibitory effects against Staphylococcus aureus and Escherichia coli, with the best inhibitory effects exhibited by derivatives 6a2, 6b1, 6b4, and 6b5.
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Mohadeseh Karbasi, Peyman Salehi, Atousa Aliahmadi, Morteza Bararjanian, Farzaneh Zandi
Summary: New N-substituted alpha-aminonitrile derivatives from menthol were synthesized using consecutive chemical reactions, and their structures were confirmed by spectroscopic techniques. The synthesized compounds showed strong inhibitory effects against Staphylococcus aureus.
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Zahra Davarzani, Peyman Salehi, S. Mohsen Asghari, Morteza Bararjanian, Ali Hamrahi Mohsen, Helia Dehghan Harati
Summary: In this study, 20 amino acid conjugated derivatives of noscapine and cotarnine were synthesized and evaluated for their anticancer activity. The results showed that noscapine-tryptophan exhibited higher antitumor activity and inhibited tumor growth more effectively in a mouse model of mammary carcinoma, without adverse effects.
